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Article: Genetic Variations in the Purinergic P2X7 Receptor Are Associated with the Immune Response to Ocular Toxoplasmosis in Colombia.

Naranjo-Galvis, Carlos A / McLeod, Rima / Gómez-Marín, Jorge Enrique / de-la-Torre, Alejandra / Rocha-Roa, Cristian / Cardona, Néstor / Sepúlveda-Arias, Juan Carlos

Microorganisms

2023 Volume 11, Issue 10

Abstract: Ocular toxoplasmosis (OT) is characterized by inflammation within the eye and is the most recognized clinical manifestation of toxoplasmosis. The objective of this study was to identify new single-nucleotide polymorphisms (SNPs) in ... ...

Abstract	Ocular toxoplasmosis (OT) is characterized by inflammation within the eye and is the most recognized clinical manifestation of toxoplasmosis. The objective of this study was to identify new single-nucleotide polymorphisms (SNPs) in the
Language	English
Publishing date	2023-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11102508
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Article ; Online: Stratum Corneum Hydration As a Potential Marker of Response to Dupilumab in Atopic Dermatitis: A Prospective Observational Study.

Montero-Vilchez, Trinidad / Rodriguez-Pozo, Juan-Angel / Cuenca-Barrales, Carlos / Sanabria-de-la-Torre, Raquel / Torres-de-Pinedo, Jesus-Manuel / Arias-Santiago, Salvador

Dermatitis : contact, atopic, occupational, drug

2023

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2144723-8
ISSN	2162-5220 ; 1532-8163 ; 1710-3568
ISSN (online)	2162-5220 ; 1532-8163
ISSN	1710-3568
DOI	10.1089/derm.2023.0176
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Article ; Online: Functional stability: From soil aggregates to landscape scale in a region severely affected by gully erosion in semi-arid central Mexico

de la Torre-Robles, Lourdes / Muñoz-Robles, Carlos / Huber-Sannwald, Elisabeth / Antonio Reyes-Agüero, Juan

Catena. 2023 Mar., v. 222 p.106864-

2023

Abstract: Soil aggregate stability is a vital indicator of soil structure and potential degradation and is essential to understand gully erosion in arid and semi-arid regions. Stability of soil aggregates depends on soil mass properties, local conditions (within ... ...

Abstract	Soil aggregate stability is a vital indicator of soil structure and potential degradation and is essential to understand gully erosion in arid and semi-arid regions. Stability of soil aggregates depends on soil mass properties, local conditions (within the gully), and hillslope conditions. The objectives of this study were 1) to analyze soil aggregate stability at three gully wall positions: headscarps, sidewalls, and gully bottoms, and 2) to explore the relationships between soil aggregate stability and local and landscape conditions to know how stability at different scales is interrelated. Soil macro aggregate stability was estimated from soil samples using the soil aggregate stability kit. Conversely, Cornell infiltrometers were used to evaluate soil microaggregate stability by applying 5-min rainfall events with an intensity of 150 mm⁻¹. Local (within gully) conditions were registered in the field using indicators from the ephemeral drainage line assessment method. Landscape conditions (outside gully), such as terrain attributes, anthropogenic features, and vegetation cover, were computed from topographic maps, digital elevation models, and satellite imagery. Relationships between soil aggregate stability and local and landscape conditions were explored using classification and regression trees. The highest soil macro and micro aggregate stability were found at the gully headscarps, while gully bottoms had the lowest soil aggregate stability. Soil macroaggregate stability was related to terrain attributes, ground cover, and gully dimensions. In contrast, microaggregate stability was associated with ground cover, terrain attributes, gully dimensions, and distance to roads and farm dams. Our study showed that soil aggregate stability differs along gully walls and that soil aggregate stability can be related to different variables at the local and hillslope scales. This knowledge is a valuable indicator for understanding gully erosion and the foundation for restoration strategies in semi-arid regions.
Keywords	aggregate stability ; catenas ; drainage ; farms ; gully erosion ; infiltrometers ; landscapes ; rain ; remote sensing ; soil aggregates ; soil structure ; topographic slope ; vegetation cover ; Mexico ; Erosion ; Hillslope scale ; Local scale ; Semi-arid areas
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	519608-5
ISSN	1872-6887 ; 0008-7769 ; 0341-8162
ISSN (online)	1872-6887 ; 0008-7769
ISSN	0341-8162
DOI	10.1016/j.catena.2022.106864
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Article: Clinical characterization of patients with HLA-B27-associated uveitis and evaluation of the impact of systemic treatment on the recurrence rate: a cross-sectional study.

Pineda-Sierra, Juan Sebastián / Cifuentes-González, Carlos / Rojas-Carabali, William / Muñoz-Vargas, Paula Tatiana / Henao-Posada, Alejandro / de-la-Torre, Alejandra

Journal of ophthalmic inflammation and infection

2023 Volume 13, Issue 1, Page(s) 38

Abstract: Introduction: Despite HLA-B27-associated uveitis is one of the most frequent etiologies of uveitis worldwide, there are scarce studies on the clinical spectrum of this disease and the implications of therapeutic strategies used in the Latin-American ... ...

Abstract	Introduction: Despite HLA-B27-associated uveitis is one of the most frequent etiologies of uveitis worldwide, there are scarce studies on the clinical spectrum of this disease and the implications of therapeutic strategies used in the Latin-American population, with none conducted in Colombia. Thus, this study aimed to describe the clinical characteristics of a cohort of patients with positive HLA-B27-associated uveitis in Colombia and evaluate the impact of systemic treatment on the recurrence rate. Methods: We retrospectively reviewed 490 clinical charts of patients with uveitis, searching for those with positive HLA-B27-associated uveitis over eight years in a referral center in Bogotá, Colombia. We used descriptive statistics to summarize demographic and clinical characteristics and conducted a Chi-square test, Fisher Exact test, Spearman correlation, and Mann-Whitney test to assess associations between treatment strategies and the recurrences rate. Results: We analyzed 39 patients (59% females) with positive HLA-B27-associated uveitis, with a median age at the first consultation of 44.5 years (Range: 2-80) and a mean follow-up time of 86.4 weeks (1.65 years). Most patients had unilateral uveitis (53.8%) and an anterior anatomical diagnosis (76.6%); two had anterior chamber fibrinous reaction, and only one had hypopyon. Most patients did not show associated systemic symptoms (66.7%). Topical corticosteroids, NSAIDs, methotrexate, mydriatics, and adalimumab were the most used treatments. The most common complications included cataracts, posterior synechiae, and macular edema. We identified that the rate of recurrences decreases over time (r = -0.6361, P = 0.002571), and this decrease seems to be associated with the initiation of disease-modifying antirheumatic drugs (DMARDs) in chronic and recurrent cases. Conclusion: The clinical spectrum of HLA-B27-associated uveitis in Colombian patients is distinct from other latitudes. Notably, we found a female predominance, older age at presentation, higher frequency of bilateral and vitreous involvement, and lower frequency of concomitant systemic diseases. Additionally, our results suggest that DMARDs such as methotrexate and biologic agents are good therapeutic options to avoid recurrences in chronic and recurrent cases.
Language	English
Publishing date	2023-08-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2592309-2
ISSN	1869-5760
ISSN	1869-5760
DOI	10.1186/s12348-023-00352-3
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Article ; Online: CD8+ T-cell Exhaustion Phenotype in Human Asymptomatic and Ocular Toxoplasmosis.

García-López, Laura Lorena / Vargas-Montes, Mónica / Osorio-Méndez, Juan Felipe / Cardona, Néstor / Hernández De Los Ríos, Alejandro / Toro-Acevedo, Carlos Andrés / Arenas-García, Juan Camilo / Mantilla-Muriel, Luz Eliana / Torres, Elizabeth / Valencia-Hernández, Juan D / Acosta-Dávila, Alejandro / de-la-Torre, Alejandra / Celis-Giraldo, Daniel / Mejía Oquendo, Manuela / Sepúlveda-Arias, Juan Carlos / Gómez-Marín, Jorge Enrique

Ocular immunology and inflammation

2023 , Page(s) 1–10

Abstract: This work analyzed exhaustion markers in CD8+ T-cell subpopulations in 21 samples of peripheral blood mononuclear cells (PBMCs) from individuals with ocular toxoplasmosis ( ...

Abstract	This work analyzed exhaustion markers in CD8+ T-cell subpopulations in 21 samples of peripheral blood mononuclear cells (PBMCs) from individuals with ocular toxoplasmosis (
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2023.2217906
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Article: Effect of Foliar Application of Hydrogen Peroxide Macroconcentrations on Growth Parameters, Phenolic Compounds and Antioxidant Capacity in the Leaves and Seeds of

Ferriz-Martínez, Roberto Augusto / Espinosa-Villarreal, Nayeli / Chávez-Servín, Jorge Luis / Mercado-Luna, Adán / de la Torre-Carbot, Karina / Serrano-Arellano, Juan / Saldaña, Carlos / García-Gasca, Teresa

Plants (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: Amaranth has many interesting features, both nutritional and otherwise, that make it attractive as a food crop. Plants grown in greenhouses have higher yields but lower nutritional value compared to those grown in open fields. This prompted an interest ... ...

Abstract	Amaranth has many interesting features, both nutritional and otherwise, that make it attractive as a food crop. Plants grown in greenhouses have higher yields but lower nutritional value compared to those grown in open fields. This prompted an interest in studying viable elicitors for the production of amaranth. Small hydrogen peroxide (H
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12071499
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Article: Analysis of the Risk of Wear on Cemented and Uncemented Polyethylene Liners According to Different Variables in Hip Arthroplasty.

De la Torre, Basilio / Barrios, Loreto / De la Torre-Mosquera, Juan / Bujan, Julia / Ortega, Miguel A / González-Bravo, Carlos

Materials (Basel, Switzerland)

2021 Volume 14, Issue 23

Abstract: Wear debris in total hip arthroplasty is one of the main causes of loosening and failure, and the optimal acetabular fixation for primary total hip arthroplasty is still controversial because there is no significant difference between cemented and ... ...

Abstract	Wear debris in total hip arthroplasty is one of the main causes of loosening and failure, and the optimal acetabular fixation for primary total hip arthroplasty is still controversial because there is no significant difference between cemented and uncemented types for long-term clinical and functional outcome. To assess and predict, from a theoretical viewpoint, the risk of wear with two types of polyethylene liners, cemented and uncemented, a simulation using the finite element (FE) method was carried out. The risk of wear was analyzed according to different variables: the polyethylene acetabular component's position with respect to the center of rotation of the hip; the thickness of the polyethylene insert; the material of the femoral head; and the relationship of the cervical-diaphyseal morphology of the proximal end of the femur to the restoration of the femoral offset. In all 72 simulations studied, a difference was observed in favour of a cemented solution with respect to the risk of wear. With regard to the other variables, the acetabular fixation, the thickness of the polyethylene, and the acetabular component positioning were statistically significant. The highest values for the risk of wear corresponded to a smaller thickness (5.3 mm), and super-lateral positioning at 25 mm reached the highest value of the von Mises stress. According to our results, for the reconstruction of the acetabular side, a cemented insert with a thickness of at least 5 mm should be used at the center of rotation.
Language	English
Publishing date	2021-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14237243
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Article: Neutralizing Antibodies as Predictors of Vaccine Breakthrough Infection in Healthcare Workers Vaccinated with or without a Heterologous Booster Dose: A Cohort Study during the Third COVID-19 Wave in Peru.

Hueda-Zavaleta, Miguel / Gómez de la Torre, Juan C / Cáceres-DelAguila, José Alonso / Muro-Rojo, Cecilia / De La Cruz-Escurra, Nathalia / Copaja-Corzo, Cesar / Aragón-Ayala, Carlos J / Benítes-Zapata, Vicente A

Vaccines

2023 Volume 11, Issue 2

Abstract: We evaluated neutralizing antibody (NAbs) levels as a protective factor against vaccine breakthrough infection (VBI) in healthcare workers (HCWs) during the third COVID-19 wave in Peru. This retrospective cohort study employed the information from a ... ...

Abstract	We evaluated neutralizing antibody (NAbs) levels as a protective factor against vaccine breakthrough infection (VBI) in healthcare workers (HCWs) during the third COVID-19 wave in Peru. This retrospective cohort study employed the information from a private laboratory in Lima (Peru) of HCW who received only two BBIBP-CorV vaccines or (additionally) a heterologous booster with BNT162b2. We evaluated the association between the VBI and the levels of NAbs at 21, 90, 180, and 210 days after the BBIBP-CorV second dose. NAbs were calculated with the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit (surrogate virus neutralization test (sVNT)) and the Elecsys
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11020447
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Article ; Online: Molecular Tracking of the Origin of Vesicular Stomatitis Outbreaks in 2004 and 2018, Ecuador.

Vasco-Julio, David / Aguilar, Dayana / Maldonado, Alexander / de la Torre, Euclides / Cisneros-Montufar, Maria Soledad / Bastidas-Caldes, Carlos / Navarro, Juan-Carlos / de Waard, Jacobus H

Veterinary sciences

2023 Volume 10, Issue 3

Abstract: The Vesicular Stomatitis Virus (VSV) is an arbovirus causing vesicular stomatitis (VS) in livestock. There are two serotypes recognized: New Jersey (VSNJV) and Indiana (VSIV). The virus can be transmitted directly by contact or by vectors. In 2018, ... ...

Abstract	The Vesicular Stomatitis Virus (VSV) is an arbovirus causing vesicular stomatitis (VS) in livestock. There are two serotypes recognized: New Jersey (VSNJV) and Indiana (VSIV). The virus can be transmitted directly by contact or by vectors. In 2018, Ecuador experienced an outbreak of Vesicular Stomatitis (VS) in cattle, caused by VSNJV and VSVIV, with 399 cases reported distributed over 18 provinces. We determined the phylogenetic relationships among 67 strains. For the construction of phylogenetic trees, the viral phosphoprotein gene was sequenced, and trees were constructed based on the Maximum Likelihood method using 2004 outbreak strains from Ecuador (GenBank) and the 2018 sequences (this article). We built a haplotype network for VSNJV to trace the origin of the 2004 and 2018 epizootics through topology and mutation connections. These analyses suggest two different origins, one related to the 2004 outbreak and the other from a transmission source in 2018. Our analysis also suggests different transmission patterns; several small and independent outbreaks, most probably transmitted by vectors in the Amazon, and another outbreak caused by the movement of livestock in the Andean and Coastal regions. We recommend further research into vectors and vertebrate reservoirs in Ecuador to clarify the mechanisms of the reemergence of the virus.
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci10030181
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Article ; Online: Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases.

Izquierdo-Condoy, Juan S / Vásconez-Gonzáles, Jorge / Morales-Lapo, Estefanía / Tello-De-la-Torre, Andrea / Naranjo-Lara, Patricio / Fernández, Ricardo / Hidalgo, Marlon R / Escobar, Adriana / Yépez, Vanessa Herrera / Díaz, Ana María / Oliva, Carlos / Ortiz-Prado, Esteban

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1293782

Abstract: Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history. Their impact extends far beyond the acute phase, characterized by the ... ...

Abstract	Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history. Their impact extends far beyond the acute phase, characterized by the majority of symptom presentations, to a multitude of adverse events and sequelae that follow viral, parasitic, fungal, or bacterial infections. In this context, myriad sequelae related to various infectious diseases have been identified, spanning short to long-term durations. Although these sequelae are known to affect thousands of individuals individually, a comprehensive evaluation of all potential long-term effects of infectious diseases has yet to be undertaken. We present a comprehensive literature review delineating the primary sequelae attributable to major infectious diseases, categorized by systems, symptoms, and duration. This compilation serves as a crucial resource, illuminating the long-term ramifications of infectious diseases for healthcare professionals worldwide. Moreover, this review highlights the substantial burden that these sequelae impose on global health and economies, a facet often overshadowed by the predominant focus on the acute phase. Patients are frequently discharged following the resolution of the acute phase, with minimal long-term follow-up to comprehend and address potential sequelae. This emphasizes the pressing need for sustained vigilance, thorough patient monitoring, strategic health management, and rigorous research to understand and mitigate the lasting economic and health impacts of infectious diseases more fully.
MeSH term(s)	Humans ; Communicable Diseases/complications ; Causality ; Risk Factors ; Bacterial Infections
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1293782
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