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  1. Article ; Online: Foreword - Aquaporins at thirty.

    Agre, Peter

    Biochimica et biophysica acta. Biomembranes

    2022  Volume 1864, Issue 8, Page(s) 183936

    MeSH term(s) Aquaporins ; Water/metabolism
    Chemical Substances Aquaporins ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-04-16
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 60-7
    ISSN 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamem.2022.183936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Aquaporins

    Agre, Peter / Beitz, Eric

    (Handbook of experimental pharmacology ; 190)

    2009  

    Author's details Eric Beltz, ed. Contributors: P. Agre
    Series title Handbook of experimental pharmacology ; 190
    Collection
    Keywords Aquaporins ; Aquaporine ; Membranproteine
    Subject Biomembran ; AQP
    Subject code 572.696
    Language English
    Size XVI, 424 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT015753407
    ISBN 3-540-79884-6 ; 978-3-540-79884-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 6750 order for loan Magazin
    2009 A 168 order for loan Magazin

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  3. Article: Retrospective Evaluation of a Dexamethasone Sparing Antiemetic Regimen: An Antiemetic Prophylaxis Study on NEPA (Netupitant Plus Palonosetron) for Preventing Chemotherapy-Induced Nausea and Vomiting (CINV) in Cancer Patients.

    Agre, Suhas / Agre, Madhura / Pol, Pooja / Tonse, Mubarakunnisa / Mohanty, Mitasha / Shaikh, Alfiya

    Cureus

    2023  Volume 15, Issue 11, Page(s) e49763

    Abstract: Background Corticosteroids, specifically dexamethasone (DEX), have been extensively utilized for the prevention of chemotherapy-induced nausea and vomiting (CINV). However, their usage is associated with a range of adverse events. In contrast, the ... ...

    Abstract Background Corticosteroids, specifically dexamethasone (DEX), have been extensively utilized for the prevention of chemotherapy-induced nausea and vomiting (CINV). However, their usage is associated with a range of adverse events. In contrast, the combination of Netupitant Plus Palonosetron (NEPA) with a single dose of DEX provides comparable efficacy in preventing CINV over a five-day period following chemotherapy administration. This regimen offers the advantage of reducing the need for additional doses of DEX, particularly in the high-risk setting of HEC (Highly emetic chemotherapy). Objective To evaluate dexamethasone sparing anti-emetic regimen (single dose dexamethasone with NEPA) for prophylaxis of CINV in patients receiving HEC. Methodology This is a retrospective, observational, real-world, single-center study including data of 69 patients who received high-dose emetogenic chemotherapy and were administered DEX (8 or 12 mg) on day 1, with no dose of DEX on days 2, 3, and 4, combined with an oral combination of tablet netupitant 300 mg and palonosetron 0.5 mg. NEPA was taken orally an hour prior to the start of the HEC cycle. The primary efficacy endpoint was complete response (CR) which is defined as no nausea, emesis, or no rescue medication during the Acute (< 24 hours) and Delayed Phase (25-120 hours) of chemotherapy. Results The overall CR achieved in the acute and delayed phase for vomiting is 100% at all four follow-ups. The CR achieved in the acute phase is 95.7% whereas 98.6% of patients showed CR in the delayed phase respectively. No patient required any rescue medication. No acute and delayed phase of vomiting was reported. Conclusion A simplified regimen of NEPA plus single-dose DEX offers effective CINV prevention throughout five days post-chemotherapy with the advantage of sparing patients additional doses of DEX in the high-emetic-risk setting chemotherapy.
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Highly informative SNP marker panels in yam (Dioscorea rotundata) for genomic selection and prediction

    Agre, A.P. / Asfaw, A.

    2023  

    Keywords food security ; yams ; food production ; food quality ; single nucleotide polymorphisms
    Language English
    Publishing date 2023-09-13T15:03:48Z
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Human Plasmodium vivax mosquito experimental transmission.

    Sullivan, David J / Agre, Peter

    The Journal of clinical investigation

    2020  Volume 130, Issue 6, Page(s) 2800–2802

    Abstract: ... for both P. vivax and P. falciparum, controlled human transmission to mosquitoes falls short for both species ... In this issue of the JCI, Collins et al. present groundbreaking work that establishes a system to transmit P ... vivax gametocytes from humans to mosquitoes. The authors injected a unique human isolate of P. vivax ...

    Abstract Plasmodium vivax bench research greatly lags behind Plasmodium falciparum because of an inability to culture in vitro. A century ago, intentionally inducing a malaria infection was a strategy commonly used to cure late-stage syphilis. These controlled human malaria infections were used with expertise and persisted to the end of World War II. While controlled malaria liver-stage infection has been achieved for both P. vivax and P. falciparum, controlled human transmission to mosquitoes falls short for both species. In this issue of the JCI, Collins et al. present groundbreaking work that establishes a system to transmit P. vivax gametocytes from humans to mosquitoes. The authors injected a unique human isolate of P. vivax that reached high gametocyte density within weeks. This study provides a technical advance that will facilitate the study and eradication of the human parasite P. vivax.
    MeSH term(s) Animals ; Culicidae ; Humans ; Malaria, Falciparum ; Malaria, Vivax ; Plasmodium falciparum ; Plasmodium vivax
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI135794
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  6. Article ; Online: Genetic purity of yam (Dioscorea spp.) multiplied through different seed multiplication techniques based on DArT SNP markers

    Maroya, N. / Agre, A.P. / Balogun, M.

    Plant Genetic Resources: Characterization and Utilization

    2023  

    Abstract: Open Access Article ... Obtaining high-quality planting material for cultivation is a persisting challenge for yam (Dioscorea spp.) production in Africa. Efforts to provide a solution to this challenge have led to varying seed multiplication techniques but ...

    Abstract Open Access Article

    Obtaining high-quality planting material for cultivation is a persisting challenge for yam (Dioscorea spp.) production in Africa. Efforts to provide a solution to this challenge have led to varying seed multiplication techniques but whose efficiency in maintaining the genetic purity of yam genotypes during the rapid multiplication process is yet unknown. Three improved varieties Swaswa, Kpamyo and Asiedu were multiplied through tissue culture, aeroponics system, field condition and vine cutting techniques. Leaf samples were collected at every stage of multiplication in the different techniques as well as the original mother plant for DNA fingerprinting. From a total of 16,922 SNP markers, an average heterozygosity of 0.091 was obtained with minor allele frequency of 0.119, and polymorphic information content of 0.166. The transition to transversion ratio was 62:38%. Hierarchical clustering of the genotypes and technologies discriminated the multiplied materials into three clusters with the first cluster consisting of only the variety Asiedu multiplied through aeroponics, vine and tubers collected from vine cutting and grown from the field. The second cluster consisted predominantly of the variety Kpamyo, with a little admixture from Asiedu. The third cluster consisted of only Swaswa. The different seed multiplication methods showed great potentials in conserving the genetic purity of genotypes used. Therefore, the use of these seed multiplication techniques could offer a lasting solution to the low multiplication ratio of yam without compromising the genetic integrity and offers a great opportunity for establishing a formal yam seed system.
    Keywords yams ; dioscorea ; single nucleotide polymorphism ; genotypes ; seed multiplication ; tissue culture
    Language English
    Publishing date 2023-04-13T08:50:08Z
    Publisher Cambridge University Press
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Invesigate How Cultural and Socioeconomic Factors Influence Oral Cancer Prevention Behaviors, Screening Uptake, and Treatment Outcomes.

    Ranjan, Madhu / Tushar / Parekh, Nirav Hemant / Dixit, Arti / Rakshit, Pinaki / Agre, Bhagyashree P / Badiyani, Bhumika Kamal / Kumar, Amit

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S786–S788

    Abstract: Background: Oral cancer is a significant global health issue, with prevention and early detection being pivotal for improved outcomes. This study investigates the impact of cultural and socioeconomic factors on oral cancer prevention behaviors, ... ...

    Abstract Background: Oral cancer is a significant global health issue, with prevention and early detection being pivotal for improved outcomes. This study investigates the impact of cultural and socioeconomic factors on oral cancer prevention behaviors, screening participation, and treatment outcomes.
    Materials and methods: A cross-sectional study design was employed, involving a sample size of 1,000 participants. Participants were recruited through stratified sampling to ensure cultural and socioeconomic diversity. Statistical analyses, including logistic regression, were used to explore associations between factors and outcomes.
    Results: The study revealed multifaceted influences of cultural and socioeconomic factors on oral cancer-related aspects. Cultural factors significantly influenced prevention behaviors, with participants from certain cultural backgrounds exhibiting higher rates of tobacco use and lower rates of dietary adherence). Socioeconomic status played a role in screening uptake, with individuals from lower income brackets less likely to undergo regular screenings.
    Conclusion: Cultural and socioeconomic factors have a substantial influence on oral cancer prevention behaviors, screening participation, and treatment outcomes.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_1009_23
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  8. Article: Gordon Wilson lecture: opening doors worldwide through medical science: personal reflections.

    Agre, Peter

    Transactions of the American Clinical and Climatological Association

    2014  Volume 125, Page(s) 108–121

    MeSH term(s) Aquaporins/history ; Aquaporins/isolation & purification ; Aquaporins/metabolism ; Bacterial Toxins/history ; Bacterial Toxins/isolation & purification ; Biomedical Research/history ; Cooperative Behavior ; Diarrhea/history ; Diarrhea/microbiology ; Diffusion of Innovation ; Enterotoxins/history ; Enterotoxins/isolation & purification ; Escherichia coli Proteins/history ; Escherichia coli Proteins/isolation & purification ; History, 20th Century ; History, 21st Century ; Humans ; Interdisciplinary Communication ; International Cooperation ; Malaria/history ; Malaria/parasitology ; Narration
    Chemical Substances Aquaporins ; Bacterial Toxins ; Enterotoxins ; Escherichia coli Proteins
    Language English
    Publishing date 2014-08-13
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article ; Lecture ; Portrait ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603823-2
    ISSN 0065-7778
    ISSN 0065-7778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Variability and genetic merits of white Guinea yam landraces in Nigeria.

    Agre, Paterne A / Edemodu, Alex / Obidiegwu, Jude E / Adebola, Patrick / Asiedu, Robert / Asfaw, Asrat

    Frontiers in plant science

    2023  Volume 14, Page(s) 1051840

    Abstract: Introduction: Landraces represent a significant gene pool of African cultivated white Guinea yam diversity. They could, therefore, serve as a potential donor of important traits such as resilience to stresses as well as food quality attributes that may ... ...

    Abstract Introduction: Landraces represent a significant gene pool of African cultivated white Guinea yam diversity. They could, therefore, serve as a potential donor of important traits such as resilience to stresses as well as food quality attributes that may be useful in modern yam breeding. This study assessed the pattern of genetic variability, quantitative trait loci (QTLs), alleles, and genetic merits of landraces, which could be exploited in breeding for more sustainable yam production in Africa.
    Methods: A total of 86 white Guinea yam landraces representing the popular landraces in Nigeria alongside 16 elite clones were used for this study. The yam landraces were genotyped using 4,819 DArTseq SNP markers and profiled using key productivity and food quality traits.
    Results and discussion: Genetic population structure through admixture and hierarchical clustering methods revealed the presence of three major genetic groups. Genome-wide association scan identified thirteen SNP markers associated with five key traits, suggesting that landraces constitute a source of valuable genes for productivity and food quality traits. Further dissection of their genetic merits in yam breeding using the Genomic Prediction of Cross Performance (GPCP) allowed identifying several landraces with high crossing merit for multiple traits. Thirteen landraces were identified as potential genitors to develop segregating progenies to improve multiple traits simultaneously for desired gains in yam breeding. Results of this study provide valuable insights into the patterns and the merits of local genetic diversity which can be utilized for identifying desirable genes and alleles of interest in yam breeding for Africa.
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1051840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Red blood cell membranes

    Agre, Peter

    structure ; function ; clinical implications

    (Hematology ; 11)

    1989  

    Author's details ed. by Peter Agre
    Series title Hematology ; 11
    Collection
    Keywords Erythrocyte Membrane / anatomy & histology ; Erythrocyte Membrane / physiology ; Erythrozytenmembran ; Erythrozyt
    Subject Erythrocyt ; Rotes Blutkörperchen (reif) ; Erythrozyten ; Erythrocyten ; Erythrozytenplasmalemma
    Size XX, 733 S. : Ill., graph. Darst.
    Edition 1. pr.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003332580
    ISBN 0-8247-8022-1 ; 978-0-8247-8022-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 3124 order for loan Magazin

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