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  1. Article ; Online: Epigenomic effects of vitamin D in colorectal cancer.

    Khayami, Reza / Goltzman, David / Rabbani, Shafaat A / Kerachian, Mohammad Amin

    Epigenomics

    2022  Volume 14, Issue 19, Page(s) 1213–1228

    Abstract: Vitamin D regulates a plethora of physiological processes in the human body and has been proposed ... to exert several anticancer effects. Epigenetics plays an important role in regulating vitamin D actions ... such as lncRNAs, miRNAs, methylation and acetylation influenced by vitamin D and its downstream targets ...

    Abstract Vitamin D regulates a plethora of physiological processes in the human body and has been proposed to exert several anticancer effects. Epigenetics plays an important role in regulating vitamin D actions. In this review, we highlight the recent advances in the understanding of different epigenetic factors such as lncRNAs, miRNAs, methylation and acetylation influenced by vitamin D and its downstream targets in colorectal cancer to find more potential therapeutic targets. We discuss how vitamin D exerts anticancer properties through interactions between the vitamin D receptor and genes (e.g.,
    MeSH term(s) Humans ; Epigenomics ; Vitamin D/therapeutic use ; DNA Methylation ; Epigenesis, Genetic ; Vitamins ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Tumor Microenvironment
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2022-0288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Functions of vitamin D in bone.

    Goltzman, D

    Histochemistry and cell biology

    2018  Volume 149, Issue 4, Page(s) 305–312

    Abstract: Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic ... conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH) ...

    Abstract Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic conversion to its active form, 1,25-dihydroxy vitamin D [1,25(OH)
    MeSH term(s) Animals ; Bone and Bones/metabolism ; Humans ; Receptors, Calcitriol/metabolism ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism
    Chemical Substances Receptors, Calcitriol ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2018-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-018-1648-y
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  3. Article: Mechanisms of action of vitamin D in delaying aging and preventing disease by inhibiting oxidative stress.

    Miao, Dengshun / Goltzman, David

    Vitamins and hormones

    2022  Volume 121, Page(s) 293–318

    Abstract: Although several recent studies have shown that vitamin D supplementation beneficially decreases ... oxidative stress parameters, there is no consensus on this subject in humans. Thus the role of vitamin D ... of active vitamin D has no effect on all-cause mortality, cannot reduce the fracture risk of the elderly ...

    Abstract Although several recent studies have shown that vitamin D supplementation beneficially decreases oxidative stress parameters, there is no consensus on this subject in humans. Thus the role of vitamin D supplementation has recently become a controversial topic because large intervention studies in humans have not shown significant benefits. These studies have indicated that supplementation with precursor forms of active vitamin D has no effect on all-cause mortality, cannot reduce the fracture risk of the elderly, cannot reduce the incidence of cancer or cardiovascular disease in the elderly, and cannot significantly reduce the incidence risk of diabetes in the elderly. However, a link between several age-related diseases and enhanced oxidative stress has been found in mice with insufficient or deficient 1,25-dihydroxyvitamin D (1,25(OH)
    MeSH term(s) Humans ; Mice ; Animals ; Aged ; Vitamin D/pharmacology ; Vitamin D/metabolism ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/pharmacology ; Vitamins/pharmacology ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Oxidative Stress ; Aging ; Antioxidants/pharmacology
    Chemical Substances Vitamin D (1406-16-2) ; NF-E2-Related Factor 2 ; Vitamins ; Receptors, Calcitriol ; Antioxidants
    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2022.09.004
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  4. Article ; Online: 1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.

    Chen, Jie / Zhang, Jiao / Li, Jie / Qin, Ran / Lu, Na / Goltzman, David / Miao, Dengshun / Yang, Renlei

    International journal of biological sciences

    2023  Volume 19, Issue 2, Page(s) 610–624

    Abstract: Emerging observational data suggest that vitamin D deficiency is associated with the onset and ... progression of knee osteoarthritis (OA). However, the relationship between vitamin D level and OA and the role ... of vitamin D supplementation in the prevention of knee OA are controversial. To address these issues ...

    Abstract Emerging observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, the relationship between vitamin D level and OA and the role of vitamin D supplementation in the prevention of knee OA are controversial. To address these issues, we analyzed the articular cartilage phenotype of 6- and 12-month-old wild-type and 1α(OH)ase
    MeSH term(s) Animals ; Mice ; Aging/metabolism ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Down-Regulation ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/pathology ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Vitamin D/metabolism ; Vitamin D Deficiency/complications
    Chemical Substances 1,25-dihydroxyvitamin D (66772-14-3) ; Sirt1 protein, mouse (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-01-01
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.78785
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  5. Article: Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.

    Wang, Peng / Yang, Cuicui / Lu, Jinhong / Ren, Yongxin / Goltzman, David / Miao, Dengshun

    Journal of orthopaedic translation

    2023  Volume 40, Page(s) 13–26

    Abstract: Background: It has been demonstrated that vitamin D deficiency is associated with an increased ... by active vitamin D deficiency has not been reported. Thus, the purpose of this study was to e investigate ... the role and mechanism of 1,25-dihydroxyvitamin D (1,25(OH): Methods: The phenotypes ...

    Abstract Background: It has been demonstrated that vitamin D deficiency is associated with an increased risk of patients developing lumbar disc herniation. However, intervertebral disc degeneration caused by active vitamin D deficiency has not been reported. Thus, the purpose of this study was to e investigate the role and mechanism of 1,25-dihydroxyvitamin D (1,25(OH)
    Methods: The phenotypes of intervertebral discs were compared in wild-type mice and mice with heterozygous deletion of 1α-hydroxylase [1α(OH)ase
    Results: 1,25(OH)
    Conclusion: Results from this study indicate that the 1,25(OH)
    Language English
    Publishing date 2023-05-05
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2747531-1
    ISSN 2214-031X
    ISSN 2214-031X
    DOI 10.1016/j.jot.2023.04.003
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  6. Article: Role of 1,25-dihydroxyvitamin D in alleviating alveolar bone loss and gingival inflammation in ligature-induced periodontitis.

    Gong, Aixiu / Liu, Yining / Xu, Fangrong / Chu, Yiting / Wu, Jun / Goltzman, David / Miao, Dengshun

    American journal of translational research

    2022  Volume 14, Issue 5, Page(s) 3079–3091

    Abstract: Objectives: The goal of this study was to assess if endogenous 1,25(OH): Methods: A model of ligature-induced experimental periodontitis was generated in wild-type (WT) and Cyp27b1-knockout (KO) mice on a rescue diet (RD), and un-ligated genotype- ... ...

    Abstract Objectives: The goal of this study was to assess if endogenous 1,25(OH)
    Methods: A model of ligature-induced experimental periodontitis was generated in wild-type (WT) and Cyp27b1-knockout (KO) mice on a rescue diet (RD), and un-ligated genotype-matched littermates as control, or in WT mice on a normal diet (ND) with vehicle treatment or 1,25(OH)
    Results: In WT mice, ligature-induced alveolar bone loss occurred by inhibiting alveolar bone formation. This was characterized by reduction of osteoblast numbers, alkaline phosphatase activity and type I collagen synthesis, as well as by augmentation of osteoclastic alveolar bone resorption and gingival inflammation, including increases of osteoclast numbers, inflammatory positive cells and up-regulation of mRNA expression levels of inflammatory cytokines. Alveolar bone destruction and gingival inflammation were more severe in diet-matched Cyp27b1-KO mice than in WT littermates on RD. Supplementation of exogenous 1,25(OH)
    Conclusions: Endogenous 1,25(OH)
    Language English
    Publishing date 2022-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  7. Article ; Online: Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis.

    Goltzman, David / Mannstadt, Michael / Marcocci, Claudio

    Frontiers of hormone research

    2018  Volume 50, Page(s) 1–13

    Abstract: ... of 25-hydroxyvitamin D (25[OH]D) to 1,25(OH)2D, likely over several hours, which in turn will augment ...

    Abstract Classic endocrine feedback loops ensure the regulation of blood calcium. Calcium in the extracellular fluid (ECF) binds and activates the calcium sensing receptor (CaSR) on the parathyroid cells, leading to an increase in intracellular calcium. This in turn leads to a reduced parathyroid hormone (PTH) release. Hypocalcemia leads to the opposite sequence of events, namely, lowered intracellular calcium and increased PTH production and secretion. PTH rapidly increases renal calcium reabsorption and, over hours to days, enhances osteoclastic bone resorption and liberates both calcium and phosphate from the skeleton. PTH also increases fibroblast growth factor 23 (FGF23) release from mature osteoblasts and osteocytes. PTH stimulates the renal conversion of 25-hydroxyvitamin D (25[OH]D) to 1,25(OH)2D, likely over several hours, which in turn will augment intestinal calcium absorption. Prolonged hypocalcemia and exposure to elevated PTH may also result in 1,25(OH)2D-mediated calcium and phosphorus release from bone. These effects restore the ECF calcium to normal and inhibit further production of PTH and 1,25(OH)2D. Additionally, FGF23 can be released from bone by 1,25(OH)2D and can in turn reduce 1,25(OH)2D concentrations. FGF23 has also been reported to decrease PTH production. When ECF calcium is in the hypercalcemic range, PTH secretion is reduced and renal 1,25(OH)2D production is decreased. In addition, the elevated calcium per se stimulates the renal CaSR, thus inducing calciuria. Therefore, suppression of PTH release and 1,25(OH)2D synthesis and stimulation of the renal CaSR lead to reduced renal calcium reabsorption, decreased skeletal calcium release, and decreased intestinal calcium absorption, resulting in the normalization of the elevated ECF calcium.
    MeSH term(s) Calcium/metabolism ; Homeostasis/physiology ; Humans ; Parathyroid Hormone/metabolism ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism
    Chemical Substances Parathyroid Hormone ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-3762 ; 0301-3073
    ISSN (online) 1662-3762
    ISSN 0301-3073
    DOI 10.1159/000486060
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  8. Article ; Online: Author response to letter to editor OSIN-D-23-00809: ALDH2 polymorphism rs671 and alcohol consumption: possible explanatory factors for race/ethnic differences in bone density.

    Morin, Suzanne N / Berger, Claudie / Papaioannou, Alexandra / Cheung, Angela M / Rahme, Elham / Leslie, William D / Goltzman, David

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2023  Volume 34, Issue 12, Page(s) 2137–2138

    MeSH term(s) Humans ; Bone Density/genetics ; Alcohol Drinking/genetics ; Risk Factors ; Aldehyde Dehydrogenase, Mitochondrial/genetics
    Chemical Substances ALDH2 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3)
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Letter
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-023-06911-7
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  9. Article: 1,25-Dihydroxyvitamin D deficiency induces sarcopenia by inducing skeletal muscle cell senescence.

    Yu, Shuxiang / Ren, Biqi / Chen, Haiyun / Goltzman, David / Yan, Jianshe / Miao, Dengshun

    American journal of translational research

    2021  Volume 13, Issue 11, Page(s) 12638–12649

    Abstract: To determine if 1,25(OH) ...

    Abstract To determine if 1,25(OH)
    Language English
    Publishing date 2021-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  10. Article ; Online: Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.

    Yang, Renlei / Zhang, Jiao / Li, Jie / Qin, Ran / Chen, Jie / Wang, Rong / Goltzman, David / Miao, Dengshun

    Free radical biology & medicine

    2021  Volume 178, Page(s) 246–261

    Abstract: Previous studies have shown that 1,25(OH) ...

    Abstract Previous studies have shown that 1,25(OH)
    MeSH term(s) Animals ; Kelch-Like ECH-Associated Protein 1/genetics ; Male ; Mice ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Osteogenesis ; Osteoporosis/drug therapy ; Osteoporosis/genetics ; Receptors, Calcitriol/metabolism ; Vitamin D/analogs & derivatives
    Chemical Substances Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Receptors, Calcitriol ; Vitamin D (1406-16-2) ; 1,25-dihydroxyvitamin D (66772-14-3)
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2021.12.010
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