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Article ; Online: Skin diseases in the Da Qing Diabetes Study: a cross-sectional study.

Shen, Chang-Bing / Qian, Xin / Yu, Rui-Xing / Ji, Xue-Lei / Shi, Yin-Juan / Gao, Jing / Li, Cheng-Xu / Li, Ke-Ke / Fei, Wen-Min / Shen, Xue / Wang, Zi-Yi / Han, Yang / Ning, Xiao-Li / Ko, Randy / Hsu, Yi-Hsiang / Yin, Xian-Yong / Li, Guang-Wei / Cui, Yong

Chinese medical journal

2021 Volume 134, Issue 10, Page(s) 1191–1198

Abstract: ... and T2DM.: Methods: We collected 383 subjects from the Da Qing Diabetes Study during the period ... of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study ...

Abstract	Background: The prevalence of skin diseases and diabetes mellitus (DM) are prominent around the world. The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM (T2DM) is limited, leading to limited recognition of the correlations between skin diseases and T2DM. Methods: We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st, 2016. The subjects were categorized into three groups: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. The prevalence and clinical characteristics of skin diseases were recorded and investigated. Results: In this cross-sectional study, 383 individuals with ages ranging from 53 to 89-year-old were recruited. The overall prevalence of skin diseases was 93.5%, and 75.7% of individuals had two or more kinds of skin diseases. Additionally, there were 47 kinds of comorbid skin diseases in patients with T2DM, of which eight kinds of skin diseases had a prevalence >10%. The prevalence of skin diseases in NGT, IGT, and T2DM groups were 93.3%, 91.5%, and 96.6%, respectively; stratified analysis by categories showed a statistically significant difference in "disturbances of pigmentation" and "neurological and psychogenic dermatoses". The duration of T2DM also significantly associated with the prevalence of "disturbances of pigmentation" and "neurological and psychogenic dermatoses". Subsequently, the prevalence of "disturbances of pigmentation" was higher in males than females in NGT (P < 0.01) and T2DM (P < 0.01) groups. In addition, the difference in the prevalence of "disturbances of pigmentation" was also significant in NGT and T2DM groups (P < 0.01). Conclusions: There was a high prevalence of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study, increased awareness and intervention measures should be implemented.
MeSH term(s)	Aged ; Aged, 80 and over ; Blood Glucose ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Glucose Intolerance/epidemiology ; Glucose Tolerance Test ; Humans ; Male ; Middle Aged ; Skin Diseases/epidemiology
Chemical Substances	Blood Glucose
Language	English
Publishing date	2021-04-14
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000001453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Skin diseases in the Da Qing Diabetes Study

Chang-Bing Shen / Xin Qian / Rui-Xing Yu / Xue-Lei Ji / Yin-Juan Shi / Jing Gao / Cheng-Xu Li / Ke-Ke Li / Wen-Min Fei / Xue Shen / Zi-Yi Wang / Yang Han / Xiao-Li Ning / Randy Ko / Yi-Hsiang Hsu / Xian-Yong Yin / Guang-Wei Li / Yong Cui / Li-Shao Guo

Chinese Medical Journal, Vol 134, Iss 10, Pp 1191-

a cross-sectional study

2021 Volume 1198

Abstract: ... and T2DM. Methods:. We collected 383 subjects from the Da Qing Diabetes Study during the period ... diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study ...

Abstract	Abstract. Background:. The prevalence of skin diseases and diabetes mellitus (DM) are prominent around the world. The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM (T2DM) is limited, leading to limited recognition of the correlations between skin diseases and T2DM. Methods:. We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st, 2016. The subjects were categorized into three groups: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM. The prevalence and clinical characteristics of skin diseases were recorded and investigated. Results:. In this cross-sectional study, 383 individuals with ages ranging from 53 to 89-year-old were recruited. The overall prevalence of skin diseases was 93.5%, and 75.7% of individuals had two or more kinds of skin diseases. Additionally, there were 47 kinds of comorbid skin diseases in patients with T2DM, of which eight kinds of skin diseases had a prevalence >10%. The prevalence of skin diseases in NGT, IGT, and T2DM groups were 93.3%, 91.5%, and 96.6%, respectively; stratified analysis by categories showed a statistically significant difference in “disturbances of pigmentation” and “neurological and psychogenic dermatoses”. The duration of T2DM also significantly associated with the prevalence of “disturbances of pigmentation” and “neurological and psychogenic dermatoses”. Subsequently, the prevalence of “disturbances of pigmentation” was higher in males than females in NGT (P < 0.01) and T2DM (P < 0.01) groups. In addition, the difference in the prevalence of “disturbances of pigmentation” was also significant in NGT and T2DM groups (P < 0.01). Conclusions:. There was a high prevalence of skin diseases in the Da Qing Diabetes Study. To address the skin diseases in the Da Qing Diabetes Study, increased awareness and intervention measures should be implemented.
Keywords	Medicine ; R
Subject code	571
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
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Article ; Online: Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice.

Wang, Anlu / Guan, Baoyi / Shao, Chang / Zhao, Lin / Li, Qiuyi / Hao, Haiping / Gao, Zhuye / Chen, Keji / Hou, Yuanlong / Xu, Hao

Phytomedicine : international journal of phytotherapy and phytopharmacology

2022 Volume 103, Page(s) 154220

Abstract: ... characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction ...

Abstract	Background: Atherosclerosis (AS) is a key pathological factor in cardiovascular disease (CVD) and is characterized by high mortality and morbidity worldwide. Metabolic disorders, including pathoglycemia and dyslipidemia that lead to chronic inflammation, represent the prominent pathological characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically proven to be effective for patients with CVD. However, the underlying mechanisms have not been completely elucidated. Purpose: To investigate the protective effects of QXJYG against AS and its potential mechanisms. Methods: QXJYG was orally administered at doses of 1.664 and 4.992 g·kg Results: QXJYG retarded HFD-induced weight gain and reduced the increased serum levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol, whereas high-dose QXJYG increased the serum level of high-density lipoprotein-cholesterol in HFD-fed ApoE-/- mice. Meanwhile, QXJYG reduced the serum levels, as well as aortas mRNA levels of the inflammatory cytokines, IL-1β and IL-6, which indicates that QXJYG is effective against metaflammation. Mechanistically, QXJYG reshaped the gut microbiota and its associated bile acids (BAs) metabolomic phenotype, partly by increasing the levels of BA synthesis enzymes, hepatic CYP7A1, and CYP27A1, while decreasing ileal FGF15 and β-Klotho mRNA expression, favoring facilitated de novo BAs synthesis and thereby driving cholesterol catabolic excretion. Conclusion: Our findings indicate that QXJYG is effective against HFD-triggered chronic inflammation, and contributes to the alleviation of AS development, and the antiatherogenic properties of QXJYG may be partly due to the remodeling of the gut microbiota and BA metabolism. Although the results are encouraging, further clinical studies of anti-AS herbal medicines are required to elucidate the full potential of the gut microbiota and BA metabolism.
MeSH term(s)	Animals ; Apolipoproteins E ; Atherosclerosis/metabolism ; Cholesterol/metabolism ; Diet, High-Fat/adverse effects ; Drugs, Chinese Herbal ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Inflammation/metabolism ; Liver ; Mice ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; RNA, Ribosomal, 16S
Chemical Substances	Apolipoproteins E ; Drugs, Chinese Herbal ; RNA, Messenger ; RNA, Ribosomal, 16S ; qing-xin-jie-yu granules ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-06-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154220
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Article: Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice

Wang, Anlu / Guan, Baoyi / Shao, Chang / Zhao, Lin / Li, Qiuyi / Hao, Haiping / Gao, Zhuye / Chen, Keji / Hou, Yuanlong / Xu, Hao

Phytomedicine. 2022 Aug., v. 103

2022

Abstract: ... of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically ...

Abstract	Atherosclerosis (AS) is a key pathological factor in cardiovascular disease (CVD) and is characterized by high mortality and morbidity worldwide. Metabolic disorders, including pathoglycemia and dyslipidemia that lead to chronic inflammation, represent the prominent pathological characteristics of atherosclerotic CVD, Qing-Xin-Jie-Yu Granule (QXJYG) is a Chinese traditional decoction that has been clinically proven to be effective for patients with CVD. However, the underlying mechanisms have not been completely elucidated. To investigate the protective effects of QXJYG against AS and its potential mechanisms. QXJYG was orally administered at doses of 1.664 and 4.992 g·kg⁻¹·d⁻¹ in a high-fat diet (HFD)-induced AS model using ApoE-/- mice. Histopathological and immunohistochemical analyses, ELISA, untargeted and targeted metabolomics analysis, 16S rRNA analysis, and RT-qPCR were performed to identify the therapeutic effects and mechanisms of QXJYG in treating HFD-induced AS. QXJYG retarded HFD-induced weight gain and reduced the increased serum levels of total cholesterol, triglycerides, and low-density lipoprotein-cholesterol, whereas high-dose QXJYG increased the serum level of high-density lipoprotein-cholesterol in HFD-fed ApoE-/- mice. Meanwhile, QXJYG reduced the serum levels, as well as aortas mRNA levels of the inflammatory cytokines, IL-1β and IL-6, which indicates that QXJYG is effective against metaflammation. Mechanistically, QXJYG reshaped the gut microbiota and its associated bile acids (BAs) metabolomic phenotype, partly by increasing the levels of BA synthesis enzymes, hepatic CYP7A1, and CYP27A1, while decreasing ileal FGF15 and β-Klotho mRNA expression, favoring facilitated de novo BAs synthesis and thereby driving cholesterol catabolic excretion. Our findings indicate that QXJYG is effective against HFD-triggered chronic inflammation, and contributes to the alleviation of AS development, and the antiatherogenic properties of QXJYG may be partly due to the remodeling of the gut microbiota and BA metabolism. Although the results are encouraging, further clinical studies of anti-AS herbal medicines are required to elucidate the full potential of the gut microbiota and BA metabolism.
Keywords	atherosclerosis ; bile ; blood serum ; excretion ; gene expression ; high fat diet ; histopathology ; homeostasis ; hyperlipidemia ; ileum ; immunohistochemistry ; inflammation ; interleukin-6 ; intestinal microorganisms ; metabolism ; metabolomics ; morbidity ; mortality ; phenotype ; weight gain
Language	English
Dates of publication	2022-08
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2022.154220
Database	NAL-Catalogue (AGRICOLA)

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Article: Qing Yan Li Ge Tang, a Chinese Herbal Formula, Induces Autophagic Cell Death through the PI3K/Akt/mTOR Pathway in Nasopharyngeal Carcinoma Cells In Vitro.

Yang, Ching-Huey / Tung, Kuo-Lung / Wu, Yen-Ting / Liu, Cheng / Lin, Sheng-Chieh / Yang, Chun-Chuan / Wu, Chin-Han / Chang, Hong-Yi / Wu, Shih-Yi / Huang, Bu-Miin / Lan, Yu-Yan

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 9925684

Abstract: ... in this study, we aimed to investigate whether a Chinese herbal formula, Qing Yan Li Ge Tang (QYLGT), has ...

Abstract	Since a portion of patients with nasopharyngeal carcinoma (NPC) do not benefit much from current standard treatments, it is still needed to discover new therapeutic drugs to improve the prognosis of the patients. Considering that Chinese traditional medicine plays a role in inhibiting tumor progression, in this study, we aimed to investigate whether a Chinese herbal formula, Qing Yan Li Ge Tang (QYLGT), has the anticancer activity in NPC cells and explore the underlying mechanism as well. MTT assay, colony formation assay, immunoblotting assay, and DNA laddering assay were performed to assess cell viability, cell colony formation, protein expression, and DNA fragmentation, respectively. Results show that QYLGT was able to inhibit the cell viability and decrease colony formation ability in NPC cells. QYLGT could also increase the formation of intracellular vacuoles and induce the autophagy-related protein expressions, including Atg3, Atg6, and Atg12-Atg5 conjugate in NPC cells. Treatment with an autophagy inhibitor, 3-methyladenine, could significantly recover QYLGT-inhibited cell viability of NPC cells. In addition, QYLGT did not significantly induce apoptosis in NPC cells. We also found that QYLGT had the ability to activate phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of the rapamycin (mTOR) pathway. Treatment with PI3K inhibitors, LY294002 and wortmannin, or mTOR inhibitors, rapamycin and Torin 1, could not only recover QYLGT-inhibited cell viability of NPC cells but also inhibit Atg3 expression. Taken together, our results demonstrated that QYLGT could induce autophagic cell death in NPC cells through the PI3K/Akt/mTOR pathway.
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/9925684
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Article: Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models.

Yu, Ya-Ya / Zhu, Yan-Juan / Zou, Ying / Xiao, Zhen-Zhen / Shi, Shuai / Liu, Yi-Hong / Chang, Xue-Song / Chen, Ya-Dong / Zhang, Hai-Bo

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 9911935

Abstract: Patients with EGFR gene mutation often obtain de novo resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or develop secondary resistance to EGFR-TKIs after taking EGFR-TKI therapy. Traditional Chinese medicine (TCM) ... ...

Abstract	Patients with EGFR gene mutation often obtain de novo resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or develop secondary resistance to EGFR-TKIs after taking EGFR-TKI therapy. Traditional Chinese medicine (TCM) with different treatment principles, in combination with EGFR-TKIs, plays an important role in the treatment of cancers including resistant non-small cell lung cancer (NSCLC). However, inappropriate use of TCM herbs may induce resistance to gefitinib. Therefore, it is of a great value to evaluate which TCM treatment principle should be combined with EGFR-TKIs, and which one should be avoided, and find out the potential mechanisms. The lentiviral transfection assay was used for overexpression of
Language	English
Publishing date	2021-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/9911935
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Article: Erratum to "Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models".

Yu, Ya-Ya / Zhu, Yan-Juan / Zou, Ying / Xiao, Zhen-Zhen / Shi, Shuai / Liu, Yi-Hong / Chang, Xue-Song / Chen, Ya-Dong / Zhang, Hai-Bo

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9808974

Abstract: This corrects the article DOI: 10.1155/2021/9911935.]. ...

Abstract	[This corrects the article DOI: 10.1155/2021/9911935.].
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9808974
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Article ; Online: Network pharmacology strategy for revealing the pharmacological mechanism of pharmacokinetic target components of San-Ye-Tang-Zhi-Qing formula for the treatment of type 2 diabetes mellitus.

Liu, Wei / Chen, Xuanhao / Ge, Yuanyuan / Wang, Huilin / Phosat, Charupan / Li, Jin / Mao, Hao-Ping / Gao, Xiu-Mei / Chang, Yan-Xu

Journal of ethnopharmacology

2020 Volume 260, Page(s) 113044

Abstract: Ethnopharmacological relevance: San-Ye-Tang-Zhi-Qing formula (SYTZQ) is an effective prescription ...

Abstract	Ethnopharmacological relevance: San-Ye-Tang-Zhi-Qing formula (SYTZQ) is an effective prescription for the treatment of pre-diabetes disorders of glycolipid metabolism in type 2 diabetes mellitus (T2DM). It consists of five Chinese herbs including Mori Folium, Nelumbinis Folium, Crataegi Folium, Salviae Miltiorrhizae Radix et Rhizoma and Paeoniae Radix Rubra. Aim of the study: This study was aimed to reveal the pharmacological mechanism of pharmacokinetic target components of SYTZQ for the treatment of T2DM. Materials and methods: A rapid, precise and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to quantify simultaneously nuciferin, vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside, paeoniflorin and rosmarinic acid in rat plasma after oral administration of SYTZQ. The network pharmacology was used to analyze the effect of the compounds absorbed into the blood of SYTZQ on T2DM. The effects of paeoniflorin, nuciferine and rosmarinic acid on adipogenic differentiation were validated in vitro experiments. Results: The separation was performed on an ACQUITY UHPLC HSS T3 column (2.1 mm × 100 mm, 1.7 μm) using acetonitrile and 0.1% (v/v) formic acid in water as the mobile phase in gradient elution. The calibration curves of five analytes showed good linearity (r ≥ 0.9991) with the lower limits of quantification (LLOQ) between 0.3 and 5.0 ng/mL. The recoveries and matrix effects of five analytes ranged from 81.1% to 113%. The RSDs of inter-day and intra-day precision were all within 13.7%. The validated method was successfully applied to the pharmacokinetic study of five ingredients after oral administration of SYTZQ to rat. 39 major targets and 22 candidate pathways of five compounds absorbed into the blood of rats after administration of SYTZQ were identified and successfully constructed a compound-target-disease-pathway network. It was confirmed that paeniforin, nuciferine and rosmarinic acid could decrease the adipogenicity differentiation in vitro experiments. Conclusions: The pharmacokinetic parameters indicated that the five components (nuciferin, vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside, paeoniflorin and rosmarinic acid) were absorbed and eliminated quickly in vivo. These five absorbed components were associated with 22 pathways, including insulin resistance, regulation of lipolysis in adipocytes, PI3k/AKT-, TNF-, cAMP- and cGMP-PKG-signaling pathway. Paeoniflorin, nuciferine and rosmarinic acid have the effect of inhibiting adipocyte differentiation. This study could provide more reference for quality control, and provide a firm basis for evaluating the clinical efficiency of SYTZQ.
MeSH term(s)	Adipocytes/drug effects ; Adipocytes/metabolism ; Adipogenesis/drug effects ; Administration, Oral ; Animals ; Cells, Cultured ; Chromatography, High Pressure Liquid ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Energy Metabolism/drug effects ; Female ; Gastrointestinal Absorption ; Gene Regulatory Networks ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/blood ; Hypoglycemic Agents/pharmacokinetics ; Male ; Metabolomics ; Mice, Inbred C57BL ; Protein Interaction Maps ; Rats, Sprague-Dawley ; Signal Transduction ; Systems Biology ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; Hypoglycemic Agents
Language	English
Publishing date	2020-06-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113044
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Article ; Online: Indole alkaloids indigodoles A-C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties.

Lee, Chia-Lin / Wang, Chien-Ming / Hu, Hao-Chun / Yen, Hung-Rong / Song, Ying-Chyi / Yu, Sheng-Jie / Chen, Chao-Jung / Li, Wei-Chu / Wu, Yang-Chang

Phytochemistry

2019 Volume 162, Page(s) 39–46

Abstract: Qing Dai (Naturalis Indigo) is a traditional Chinese medicine (TCM) used as a topical agent ... compounds were isolated from this preparation of Qing Dai and their structures were elucidated ... indole alkaloids could contribute to anti-IL 17 properties of Qing Dai. ...

Abstract	Qing Dai (Naturalis Indigo) is a traditional Chinese medicine (TCM) used as a topical agent in moderate psoriasis, targeting interleukin-17 (IL-17). In this study, it was prepared from the aerial parts of Strobilanthes cusia. Three undescribed indole alkaloid derivatives, indigodoles A-C, along with seven known compounds were isolated from this preparation of Qing Dai and their structures were elucidated from spectroscopic data, including NMR, MS, UV, IR, optical rotation, and CD. As well, most compounds were tested against IL-17. Indigodole C and tryptanthrin could significantly inhibit IL-17 production of Th17 cells. In addition, indigodole A and indirubin showed notably anti-IL-17 gene expression in dose-dependent effects without cytotoxicities toward Th17 and Jurkat cells, respectively. Overall, our studies indicate that the aforementioned indole alkaloids could contribute to anti-IL 17 properties of Qing Dai.
MeSH term(s)	Acanthaceae/chemistry ; Animals ; Drugs, Chinese Herbal/chemistry ; Indole Alkaloids/chemistry ; Indole Alkaloids/pharmacology ; Interleukin-17/antagonists & inhibitors ; Interleukin-17/biosynthesis ; Medicine, Chinese Traditional ; Mice ; Models, Molecular ; Molecular Conformation ; Plant Components, Aerial/chemistry ; Th17 Cells/drug effects ; Th17 Cells/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Indole Alkaloids ; Interleukin-17 ; Qingdai compound (R1R8QUL21Z)
Language	English
Publishing date	2019-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2019.02.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models

Ya-Ya Yu / Yan-Juan Zhu / Ying Zou / Zhen-Zhen Xiao / Shuai Shi / Yi-Hong Liu / Xue-Song Chang / Ya-Dong Chen / Hai-Bo Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: ... in PC-9-PIK3CA-M and H1975 cells treated by the typical cooling-heat drug, Qing-kai-ling (QKL) and Tan ... re-qing (TRQ), or the typical warming-yang drug, Shen-fu (SF) and gefitinib treatment, were detected ...

Abstract	Patients with EGFR gene mutation often obtain de novo resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or develop secondary resistance to EGFR-TKIs after taking EGFR-TKI therapy. Traditional Chinese medicine (TCM) with different treatment principles, in combination with EGFR-TKIs, plays an important role in the treatment of cancers including resistant non-small cell lung cancer (NSCLC). However, inappropriate use of TCM herbs may induce resistance to gefitinib. Therefore, it is of a great value to evaluate which TCM treatment principle should be combined with EGFR-TKIs, and which one should be avoided, and find out the potential mechanisms. The lentiviral transfection assay was used for overexpression of PIK3CA mutation gene in PC-9 cells to construct PC-9-PIK3CA-mutation (PC-9-PIK3CA-M) cells. Cell proliferation, apoptosis, and the expression of EGFR/PI3K/AKT and EGFR/RAS/RAF/ERK in PC-9-PIK3CA-M and H1975 cells treated by the typical cooling-heat drug, Qing-kai-ling (QKL) and Tan-re-qing (TRQ), or the typical warming-yang drug, Shen-fu (SF) and gefitinib treatment, were detected by MTT, Annexin V/PI double labeling, and Western blot assays, respectively. Tumor xenograft and immunohistochemistry experiments were carried out to confirm the in vitro findings. PC-9-PIK3CA-M cells were less sensitive to gefitinib, when compared with PC-9 cells. QKL injection and TRQ injection, not SF injection, combined with gefitinib induced significantly increased cell growth inhibition and apoptosis in PC-9-PIK3CA-M and H1975 cells. SF injection antagonized the effect of gefitinib in promoting cancer cell apoptosis. QKL injection and TRQ injection increased the sensitivity of gefitinib by inhibiting the phosphorylation of AKT or ERK in H1975 and PC-9-PIK3CA-M cells. Similar findings were observed in vivo in H1975 xenograft mouse model. QKL and TRQ, with cooling-heat TCM treatment principle, should be combined with gefitinib in the treatment of NSCLC. Furthermore, warming-yang drug SF should ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610 ; 616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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