LIVIVO - Search results -

Search results

Result 1 - 10 of total 31

Search options

Article ; Online: Oral and oropharyngeal malignant minor salivary gland tumors: a retrospective study.

Valletti, Paolo Aluffi / Campagnoli, Massimo / Dell'Era, Valeria / Garzaro, Massimiliano / Boffano, Paolo / Neirotti, Francesca / Mazzer, Anna Maria / Brucoli, Matteo

Journal of stomatology, oral and maxillofacial surgery

2024 , Page(s) 101893

Abstract: Introduction: Tumors of minor salivary gland origin are uncommon lesions, representing 2-3% of all malignant neoplasms of the upper aerodigestive tract and 9-23% of all salivary gland tumors. The aim of this study is to report the demographic features, ... ...

Abstract	Introduction: Tumors of minor salivary gland origin are uncommon lesions, representing 2-3% of all malignant neoplasms of the upper aerodigestive tract and 9-23% of all salivary gland tumors. The aim of this study is to report the demographic features, sites, histological types and the management and outcomes of oral and oropharyngeal minor salivary gland tumors diagnosed and treated in a University Hospital with a multidisciplinary head and neck team. Materials and methods: A single-center retrospective observational study was conducted in a cohort of patients who received diagnosis of minor salivary gland carcinoma of oropharynx and oral cavity between July 30th 2000 and 30th September 2021. The following data of the included patients were collected: age, gender, smoke history, alcohol consumption, past medical history, comorbidities, anatomic location of the tumor, histopathology, staging, management, and outcomes. Results: A total of 30 cases (16 females, 14 males) of oral and oropharyngeal minor salivary gland tumors were reviewed. The most frequent histotype was polymorphous adenocarcinoma (12 patients). The majority of patients presented with low stage at diagnosis, with 66,66% of the population classified as stage I or II at diagnosis. On the whole, 29 patients out of 30 benefitted from a surgical approach as first treatment. In 11 patients, adjuvant radiotherapy was performed and in 6 cases it was associated with chemotherapy. Brachytherapy with different timing was performed in 5 cases. The recurrence rate was 26.66%. Overall disease specific survival at five and ten years was found to be approximately 81% and 33% respectively. Conclusions: Surgery is still considered to be the gold standard of the treatment of minor salivary gland tumors. Radiation therapy, in spite of not being considered as a curative primary treatment for salivary malignancies, is extensively used as an adjuvant treatment.
Language	English
Publishing date	2024-04-24
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2024.101893
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Neurodegeneration: can metabolites from

Cavalloro, Valeria / Marchesi, Nicoletta / Linciano, Pasquale / Rossi, Daniela / Campagnoli, Lucrezia Irene Maria / Fossati, Alice / Ahmed, Karzan Mahmood / Malacrida, Alessio / Miloso, Mariarosaria / Mazzeo, Giuseppe / Abbate, Sergio / Longhi, Giovanna / Ambrosio, Francesca Alessandra / Costa, Giosuè / Alcaro, Stefano / Pascale, Alessia / Martino, Emanuela / Collina, Simona

Frontiers in pharmacology

2024 Volume 15, Page(s) 1309766

Abstract: The number of patients affected by neurodegenerative diseases is increasing worldwide, and no effective treatments have been developed yet. Although precision medicine could represent a powerful tool, it remains a challenge due to the high variability ... ...

Abstract	The number of patients affected by neurodegenerative diseases is increasing worldwide, and no effective treatments have been developed yet. Although precision medicine could represent a powerful tool, it remains a challenge due to the high variability among patients. To identify molecules acting with innovative mechanisms of action, we performed a computational investigation using SAFAN technology, focusing specifically on HuD. This target belongs to the human embryonic lethal abnormal visual-like (ELAV) proteins and plays a key role in neuronal plasticity and differentiation. The results highlighted that the molecule able to bind the selected target was (
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1309766
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Moral Distress and Burnout in Neonatal Intensive Care Unit Healthcare Providers: A Cross-Sectional Study in Italy.

Carletto, Sara / Ariotti, Maria Chiara / Garelli, Giulia / Di Noto, Ludovica / Berchialla, Paola / Malandrone, Francesca / Guardione, Roberta / Boarino, Floriana / Campagnoli, Maria Francesca / Savant Levet, Patrizia / Bertino, Enrico / Ostacoli, Luca / Coscia, Alessandra

International journal of environmental research and public health

2022 Volume 19, Issue 14

Abstract: Moral distress (MD) in healthcare providers is widely recognized as a serious issue in critical care contexts. It has the potential to have negative impacts on both personal and professional wellbeing, the quality of care provided and staff turnover. The ...

Abstract	Moral distress (MD) in healthcare providers is widely recognized as a serious issue in critical care contexts. It has the potential to have negative impacts on both personal and professional wellbeing, the quality of care provided and staff turnover. The aim of this study was to investigate the relationship between MD and burnout among neonatal intensive care unit (NICU) healthcare professionals and identify the possible factors associated with its occurrence. Participants were asked to complete an online survey, which covered sociodemographic and professional information and included two self-report questionnaires (Italian Moral Distress Scale-Revised and Maslach Burnout Inventory). The sample comprised 115 healthcare providers (nurses and physiotherapists: 66.1%; physicians: 30.4%; healthcare assistants: 3.5%) working in four NICUs located within the province of Turin, Italy. The results revealed overall low levels of MD, with no significant differences between nurses/physiotherapists and physicians. Nurses/physiotherapists showed a statistically significant higher percentage of personal accomplishment burnout (32.9%) compared with physicians (8.6%;
MeSH term(s)	Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; Cross-Sectional Studies ; Health Personnel ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Morals ; Surveys and Questionnaires
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19148526
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid?

Marchesi, Nicoletta / Linciano, Pasquale / Campagnoli, Lucrezia Irene Maria / Fahmideh, Foroogh / Rossi, Daniela / Costa, Giosuè / Ambrosio, Francesca Alessandra / Barbieri, Annalisa / Collina, Simona / Pascale, Alessia

International journal of molecular sciences

2023 Volume 24, Issue 15

Abstract: The RNA-binding protein HuD has been shown to play a crucial role in gene regulation in the nervous system and is involved in various neurological and psychiatric diseases. In this study, through the creation of an interaction network on HuD and its ... ...

Abstract	The RNA-binding protein HuD has been shown to play a crucial role in gene regulation in the nervous system and is involved in various neurological and psychiatric diseases. In this study, through the creation of an interaction network on HuD and its potential targets, we identified a strong association between HuD and several diseases of the nervous system. Specifically, we focused on the relationship between HuD and the brain-derived neurotrophic factor (BDNF), whose protein is implicated in several neuronal diseases and is involved in the regulation of neuronal development, survival, and function. To better investigate this relationship and given that we previously demonstrated that folic acid (FA) is able to directly bind HuD itself, we performed in vitro experiments in neuron-like human SH-SY5Y cells in the presence of FA, also known to be a pivotal environmental factor influencing the nervous system development. Our findings show that FA exposure results in a significant increase in both HuD and BDNF transcripts and proteins after 2 and 4 h of treatment, respectively. Similar data were obtained after 2 h of FA incubation followed by 2 h of washout. This increase was no longer detected upon 24 h of FA exposure, probably due to a signaling shutdown mechanism. Indeed, we observed that following 24 h of FA exposure HuD is methylated. These findings indicate that FA regulates BDNF expression via HuD and suggest that FA can behave as an epigenetic modulator of HuD in the nervous system acting via short- and long-term mechanisms. Finally, the present results also highlight the potential of BDNF as a therapeutic target for specific neurological and psychiatric diseases.
MeSH term(s)	Humans ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; ELAV Proteins/genetics ; ELAV Proteins/metabolism ; ELAV-Like Protein 4/genetics ; Neuroblastoma/metabolism ; Neurons/metabolism
Chemical Substances	Brain-Derived Neurotrophic Factor ; ELAV Proteins ; ELAV-Like Protein 4
Language	English
Publishing date	2023-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241512201
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Adherence to Mediterranean Diet and Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis.

Nucci, Daniele / Nardi, Mariateresa / Cinnirella, Andrea / Campagnoli, Emanuela / Maffeo, Manuel / Perrone, Pier Mario / Shishmintseva, Viktoriia / Grosso, Francesca Maria / Castrofino, Ambra / Castaldi, Silvana / Romanò, Luisa / Gianfredi, Vincenza

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: Pancreatic cancer (PC) represents the 6th cause of cancer death. Although the aetiology of PC is not completely understood, numerous risk factors have been identified in association with this cancer, among them diet. However, little is known about the ... ...

Abstract	Pancreatic cancer (PC) represents the 6th cause of cancer death. Although the aetiology of PC is not completely understood, numerous risk factors have been identified in association with this cancer, among them diet. However, little is known about the association between the Mediterranean Diet (MedDiet) and the risk of PC. For this reason, we conducted a systematic review with meta-analysis according to the PRISMA guidelines, searching on three databases (PubMed/MEDLINE, Scopus, and EMBASE). The protocol was registered in PROSPERO. Both fixed and random effect models were performed. The Effect size was reported as a hazard ratio (HR) with a 95% Confidence Interval (CI). A total of eight articles were included. The methodological quality of the included meta-analyses was high. Our results show that a higher adherence to the MedDiet is associated with a lower risk of PC [HR:0.82 (0.76-0.88)
MeSH term(s)	Humans ; Diet, Mediterranean ; Risk Factors ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/prevention & control ; Incidence ; Pancreatic Neoplasms
Language	English
Publishing date	2023-01-29
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20032403
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Adherence to Mediterranean Diet and Risk of Pancreatic Cancer

Daniele Nucci / Mariateresa Nardi / Andrea Cinnirella / Emanuela Campagnoli / Manuel Maffeo / Pier Mario Perrone / Viktoriia Shishmintseva / Francesca Maria Grosso / Ambra Castrofino / Silvana Castaldi / Luisa Romanò / Vincenza Gianfredi

International Journal of Environmental Research and Public Health, Vol 20, Iss 2403, p

Systematic Review and Meta-Analysis

2023 Volume 2403

Abstract	Pancreatic cancer (PC) represents the 6th cause of cancer death. Although the aetiology of PC is not completely understood, numerous risk factors have been identified in association with this cancer, among them diet. However, little is known about the association between the Mediterranean Diet (MedDiet) and the risk of PC. For this reason, we conducted a systematic review with meta-analysis according to the PRISMA guidelines, searching on three databases (PubMed/MEDLINE, Scopus, and EMBASE). The protocol was registered in PROSPERO. Both fixed and random effect models were performed. The Effect size was reported as a hazard ratio (HR) with a 95% Confidence Interval (CI). A total of eight articles were included. The methodological quality of the included meta-analyses was high. Our results show that a higher adherence to the MedDiet is associated with a lower risk of PC [HR:0.82 (0.76–0.88) p < 0.001, based on 1,301,320 subjects]. The results were also confirmed in sensitivity and subgroups analyses (avoidance of potential overlapping effects, type of tools used to assess dietary intake and the diagnosis of PC, prevalence and incidence of PC risk, country where the studies took place, sex, and cancer site). Promoting a higher adherence to the MedDiet could be an effective approach to reduce the risk of PC.
Keywords	pancreatic cancer ; Mediterranean diet ; diet ; systematic review ; meta-analysis ; pancreas ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Influenza Vaccination Campaign during the COVID-19 Pandemic: The Experience of a Research and Teaching Hospital in Milan.

Perrone, Pier Mario / Biganzoli, Giacomo / Lecce, Maurizio / Campagnoli, Emanuela Maria / Castrofino, Ambra / Cinnirella, Andrea / Fornaro, Federica / Gallana, Claudia / Grosso, Francesca Maria / Maffeo, Manuel / Shishmintseva, Viktoriia / Pariani, Elena / Castaldi, Silvana

International journal of environmental research and public health

2021 Volume 18, Issue 11

Abstract: Background: During the COVID-19 pandemic, more than ever, optimal influenza vaccination coverage among healthcare workers (HCWs) is crucial to avoid absenteeism and disruption of health services, as well as in-hospital influenza outbreaks. The aim of ... ...

Abstract	Background: During the COVID-19 pandemic, more than ever, optimal influenza vaccination coverage among healthcare workers (HCWs) is crucial to avoid absenteeism and disruption of health services, as well as in-hospital influenza outbreaks. The aim of this study is to analyze the 2020 influenza vaccination campaign, comparing it with the previous year's in a research and teaching hospital in Northern Italy. Methods: adopting an approach based on combined strategies, three interventions were deployed: a promotional and educational campaign, vaccination delivery through both ad hoc and on-site ambulatories, and a gaming strategy. Personal data and professional categories were collected and analyzed using univariate logistic regression. Vaccinated HCWs were asked to fill in a questionnaire to describe their reasons for vaccination adherence. Results: the vaccination coverage rate (VCR) was 43.1%, compared to 21.5% in 2019. The highest increase was registered among administrative staff (308.3%), while physicians represent the most vaccinated category (n = 600). Moreover, residents (prevalence ratio (PR): 1.12; 95% CI 1.04-1.20), as well as intensive care (PR: 1.44; 95% CI: 1.24-1.69) and newborn workers (PR: 1.41; 95% CI: 1.20-1.65) were, respectively, the categories most frequently vaccinated for the first time. Conclusion: the significant increase in vaccination coverage rate confirms the suitability of the combined strategy of delivering the flu vaccination campaign and represents a first step towards reaching WHO recommended vaccination rates.
MeSH term(s)	Attitude of Health Personnel ; COVID-19 ; Health Personnel ; Hospitals, Teaching ; Humans ; Immunization Programs ; Infant, Newborn ; Influenza Vaccines ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Italy/epidemiology ; Pandemics/prevention & control ; SARS-CoV-2 ; Surveys and Questionnaires ; Vaccination
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2021-05-30
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph18115874
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: MEK Inhibition in a Newborn with

Mussa, Alessandro / Carli, Diana / Giorgio, Elisa / Villar, Anna Maria / Cardaropoli, Simona / Carbonara, Caterina / Campagnoli, Maria Francesca / Galletto, Paolo / Palumbo, Martina / Olivieri, Simone / Isella, Claudio / Andelfinger, Gregor / Tartaglia, Marco / Botta, Giovanni / Brusco, Alfredo / Medico, Enzo / Ferrero, Giovanni Battista

Genes

2021 Volume 13, Issue 1

Abstract: ... ...

Abstract	The
MeSH term(s)	Cardiomyopathy, Hypertrophic/drug therapy ; Fatal Outcome ; Female ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/prevention & control ; Infant, Newborn ; MAP Kinase Kinase Kinases/antagonists & inhibitors ; Noonan Syndrome/genetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-raf/genetics ; Whole Exome Sequencing
Chemical Substances	Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; Raf1 protein, human (EC 2.7.11.1) ; MAP Kinase Kinase Kinases (EC 2.7.11.25)
Language	English
Publishing date	2021-12-21
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13010006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Detection of SARS-CoV-2 in Milk From COVID-19 Positive Mothers and Follow-Up of Their Infants.

Bertino, Enrico / Moro, Guido Eugenio / De Renzi, Giuseppe / Viberti, Giuseppina / Cavallo, Rossana / Coscia, Alessandra / Rubino, Carlotta / Tonetto, Paola / Sottemano, Stefano / Campagnoli, Maria Francesca / Soldi, Antonella / Mostert, Michael / Cresi, Francesco / Lembo, David

Frontiers in pediatrics

2020 Volume 8, Page(s) 597699

Abstract: Background: ...

Abstract	Background:
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2020.597699
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Influenza Vaccination Campaign during the COVID-19 Pandemic

Pier Mario Perrone / Giacomo Biganzoli / Maurizio Lecce / Emanuela Maria Campagnoli / Ambra Castrofino / Andrea Cinnirella / Federica Fornaro / Claudia Gallana / Francesca Maria Grosso / Manuel Maffeo / Viktoriia Shishmintseva / Elena Pariani / Silvana Castaldi

International Journal of Environmental Research and Public Health, Vol 18, Iss 5874, p

The Experience of a Research and Teaching Hospital in Milan

2021 Volume 5874

Abstract	Background: During the COVID-19 pandemic, more than ever, optimal influenza vaccination coverage among healthcare workers (HCWs) is crucial to avoid absenteeism and disruption of health services, as well as in-hospital influenza outbreaks. The aim of this study is to analyze the 2020 influenza vaccination campaign, comparing it with the previous year’s in a research and teaching hospital in Northern Italy. Methods: adopting an approach based on combined strategies, three interventions were deployed: a promotional and educational campaign, vaccination delivery through both ad hoc and on-site ambulatories, and a gaming strategy. Personal data and professional categories were collected and analyzed using univariate logistic regression. Vaccinated HCWs were asked to fill in a questionnaire to describe their reasons for vaccination adherence. Results: the vaccination coverage rate (VCR) was 43.1%, compared to 21.5% in 2019. The highest increase was registered among administrative staff (308.3%), while physicians represent the most vaccinated category (n = 600). Moreover, residents (prevalence ratio (PR): 1.12; 95% CI 1.04–1.20), as well as intensive care (PR: 1.44; 95% CI: 1.24–1.69) and newborn workers (PR: 1.41; 95% CI: 1.20–1.65) were, respectively, the categories most frequently vaccinated for the first time. Conclusion: the significant increase in vaccination coverage rate confirms the suitability of the combined strategy of delivering the flu vaccination campaign and represents a first step towards reaching WHO recommended vaccination rates.
Keywords	influenza vaccine ; vaccination adherence ; healthcare workers vaccination ; vaccination refusal ; Medicine ; R
Subject code	360
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED