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  1. Article ; Online: Reversible O-H Bond Activation by Tripodal tris(Nitroxide) Aluminum and Gallium Complexes.

    Scott, Joseph S / Maenaga, Mika L / Woodside, Audra J / Guo, Vivian W / Cheriel, Alex R / Gau, Michael R / Rablen, Paul R / Graves, Christopher R

    Inorganic chemistry

    2024  Volume 63, Issue 9, Page(s) 4028–4038

    Abstract: Herein, we report the preparation and characterization of the Group 13 metal complexes of a tripodal tris(nitroxide)-based ligand, designated ( ... ...

    Abstract Herein, we report the preparation and characterization of the Group 13 metal complexes of a tripodal tris(nitroxide)-based ligand, designated (TriNOx
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c02902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Structural comparison of multi-walled carbon nanotubes produced from polypropylene and polystyrene waste plastics

    Graves, Katherine A. / Higgins, Luke J.R. / Nahil, Mohamad A. / Mishra, Bhoopesh / Williams, Paul T.

    Journal of analytical and applied pyrolysis. 2022 Jan., v. 161

    2022  

    Abstract: Polypropylene and polystyrene were processed in a pyrolysis/catalytic reactor with a Ni-Fe/Al₂O₃ catalyst to produce carbon nanotubes (CNTs). A high yield of catalyst carbon deposits were produced; 33.5 g 100 g⁻¹ polypropylene and 29.5 g 100 g⁻¹ ... ...

    Abstract Polypropylene and polystyrene were processed in a pyrolysis/catalytic reactor with a Ni-Fe/Al₂O₃ catalyst to produce carbon nanotubes (CNTs). A high yield of catalyst carbon deposits were produced; 33.5 g 100 g⁻¹ polypropylene and 29.5 g 100 g⁻¹ polystyrene and consisted of multi-walled carbon nanotubes (MWCNTs). X-ray diffraction (XRD) of the Ni-Fe/Al₂O₃ catalyst suggested the active metal was a Ni-Fe alloy which was confirmed using X-ray absorption near edge structure (XANES); extended X-ray absorption fine structure (EXAFS) analysis showed that the alloy was primarily FeNi₂. Electron microscopy showed that the MWCNTs were entangled, several μm in length and ~50 nm in diameter comprising ~30 graphene layers. Optical Raman spectroscopy confirmed the carbons to be of high purity and crystallinity with polypropylene showing a higher degree of graphitisation and fewer defects compared to those produced from polystyrene. X-ray Raman scattering spectroscopy of the MWCNTS confirmed their graphitic carbon composition, but demonstrated poor alignment. Commercially produced MWCNTs showed a high degree of graphitisation, with less metal impurities and were of long length (several μm), straighter, smaller diameter (~10 nm) and with fewer number of graphene layers (~12) in the CNT wall compared with the plastic derived MWCNTs.
    Keywords Raman spectroscopy ; X-radiation ; X-ray absorption spectroscopy ; X-ray diffraction ; alloys ; carbon nanotubes ; catalysts ; crystal structure ; electron microscopy ; graphene ; plastics ; polypropylenes ; polystyrenes ; pyrolysis
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 0165-2370
    DOI 10.1016/j.jaap.2021.105396
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: On-farm greenhouse gas emissions associated with the cultivation of two new bioenergy crops in the UK

    Laura Cumplido-Marin / Anil R. Graves / Paul J. Burgess / Adrian Williams

    Energy Nexus, Vol 8, Iss , Pp 100162- (2022)

    2022  

    Abstract: Before using novel energy crops to produce bioenergy, feasibility studies should be completed to determine their effect on net greenhouse gas emissions. The current study developed a model to study the greenhouse gas emissions associated with the ... ...

    Abstract Before using novel energy crops to produce bioenergy, feasibility studies should be completed to determine their effect on net greenhouse gas emissions. The current study developed a model to study the greenhouse gas emissions associated with the cultivation of two novel bioenergy crops: Sida hermaphrodita (L.) Rusby and Silphium perfoliatum L., using Intergovernmental Panel on Climate Change (IPCC) guidelines. The establishment and cultivation of Sida hermaphrodita and Silphium perfoliatum were compared with an arable rotation, short rotation coppice (SRC) and Miscanthus. Under the assumptions specified in the current study, including annual fertilisation and a high root: shoot ratio for Sida, the cultivation of Sida hermaphrodita and Silphium perfoliatum resulted in a mean net emission of 3.0 Mg CO2eq ha−1y−1 and mean net sequestration of 0.6 Mg CO2eq ha−1y−1 respectively over a 16 year rotation. This compared to predicted mean net emissions of 4.2 Mg CO2eq ha−1y−1 for an arable rotation, and intermediate values for the SRC and Miscanthus crop (1.0 and 2.2 Mg CO2eq ha− 1y− 1, respectively).
    Keywords Cup plant ; Virginia fanpetals ; Virginia mallow ; Greenhouse gas emissions ; Bioenergy crops ; Renewable energy sources ; TJ807-830 ; Agriculture (General) ; S1-972
    Subject code 571
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction to "Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues".

    Graves, Paul R / Aponte-Collazo, Lucas J / Fennell, Emily M J / Graves, Adam C / Hale, Andrew E / Dicheva, Nedyalka / Herring, Laura E / Gilbert, Thomas S K / East, Michael P / McDonald, Ian M / Lockett, Matthew R / Ashamalla, Hani / Moorman, Nathaniel J / Karanewsky, Donald S / Iwanowicz, Edwin J / Holmuhamedov, Ekhson / Graves, Lee M

    ACS chemical biology

    2022  Volume 17, Issue 8, Page(s) 2377–2378

    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Published Erratum
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.2c00545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting the succinate receptor effectively inhibits periodontitis.

    Guo, Yuqi / Xu, Fangxi / Thomas, Scott C / Zhang, Yanli / Paul, Bidisha / Sakilam, Satish / Chae, Sungpil / Li, Patty / Almeter, Caleb / Kamer, Angela R / Arora, Paramjit / Graves, Dana T / Saxena, Deepak / Li, Xin

    Cell reports

    2022  Volume 40, Issue 12, Page(s) 111389

    Abstract: Periodontal disease (PD) is one of the most common inflammatory diseases in humans and is initiated by an oral microbial dysbiosis that stimulates inflammation and bone loss. Here, we report an abnormal elevation of succinate in the subgingival plaque of ...

    Abstract Periodontal disease (PD) is one of the most common inflammatory diseases in humans and is initiated by an oral microbial dysbiosis that stimulates inflammation and bone loss. Here, we report an abnormal elevation of succinate in the subgingival plaque of subjects with severe PD. Succinate activates succinate receptor-1 (SUCNR1) and stimulates inflammation. We detected SUCNR1 expression in the human and mouse periodontium and hypothesize that succinate activates SUCNR1 to accelerate periodontitis through the inflammatory response. Administration of exogenous succinate enhanced periodontal disease, whereas SUCNR1 knockout mice were protected from inflammation, oral dysbiosis, and subsequent periodontal bone loss in two different models of periodontitis. Therapeutic studies demonstrated that a SUCNR1 antagonist inhibited inflammatory events and osteoclastogenesis in vitro and reduced periodontal bone loss in vivo. Our study reveals succinate's effect on periodontitis pathogenesis and provides a topical treatment for this disease.
    MeSH term(s) Alveolar Bone Loss/drug therapy ; Animals ; Dysbiosis ; Humans ; Inflammation/metabolism ; Mice ; Mice, Knockout ; Periodontal Diseases ; Periodontitis/drug therapy ; Succinic Acid/metabolism
    Chemical Substances Succinic Acid (AB6MNQ6J6L)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111389
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  6. Article: Coxiella burnetii

    Mathews, Karen O / Toribio, Jenny-Ann / Norris, Jacqueline M / Phalen, David / Wood, Nicholas / Graves, Stephen R / Sheehy, Paul A / Bosward, Katrina L

    One health (Amsterdam, Netherlands)

    2020  Volume 12, Page(s) 100197

    Abstract: ... Coxiella ... ...

    Abstract Coxiella burnetii
    Language English
    Publishing date 2020-11-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2020.100197
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  7. Article ; Online: Identification of novel mutant p53 interacting proteins by proteomic analysis.

    Deb, Sumitra / Graves, Paul R

    Methods in molecular biology (Clifton, N.J.)

    2013  Volume 962, Page(s) 85–94

    Abstract: Protein-protein interaction studies can provide valuable insight into protein function. One of the most practical and high-yielding approaches is immunoprecipitation of a bait protein followed by mass spectrometry to identify co-precipitating proteins. ... ...

    Abstract Protein-protein interaction studies can provide valuable insight into protein function. One of the most practical and high-yielding approaches is immunoprecipitation of a bait protein followed by mass spectrometry to identify co-precipitating proteins. Here we describe an effective and simplified version of this method that can be performed in most laboratories using standard laboratory equipment (apart from the mass spectrometer). We further demonstrate the utility of this method to identify proteins that specifically interact with mutant forms of the tumor suppressor protein, p53.
    MeSH term(s) Blotting, Western ; Cell Line, Tumor ; Electrophoresis, Polyacrylamide Gel ; Humans ; Immunoprecipitation ; Mass Spectrometry ; Mutant Proteins/genetics ; Mutant Proteins/isolation & purification ; Mutation ; Proteomics/methods ; Transfection ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/isolation & purification
    Chemical Substances Mutant Proteins ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2013
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-62703-236-0_7
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  8. Article: Understanding mitochondrial genetic abnormalities in cancer etiology: a proteomics approach.

    Graves, Paul R

    Cancer biology & therapy

    2006  Volume 5, Issue 8, Page(s) 976–977

    MeSH term(s) Cell Nucleus/metabolism ; DNA, Mitochondrial/genetics ; Humans ; Mitochondria/genetics ; Mitochondrial Proteins/metabolism ; Neoplasms/etiology ; Proteome/analysis ; Proteomics
    Chemical Substances DNA, Mitochondrial ; Mitochondrial Proteins ; Proteome
    Language English
    Publishing date 2006-08-21
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2146305-0
    ISSN 1538-4047
    ISSN 1538-4047
    DOI 10.4161/cbt.5.8.5061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Relapsing Encephalomyelitis After COVID-19 Infection and Vaccination: From the National MS Society Case Conference Proceedings.

    Roy, Shuvro / Barreras, Paula / Pardo, Carlos A / Graves, Jennifer S / Zamvil, Scott S / Newsome, Scott D

    Neurology(R) neuroimmunology & neuroinflammation

    2023  Volume 10, Issue 3

    Abstract: Prior case studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its vaccines may unmask CNS neuroinflammatory conditions. We present a case of relapsing steroid-responsive encephalomyelitis after SARS-CoV-2 infection and ... ...

    Abstract Prior case studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its vaccines may unmask CNS neuroinflammatory conditions. We present a case of relapsing steroid-responsive encephalomyelitis after SARS-CoV-2 infection and subsequent COVID-19 vaccination. We also characterize the frequency of CNS neuroinflammatory events reported in the literature after both SARS-CoV-2 infection and COVID-19 vaccination.
    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Encephalomyelitis/diagnosis ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000200112
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  10. Article: Embedded racism: Inequitable niche construction as a neglected evolutionary process affecting health.

    Ivey Henry, Paula / Spence Beaulieu, Meredith R / Bradford, Angelle / Graves, Joseph L

    Evolution, medicine, and public health

    2023  Volume 11, Issue 1, Page(s) 112–125

    Abstract: Racial health disparities are a pervasive feature of modern experience and structural racism is increasingly recognized as a public health crisis. Yet evolutionary medicine has not adequately addressed the racialization of health and disease, ... ...

    Abstract Racial health disparities are a pervasive feature of modern experience and structural racism is increasingly recognized as a public health crisis. Yet evolutionary medicine has not adequately addressed the racialization of health and disease, particularly the systematic embedding of social biases in biological processes leading to disparate health outcomes delineated by socially defined race. In contrast to the sheer dominance of medical publications which still assume genetic 'race' and omit mention of its social construction, we present an alternative biological framework of racialized health. We explore the unifying evolutionary-ecological principle of niche construction as it offers critical insights on internal and external biological and behavioral feedback processes environments at every level of the organization. We Integrate insights of niche construction theory in the context of human evolutionary and social history and phenotype-genotype modification, exposing the extent to which racism is an evolutionary mismatch underlying inequitable disparities in disease. We then apply ecological models of niche exclusion and exploitation to institutional and interpersonal racial constructions of population and individual health and demonstrate how discriminatory processes of health and harm apply to evolutionarily relevant disease classes and life-history processes in which socially defined race is poorly understood and evaluated. Ultimately, we call for evolutionary and biomedical scholars to recognize the salience of racism as a pathogenic process biasing health outcomes studied across disciplines and to redress the neglect of focus on research and application related to this crucial issue.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2684837-5
    ISSN 2050-6201
    ISSN 2050-6201
    DOI 10.1093/emph/eoad007
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