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Article ; Online: Calcium carbonate precipitating extremophilic bacteria in an Alpine ice cave.

Lange-Enyedi, Nóra Tünde / Németh, Péter / Borsodi, Andrea K / Spötl, Christoph / Makk, Judit

2024 Volume 14, Issue 1, Page(s) 2710

Abstract: Extensive research has provided a wealth of data on prokaryotes in caves and their role in biogeochemical cycles. Ice caves in carbonate rocks, however, remain enigmatic environments with limited knowledge of their microbial taxonomic composition. In ... ...

Abstract	Extensive research has provided a wealth of data on prokaryotes in caves and their role in biogeochemical cycles. Ice caves in carbonate rocks, however, remain enigmatic environments with limited knowledge of their microbial taxonomic composition. In this study, bacterial and archaeal communities of the Obstans Ice Cave (Carnic Alps, Southern Austria) were analyzed by next-generation amplicon sequencing and by cultivation of bacterial strains at 10 °C and studying their metabolism. The most abundant bacterial taxa were uncultured Burkholderiaceae and Brevundimonas spp. in the drip water, Flavobacterium, Alkanindiges and Polaromonas spp. in the ice, Pseudonocardia, Blastocatella spp., uncultured Pyrinomonadaceae and Sphingomonadaceae in carbonate precipitates, and uncultured Gemmatimonadaceae and Longimicrobiaceae in clastic cave sediments. These taxa are psychrotolerant/psychrophilic and chemoorganotrophic bacteria. On a medium with Mg
MeSH term(s)	Archaea/classification ; Bacteria/classification ; Calcium Carbonate/metabolism ; Ice ; Phylogeny ; Extremophiles/classification
Chemical Substances	Calcium Carbonate (H0G9379FGK) ; Ice
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53131-y
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Article ; Online: Negative Influence by the Force: Mechanically Induced Hyperpolarization via K

Lengyel, Miklós / Enyedi, Péter / Czirják, Gábor

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: The two-pore domain ... ...

Abstract	The two-pore domain K
MeSH term(s)	Animals ; Cell Membrane/metabolism ; Humans ; Lipid Bilayers/metabolism ; Membrane Potentials/physiology ; Physical Phenomena ; Potassium Channels, Tandem Pore Domain/metabolism
Chemical Substances	Lipid Bilayers ; Potassium Channels, Tandem Pore Domain
Language	English
Publishing date	2021-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22169062
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Article ; Online: Rare diseases caused by abnormal calcium sensing and signalling.

Tőke, Judit / Czirják, Gábor / Enyedi, Péter / Tóth, Miklós

Endocrine

2021 Volume 71, Issue 3, Page(s) 611–617

Abstract: The calcium-sensing receptor (CaSR) provides the major mechanism for the detection of extracellular calcium concentration in several cell types, via the induction of G-protein-coupled signalling. Accordingly, CaSR plays a pivotal role in calcium ... ...

Abstract	The calcium-sensing receptor (CaSR) provides the major mechanism for the detection of extracellular calcium concentration in several cell types, via the induction of G-protein-coupled signalling. Accordingly, CaSR plays a pivotal role in calcium homeostasis, and the CaSR gene defects are related to diseases characterized by serum calcium level changes. Activating mutations of the CaSR gene cause enhanced sensitivity to extracellular calcium concentration resulting in autosomal dominant hypocalcemia or Bartter-syndrome type V. Inactivating CaSR gene mutations lead to resistance to extracellular calcium. In these cases, familial hypocalciuric hypercalcaemia (FHH1) or neonatal severe hyperparathyroidism (NSHPT) can develop. FHH2 and FHH3 are associated with mutations of genes of partner proteins of calcium signal transduction. The common polymorphisms of the CaSR gene have been reported not to affect the calcium homeostasis itself; however, they may be associated with the increased risk of malignancies.
MeSH term(s)	Calcium ; Humans ; Hypercalcemia/genetics ; Hypocalcemia/genetics ; Infant, Newborn ; Mutation ; Rare Diseases ; Receptors, Calcium-Sensing/genetics
Chemical Substances	Receptors, Calcium-Sensing ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-021-02620-5
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Article ; Online: Negative Influence by the Force

Miklós Lengyel / Péter Enyedi / Gábor Czirják

International Journal of Molecular Sciences, Vol 22, Iss 9062, p

Mechanically Induced Hyperpolarization via K 2P Background Potassium Channels

2021 Volume 9062

Abstract: The two-pore domain K 2P subunits form background (leak) potassium channels, which are characterized by constitutive, although not necessarily constant activity, at all membrane potential values. Among the fifteen pore-forming K 2P subunits encoded by ... ...

Abstract	The two-pore domain K 2P subunits form background (leak) potassium channels, which are characterized by constitutive, although not necessarily constant activity, at all membrane potential values. Among the fifteen pore-forming K 2P subunits encoded by the KCNK genes, the three members of the TREK subfamily, TREK-1, TREK-2, and TRAAK are mechanosensitive ion channels. Mechanically induced opening of these channels generally results in outward K + current under physiological conditions, with consequent hyperpolarization and inhibition of membrane potential-dependent cellular functions. In the past decade, great advances have been made in the investigation of the molecular determinants of mechanosensation, and members of the TREK subfamily have emerged among the best-understood examples of mammalian ion channels directly influenced by the tension of the phospholipid bilayer. In parallel, the crucial contribution of mechano-gated TREK channels to the regulation of membrane potential in several cell types has been reported. In this review, we summarize the general principles underlying the mechanical activation of K 2P channels, and focus on the physiological roles of mechanically induced hyperpolarization.
Keywords	mechanosensitive ; potassium channel ; membrane tension ; stretch ; KCNK2 ; KCNK4 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Get reliable laboratory findings - how to recognize the deceptive effects of angiotensin-converting enzyme inhibitor therapy in the laboratory diagnostics of sarcoidosis?

Szabó, Attila Ádám / Enyedi, Enikő Edit / Altorjay, István Tibor / Hajnal, Péter / Pintér, Tamás Bence / Mányiné, Ivetta Siket / Váradi, Csongor / Bányai, Emese / Tóth, Attila / Papp, Zoltán / Fagyas, Miklós

Clinical chemistry and laboratory medicine

2024

Abstract: Objectives: Serum angiotensin-converting enzyme (ACE) is the only biomarker routinely used in the laboratory diagnostics of sarcoidosis, and ACE inhibitor (ACEi) drugs are among the most prescribed drugs worldwide. Taking ACEi can mislead medical teams ... ...

Abstract	Objectives: Serum angiotensin-converting enzyme (ACE) is the only biomarker routinely used in the laboratory diagnostics of sarcoidosis, and ACE inhibitor (ACEi) drugs are among the most prescribed drugs worldwide. Taking ACEi can mislead medical teams by lowering ACE activity, delaying diagnosis and giving a false impression of disease activity of sarcoidosis. We aimed to develop a simple method to detect the presence of ACEi drugs in samples, to investigate the ACEi medication-caused interference and consequences in a retrospective study. Methods: ACE activity and the level of ACE inhibition were determined for 1823 patients with suspected sarcoidosis. These values were compared with the therapeutic information at the first and follow-up visits. Results: A total of 302 patients had biochemical evidence of an ACEi drug effect during diagnostic ACE activity testing. In their case, ACE activity was significantly lower (median(IQR): 4.41 U/L(2.93-6.72)) than in patients not taking ACEi (11.32 U/L(8.79-13.92), p<0.01). In 62 sarcoidosis patients, the ACEi reduced ACE activity to the reference range or below. Only in 40 % of the cases was the medication list recorded in the outpatient chart and only in 3 cases was low ACE activity associated with ACEi use. 67 % of the repeated ACE activity measurements were also performed during ACEi therapy. Conclusions: Our study revealed that the use of ACEi is common in patients with suspected sarcoidosis. The ACE activity lowering effect of ACEi drugs may escape the attention of medical teams which can lead to diagnostic errors and unnecessary tests. Nevertheless, these pitfalls can be avoided by using a method suggested by our team.
Language	English
Publishing date	2024-01-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2023-1288
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Article ; Online: TRESK (K2P18.1) Background Potassium Channel Is Activated by Novel-Type Protein Kinase C via Dephosphorylation.

Pergel, Enikő / Lengyel, Miklós / Enyedi, Péter / Czirják, Gábor

Molecular pharmacology

2019 Volume 95, Issue 6, Page(s) 661–672

Abstract: TRESK (K2P18.1) background ... ...

Abstract	TRESK (K2P18.1) background K
MeSH term(s)	Animals ; Animals, Genetically Modified ; Calcineurin/metabolism ; Humans ; Mutation ; Phosphorylation ; Potassium Channels/genetics ; Potassium Channels/metabolism ; Protein Kinase C/metabolism ; Serine/metabolism ; Tetradecanoylphorbol Acetate/pharmacology ; Xenopus laevis/genetics ; Xenopus laevis/growth & development
Chemical Substances	KCNK18 protein, human ; Potassium Channels ; Serine (452VLY9402) ; Protein Kinase C (EC 2.7.11.13) ; Calcineurin (EC 3.1.3.16) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
Language	English
Publishing date	2019-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	124034-1
ISSN	1521-0111 ; 0026-895X
ISSN (online)	1521-0111
ISSN	0026-895X
DOI	10.1124/mol.119.116269
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Article ; Online: TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.

Lengyel, Miklós / Czirják, Gábor / Jacobson, David A / Enyedi, Péter

The Journal of biological chemistry

2020 Volume 295, Issue 35, Page(s) 12408–12425

Abstract: Two-pore-domain potassium channels ( ... ...

Abstract	Two-pore-domain potassium channels (K
MeSH term(s)	Animals ; HEK293 Cells ; Humans ; Ion Transport ; Mice ; Neurons/cytology ; Neurons/metabolism ; Potassium/metabolism ; Potassium Channels/genetics ; Potassium Channels/metabolism ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Protein Multimerization ; Somatosensory Cortex/cytology ; Somatosensory Cortex/metabolism ; Xenopus laevis
Chemical Substances	Kcnk10 protein, mouse ; Potassium Channels ; Potassium Channels, Tandem Pore Domain ; Trik protein, mouse ; Potassium (RWP5GA015D)
Language	English
Publishing date	2020-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA120.014125
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Article ; Online: NGR-Based Radiopharmaceuticals for Angiogenesis Imaging: A Preclinical Review.

Trencsényi, György / Enyedi, Kata Nóra / Mező, Gábor / Halmos, Gábor / Képes, Zita

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: ... several positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radioisotopes have been applied ...

Abstract	Angiogenesis plays a crucial role in tumour progression and metastatic spread; therefore, the development of specific vectors targeting angiogenesis has attracted the attention of several researchers. Since angiogenesis-associated aminopeptidase N (APN/CD13) is highly expressed on the surface of activated endothelial cells of new blood vessels and a wide range of tumour cells, it holds great promise for imaging and therapy in the field of cancer medicine. The selective binding capability of asparagine-glycine-arginine (NGR) motif containing molecules to APN/CD13 makes radiolabelled NGR peptides promising radiopharmaceuticals for the non-invasive, real-time imaging of APN/CD13 overexpressing malignancies at the molecular level. Preclinical small animal model systems are major keystones for the evaluation of the in vivo imaging behaviour of radiolabelled NGR derivatives. Based on existing literature data, several positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radioisotopes have been applied so far for the labelling of tumour vasculature homing NGR sequences such as Gallium-68 (
MeSH term(s)	Animals ; Radiopharmaceuticals ; Endothelial Cells ; CD13 Antigens ; Cardiovascular Physiological Phenomena ; Disease Models, Animal
Chemical Substances	Radiopharmaceuticals ; CD13 Antigens (EC 3.4.11.2)
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612675
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Article ; Online: Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation.

Guntur, Divya / Olschewski, Horst / Enyedi, Péter / Csáki, Réka / Olschewski, Andrea / Nagaraj, Chandran

Biomolecules

2021 Volume 11, Issue 11

Abstract: Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell's membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or ... ...

Abstract	Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell's membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or changes in intracellular free calcium. Large conductance calcium-activated potassium (BKCa) channels assemble from pore forming and various modulatory and auxiliary subunits. They are of vital significance due to their very high unitary conductance and hence their ability to rapidly cause extreme changes in the membrane potential. The pathophysiology of lung diseases in general and pulmonary hypertension, in particular, show the implication of either decreased expression and partial inactivation of BKCa channel and its subunits or mutations in the genes encoding different subunits of the channel. Signaling molecules, circulating humoral molecules, vasorelaxant agents, etc., have an influence on the open probability of the channel in pulmonary arterial vascular cells. BKCa channel is a possible therapeutic target, aimed to cause vasodilation in constricted or chronically stiffened vessels, as shown in various animal models. This review is a comprehensive collation of studies on BKCa channels in the pulmonary circulation under hypoxia (hypoxic pulmonary vasoconstriction; HPV), lung pathology, and fetal to neonatal transition, emphasising pharmacological interventions as viable therapeutic options.
MeSH term(s)	Calcium ; Large-Conductance Calcium-Activated Potassium Channels ; Pulmonary Circulation
Chemical Substances	Large-Conductance Calcium-Activated Potassium Channels ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-11-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11111629
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Article ; Online: TRESK background potassium channel modifies the TRPV1-mediated nociceptor excitability in sensory neurons.

Lengyel, Miklós / Hajdu, Dominika / Dobolyi, Alice / Rosta, Judit / Czirják, Gábor / Dux, Mária / Enyedi, Péter

Cephalalgia : an international journal of headache

2021 Volume 41, Issue 7, Page(s) 827–838

Abstract: Background: TWIK-related spinal cord potassium channel (TRESK) background potassium channels have a key role in controlling resting membrane potential and excitability of sensory neurons. A frameshift mutation leading to complete loss of TRESK function ... ...

Abstract	Background: TWIK-related spinal cord potassium channel (TRESK) background potassium channels have a key role in controlling resting membrane potential and excitability of sensory neurons. A frameshift mutation leading to complete loss of TRESK function has been identified in members of a family suffering from migraine with aura. In the present study, we examined the role of TRESK channels on nociceptor function in mice. Methods: Calcium imaging was used to investigate the role of TRESK channels in the modulation of the response evoked by transient receptor potential vanilloid 1 (TRPV1) receptor stimulation in dorsal root ganglion neurons. Release of calcitonin gene-related peptide from trigeminal afferents and changes in meningeal blood flow were also measured. Experiments were performed on wild-type and TRESK knockout animals. Results: Inhibition of TRESK increased the TRPV1-mediated calcium signal in dorsal root ganglion neurons and potentiated capsaicin-induced increases in calcitonin gene-related peptide release and meningeal blood flow. Activation of TRESK decreased the capsaicin sensitivity of sensory neurons, leading to an attenuation of capsaicin-induced increase in meningeal blood flow. In TRESK knockout animals, TRPV1-mediated nociceptive reactions were unaffected by pretreatment with TRESK modulators. Conclusions: Pharmacological manipulation of TRESK channels influences the TRPV1-mediated functions of nociceptors. Altered TRESK function might contribute to trigeminal nociceptor sensitization in migraine patients.
MeSH term(s)	Animals ; Calcitonin Gene-Related Peptide/metabolism ; Capsaicin ; Humans ; Mice ; Migraine Disorders ; Nociceptors/metabolism ; Potassium Channels ; Potassium Channels, Tandem Pore Domain ; Sensory Receptor Cells/metabolism ; TRPV Cation Channels/genetics
Chemical Substances	KCNK18 protein, human ; Potassium Channels ; Potassium Channels, Tandem Pore Domain ; TRPV Cation Channels ; TRPV1 protein, human ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	604567-4
ISSN	1468-2982 ; 0333-1024
ISSN (online)	1468-2982
ISSN	0333-1024
DOI	10.1177/0333102421989261
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