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  1. Article ; Online: Generation of red blood cells from induced pluripotent stem cells.

    Gunawardena, Naomi / Chou, Stella T

    Current opinion in hematology

    2024  Volume 31, Issue 3, Page(s) 115–121

    Abstract: Purpose of review: Human induced pluripotent stem cells (iPSCs) are an attractive source to generate in-vitro-derived blood for use as transfusable and reagent red cells. We review recent advancements in the field and the remaining limitations for ... ...

    Abstract Purpose of review: Human induced pluripotent stem cells (iPSCs) are an attractive source to generate in-vitro-derived blood for use as transfusable and reagent red cells. We review recent advancements in the field and the remaining limitations for clinical use.
    Recent findings: For iPSC-derived red blood cell (RBC) generation, recent work has optimized culture conditions to omit feeder cells, enhance red cell maturation, and produce cells that mimic fetal or adult-type RBCs. Genome editing provides novel strategies to improve cell yield and create designer RBCs with customized antigen phenotypes.
    Summary: Current protocols support red cell production that mimics embryonic and fetal hematopoiesis and cell yield sufficient for diagnostic RBC reagents. Ongoing challenges to generate RBCs for transfusion include recapitulating definitive erythropoiesis to produce functional adult-type cells, increasing scalability of culture conditions, and optimizing high-density manufacturing capacity.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Cell Differentiation ; Erythrocytes ; Erythropoiesis ; Blood Transfusion/methods
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000810
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    Zs.A 3703: Show issues Location:
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  2. Article ; Online: Transfusion therapy for sickle cell disease: what's new?

    Chou, Stella T / Hendrickson, Jeanne E / Fasano, Ross M

    Blood advances

    2023  Volume 7, Issue 11, Page(s) 2551–2553

    MeSH term(s) Humans ; Anemia, Sickle Cell/therapy ; Blood Transfusion
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2022009283
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    Zs.A 7153: Show issues Location:
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  3. Article ; Online: Red cell genotyping: Real world use.

    Takasaki, Kaoru / Chou, Stella T

    Transfusion medicine (Oxford, England)

    2022  Volume 32, Issue 3, Page(s) 185–186

    MeSH term(s) Blood Grouping and Crossmatching ; Genotype ; Genotyping Techniques ; Humans ; Real-Time Polymerase Chain Reaction
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12869
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    Zs.A 3177: Show issues Location:
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  4. Article: Adverse events of red blood cell transfusions in patients with sickle cell disease.

    Rollins, Margo R / Chou, Stella T

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2022  Volume 61, Issue 5, Page(s) 103557

    Abstract: Blood transfusion is a common medical intervention for patients with sickle cell disease (SCD) and disease related complications. While patients with SCD are at risk for all transfusion related adverse events defined by the National Healthcare Safety ... ...

    Abstract Blood transfusion is a common medical intervention for patients with sickle cell disease (SCD) and disease related complications. While patients with SCD are at risk for all transfusion related adverse events defined by the National Healthcare Safety Network (NHSN) Biovigilance Component Hemovigilance Module Surveillance Protocol, they are uniquely susceptible to certain adverse events. This review discusses risk factors, mitigation strategies, and management recommendations for alloimmunization, hemolytic transfusion reactions, hyperviscosity and transfusion-associated iron overload in the context of SCD.
    MeSH term(s) Humans ; Erythrocyte Transfusion/adverse effects ; Erythrocyte Transfusion/methods ; Anemia, Sickle Cell ; Transfusion Reaction/complications ; Blood Safety ; Blood Transfusion/methods
    Language English
    Publishing date 2022-08-29
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2022.103557
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    Zs.A 1739: Show issues Location:
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  5. Article ; Online: "Rare" reagent red cells: rare no longer?

    Chou, Stella T

    Transfusion

    2018  Volume 58, Issue 11, Page(s) 2469–2471

    MeSH term(s) Erythrocytes/immunology ; Erythroid Precursor Cells/immunology ; Humans ; Indicators and Reagents ; Isoantibodies ; Serologic Tests
    Chemical Substances Indicators and Reagents ; Isoantibodies
    Language English
    Publishing date 2018-10-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.14958
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
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  6. Article ; Online: Red cell transfusion and alloimmunization in sickle cell disease.

    Linder, Grace E / Chou, Stella T

    Haematologica

    2021  Volume 106, Issue 7, Page(s) 1805–1815

    Abstract: Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and ... ...

    Abstract Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle cell disease and include alloimmunization, acute and delayed hemolytic transfusion reactions, and iron overload. Judicious use of red cell transfusions, optimization of red cell antigen matching, and the use of erythrocytapheresis and iron chelation can minimize adverse effects. Early recognition and management of hemolytic transfusion reactions can avert poor clinical outcomes. In this review, we discuss transfusion methods, indications, and complications in sickle cell disease with an emphasis on alloimmunization.
    MeSH term(s) Anemia, Sickle Cell/therapy ; Blood Transfusion ; Erythrocyte Transfusion/adverse effects ; Humans ; Stroke ; Transfusion Reaction
    Language English
    Publishing date 2021-07-01
    Publishing country Italy
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.270546
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    Uh III Zs.76: Show issues Location:
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  7. Article ; Online: Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease.

    Zheng, Yan / Chou, Stella T

    Clinics in laboratory medicine

    2020  Volume 41, Issue 1, Page(s) 101–119

    Abstract: Red blood cell (RBC) transfusion is critical in managing acute and chronic complications of sickle cell disease. Alloimmunization and iron overload remain significant complications of transfusion therapy and are minimized with prophylactic Rh and K ... ...

    Abstract Red blood cell (RBC) transfusion is critical in managing acute and chronic complications of sickle cell disease. Alloimmunization and iron overload remain significant complications of transfusion therapy and are minimized with prophylactic Rh and K antigen RBC matching and iron chelation. Matched sibling donor hematopoietic stem cell transplant (HSCT) is a curative therapeutic option. Autologous hematopoietic stem cell (HSC)-based gene therapy has recently shown great promise, for which obtaining sufficient HSCs is essential for success. This article discusses RBC transfusion indications and complications, transfusion support during HSCT, and HSC mobilization and collection for autologous HSCT with gene therapy.
    MeSH term(s) Anemia, Sickle Cell/therapy ; Blood Group Antigens ; Blood Transfusion ; Cell- and Tissue-Based Therapy ; Erythrocyte Transfusion/adverse effects ; Humans
    Chemical Substances Blood Group Antigens
    Language English
    Publishing date 2020-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2020.10.007
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    Zs.A 1695: Show issues Location:
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  8. Article ; Online: Generation of 2 isogenic clones from a patient with Trisomy 21 and a GATA1 mutation.

    Takasaki, Kaoru / Kumar, Sara S / Gagne, Alyssa / French, Deborah L / Chou, Stella T

    Stem cell research

    2023  Volume 69, Page(s) 103098

    Abstract: Trisomy 21 (T21), or Down Syndrome (DS), is a common chromosomal disorder resulting from a third copy of chromosome 21 (HSA21). Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with DS and is ... ...

    Abstract Trisomy 21 (T21), or Down Syndrome (DS), is a common chromosomal disorder resulting from a third copy of chromosome 21 (HSA21). Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with DS and is characterized by a mutation in the transcription factor GATA1 that results in a truncated protein (GATA1s). We generated a pair of isogenic T21 lines derived from a patient with TMD that differ only in GATA1 status. The iPSC lines were characterized for pluripotency, differentiation potential, and genomic stability. These lines are a valuable resource for studying T21 hematopoietic diseases.
    MeSH term(s) Infant, Newborn ; Humans ; Down Syndrome/genetics ; Leukemia, Megakaryoblastic, Acute/genetics ; Myeloproliferative Disorders/genetics ; Mutation/genetics ; Trisomy ; GATA1 Transcription Factor/genetics
    Chemical Substances GATA1 protein, human ; GATA1 Transcription Factor
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103098
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  9. Article ; Online: Generation of CHOPi-008-B, a euploid iPSC line from a patient with Trisomy 21 and a GATA1 mutation.

    Takasaki, Kaoru / Kumar, Sara S / Gagne, Alyssa / French, Deborah L / Chou, Stella T

    Stem cell research

    2023  Volume 72, Page(s) 103198

    Abstract: Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription ... ...

    Abstract Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription factor GATA1 that results in a truncated protein (GATA1s). We generated a euploid iPSC line with a GATA1s mutation that is isogenic to a previously published pair of T21 lines with and without a GATA1 mutation. The line was characterized for pluripotency, differentiation potential, and genomic stability. This line is a valuable isogenic control for studying the T21 hematopoietic phenotype.
    MeSH term(s) Infant, Newborn ; Humans ; Down Syndrome/genetics ; Leukemia, Megakaryoblastic, Acute/genetics ; Induced Pluripotent Stem Cells ; Mutation/genetics ; Genomic Instability ; Trisomy ; GATA1 Transcription Factor/genetics
    Chemical Substances GATA1 protein, human ; GATA1 Transcription Factor
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103198
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  10. Article ; Online: Generation of CHOPi-008-B, a euploid iPSC line from a patient with Trisomy 21 and a GATA1 mutation

    Kaoru Takasaki / Sara S. Kumar / Alyssa Gagne / Deborah L. French / Stella T. Chou

    Stem Cell Research, Vol 72, Iss , Pp 103198- (2023)

    2023  

    Abstract: Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription ... ...

    Abstract Transient myeloproliferative disorder (TMD) is a pre-leukemic condition that occurs only in neonates with Trisomy 21 (T21), and is attributed to a genetic interaction between the third copy of chromosome 21 (HSA21) and a mutation in the transcription factor GATA1 that results in a truncated protein (GATA1s). We generated a euploid iPSC line with a GATA1s mutation that is isogenic to a previously published pair of T21 lines with and without a GATA1 mutation. The line was characterized for pluripotency, differentiation potential, and genomic stability. This line is a valuable isogenic control for studying the T21 hematopoietic phenotype.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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