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Article ; Online: ASO Author Reflections: Pushing the Limits in Laparoscopic Liver Surgery for Hepatocellular Carcinoma.

Berardi, Giammauro / Colasanti, Marco / Ettorre, Giuseppe Maria

2022 Volume 29, Issue Suppl 3, Page(s) 587–588

MeSH term(s)	Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Laparoscopy ; Abdomen
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-11322-1
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Article ; Online: Inflammation-induced reorientation of reward versus punishment sensitivity is attenuated by minocycline.

De Marco, Riccardo / Barritt, Andrew W / Cercignani, Mara / Cabbai, Giulia / Colasanti, Alessandro / Harrison, Neil A

Brain, behavior, and immunity

2023 Volume 111, Page(s) 320–327

Abstract: Background: Inflammation rapidly reorients motivational state, mood is impaired, pleasurable activities avoided and sensitivity to negative stimuli enhanced. When sustained, this can precipitate major depressive episodes. In humans, this has been linked ...

Abstract	Background: Inflammation rapidly reorients motivational state, mood is impaired, pleasurable activities avoided and sensitivity to negative stimuli enhanced. When sustained, this can precipitate major depressive episodes. In humans, this has been linked to opposing actions of inflammation on striatal/insula reward/punishment learning signals while in rodents, motivational impairments can be attenuated with minocycline, implicating a mechanistic role for microglia. Here we investigated whether minocycline also inhibits the reorienting effects of lipopolysaccharide (LPS) on reward/punishment sensitivity in humans. Methods Using a crossover design, fifteen healthy volunteers underwent two experimental sessions in which they each received LPS (1 ng/kg) and placebo. Half (N = 8) received minocycline (100 mg bd) and half (N = 7) an identical looking placebo for 3½ days before each session. Six hours post-injection participants completed a probabilistic instrumental learning task in which they had to learn to select high probability reward (win £1) and avoid high probability punishment (lose £1) stimuli to maximise their gains and minimize losses. Physiological and sickness responses were sampled hourly and blood sampled at baseline, 3 and 6 h post-injection. Results LPS induced robust peripheral physiological: temperature, heart rate and immune: differential white cell, IL-6, TNF-α, IL-8, IL-10 responses (all condition × time interactions: p < 0.005), none were significantly modulated by minocycline (p > 0.1). LPS also biased behavior, enhancing punishment compared with reward sensitivity (F
MeSH term(s)	Humans ; Punishment ; Minocycline/pharmacology ; Lipopolysaccharides/pharmacology ; Depressive Disorder, Major ; Reward ; Inflammation/drug therapy
Chemical Substances	Minocycline (FYY3R43WGO) ; Lipopolysaccharides
Language	English
Publishing date	2023-04-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2023.04.010
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association of Sarcopenia and Body Composition With Postoperative 90-Day Morbidity After Liver Resection for Malignant Tumors-Reply.

Berardi, Giammauro / Colasanti, Marco / Ettorre, Giuseppe Maria

JAMA surgery

2021 Volume 156, Issue 6, Page(s) 590–591

MeSH term(s)	Body Composition ; Humans ; Liver ; Morbidity ; Neoplasms ; Sarcopenia/epidemiology
Language	English
Publishing date	2021-05-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2021.0234
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Article: Amyloid-β 25-35 Induces Neurotoxicity through the Up-Regulation of Astrocytic System X

D'Ezio, Veronica / Colasanti, Marco / Persichini, Tiziana

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 11

Abstract: Amyloid-β (Aβ) deposition, a hallmark of Alzheimer's disease, is known to induce free radical production and oxidative stress, leading to neuronal damage. During oxidative stress, several cell types (including astrocytes) can activate the nuclear factor ... ...

Abstract	Amyloid-β (Aβ) deposition, a hallmark of Alzheimer's disease, is known to induce free radical production and oxidative stress, leading to neuronal damage. During oxidative stress, several cell types (including astrocytes) can activate the nuclear factor erythroid 2-related factor 2 (Nrf2), a regulator of several phase II detoxifying and antioxidant genes, such as the System X
Language	English
Publishing date	2021-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10111685
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Article: Impact of COVID-19 Pandemic on Treatment and Outcome of Fragility Hip Fractures In Non-COVID Patients: Comparison Between the Lockdown Period, a Historical Series and the "Pandemic Normality" in a Single Institution.

Troiano, Elisa / De Sensi, Alice Giulia / Zanasi, Francesco / Facchini, Andrea / De Marco, Giulia / Colasanti, Giovanni Battista / Mondanelli, Nicola / Giannotti, Stefano

Geriatric orthopaedic surgery & rehabilitation

2023 Volume 14, Page(s) 21514593231152420

Abstract: Introduction: The COVID-19 pandemic has affected and is still deeply affecting all aspects of public life. World governments have been forced to enact restrictive measures to stem the contagion which have led to a decrease in the movement of people ... ...

Abstract	Introduction: The COVID-19 pandemic has affected and is still deeply affecting all aspects of public life. World governments have been forced to enact restrictive measures to stem the contagion which have led to a decrease in the movement of people within national territory and to a redirection of health care resources with a suspension of non-urgent procedures. In Italy, a lockdown was imposed from March 9 Methods: The aim of this paper was to examine the impact of COVID-19 on the operating volume for trauma surgeries and to determine how the pandemic affected the management of fragility hip fractures (FHFs) in non-COVID patients at a single Institution. Results: The first result was a statistically significant reduction in the overall operative volume of orthopedic trauma during the period of the first lockdown and an increase in the mean age of patients undergoing surgery, as expected. As regard to the second aim, the incidence of FHFs remained almost unchanged during the periods analysed. The population examined were superimposable in terms of demographics, comorbidities, type of fracture, peri-operative complications, percentage of operations performed within 48 hours from hospitalization and 1-year outcome. Discussion: Our results are in line with those already present in the Literature. Conclusions: Our study revealed a significant impact of the restrictive anti-contagion measures on the overall orthopedic surgical volume, but, at the same time, we could affirm that the pandemic did not affect the management of FHFs in non-COVID patients, and their results.
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589094-3
ISSN	2151-4593 ; 2151-4585
ISSN (online)	2151-4593
ISSN	2151-4585
DOI	10.1177/21514593231152420
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Article: The Role of Pre-Pandemic Mental Health Status and Personality Traits on Psychological Distress during the COVID-19 Lockdown among Italian Young Adults.

Marchetti, Daniela / Fontanesi, Lilybeth / Camisasca, Elena / Colasanti, Marco / Covelli, Venusia / Di Giandomenico, Serena / Miragoli, Sarah / Verrocchio, Maria Cristina

Behavioral sciences (Basel, Switzerland)

2023 Volume 13, Issue 2

Abstract: The COVID-19 pandemic imposed changes on day-to-day activities and had a detrimental psychological effect on the population, especially among vulnerable individuals, such as adolescents and young adults. The current study aimed to explore variables ... ...

Abstract	The COVID-19 pandemic imposed changes on day-to-day activities and had a detrimental psychological effect on the population, especially among vulnerable individuals, such as adolescents and young adults. The current study aimed to explore variables associated with anxiety, depressive and somatic symptoms in a sample of 608 Italian young adults aged 18 to 25. Data were collected using an online questionnaire administered two months into the COVID-19 lockdown, which explored several areas including sociodemographic information, pre-pandemic and current psychological distress, pre-pandemic and current levels of loneliness, and the traits of intolerance of uncertainty and boredom susceptibility. Results highlighted that having pre-existing mental health issues, being female, and the personality traits of intolerance to uncertainty and boredom susceptibility all played a role in the psychological distress experienced during the pandemic. COVID-19 contributed to negative impacts on young adults' mental health, highlighting the necessity to develop protective psychological intervention tailored for this vulnerable population.
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs13020141
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Article ; Online: External validation of scores predicting postoperative fistula after pancreatogastrostomy for pancreatoduodenectomy reconstruction. A single center experience.

Angrisani, Marco / Meniconi, Roberto Luca / Sandini, Marta / Colasanti, Marco / Ferretti, Stefano / Guglielmo, Nicola / Berardi, Giammauro / Mariano, Germano / Usai, Sofia / Braga, Marco / Gianotti, Luca / Ettorre, Giuseppe Maria

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

2023 Volume 23, Issue 7, Page(s) 852–857

Abstract: Background: Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most frequent complication of pancreatic surgery and can be fatal. Selection and stratification of patients according to the risk of POPF are important for the ... ...

Abstract	Background: Clinically relevant postoperative pancreatic fistula (CR-POPF) is the most frequent complication of pancreatic surgery and can be fatal. Selection and stratification of patients according to the risk of POPF are important for the perioperative management. Predictive metrics have been developed and validated in pancreatojejunostomy. Aim of this study is to assess whether the most used prognostic scores can be predictive of fistula following Wirsung-pancreaticogastrostomy (WPG) for pancreatoduodenectomy (PD)reconstruction. Method: This single-center prospective observational study included 212 PDs between January 2008 and October 2022 with a standardized WPG. All component variables of the six scores were separately validated in our cohort. The overall predictive ability of the six fistula scores was measured and compared with the receiver operating characteristics curves (ROC) method and expressed by the area under the ROC-curve (AUC). Univariate and multivariate logistic regression analyses were performed considering all risk factors in the scores in order to identify variables independently correlated with POPF in the WPG. Results: CR-POPF occurred in 36 of 212 (17 %) patients. All scores showed poor prognostic stratification for the development of CR-POPF. The occurrence of CR-POPF was associated with nine factors: male gender (p = 0.003); BMI (kg/m Conclusions: Our study including exclusively pancreatogastrostomies failed to validate the most used predictive scores for POPF. We found that only male gender and soft pancreatic texture are associated with POPF. Specific predictive scores following pancreatogasgtrostomy are needed.
MeSH term(s)	Humans ; Male ; Pancreas/surgery ; Pancreas/pathology ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Pancreatic Fistula/surgery ; Pancreaticoduodenectomy/adverse effects ; Pancreaticojejunostomy/adverse effects ; Postoperative Complications/etiology ; Risk Factors ; Prospective Studies
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2056680-3
ISSN	1424-3911 ; 1424-3903
ISSN (online)	1424-3911
ISSN	1424-3903
DOI	10.1016/j.pan.2023.10.004
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Zs.A 5553: Show issues

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Article: Minimally Invasive Surgery for Perihilar Cholangiocarcinoma: A Systematic Review of the Short- and Long-Term Results.

Berardi, Giammauro / Lucarini, Alessio / Colasanti, Marco / Mariano, Germano / Ferretti, Stefano / Meniconi, Roberto Luca / Guglielmo, Nicola / Angrisani, Marco / Usai, Sofia / Borcea, Maria Carola / Canali, Giulia / Moschetta, Giovanni / Ettorre, Giuseppe Maria

Cancers

2023 Volume 15, Issue 11

Abstract: Surgery and postoperative systemic chemotherapy represent the standard treatment for patients with perihilar cholangiocarcinoma (PHC). Minimally Invasive Surgery (MIS) for hepatobiliary procedures has spread worldwide in the last two decades. Since ... ...

Abstract	Surgery and postoperative systemic chemotherapy represent the standard treatment for patients with perihilar cholangiocarcinoma (PHC). Minimally Invasive Surgery (MIS) for hepatobiliary procedures has spread worldwide in the last two decades. Since resections for PHC are technically demanding, the role of MIS in this field is yet to be established. This study aimed to systematically review the existing literature on MIS for PHC, to evaluate its safety and its surgical and oncological outcomes. A systematic literature review on PubMed and SCOPUS was performed according to the PRISMA guidelines. Overall, a total of 18 studies reporting 372 MIS procedures for PHC were included in our analysis. A progressive increase in the available literature was observed over the years. A total of 310 laparoscopic and 62 robotic resections were performed. A pooled analysis showed an operative time ranging from 205.3 ± 23.9 and 840 (770-890) minutes, and intraoperative bleeding between 101.1 ± 13.6 and 1360 ± 809 mL. Minor and major morbidity rates were 43.9% and 12.7%, respectively, with a 5.6% mortality rate. R0 resections were achieved in 80.6% of patients and the number of retrieved lymph nodes ranged between 4 (3-12) and 12 (8-16). This systematic review shows that MIS for PHC is feasible, with safe postoperative and oncological outcomes. Recent data has shown encouraging results and more reports are being published. Future studies should address differences between robotic and laparoscopic approaches. Given the management and technical challenges, MIS for PHC should be performed by experienced surgeons, in high-volume centers, on selected patients.
Language	English
Publishing date	2023-06-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15113048
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Article ; Online: Does Patisiran Reduce Ocular Transthyretin Synthesis? A Pilot Study of Two Cases.

Cambieri, Chiara / Marenco, Marco / Colasanti, Tania / Mancone, Carmine / Corsi, Alessandro / Riminucci, Mara / Libonati, Laura / Moret, Federica / Chimenti, Cristina / Lambiase, Alessandro / Conti, Fabrizio / Garibaldi, Matteo / Inghilleri, Maurizio / Ceccanti, Marco

Current neuropharmacology

2023 Volume 21, Issue 12, Page(s) 2543–2549

Abstract: Background: Variant transthyretin-mediated amyloidosis (ATTR-v) is a well-characterized disease affecting the neurologic and cardiovascular systems. Patisiran has been approved for neurologic involvement as it reduces hepatic synthesis of transthyretin ( ...

Abstract	Background: Variant transthyretin-mediated amyloidosis (ATTR-v) is a well-characterized disease affecting the neurologic and cardiovascular systems. Patisiran has been approved for neurologic involvement as it reduces hepatic synthesis of transthyretin (TTR). Eye involvement is a lateonset feature increasing the risk of glaucoma and cataracts in patients. Aims: The aim of this case series was to assess whether patisiran can effectively reduce TTR synthesis in such a barrier-protected organ as the eye. Methods: Two patisiran-treated ATTR-v patients underwent serum and aqueous humor sampling to measure TTR levels detected by SDS-PAGE and immunoblotting. Serum samples were compared to healthy control (HC), whereas aqueous humor samples were compared to non-amyloidotic subjects affected by cataracts and glaucoma. Results: Serum TTR levels representative of hepatic synthesis were sharply lower in treated patients if compared to the HC (-87.5% and -93.75%, respectively). Aqueous humor TTR levels showed mild-tono reduction in treated patients compared to non-amyloidotic subjects with cataracts (-34.9% and +8.1%, respectively) and glaucoma (-41.1% and -2.1%). Conclusion: Patisiran does not seem to be as effective in inhibiting ocular TTR synthesis as it is in inhibiting hepatic synthesis. Re-engineering the envelope could allow the drug to target RPE cells thus avoiding any ocular involvement.
MeSH term(s)	Humans ; Prealbumin ; Pilot Projects ; Cataract/drug therapy ; Glaucoma/drug therapy
Chemical Substances	Prealbumin ; patisiran (50FKX8CB2Y)
Language	English
Publishing date	2023-06-22
Publishing country	United Arab Emirates
Document type	Case Reports ; Journal Article
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X21666230623094710
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Article: Amyloid-β 25-35 Induces Neurotoxicity through the Up-Regulation of Astrocytic System Xc−

D’Ezio, Veronica / Colasanti, Marco / Persichini, Tiziana

Antioxidants. 2021 Oct. 26, v. 10, no. 11

2021

Abstract: Amyloid-β (Aβ) deposition, a hallmark of Alzheimer’s disease, is known to induce free radical production and oxidative stress, leading to neuronal damage. During oxidative stress, several cell types (including astrocytes) can activate the nuclear factor ... ...

Abstract	Amyloid-β (Aβ) deposition, a hallmark of Alzheimer’s disease, is known to induce free radical production and oxidative stress, leading to neuronal damage. During oxidative stress, several cell types (including astrocytes) can activate the nuclear factor erythroid 2-related factor 2 (Nrf2), a regulator of several phase II detoxifying and antioxidant genes, such as the System Xc⁻ subunit xCT. Here, we studied (i) the effect of the Aβ fragment 25-35 (Aβ₂₅₋₃₅) on Nrf2-dependent System Xc⁻ expression in U373 human astroglial cells and (ii) the effect of Aβ₂₅₋₃₅-induced astrocytic response on neuronal cell viability using an in vitro co-culture system. We found that Aβ₂₅₋₃₅ was able to activate an antioxidant response in astrocytes, by inducing both Nrf2 activation and System Xc⁻ up-regulation. However, this astrocytic response caused an enhanced cell mortality of co-cultured SH-SY5Y cells, taken as a neuronal model. Consistently, the specific System Xc⁻ inhibitor sulfasalazine prevented the increase of both neuronal mortality and extracellular glutamate levels, thus indicating that the neurotoxic effect was due to an augmented release of glutamate through the transporter. The involvement of NMDA receptor activation in this pathway was also demonstrated using the specific inhibitor MK801 that completely restored neuronal viability at the control levels. The present study sheds light on the Nrf2/system Xc⁻ pathway in the toxicity induced by Aβ₂₅₋₃₅ and may help to better understand the involvement of astrocytes in neuronal death during Alzheimer’s disease.
Keywords	antioxidant activity ; antioxidants ; astrocytes ; cell viability ; coculture ; death ; free radicals ; glutamic acid ; humans ; models ; mortality ; neurons ; neurotoxicity ; oxidative stress ; sulfasalazine
Language	English
Dates of publication	2021-1026
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10111685
Database	NAL-Catalogue (AGRICOLA)

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