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Book ; Online ; E-Book: Greenspan's basic & clinical endocrinology

Gardner, David G. / Gardner, David G / Shoback, Dolores M / Greenspan, Francis S.

2018

Title variant	Basic & Clinical Endocrinology
MeSH term(s)	Endocrine Glands/physiology ; Endocrine System Diseases ; Hormones/physiology
Language	English
Edition	10th edition
Publisher	McGraw Hill Education
Publishing place	New York
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	978-1-259-58928-7 ; 1-259-58928-5
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A maternal ketogenic diet alters oviduct fluid nutrients and embryo histone acetylation in mice.

Whatley, Emma G / Harvey, Alexandra J / Gardner, David K

Reproduction (Cambridge, England)

2024 Volume 167, Issue 6

Abstract: In brief: A ketogenic diet (KD) elevates blood β-hydroxybutyrate to concentrations that are known to perturb the development, metabolism, histone acetylation and viability of preimplantation mouse embryos in culture. This study shows that a maternal KD ... ...

Abstract	In brief: A ketogenic diet (KD) elevates blood β-hydroxybutyrate to concentrations that are known to perturb the development, metabolism, histone acetylation and viability of preimplantation mouse embryos in culture. This study shows that a maternal KD changes available nutrient levels in the oviduct, leading to altered embryo development and epigenetic state in vivo. Abstract: A ketogenic diet elevates blood β-hydroxybutyrate to concentrations that perturb the development, metabolism, histone acetylation (H3K27ac) and viability of preimplantation mouse embryos in vitro. However, whether a ketogenic diet alters β-hydroxybutyrate concentrations within female reproductive fluid is unknown. This study aimed to quantify glucose and β-hydroxybutyrate within mouse blood and oviduct fluid following standard diet and ketogenic diet consumption and to assess whether a maternal periconceptional ketogenic diet impacts in vivo embryo development and blastocyst H3K27ac. Female C57BL/6 × CBA mice were fed a standard or ketogenic diet (n = 24 each) for 24-27 days. Glucose and β-hydroxybutyrate were quantified in blood via an electronic monitoring system and in oviduct fluid via ultramicrofluorescence. The developmental grade of flushed blastocysts was recorded, and blastocyst cell number and H3K27ac were assessed via immunofluorescence. A maternal ketogenic diet elevated β-hydroxybutyrate in day 24 blood (P < 0.001) and oviduct fluid (P < 0.05) compared with a standard diet, whereas glucose was unchanged. A periconceptional ketogenic diet did not impact blastocyst cell number; however, it significantly delayed blastocyst development (P < 0.05) and reduced trophectoderm-specific H3K27ac (P < 0.05) compared with standard diet-derived embryos. Maternal ketogenic diet consumption is, therefore, associated with reproductive tract nutrient changes and altered embryonic development and epigenetics in vivo. Future studies to assess whether periconceptional/gestational ketogenic diet consumption impacts human preimplantation, fetal, and long-term offspring development and health are warranted.
MeSH term(s)	Animals ; Female ; Diet, Ketogenic ; Histones/metabolism ; Mice ; Acetylation ; 3-Hydroxybutyric Acid/blood ; 3-Hydroxybutyric Acid/metabolism ; Embryonic Development ; Mice, Inbred C57BL ; Pregnancy ; Blastocyst/metabolism ; Mice, Inbred CBA ; Oviducts/metabolism ; Nutrients/metabolism ; Maternal Nutritional Physiological Phenomena
Chemical Substances	Histones ; 3-Hydroxybutyric Acid (TZP1275679)
Language	English
Publishing date	2024-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-24-0026
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Article ; Online: Prescriber Acceptability of a Direct-to-Patient Intervention for Benzodiazepine Receptor Agonist Deprescribing and Behavioural Management of Insomnia in Older Adults.

Murphy, Andrea L / Turner, Justin P / Rajda, Malgorzata / Allen, Kathleen G / Gardner, David M

Canadian journal on aging = La revue canadienne du vieillissement

2024 , Page(s) 1–9

Abstract: Behavioural treatments are recommended first-line for insomnia, but long-term benzodiazepine receptor agonist (BZRA) use remains common and engaging patients in a deprescribing consultation is challenging. Few deprescribing interventions directly target ... ...

Abstract	Behavioural treatments are recommended first-line for insomnia, but long-term benzodiazepine receptor agonist (BZRA) use remains common and engaging patients in a deprescribing consultation is challenging. Few deprescribing interventions directly target patients. Prescribers' support of patient-targeted interventions may facilitate their uptake. Recently assessed in the Your Answers When Needing Sleep in New Brunswick (YAWNS NB) study, Sleepwell (mysleepwell.ca) was developed as a direct-to-patient behaviour change intervention promoting BZRA deprescribing and non-pharmacological insomnia management. BZRA prescribers of YAWNS NB participants were invited to complete an online survey assessing the acceptability of Sleepwell as a direct-to-patient intervention. The survey was developed using the seven construct components of the theoretical framework of acceptability (TFA) framework. Respondents (40/250, 17.2%) indicated high acceptability, with positive responses per TFA construct averaging 32.3/40 (80.7%). Perceived as an ethical, credible, and useful tool, Sleepwell also promoted prescriber-patient BZRA deprescribing engagements (11/19, 58%). Prescribers were accepting of Sleepwell and supported its application as a direct-to-patient intervention.
Language	English
Publishing date	2024-03-08
Publishing country	Canada
Document type	Journal Article
ZDB-ID	632851-9
ISSN	1710-1107 ; 0714-9808
ISSN (online)	1710-1107
ISSN	0714-9808
DOI	10.1017/S0714980824000114
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Article ; Online: Preimplantation embryo exposure to ketone bodies exerts sex-specific effects on mouse fetal and placental transcriptomes.

Whatley, Emma G / Truong, Thi T / Harvey, Alexandra J / Gardner, David K

Reproductive biomedicine online

2023 Volume 47, Issue 5, Page(s) 103320

Abstract: ... at gestational day 14.5 were examined via RNA sequencing and DAVID functional analysis.: Results: A sexually ...

Abstract	Research question: Does in vitro exposure of preimplantation mouse embryos to the ketone bodies β-hydroxybutyrate (βOHB) and acetoacetate (AcAc) impact post-transfer fetal and placental gene expression? Design: Blastocysts cultured in vitro with or without 2 mmol/l βOHB alone ('βOHB') or combined with 0.8 mmol/l AcAc ('Keto') underwent embryo transfer. Transcriptional profiles of sexed placenta, liver and brain at gestational day 14.5 were examined via RNA sequencing and DAVID functional analysis. Results: A sexually dimorphic response to in vitro ketone exposure was observed. Both βOHB and Keto exposure down-regulated genes related to oxidative phosphorylation specifically in female liver. βOHB down-regulated female placental steroid biosynthetic processes, while Keto treatment up-regulated genes relevant to blood vessel formation and cell migration in male placenta. Brain transcriptomes were minimally affected. X-linked genes and chromatin modifiers were identified as differentially expressed in both liver and placenta, alluding to a sex-specific regulatory mechanism. Conclusions: Transient preimplantation ketone exposure perturbs sex-specific fetal liver and placental gene expression, demonstrating a developmental programming effect that warrants future investigation of the postnatal metabolic health of male and female offspring.
MeSH term(s)	Mice ; Female ; Male ; Pregnancy ; Animals ; Ketone Bodies/metabolism ; Transcriptome ; Placenta/metabolism ; 3-Hydroxybutyric Acid/metabolism ; Ketones ; Blastocyst/metabolism
Chemical Substances	Ketone Bodies ; 3-Hydroxybutyric Acid (TZP1275679) ; acetoacetic acid (4ZI204Y1MC) ; Ketones
Language	English
Publishing date	2023-07-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2023.103320
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Article: Mental health problems associated with idiopathic anaphylaxis.

Gardner, Logan S / Tan, Zihao / Brown, David / Gillis, David / Scott, James G / Prentice, Roger

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2023 Volume 19, Issue 1, Page(s) 84

Abstract: Background: Idiopathic Anaphylaxis (IA) is the most common anaphylactic syndrome in adults. Mental health problems associated with IA are not well recognised. We aimed to assess if patients diagnosed with IA were more likely to experience mental health ... ...

Abstract	Background: Idiopathic Anaphylaxis (IA) is the most common anaphylactic syndrome in adults. Mental health problems associated with IA are not well recognised. We aimed to assess if patients diagnosed with IA were more likely to experience mental health problems compared to a normative Australian population. We additionally hypothesised that the number of anaphylactic episodes would correlate with symptoms of anxiety. Methods: A total of 34 patients with at least one episode of IA were recruited from an adult immunology clinic. Patients were recruited as part of a separate study evaluating alternative aetiologies in IA. Mental health problems were measured using the Depression, Anxiety and Stress Scale (DASS-21). An extension of the survey included questions specifically focused on the psychological impact of IA. Results: Compared to population norms, those with IA had significantly higher levels of mental health problems. Statistically significant DASS-21 scores were identified for depression 4.24 vs. 2.57 (p < 0.001), anxiety 4.76 vs. 1.74 (p < 0.012), stress 7.35 vs. 3.95 (p < 0.001) and total score 16.35 vs. 8.00 (p < 0.001). There was no association between two or more episodes of anaphylaxis and increased anxiety levels (β = 0.52, CI -2.59-3.62, p = 0.74). Conclusions: This is the first paper to demonstrate that patients living with idiopathic anaphylaxis are more symptomatic for mental illness than those in the community. Screening for mental illness and referral for psychological support should be undertaken in people with IA.
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-023-00824-0
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Article ; Online: Maximal and Submaximal Intensity Isometric Knee Extensions Induce an Underestimation of Time Estimates with Both Younger And Older Adults: A Randomized Crossover Trial.

Graham, Andrew Paul / Gardner, Hayley / Chaabene, Helmi / Talpey, Scott / Alizadeh, Shahab / Behm, David G

Journal of sports science & medicine

2023 Volume 22, Issue 3, Page(s) 406–416

Abstract: Our perception of time plays a critical role in nearly all daily activities and especially in sports. There are no studies that have investigated and compared time perception during exercise in young and older adults. Thus, this study aimed to compare ... ...

Abstract	Our perception of time plays a critical role in nearly all daily activities and especially in sports. There are no studies that have investigated and compared time perception during exercise in young and older adults. Thus, this study aimed to compare the effects of exercise on time perception between younger and older adult populations. Thirty-three recreationally active participants were recruited and assigned to either the younger (university students, 9 males and 10 females) or older adults (>60 years, 8 males and 6 females). All participants completed four exercise conditions over two sessions on separate days: approximately 30-seconds of knee extensors 100%, 60% and 10% of maximum voluntary isometric contraction (MVIC), and control (no contractions). Prospective time perception was estimated (at 5-, 10-, 20-, and 30-seconds) at the beginning of each session and while performing the exercise. A main effect for condition (p < 0.001, d = 1.06) with subsequent post-hoc tests indicated participants significantly underestimated (estimated time was shorter than chronological time) time in all three exercise conditions compared to the control. There were no significant age group differences. In conclusion, exercise underestimated time estimates regardless of intensity or age. This questions the postulated intensity-dependent relationship between exercise and time perception. While older adults were expected to be less accurate in their time estimates, they may have been able to adopt alternative strategies for age-related changes in their internal clock, resulting in no significant age group differences.
MeSH term(s)	Female ; Male ; Humans ; Aged ; Cross-Over Studies ; Prospective Studies ; Knee Joint ; Exercise ; Isometric Contraction
Language	English
Publishing date	2023-09-01
Publishing country	Turkey
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2075564-8
ISSN	1303-2968 ; 1303-2968
ISSN (online)	1303-2968
ISSN	1303-2968
DOI	10.52082/jssm.2023.406
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Article ; Online: Temporal perception is distorted by submaximal and maximal isometric contractions of the knee extensors in young healthy males and females.

Gardner, Hayley R / Konrad, Andreas / Alizadeh, Shahab / Graham, Andrew / Behm, David G

Frontiers in sports and active living

2023 Volume 5, Page(s) 1185480

Abstract: Introduction: The estimate of time (temporal perception) is important for activities of daily living, sports and even survival, however time perception research needs greater scrutiny. Time estimation can influence movement decisions and determine ... ...

Abstract	Introduction: The estimate of time (temporal perception) is important for activities of daily living, sports and even survival, however time perception research needs greater scrutiny. Time estimation can influence movement decisions and determine whether the individual is successful at their goal, The objectives of this study were to examine participants perception of time at 5-, 10-, 20-, and 30-s intervals to determine possible distortions of time estimates caused by varying intensity isometric contractions, and sex differences. Methods: In this repeated measures study, 19 participants (10 females, 9 males) endured two sessions, which consisted of a cognitive task of estimating time intervals while performing an isometric knee extension at maximal, submaximal (60%), and distraction (10%) intensities and a non-active control. In addition to time estimates; heart rate (HR), tympanic temperatures and electromyography during the intervention contractions were monitored. Maximal contractions induced significantly greater time underestimations at 5-s (4.43 ± 0.93, Discussion: There was greater integrated knee extensor electromyographic activity during the maximal contractions to suggest greater neuromuscular activation that may influence time perception. However, there was no consistent effect of changes in HR or temperature on time estimates. This work adds to the growing literature of time perception during exercise to state that time is significantly underestimated when performing moderate to vigorous intensity exercise.
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2023.1185480
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Article ; Online: Acetoacetate and β-hydroxybutyrate reduce mouse embryo viability via differential metabolic and epigenetic mechanisms.

Whatley, Emma G / Truong, Thi T / Harvey, Alexandra J / Gardner, David K

Reproductive biomedicine online

2022 Volume 46, Issue 1, Page(s) 20–33

Abstract: Research question: Does the ketone acetoacetate (AcAc) alone, or combined with β-hydroxybutyrate (βOHB), impact mouse embryo development, metabolism, histone acetylation and viability?: Design: Pronucleate mouse oocytes were cultured in vitro in G1/ ... ...

Abstract	Research question: Does the ketone acetoacetate (AcAc) alone, or combined with β-hydroxybutyrate (βOHB), impact mouse embryo development, metabolism, histone acetylation and viability? Design: Pronucleate mouse oocytes were cultured in vitro in G1/G2 media supplemented with ketones (AcAc or AcAc + βOHB) at concentrations representing those in maternal serum during pregnancy (0.04 mmol/l AcAc, 0.1 mmol/l βOHB), standard diet consumption (0.1 mmol/l AcAc, 0.25 mmol/l βOHB), ketogenic diet consumption (0.8 mmol/l AcAc, 2 mmol/l βOHB) and diabetic ketoacidosis (2 mmol/l AcAc, 4 mmol/l βOHB). Day 5 blastocysts were assessed for cell allocation, glucose metabolism and histone acetylation. Day 4 blastocysts exposed to 0.8 mmol/l AcAc + 2 mmol/l βOHB were transferred to standard-fed recipient females, and E14.5 fetal and placental development assessed. Results: Exposure to 2 mmol/l AcAc or 0.8 mmol/l AcAc + 2 mmol/l βOHB did not impair blastocyst development, but significantly increased glucose consumption (P = 0.001 each), lowered glycolytic flux (P = 0.01, P < 0.001) and elevated trophectoderm (TE) histone 3 lysine 27 acetylation (H3K27ac; P < 0.001 each) compared with unexposed controls. Preimplantation AcAc + βOHB exposure reduced post-implantation fetal development by 25% (P = 0.037), and delayed female-specific fetal limb development (P = 0.019) and estimated fetal age (P = 0.019) compared with controls. Conclusion: Preimplantation exposure to ketones affects underlying metabolism and histone acetylation in blastocysts that are associated with persistent, female-specific perturbations in fetal development. A periconceptional diet that elevates ketone concentrations may impair human embryonic viability.
MeSH term(s)	Pregnancy ; Mice ; Humans ; Female ; Animals ; 3-Hydroxybutyric Acid/pharmacology ; Acetoacetates/pharmacology ; Histones ; Placenta ; Ketones
Chemical Substances	3-Hydroxybutyric Acid (TZP1275679) ; acetoacetic acid (4ZI204Y1MC) ; Acetoacetates ; Histones ; Ketones
Language	English
Publishing date	2022-09-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2022.09.018
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Article ; Online: Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells.

Lees, Jarmon G / Gardner, David K / Harvey, Alexandra J

Stem cells (Dayton, Ohio)

2020 Volume 38, Issue 5, Page(s) 624–638

Abstract: Nicotinamide adenine dinucleotide ( ... ...

Abstract	Nicotinamide adenine dinucleotide (NAD
MeSH term(s)	Cell Culture Techniques ; Cell Differentiation ; Human Embryonic Stem Cells/metabolism ; Humans ; NAD/metabolism ; Pluripotent Stem Cells/metabolism
Chemical Substances	NAD (0U46U6E8UK)
Language	English
Publishing date	2020-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1002/stem.3152
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Article ; Online: Commentary: Acute type A dissection with malperfusion syndrome: Start your stopwatch?

Yost, Gardner / Williams, David / Yang, Bo

The Journal of thoracic and cardiovascular surgery

2024

Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Editorial
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2024.02.019
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