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Article ; Online: Protocol to isolate live single cells while retaining spatial information by combining cell photolabeling and FACS.

Baldominos, Pilar / Barreiro, Olga / von Andrian, Ulrich / Sirera, Rafael / Montero-Llopis, Paula / Agudo, Judith

STAR protocols

2022 Volume 3, Issue 4, Page(s) 101795

Abstract: Single-cell techniques have revolutionized biology; however, the required sample processing inherently implies the loss of spatial localization. Here, using an approach called photoconversion of areas to dissect micro-environments (PADME), we detail ... ...

Abstract	Single-cell techniques have revolutionized biology; however, the required sample processing inherently implies the loss of spatial localization. Here, using an approach called photoconversion of areas to dissect micro-environments (PADME), we detail steps to isolate live single cells from a primary breast tumor while retaining spatial information by combining cell photolabeling and FACS (fluorescence-activated cell sorting). These live cells can be subsequently used for myriad techniques, from flow cytometry to single-cell RNA sequencing or other single cell "omics" approach. For complete details on the use and execution of this protocol, please refer to Baldominos et al. (2022).
MeSH term(s)	Flow Cytometry/methods
Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101795
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Article ; Online: Atrophy signaling pathways in respiratory and limb muscles of guinea pigs exposed to chronic cigarette smoke: role of soluble guanylate cyclase stimulation.

Peinado, Víctor Ivo / Guitart, Maria / Blanco, Isabel / Tura-Ceide, Olga / Paul, Tanja / Barberà, Joan Albert / Barreiro, Esther

American journal of physiology. Lung cellular and molecular physiology

2023 Volume 324, Issue 5, Page(s) L677–L693

Abstract: Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is characterized by a significant reduction in muscle strength and endurance. Preclinical studies show that stimulation of the soluble guanylate cyclase (sGC)-cGMP pathway ... ...

Abstract	Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is characterized by a significant reduction in muscle strength and endurance. Preclinical studies show that stimulation of the soluble guanylate cyclase (sGC)-cGMP pathway attenuates muscle mass loss and prevents cigarette smoke-induced oxidative stress, indicating that pharmacological activation of the guanylyl cyclase pathway in COPD may provide a beneficial therapeutic strategy that reaches beyond the lung. In this study, conducted in an animal model of COPD, we first set out to assess the effect of cigarette smoke (CS) on biomarkers of muscle fatigue, such as protein degradation and its transcriptional regulation, in two types of muscles with different energy demands, i.e., the diaphragm and the gastrocnemius muscle of the limbs. Second, we evaluated the administration of an sGC stimulator on these markers to study the potential efficacy of such treatment in the recovery of skeletal muscle function. Exposure to CS led to weight loss, which was associated in the gastrocnemius with increased levels of proteolytic markers of muscle atrophy (MURF-1, Atrogin-1, proteasome C8 subunit 20 s, and total protein ubiquitination), whereas the size of fast-twitch muscle fibers decreased significantly. Long-term treatment with the sGC stimulator BAY 41-2272 resulted in a significant reduction in gastrocnemius levels of the aforementioned proteolytic markers, concomitant with a weight recovery and increased cGMP levels. Remarkably, levels of some of the analyzed biomarkers differed between respiratory and limb muscles. In conclusion, targeting sGC might exert beneficial effects on muscle alterations in patients with COPD.
MeSH term(s)	Guinea Pigs ; Animals ; Soluble Guanylyl Cyclase/metabolism ; Cigarette Smoking ; Guanylate Cyclase/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Muscle, Skeletal/metabolism ; Signal Transduction ; Biomarkers/metabolism ; Atrophy/metabolism ; Atrophy/pathology
Chemical Substances	Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Guanylate Cyclase (EC 4.6.1.2) ; Biomarkers
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00258.2022
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Uc I Zs.89: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 2749: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)

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Article: Association between Breast Milk Mineral Content and Maternal Adherence to Healthy Dietary Patterns in Spain: A Transversal Study.

Sánchez, Cristina / Fente, Cristina / Barreiro, Rocío / López-Racamonde, Olga / Cepeda, Alberto / Regal, Patricia

Foods (Basel, Switzerland)

2020 Volume 9, Issue 5

Abstract: The composition of breast milk is influenced by many factors, some of which dependent on the mother and others on the child. Changes in lactation and other factors depending on the mother's physiology and anthropometric characteristics, as well as her ... ...

Abstract	The composition of breast milk is influenced by many factors, some of which dependent on the mother and others on the child. Changes in lactation and other factors depending on the mother's physiology and anthropometric characteristics, as well as her nutritional status and diet, are of key importance. Breast milk minerals have been extensively studied with highly uneven results. In this work, a comparison will made with data across the world. To understand the factors that might explain the disparity, several minerals (Na, K, Ca, P, Mg, Fe, Se and I) have been analyzed using ICP-MS in a set of human milk samples (
Language	English
Publishing date	2020-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods9050659
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Article ; Online: Association between bisphosphonate use and COVID-19 related outcomes.

Thompson, Jeffrey / Wang, Yidi / Dreischulte, Tobias / Barreiro, Olga / Gonzalez, Rodrigo J / Hanč, Pavel / Matysiak, Colette / Neely, Harold R / Rottenkolber, Marietta / Haskell, Thomas / Endres, Stefan / von Andrian, Ulrich H

eLife

2023 Volume 12

Abstract: Background: Although there are several efficacious vaccines against COVID-19, vaccination rates in many regions around the world remain insufficient to prevent continued high disease burden and emergence of viral variants. Repurposing of existing ... ...

Abstract	Background: Although there are several efficacious vaccines against COVID-19, vaccination rates in many regions around the world remain insufficient to prevent continued high disease burden and emergence of viral variants. Repurposing of existing therapeutics that prevent or mitigate severe COVID-19 could help to address these challenges. The objective of this study was to determine whether prior use of bisphosphonates is associated with reduced incidence and/or severity of COVID-19. Methods: A retrospective cohort study utilizing payer-complete health insurance claims data from 8,239,790 patients with continuous medical and prescription insurance January 1, 2019 to June 30, 2020 was performed. The primary exposure of interest was use of any bisphosphonate from January 1, 2019 to February 29, 2020. Bisphosphonate users were identified as patients having at least one bisphosphonate claim during this period, who were then 1:1 propensity score-matched to bisphosphonate non-users by age, gender, insurance type, primary-care-provider visit in 2019, and comorbidity burden. Main outcomes of interest included: (a) any testing for SARS-CoV-2 infection; (b) COVID-19 diagnosis; and (c) hospitalization with a COVID-19 diagnosis between March 1, 2020 and June 30, 2020. Multiple sensitivity analyses were also performed to assess core study outcomes amongst more restrictive matches between BP users/non-users, as well as assessing the relationship between BP-use and other respiratory infections (pneumonia, acute bronchitis) both during the same study period as well as before the COVID outbreak. Results: A total of 7,906,603 patients for whom continuous medical and prescription insurance information was available were selected. A total of 450,366 bisphosphonate users were identified and 1:1 propensity score-matched to bisphosphonate non-users. Bisphosphonate users had lower odds ratios (OR) of testing for SARS-CoV-2 infection (OR = 0.22; 95%CI:0.21-0.23; p<0.001), COVID-19 diagnosis (OR = 0.23; 95%CI:0.22-0.24; p<0.001), and COVID-19-related hospitalization (OR = 0.26; 95%CI:0.24-0.29; p<0.001). Sensitivity analyses yielded results consistent with the primary analysis. Bisphosphonate-use was also associated with decreased odds of acute bronchitis (OR = 0.23; 95%CI:0.22-0.23; p<0.001) or pneumonia (OR = 0.32; 95%CI:0.31-0.34; p<0.001) in 2019, suggesting that bisphosphonates may protect against respiratory infections by a variety of pathogens, including but not limited to SARS-CoV-2. Conclusions: Prior bisphosphonate-use was associated with dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations. Prospective clinical trials will be required to establish a causal role for bisphosphonate-use in COVID-19-related outcomes. Funding: This study was supported by NIH grants, AR068383 and AI155865, a grant from MassCPR (to UHvA) and a CRI Irvington postdoctoral fellowship, CRI2453 (to PH).
MeSH term(s)	Humans ; COVID-19/epidemiology ; Diphosphonates/therapeutic use ; COVID-19 Testing ; SARS-CoV-2 ; Retrospective Studies ; COVID-19 Vaccines ; Prospective Studies ; Respiratory Tract Infections/drug therapy ; Bronchitis/drug therapy
Chemical Substances	Diphosphonates ; COVID-19 Vaccines
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.79548
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Article: Effects of Exercise Training on Circulating Biomarkers of Endothelial Function in Pulmonary Arterial Hypertension.

Rodríguez-Chiaradía, Diego A / Khilzi, Karys / Blanco, Isabel / Rodó-Pin, Anna / Martin-Ontiyuelo, Clara / Herranz Blasco, Anna / Garcia-Lucio, Jessica / Molina, Lluis / Marco, Ester / Barreiro, Esther / Piccari, Lucilla / Peinado, Victor I / Garcia, Agustín R / Tura-Ceide, Olga / Barberà, Joan Albert

Biomedicines

2023 Volume 11, Issue 7

Abstract: Introduction: In stable patients with pulmonary arterial hypertension (PAH), pulmonary rehabilitation (PR) is an effective, safe and cost-effective non-pharmacological treatment. However, the effects of PR on vascular function have been poorly explored. ...

Abstract	Introduction: In stable patients with pulmonary arterial hypertension (PAH), pulmonary rehabilitation (PR) is an effective, safe and cost-effective non-pharmacological treatment. However, the effects of PR on vascular function have been poorly explored. This study aimed to compare the amounts of circulating progenitor cells (PCs) and endothelial microvesicles (EMVs) in patients with PAH before and after 8 weeks of endurance exercise training as markers of vascular competence. Methods: A prospective study of 10 consecutive patients with PAH that successfully finished a PR program (8 weeks) was carried out before and after this intervention. Levels of circulating PCs defined as CD34+CD45low progenitor cells and levels of EMVs (CD31+ CD42b-) were measured by flow cytometry. The ratio of PCs to EMVs was taken as a measure of the balance between endothelial damage and repair capacity. Results: All patients showed training-induced increases in endurance time (mean change 287 s). After PR, the number of PCs (CD34+CD45low/total lymphocytes) was increased ( Conclusion: Our study shows, for the first time, that endurance exercise training in patients with stable PAH has a positive effect, promoting potential mechanisms of damage/repair in favor of repair. This effect could contribute to a positive hemodynamic and clinical response.
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11071822
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Article ; Online: Targeting Antioxidants to Interfaces: Control of the Oxidative Stability of Lipid-Based Emulsions.

Mitrus, Olga / Żuraw, Malgorzata / Losada-Barreiro, Sonia / Bravo-Díaz, Carlos / Paiva-Martins, Fátima

Journal of agricultural and food chemistry

2019 Volume 67, Issue 11, Page(s) 3266–3274

Abstract: The oxidation of lipid-based emulsions and nanoemulsions strongly affects their overall quality and safety. Moreover, introduction of oxidatively unstable emulsions into biological systems either as an energy source in parenteral nutrition or as delivery ...

Abstract	The oxidation of lipid-based emulsions and nanoemulsions strongly affects their overall quality and safety. Moreover, introduction of oxidatively unstable emulsions into biological systems either as an energy source in parenteral nutrition or as delivery systems of bioactives may promote oxidation "in situ" leading to the overproduction of reactive oxygen species, initiating new harmful oxidative reactions and increasing the oxidative damage. Addition of antioxidants, AOs, may help to prevent the oxidative degradation of unsaturated lipids. Nevertheless, prediction of the optimal antioxidant or set of antioxidants and their efficiency is still far from being completely understood because the site of reaction is often uncertain and because the effective concentrations of reactants in the different regions of the emulsion have been frequently overlooked. Furthermore, the absence of quantitative relationships between the hydrophobicity of the antioxidants and their partitioning among the oil, water, and interfacial regions hampers their optimal use. Here we investigated the effects of gallic acid and some of its alkyl derivatives on the oxidative stability of soybean oil-in-water emulsions and determined their effective concentrations in the different regions of the emulsion (aqueous, oil, and interface). The results provide physical evidence for the crucial role played by the interfacial region in the reaction between antioxidants and lipid radicals: a direct relationship between interfacial concentrations and the oxidative stability could be established. The results indicate that AOs accumulate in the interfacial region, where the effective concentration is 20-180 times higher than the stoichiometric concentrations. Control of the hydrophobicity of the AOs and of the surfactant concentration allows control of interfacial concentrations: the lower the concentration of surfactant employed, the higher the effective interfacial concentration.
MeSH term(s)	Antioxidants/chemistry ; Emulsions/chemistry ; Gallic Acid/chemistry ; Hydrophobic and Hydrophilic Interactions ; Oxidation-Reduction ; Soybean Oil/chemistry ; Surface-Active Agents/chemistry ; Water/chemistry
Chemical Substances	Antioxidants ; Emulsions ; Surface-Active Agents ; Water (059QF0KO0R) ; Gallic Acid (632XD903SP) ; Soybean Oil (8001-22-7)
Language	English
Publishing date	2019-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.8b06545
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Article: Recommendations of the Spanish Group on Crohn's Disease and Ulcerative Colitis on the importance, screening and vaccination in inflammatory bowel disease patients.

Ferreiro-Iglesias, Rocío / Piqueras, Marta / Ricart, Elena / Sempere, Laura / Roca, Mariona / Martín de Carpi, Javier / Benítez, Olga / Zabana, Yamile / Mañosa, Míriam / Rodríguez-Moranta, Francisco / Barreiro-de Acosta, Manuel

Gastroenterologia y hepatologia

2022 Volume 45, Issue 10, Page(s) 805–818

Abstract: Patients with inflammatory bowel disease (IBD) may require different immunosuppressive treatments throughout their illness. It is essential to assess the immunization status of patients at diagnosis or, if this is not possible, at least before the ... ...

Title translation	Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa sobre la importancia, el cribado y la vacunación en pacientes con enfermedad inflamatoria intestinal.
Abstract	Patients with inflammatory bowel disease (IBD) may require different immunosuppressive treatments throughout their illness. It is essential to assess the immunization status of patients at diagnosis or, if this is not possible, at least before the beginning of immunosuppressive therapy and, subsequently, administering the appropriate vaccines. Therefore, the aim of this work is to establish clear and concise recommendations on vaccination in patients with IBD in the different settings of our clinical practice including vaccination in children, during pregnancy, breastfeeding or on trips. This consensus document emphasises the differences between inactivated and attenuated vaccines and the different degrees of immunosuppression and correlates them with the administration of both mandatory and optional vaccines recommended to our patients with IBD. Finally, as a summary, 17 recommendations are established based on the available scientific evidence and expert opinion. A multidisciplinary team with extensive experience in IBD and vaccination, made up of specialists in gastroenterology, paediatrics, nursing and pharmacy, has participated in the preparation of these recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis.
MeSH term(s)	Pregnancy ; Female ; Humans ; Child ; Colitis, Ulcerative/drug therapy ; Crohn Disease/drug therapy ; Inflammatory Bowel Diseases/drug therapy ; Immunosuppressive Agents/adverse effects ; Vaccination ; Chronic Disease
Chemical Substances	Immunosuppressive Agents
Language	Spanish
Publishing date	2022-05-14
Publishing country	Spain
Document type	Practice Guideline ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2022.03.012
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Article ; Online: Leukocytes whisper to endothelial guards.

Sánchez-Madrid, Francisco / Barreiro, Olga

Blood

2009 Volume 113, Issue 24, Page(s) 6048–6049

Language	English
Publishing date	2009-06-11
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2009-03-210336
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Article ; Online: PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells.

JCI insight

2023 Volume 8, Issue 24

Abstract: Secondary lymphedema occurs in up to 20% of patients after lymphadenectomy performed for the surgical management of tumors involving the breast, prostate, uterus, and skin. Patients develop progressive edema of the affected extremity due to retention of ... ...

Abstract	Secondary lymphedema occurs in up to 20% of patients after lymphadenectomy performed for the surgical management of tumors involving the breast, prostate, uterus, and skin. Patients develop progressive edema of the affected extremity due to retention of protein-rich lymphatic fluid. Despite compression therapy, patients progress to chronic lymphedema in which noncompressible fibrosis and adipose tissue are deposited within the extremity. The presence of fibrosis led to our hypothesis that rosiglitazone, a PPARγ agonist that inhibits fibrosis, would reduce fibrosis in a mouse model of secondary lymphedema after hind limb lymphadenectomy. In vivo, rosiglitazone reduced fibrosis in the hind limb after lymphadenectomy. Our findings verified that rosiglitazone reestablished the adipogenic features of TGF-β1-treated mesenchymal cells in vitro. Despite this, rosiglitazone led to a reduction in adipose tissue deposition. Single-cell RNA-Seq data obtained from human tissues and flow cytometric and histological evaluation of mouse tissues demonstrated increased presence of PDGFRα+ cells in lymphedema; human tissue analysis verified these cells have the capacity for adipogenic and fibrogenic differentiation. Upon treatment with rosiglitazone, we noted a reduction in the overall quantity of PDGFRα+ cells and LipidTOX+ cells. Our findings provide a framework for treating secondary lymphedema as a condition of fibrosis and adipose tissue deposition, both of which, paradoxically, can be prevented with a pro-adipogenic agent.
MeSH term(s)	Male ; Female ; Humans ; Mice ; Animals ; Receptor, Platelet-Derived Growth Factor alpha ; PPAR gamma ; Rosiglitazone/pharmacology ; Rosiglitazone/therapeutic use ; Lymphedema/drug therapy ; Fibrosis
Chemical Substances	Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; PPAR gamma ; Rosiglitazone (05V02F2KDG)
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.165324
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Article ; Online: Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules.

Vollmann, Elisabeth H / Rattay, Kristin / Barreiro, Olga / Thiriot, Aude / Fuhlbrigge, Rebecca A / Vrbanac, Vladimir / Kim, Ki-Wook / Jung, Steffen / Tager, Andrew M / von Andrian, Ulrich H

Nature communications

2021 Volume 12, Issue 1, Page(s) 6230

Abstract: T cells undergo rigorous selection in the thymus to ensure self-tolerance and prevent autoimmunity, with this process requiring innocuous self-antigens (Ags) to be presented to thymocytes. Self-Ags are either expressed by thymic stroma cells or ... ...

Abstract	T cells undergo rigorous selection in the thymus to ensure self-tolerance and prevent autoimmunity, with this process requiring innocuous self-antigens (Ags) to be presented to thymocytes. Self-Ags are either expressed by thymic stroma cells or transported to the thymus from the periphery by migratory dendritic cells (DCs); meanwhile, small blood-borne peptides can access the thymic parenchyma by diffusing across the vascular lining. Here we describe an additional pathway of thymic Ag acquisition that enables circulating antigenic macromolecules to access both murine and human thymi. This pathway depends on a subset of thymus-resident DCs, distinct from both parenchymal and circulating migratory DCs, that are positioned in immediate proximity to thymic microvessels where they extend cellular processes across the endothelial barrier into the blood stream. Transendothelial positioning of DCs depends on DC-expressed CX
MeSH term(s)	Animals ; Autoantigens/immunology ; Blood/immunology ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/immunology ; Cell Differentiation ; Cell Movement ; Chemokine CX3CL1/genetics ; Chemokine CX3CL1/immunology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Endothelial Cells/cytology ; Endothelial Cells/immunology ; Humans ; Mice ; Mice, Inbred C57BL ; Self Tolerance ; Thymocytes/cytology ; Thymocytes/immunology ; Thymus Gland/cytology ; Thymus Gland/immunology
Chemical Substances	Autoantigens ; CX3C Chemokine Receptor 1 ; Chemokine CX3CL1 ; Cx3cl1 protein, mouse ; Cx3cr1 protein, mouse
Language	English
Publishing date	2021-10-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-26446-x
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