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  1. Article ; Online: Knowledge-based diagnosis and prediction using big data and deep learning in precision medicine.

    Kim, Wun-Jae

    Investigative and clinical urology

    2018  Volume 59, Issue 2, Page(s) 69–71

    MeSH term(s) Artificial Intelligence ; Big Data ; Biomedical Technology/methods ; Biomedical Technology/trends ; Deep Learning ; Human Genome Project ; Humans ; Inventions ; Precision Medicine/methods ; Precision Medicine/trends
    Language English
    Publishing date 2018-02-28
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.2018.59.2.69
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How can we best manage biochemical failure after radical prostatectomy?

    Kim, Won Tae / Kim, Jiyeon / Kim, Wun-Jae

    Investigative and clinical urology

    2022  Volume 63, Issue 6, Page(s) 592–601

    Abstract: Biochemical recurrence (BCR) is common after radical prostatectomy, but effective treatment options for men with BCR after curative treatment remain controversial. Although prostate-specific antigen is widely used as a surrogate marker for prostate ... ...

    Abstract Biochemical recurrence (BCR) is common after radical prostatectomy, but effective treatment options for men with BCR after curative treatment remain controversial. Although prostate-specific antigen is widely used as a surrogate marker for prostate cancer survival, it cannot fully differentiate between prostate-cancer-specific survival and overall survival. Thus, it is challenging for physicians to determine the timing of treatment to halt or slow the clinical progression of disease in patients with BCR while avoiding overtreatment for patients whose disease may not progress beyond BCR. Adjuvant therapy for radical prostatectomy or radiotherapy in intermediate- or high-risk localized prostate cancer has a benefit in terms of disease progression and survival but is not recommended in low-risk prostate cancer because of the significant adverse effects related to radiotherapy and androgen-deprivation therapy (ADT). Salvage radiotherapy (SRT) is also recommended for patients with BCR after radical prostatectomy. Several options for management of BCR after radical prostatectomy include SRT to the prostatic bed and/or pelvis, continuous or intermittent ADT, or observation. Patients' comorbidity, preferences, and cancer-related factors must be considered when deciding the best management strategy. Modern imaging technology such as positron emission tomography imaging of prostate-specific membrane antigen-positive regions enables earlier detection of disease progression, thus enhancing decision making for future disease management.
    MeSH term(s) Male ; Humans ; Prostate ; Androgen Antagonists/therapeutic use ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/radiotherapy ; Neoplasm Recurrence, Local/surgery ; Prostatectomy/adverse effects ; Prostatectomy/methods ; Prostate-Specific Antigen ; Salvage Therapy/methods ; Disease Progression ; Retrospective Studies
    Chemical Substances Androgen Antagonists ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-11-05
    Publishing country Korea (South)
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.20220294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The therapeutic and prognostic implications of molecular biomarkers in urothelial carcinoma.

    Kang, Ho Won / Kim, Wun-Jae / Yun, Seok Joong

    Translational cancer research

    2022  Volume 9, Issue 10, Page(s) 6609–6623

    Abstract: Urothelial cell carcinoma (UCC) of the bladder and upper urinary tract is a heterogeneous disease with distinct biologic features resulting in different clinical behaviors. Bladder cancer (BC) is classified into non-muscle invasive BC (NMIBC) and muscle ... ...

    Abstract Urothelial cell carcinoma (UCC) of the bladder and upper urinary tract is a heterogeneous disease with distinct biologic features resulting in different clinical behaviors. Bladder cancer (BC) is classified into non-muscle invasive BC (NMIBC) and muscle invasive BC (MIBC). NMIBC is associated with high recurrence rates and risk of progression to invasive disease, whereas MIBC is complicated by systemic recurrence after radical cystectomy because of the limited efficacy of available therapies. UCC of the upper urinary tract (UUT-UCC) is a rare but aggressive urologic cancer characterized by multifocality, local recurrence, and metastasis. Conventional histopathologic evaluation of UCC, including tumor stage and grade, cannot accurately predict the behavior of BC and UUT-UCC. Recent clinical and preclinical studies aimed at understanding the molecular landscape of UCC have provided insight into molecular subtyping, inter- or intratumoral heterogeneity, and potential therapeutic targets. Combined analysis of molecular markers and standard pathological features may improve risk stratification and help monitor tumor progression and treatment response, ultimately improving patient outcomes. This review discusses prognostic and therapeutic biomarkers for BC and UUT-UCC, and describes recent advances in molecular stratification that may guide prognosis, patient stratification, and treatment selection.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-20-1243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Changing landscape of diagnosis and treatment of bladder cancer.

    Kim, Wun-Jae

    Investigative and clinical urology

    2016  Volume 57 Suppl 1, Page(s) S1–3

    MeSH term(s) Humans ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/etiology ; Urinary Bladder Neoplasms/therapy
    Language English
    Publishing date 2016-06-10
    Publishing country Korea (South)
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.2016.57.S1.S1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bisphenol A regulates bladder cells responses via control of G2/M-phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor-associated MMP modulation.

    Song, Jun-Hui / Hwang, Byungdoo / Park, Solbi / Kim, Soobin / Kim, Dong-Ho / Choi, Yung Hyun / Kim, Wun-Jae / Moon, Sung-Kwon

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 3, Page(s) e23662

    Abstract: Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In ... ...

    Abstract Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In this study, we explored regulatory mechanisms for the adverse effects of BPA in human bladder BdFC and T24 cells. BPA induced extrinsic and intrinsic apoptosis and G2/M cell cycle arrest caused by the ATM-CHK1/CHK2-CDC25c-CDC2 signaling, which ultimately inhibited the growth of human bladder cells. We also found that BPA decreased the binding activity of AP-1 and NF-κB transcription factors in human bladder cells, which inhibited migration and invasion through matrix metallopeptidase-2 and -9 inactivation. Phosphorylation of MAPKs was implicated with BPA-mediated detrimental effects in human bladder cells. Collectively, our results provide a novel explanation for the underlying molecular mechanisms that BPA induces cytotoxicity in human bladder cells.
    MeSH term(s) Humans ; Transcription Factors ; Urinary Bladder ; Phosphorylation ; Apoptosis ; G2 Phase Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Cycle ; Benzhydryl Compounds ; Phenols
    Chemical Substances bisphenol A (MLT3645I99) ; Transcription Factors ; Benzhydryl Compounds ; Phenols
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage.

    Park, Cheol / Cha, Hee-Jae / Hwangbo, Hyun / Bang, EunJin / Kim, Heui-Soo / Yun, Seok Joong / Moon, Sung-Kwon / Kim, Wun-Jae / Kim, Gi-Young / Lee, Seung-On / Shim, Jung-Hyun / Choi, Yung Hyun

    Biomolecules & therapeutics

    2024  

    Abstract: Mangiferin is a kind of natural xanthone glycosides and is known to have various pharmacological activities. However, since the beneficial efficacy of this compound has not been reported in retinal pigment epithelial (RPE) cells, this study aimed to ... ...

    Abstract Mangiferin is a kind of natural xanthone glycosides and is known to have various pharmacological activities. However, since the beneficial efficacy of this compound has not been reported in retinal pigment epithelial (RPE) cells, this study aimed to evaluate whether mangiferin could protect human RPE ARPE-19 cells from oxidative injury mimicked by hydrogen peroxide (H
    Language English
    Publishing date 2024-04-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2734146-X
    ISSN 2005-4483 ; 1976-9148
    ISSN (online) 2005-4483
    ISSN 1976-9148
    DOI 10.4062/biomolther.2023.175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Innovative technologies for the smart E-Healthcare system.

    Kim, Wun-Jae / Kim, Jayoung

    Investigative and clinical urology

    2018  Volume 60, Issue 1, Page(s) 1–3

    MeSH term(s) Delivery of Health Care/methods ; Education, Medical, Graduate/methods ; Humans ; Pain Management/methods ; Surgical Procedures, Operative/education ; Virtual Reality ; Virtual Reality Exposure Therapy/methods
    Language English
    Publishing date 2018-12-31
    Publishing country Korea (South)
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.2019.60.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?

    Kim, Wun-Jae

    International neurourology journal

    2015  Volume 19, Issue 2, Page(s) 55–66

    Abstract: The 5´-AMP-activated protein kinase (AMPK) is a key regulator of cellular metabolism and energy homeostasis in mammalian tissues. Metabolic adaptation is a critical step in ensuring cell survival during metabolic stress. Because of its critical role in ... ...

    Abstract The 5´-AMP-activated protein kinase (AMPK) is a key regulator of cellular metabolism and energy homeostasis in mammalian tissues. Metabolic adaptation is a critical step in ensuring cell survival during metabolic stress. Because of its critical role in the regulation of glucose homeostasis and carbohydrate, lipid, and protein metabolism, AMPK is involved in many human diseases, including cancers. Although AMPK signaling was originally characterized as a tumor-suppressive signaling pathway, several lines of evidence suggest that AMPK plays a much broader role and cannot simply be defined as either an oncogenic regulator or tumor suppressor. Notably, several recent studies demonstrated that the antitumorigenic effects of many indirect AMPK activators, such as metformin, do not depend on AMPK. Conversely, activation of AMPK induces the progression of cancers, emphasizing its oncogenic effect. Bladder cancer can be divided into two groups: non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). The molecular mechanisms underlying these two types of cancer are distinct: NMIBC is associated with activation of the Ras pathway, whereas MIBC is characterized by loss of major tumor suppressors. Importantly, both pathways are connected to the mammalian target of rapamycin (mTOR) pathway. In addition, our recent metabolomic findings suggest that β-oxidation of fatty acids is an important factor in the development of bladder cancer. Both mTOR and β-oxidation are tightly associated with the AMPK pathway. Here, I summarize and discuss the recent findings on the two distinct roles of AMPK in cancer, as well as the relationship between bladder cancer and AMPK.
    Language English
    Publishing date 2015-06-29
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2584447-7
    ISSN 2093-6931 ; 2093-4777
    ISSN (online) 2093-6931
    ISSN 2093-4777
    DOI 10.5213/inj.2015.19.2.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bisphenol A exposure inhibits vascular smooth muscle cell responses: Involvement of proliferation, migration, and invasion.

    Kim, Hoon / Park, Hongbum / Hwang, Byungdoo / Kim, Soobin / Choi, Yung Hyun / Kim, Wun-Jae / Moon, Sung-Kwon

    Environmental toxicology and pharmacology

    2023  Volume 98, Page(s) 104060

    Abstract: Previous studies have associated bisphenol A (BPA) with malignant tumor formation, infertility, and atherosclerosis in vitro and in vivo. However, the precise mechanisms through which BPA affects the cardiovascular system under normal conditions remain ... ...

    Abstract Previous studies have associated bisphenol A (BPA) with malignant tumor formation, infertility, and atherosclerosis in vitro and in vivo. However, the precise mechanisms through which BPA affects the cardiovascular system under normal conditions remain unclear. Therefore, this study investigated the biological mechanisms through which BPA affects the responses of aortic vascular smooth muscle cells (VSMCs). BPA treatment inhibited the proliferative activity of VSMCs and induced G
    MeSH term(s) Muscle, Smooth, Vascular ; Cell Proliferation ; Cells, Cultured ; Phosphorylation ; p38 Mitogen-Activated Protein Kinases/metabolism ; Myocytes, Smooth Muscle/metabolism ; Cell Movement
    Chemical Substances bisphenol A (MLT3645I99) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2023-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2023.104060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: COL6A1

    Kim, Kyeong / Byun, Young Joon / Zheng, Chuang-Ming / Moon, Sungmin / Jo, Soo Jeong / Kang, Ho Won / Kim, Won Tae / Choi, Yung Hyun / Moon, Sung-Kwon / Kim, Wun-Jae / Piao, Xuan-Mei / Yun, Seok Joong

    Investigative and clinical urology

    2024  Volume 65, Issue 1, Page(s) 94–103

    Abstract: Purpose: T1 high grade (T1HG) bladder cancer (BC) is a type of non-muscle invasive BC (NMIBC) that is recognized as an aggressive subtype with a heightened propensity for progression. Current risk stratification methods for NMIBC rely on ... ...

    Abstract Purpose: T1 high grade (T1HG) bladder cancer (BC) is a type of non-muscle invasive BC (NMIBC) that is recognized as an aggressive subtype with a heightened propensity for progression. Current risk stratification methods for NMIBC rely on clinicopathological indicators; however, these approaches do not adequately capture the aggressive nature of T1HG BC. Thus, new, more accurate biomarkers for T1HG risk stratification are needed. Here, we enrolled three different patient cohorts and investigated expression of collagen type VI alpha 1 (
    Materials and methods: Samples from 298 BC patients were subjected to RNA sequencing and real-time polymerase chain reaction.
    Results: We found that T1HG BC and muscle invasive BC (MIBC) exhibited comparable expression of
    Conclusions: These findings suggest that
    MeSH term(s) Humans ; Non-Muscle Invasive Bladder Neoplasms ; Prognosis ; Urinary Bladder ; Urinary Bladder Neoplasms/genetics ; Risk Assessment
    Language English
    Publishing date 2024-01-10
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.20230227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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