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  1. Article ; Conference proceedings: Symposium on Ion Channels

    Hebert, Steven C.

    [circa 1995]

    1995  

    Institution Symposium on Ion Channels
    Author's details guest eds.: Steven C. Hebert
    Collection Kidney international
    Keywords Ion Channels / congresses
    Language English
    Size Ill., graph. Darst.
    Publishing place 1995
    Publishing country United States
    Document type Article ; Conference proceedings
    Note In: Kidney international. - ISSN 0085-2538. - 48 (1995),4, S. 917 - 1205
    HBZ-ID HT006795270
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Zs A 797 -48-

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  2. Book: Seldin and Giebisch's the kidney / 2

    Alpern, Robert J. / Hebert, Steven C. / Seldin, Donald W. / Giebisch, Gerhard

    physiology and pathophysiology

    2008  

    Author's details ed. Robert J. Alpern
    Collection Seldin and Giebisch's the kidney
    Language English
    Size XXIII, S. 1429 - 2871, [10] Bl. : Ill., graph. Darst.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015039325
    ISBN 978-0-12-088490-2 ; 0-12-088490-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 A 5763 order for loan Magazin

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  3. Book: Seldin and Giebisch's the kidney / 1

    Alpern, Robert J. / Hebert, Steven C. / Seldin, Donald W. / Giebisch, Gerhard

    physiology and pathophysiology

    2008  

    Author's details ed. Robert J. Alpern
    Collection Seldin and Giebisch's the kidney
    Language English
    Size XXIII, 1427 S., [6] Bl. : Ill., graph. Darst.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015039292
    ISBN 978-0-12-088489-6 ; 0-12-088489-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 5762 order for loan Magazin

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  4. Book ; Collection: Seldin and Giebisch's the kidney

    Alpern, Robert J. / Hebert, Steven C. / Seldin, Donald W. / Giebisch, Gerhard

    physiology and pathophysiology

    2008  

    Title variant The kidney
    Author's details ed. Robert J. Alpern
    Keywords Kidney / physiology ; Kidney Diseases / physiopathology
    Language English
    Dates of publication 2008-9999
    Edition 4. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Collection (display volumes)
    Old title 3. Aufl. u.d.T. The kidney
    HBZ-ID HT015039194
    ISBN 0-12-088488-7 ; 978-0-12-088488-9
    Database Catalogue ZB MED Medicine, Health

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  5. Article: "Multisystem Inflammatory Syndrome in Children"-Like Disease after COVID-19 Vaccination (MIS-V) with Potential Significance of Functional Active Autoantibodies Targeting G-Protein-Coupled Receptors (GPCR-fAAb) for Pathophysiology and Therapy.

    Schmidt, Marius / Hébert, Steven / Wallukat, Gerd / Ponader, Rolf / Krickau, Tobias / Galiano, Matthias / Reutter, Heiko / Woelfle, Joachim / Agaimy, Abbas / Mardin, Christian / Hoerning, André / Hohberger, Bettina

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 12

    Abstract: ... in children (MIS-C). However, similar symptoms may occur and have been described as Multisystemic inflammatory ... of a 12-year-old boy who was identified with MIS-C symptoms without previous SARS-CoV-2 infection after ... which, in some instances, can lead to multiorgan failure. Despite its rarity, post-vaccine MIS-C-like disease may develop ...

    Abstract Background: An infection with SARS-CoV-2 can trigger a systemic disorder by pathological autoimmune processes. A certain type of this dysregulation is known as Multisystemic inflammatory syndrome in children (MIS-C). However, similar symptoms may occur and have been described as Multisystemic inflammatory syndrome after SARS-CoV-2 Vaccination (MIS-V) following vaccination against SARS-CoV-2. We report the case of a 12-year-old boy who was identified with MIS-C symptoms without previous SARS-CoV-2 infection after receiving two doses of the Pfizer-BioNTech COVID-19 vaccine approximately one month prior to the onset of symptoms. He showed polyserositis, severe gastrointestinal symptoms and, consequently, a manifestation of a multiorgan failure. IgG antibodies against spike proteins of SARS-CoV-2 were detected, indicating a successful vaccination, while SARS-CoV-2 Nucleocapsid protein antibodies and SARS-CoV-2 PCR were not detected. Several functional, active autoantibodies against G-protein-coupled receptors (GPCR-fAAb), previously associated with Long COVID disease, were detected in a cardiomyocyte bioassay. Immunosuppression with steroids was initiated. Due to side effects, treatment with steroids and later interleukin 1 receptor antagonists had to be terminated. Instead, immunoadsorption was performed and continued with tacrolimus and mycophenolic acid therapy, leading to improvement and discharge after 79 days. GPCR-fAAb decreased during therapy and remained negative after clinical curing and under continued immunosuppressive therapy with tacrolimus and mycophenolic acid. Follow-up of the patient showed him in good condition after one year.
    Conclusions: Infection with SARS-CoV-2 shows a broad and severe variety of symptoms, partly due to autoimmune dysregulation, which, in some instances, can lead to multiorgan failure. Despite its rarity, post-vaccine MIS-C-like disease may develop into a serious condition triggered by autoimmune dysregulation. The evidence of circulating GPCR-fAAb and their disappearance after therapy suggests a link of GPCR-fAAb to the clinical manifestations. Thus, we hypothesize a potential role of GPCR-fAAb in pathophysiology and their potential importance for the therapy of MIS-C or MIS-V. However, this observation needs further investigation to prove a causative correlation.
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10121836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Associations between the Dietary Inflammatory Index and Sleep Metrics in the Energy Balance Study (EBS).

    Farrell, Emily T / Wirth, Michael D / McLain, Alexander C / Hurley, Thomas G / Shook, Robin P / Hand, Gregory A / Hébert, James R / Blair, Steven N

    Nutrients

    2023  Volume 15, Issue 2

    Abstract: 1) Background: Sleep, a physiological necessity, has strong inflammatory underpinnings. Diet is a strong moderator of systemic inflammation. This study explored the associations between the Dietary Inflammatory Index (DII®) and sleep duration, timing, ... ...

    Abstract (1) Background: Sleep, a physiological necessity, has strong inflammatory underpinnings. Diet is a strong moderator of systemic inflammation. This study explored the associations between the Dietary Inflammatory Index (DII®) and sleep duration, timing, and quality from the Energy Balance Study (EBS). (2) Methods: The EBS (n = 427) prospectively explored energy intake, expenditure, and body composition. Sleep was measured using BodyMedia’s SenseWear® armband. DII scores were calculated from three unannounced dietary recalls (baseline, 1-, 2-, and 3-years). The DII was analyzed continuously and categorically (very anti-, moderately anti-, neutral, and pro-inflammatory). Linear mixed-effects models estimated the DII score impact on sleep parameters. (3) Results: Compared with the very anti-inflammatory category, the pro-inflammatory category was more likely to be female (58% vs. 39%, p = 0.02) and African American (27% vs. 3%, p < 0.01). For every one-unit increase in the change in DII score (i.e., diets became more pro-inflammatory), wake-after-sleep-onset (WASO) increased (βChange = 1.00, p = 0.01), sleep efficiency decreased (βChange = −0.16, p < 0.05), and bedtime (βChange = 1.86, p = 0.04) and waketime became later (βChange = 1.90, p < 0.05). Associations between bedtime and the DII were stronger among African Americans (βChange = 6.05, p < 0.01) than European Americans (βChange = 0.52, p = 0.64). (4) Conclusions: Future studies should address worsening sleep quality from inflammatory diets, leading to negative health outcomes, and explore potential demographic differences.
    MeSH term(s) Humans ; Female ; Male ; Diet ; Inflammation ; Sleep ; Energy Intake ; Polysomnography
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15020419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: "Multisystem Inflammatory Syndrome in Children" (MIS-C) after COVID-19 Infection in the Metropolitan Area of Nuremberg-Erlangen, Germany-Expectations and Results of a Two-Year Period.

    Hébert, Steven / Schmidt, Marius / Topf, Georg / Rieger, Daniel / Klinge, Jens / Vermehren, Jan / Fusch, Christoph / Grillhösl, Christian / Schroth, Michael / Toni, Irmgard / Reutter, Heiko / Morhart, Patrick / Hanslik, Gregor / Mulzer, Linda / Woelfle, Joachim / Hohberger, Bettina / Hoerning, André

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 8

    Abstract: Background: Multisystemic Inflammatory Syndrome in children (MIS-C) is a rare autoimmune disorder ... occurring after a latency period following acute SARS-CoV-2 infection. The therapeutic regime of MIS-C is ... to gain further knowledge about MIS-C. Thus, we aimed to investigate the incidence, symptoms ...

    Abstract Background: Multisystemic Inflammatory Syndrome in children (MIS-C) is a rare autoimmune disorder occurring after a latency period following acute SARS-CoV-2 infection. The therapeutic regime of MIS-C is adapted to the therapy of the Kawasaki disease, as clinical symptoms are similar. Since the Kawasaki disease can potentially result in severe symptoms, which may even affect long-term health, it is essential to gain further knowledge about MIS-C. Thus, we aimed to investigate the incidence, symptoms, therapeutical procedure and outcome of MIS-C patients in the metropolitan area of Nuremberg-Erlangen during the SARS-CoV2 pandemic.
    Material and methods: Retrospective analysis of clinical charts of MIS-C patients was carried out at three children's hospitals covering the medical care of the metropolitan area of Nuremberg-Erlangen in Germany. Demographic characteristics and symptoms at first visit, their clinical course, therapeutic regime and outcome were recorded within the time period January 2021-December 2022.
    Results: Analysis of 10 patients (5 male, 5 female) with MIS-C resulting in an incidence of 2.14/100.000 children. The median time between COVID-19 infection and admission to hospital was 5 weeks. The median age was 7 years. Symptoms comprised fever (100%), rash (70%), bilateral non-purulent conjunctivitis (70%) and urticaria (20%). At the time of presentation, diagnosis-defining inflammation parameters were increased and the range for C-reactive protein was 4.13 mg/dL to 28 mg/dL, with a median of 24.7 mg/dL. Procalcitonin was initially determined in six patients (1.92 ng/mL to 21.5 ng/mL) with a median value of 5.5 pg/mL. Two patients displayed leukocytosis and two displayed leukopenia. None of the patients presented coronary pathologies. Nine of the ten patients received intravenous immunoglobulin (IVIG) therapy. In addition, patients received intravenous steroids (80%) and acetylsalicylic acid (80%).
    Conclusion: SARS-CoV virus may rarely exert multiorgan manifestations due to hyperinflammatory immunological processes. Within two years of the COVID-19 pandemic, we identified ten patients with COVID-induced MIS-C in the metropolitan area Nuremberg-Erlangen. In the description of the patient collective, we can confirm that MIS-C is distinguished from the Kawasaki disease by the lack of coronary manifestations. Interestingly, although having monitored all pediatric facilities in the investigated area, we find lower incidences of MIS-C compared to findings in the literature. In conclusion, an overestimation of incidences in the upcoming MIS-C during the pandemic needs to be considered.
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10081363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice.

    Litzler, Ludivine C / Zahn, Astrid / Dionne, Kiersten L / Sprumont, Adrien / Ferreira, Silvana R / Slattery, Michael R F / Methot, Stephen P / Patenaude, Anne-Marie / Hébert, Steven / Kabir, Nisha / Subramani, Poorani Ganesh / Jung, Seolkyoung / Richard, Stéphane / Kleinman, Claudia L / Di Noia, Javier M

    The Journal of experimental medicine

    2023  Volume 220, Issue 9

    Abstract: Positively selected germinal center B cells (GCBC) can either resume proliferation and somatic hypermutation or differentiate. The mechanisms dictating these alternative cell fates are incompletely understood. We show that the protein arginine ... ...

    Abstract Positively selected germinal center B cells (GCBC) can either resume proliferation and somatic hypermutation or differentiate. The mechanisms dictating these alternative cell fates are incompletely understood. We show that the protein arginine methyltransferase 1 (Prmt1) is upregulated in murine GCBC by Myc and mTORC-dependent signaling after positive selection. Deleting Prmt1 in activated B cells compromises antibody affinity maturation by hampering proliferation and GCBC light zone to dark zone cycling. Prmt1 deficiency also results in enhanced memory B cell generation and plasma cell differentiation, albeit the quality of these cells is compromised by the GCBC defects. We further demonstrate that Prmt1 intrinsically limits plasma cell differentiation, a function co-opted by B cell lymphoma (BCL) cells. Consistently, PRMT1 expression in BCL correlates with poor disease outcome, depends on MYC and mTORC1 activity, is required for cell proliferation, and prevents differentiation. Collectively, these data identify PRMT1 as a determinant of normal and cancerous mature B cell proliferation and differentiation balance.
    MeSH term(s) Animals ; Mice ; Antibody Affinity ; B-Lymphocytes ; Cell Differentiation ; Germinal Center ; Protein-Arginine N-Methyltransferases/genetics ; Cell Proliferation
    Chemical Substances Protein-Arginine N-Methyltransferases (EC 2.1.1.319)
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20220381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bioelectrical impedance phase angle is associated with physical performance before but not after simulated multi-stressor military operations.

    Varanoske, Alyssa N / Harris, Melissa N / Hebert, Callie / Johannsen, Neil M / Heymsfield, Steven B / Greenway, Frank L / Ferrando, Arny A / Rood, Jennifer C / Pasiakos, Stefan M

    Physiological reports

    2023  Volume 11, Issue 6, Page(s) e15649

    Abstract: Physical performance decrements observed during multi-stressor military operations may be attributed, in part, to cellular membrane dysfunction, which is quantifiable using phase angle (PhA) derived from bioelectrical impedance analysis (BIA). Positive ... ...

    Abstract Physical performance decrements observed during multi-stressor military operations may be attributed, in part, to cellular membrane dysfunction, which is quantifiable using phase angle (PhA) derived from bioelectrical impedance analysis (BIA). Positive relationships between PhA and performance have been previously reported in cross-sectional studies and following longitudinal exercise training programs, but whether changes in PhA are indicative of acute decrements in performance during military operations is unknown. Data from the Optimizing Performance for Soldiers II study, a clinical trial examining the effects of exogenous testosterone administration on body composition and performance during military stress, was used to evaluate changes in PhA and their associations with physical performance. Recreationally active, healthy males (n = 34; 26.6 ± 4.3 years; 77.9 ± 12.4 kg) were randomized to receive testosterone undecanoate or placebo before a 20-day simulated military operation, which was followed by a 23-day recovery period. PhA of the whole-body (Whole) and legs (Legs) and physical performance were measured before (PRE) and after (POST) the simulated military operation as well as in recovery (REC). Independent of treatment, PhA
    MeSH term(s) Male ; Humans ; Electric Impedance ; Cross-Sectional Studies ; Military Personnel ; Body Composition/physiology ; Exercise
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Conference proceedings: Multisystem Inflammatory Syndrome in Children” (MIS-C) after COVID-19 infection in the Metropolitan Area Nuremberg-Erlangen with a case of MIS-C like disease following SARS-CoV-2 mRNA vaccination

    Hébert, Steven / Schmidt, Marius / Wallukat, G / Ponader, R / Topf, Georg / Rieger, Daniel / Klinge, Jens / Vermehren, J / Fusch, Christoph / Grillhoesl, C / Schroth, Michael / Krickau, Tobias / Toni, I / Reutter, Heiko / Morhart, Patrick / Hanslik, Gregor / Mulzer, Linda / Woelfle, Joachim / Agaimy, A /
    Hohberger, Bettina / Hoerning, André

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language English
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769326
    Database Thieme publisher's database

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