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  1. Article ; Online: The Multilevel Engagement Theory

    Muhammad Hassan Raza

    International Journal of Qualitative Research, Vol 2, Iss 3, Pp 223-

    2023  Volume 237

    Abstract: The purpose of this article is to present the multilevel engagement theory to conduct research studies and explain real-life situations. The multilevel engagement theory considers culture and diversity as central aspects along with the multilevel ... ...

    Abstract The purpose of this article is to present the multilevel engagement theory to conduct research studies and explain real-life situations. The multilevel engagement theory considers culture and diversity as central aspects along with the multilevel influences and sociocultural and historical contexts for understanding complex relationships and functioning among individuals, groups, and families in societies around the world. A critical review and assessment of the contemporary theories were conducted which uncovered important gaps and helped the author to demonstrate the contribution of the multilevel engagement theory in the relevant fields of study. Then, the author discussed the principles, assumptions, concepts, and propositions of the multilevel engagement theory. The use, application, and operationalization of the multilevel engagement theory in empirical research were also described with specific examples. The author also provided specific and testable hypotheses and qualitative themes for additional clarity and explanation of the multilevel engagement theory. The multilevel engagement theory offers researchers a comprehensive theoretical framework and a unique lens for studying family relationships and functioning in contextualized and inclusive manners. The implications and limitations are discussed.
    Keywords culture and diversity ; family relationships and functioning ; multilevel influences ; sociocultural and historical times ; the multilevel engagement theory ; Social Sciences ; H
    Subject code 360
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher CV. Literasi Indonesia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Addressing comprehensive complexities a striking familial hypercholesterolemia case study.

    Rasheed, Shazia / Kubra, Ghulam / Baqai, Lubna / Raza, Muhammad Liaquat / Hassan, Fariha / Rizvi, Syed Ghazi Abbas

    The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

    2024  Volume 76, Issue 1, Page(s) 51

    Abstract: Background: Premature aortic involvement and comprehensive management strategies in familial hypercholesterolemia familial hypercholesterolemia (FH), a rare autosomal dominant genetic disorder, poses significant challenges due to its propensity for ... ...

    Abstract Background: Premature aortic involvement and comprehensive management strategies in familial hypercholesterolemia familial hypercholesterolemia (FH), a rare autosomal dominant genetic disorder, poses significant challenges due to its propensity for elevated low-density lipoprotein cholesterol, premature coronary heart disease, and vascular atherosclerosis.
    Case presentation: Unraveling Cardiovascular Complexities: A Striking Familial Hypercholesterolemia. This case study delves into a remarkable instance of FH in a 16-year-old female who presented with chest pain and worsening dyspnea. Diagnostic evaluation revealed distinct electrocardiographic changes, elevated troponin levels, and profound dyslipidemia. Remarkable findings on transthoracic echocardiography, computed tomography angiography, and catheterization prompted multidisciplinary interventions and demonstrated remarkable enhancements in ventricular function, mitral regurgitation, and aortic stenosis.
    Conclusion: The case study underscores the urgency of comprehensive management strategies in confronting the myriad challenges of FH, emphasizing the value of early intervention, innovative therapies, and rigorous imaging modalities for unraveling the intricate cardiovascular manifestations of this condition.
    Language English
    Publishing date 2024-04-20
    Publishing country Germany
    Document type Journal Article
    ISSN 2090-911X
    ISSN (online) 2090-911X
    DOI 10.1186/s43044-024-00483-5
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  3. Article: Efficacy, Safety, and Role of Antiplatelet Drugs in the Management of Acute Coronary Syndrome: A Comprehensive Review of Literature.

    Abubakar, Muhammad / Raza, Saud / Hassan, Khawaja Mushammar / Javed, Izzah / Hassan, Khawaja Momal / Farrukh, Fiza / Hassan, Khawaja Muthammir / Faraz, Muhammad Ahmad

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36335

    Abstract: Acute coronary syndrome (ACS) is a complex condition characterized by myocardial ischemia or infarction which can lead to significant morbidity and death. Antiplatelet drugs play a crucial role in the management of ACS and have been shown to minimize the ...

    Abstract Acute coronary syndrome (ACS) is a complex condition characterized by myocardial ischemia or infarction which can lead to significant morbidity and death. Antiplatelet drugs play a crucial role in the management of ACS and have been shown to minimize the incidence of significant adverse cardiovascular events and recurrent myocardial infarction (MI). This comprehensive literature review is intended to summarize current information on the effectiveness, safety, and function of frequently used antiplatelet medications in treating ACS. Aspirin, clopidogrel, prasugrel, ticagrelor, abciximab, tirofiban, dipyridamole, cilostazol, and novel antiplatelets are included in the review. Aspirin's effectiveness as a first-line antiplatelet medication in ACS is well established. It has significantly lowered the risk of serious adverse cardiovascular events. Clopidogrel, prasugrel, and ticagrelor are P2Y12 receptor inhibitors found to lower the incidence of recurrent ischemia episodes in ACS patients. Using glycoprotein IIb/IIIa inhibitors such as abciximab, tirofiban, and eptifibatide is effective in managing ACS, especially in high-risk patients. Dipyridamole effectively reduces the risk of recurrent ischemic events in patients with ACS, particularly when used with aspirin. Cilostazol, a phosphodiesterase III inhibitor, has also been shown to reduce the risk of major adverse cardiovascular events (MACE) in patients with ACS. Antiplatelet drugs' safety in managing ACS has also been well established. Aspirin is generally well-tolerated with a low risk of adverse effects, although the risk of bleeding events, particularly gastrointestinal bleeding, cannot be eliminated. The P2Y12 receptor inhibitors have been associated with a small increase in the risk of bleeding events, particularly in patients with a high risk of bleeding. The glycoprotein IIb/IIIa inhibitors are associated with a higher risk of bleeding than other antiplatelet drugs, especially in high-risk patients. To summarize, antiplatelet drugs play a crucial role in the management of ACS, and the efficacy and safety of these drugs have been well-established in the literature. The choice of antiplatelet drugs will depend on the patient's risk factors, including age, comorbidities, and bleeding risk. The novel antiplatelets may offer new therapeutic options for managing ACS, and further studies are needed to determine their role in managing this complex condition.
    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36335
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  4. Article ; Online: Indigo

    Raza, Hassan A / Horowitz, James / Yuriditsky, Eugene

    Future cardiology

    2023  Volume 19, Issue 10, Page(s) 469–475

    Abstract: Anticoagulation is mainstay therapy for patients with acute pulmonary embolism while systemic thrombolysis is reserved for those with hemodynamic instability. Over the last decade, percutaneous interventional options have entered the landscape aimed to ... ...

    Abstract Anticoagulation is mainstay therapy for patients with acute pulmonary embolism while systemic thrombolysis is reserved for those with hemodynamic instability. Over the last decade, percutaneous interventional options have entered the landscape aimed to achieve rapid pharmacomechanical pulmonary artery recanalization. The Penumbra Indigo
    MeSH term(s) Humans ; Indigo Carmine ; Treatment Outcome ; Thrombectomy/adverse effects ; Pulmonary Embolism/surgery ; Pulmonary Embolism/etiology ; Thrombolytic Therapy
    Chemical Substances Indigo Carmine (D3741U8K7L)
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2022-0134
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  5. Article: Thyrotoxic Periodic Paralysis: The Peril of Potassium Replacement.

    Yoon, Sean Ho / Raza, Hassan

    Cureus

    2022  Volume 14, Issue 12, Page(s) e32926

    Abstract: Hypokalemic periodic paralysis (HPP) is a clinical condition of sudden-onset, recurrent transient episodes of weakness caused by severe hypokalemia. Thyrotoxic periodic paralysis (TPP) is a specific subgroup of the HPP spectrum, where hypokalemia occurs ... ...

    Abstract Hypokalemic periodic paralysis (HPP) is a clinical condition of sudden-onset, recurrent transient episodes of weakness caused by severe hypokalemia. Thyrotoxic periodic paralysis (TPP) is a specific subgroup of the HPP spectrum, where hypokalemia occurs in the setting of thyrotoxicosis, and the repletion of potassium must be performed with caution. A male in his second decade of life with hyperthyroidism non-adherent to methimazole presented with acute-onset bilateral lower extremity weakness. On physical examination, the patient had diffuse thyromegaly and tremors on outstretched hands. Bilateral lower extremity weakness and decreased reflexes were also noted, with preserved muscle tone and normal passive range of motion. Labs demonstrated hyperactive thyroid function and severe hypokalemia at 1.7 mEq/L, with U waves present on the electrocardiogram. In the intensive care unit, the patient received methimazole and propranolol for thyrotoxicosis and a total dose of 60 mEq/L of potassium replacement therapy. Despite the expected correction by 0.6 mEq/L, his follow-up potassium level dramatically increased to 5.7 mEq/L, resulting in the actual correction of 4.0 mEq/L. Within a few hours, the patient regained his baseline strength with a significant improvement in tremors. Patients with TPP present with acute-onset extremity weakness and severe hypokalemia, which reverses quickly with potassium repletion. Clinicians should not only treat thyrotoxicosis but also avoid overly aggressive repletion of potassium as this may lead to rebound hyperkalemia when the initial transcellular potassium shift is reversed.
    Language English
    Publishing date 2022-12-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.32926
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  6. Article: Pathways to prevention: insights on stemming HIV outbreaks in Larkana, Pakistan.

    Raza, Hussain Ahmed / Raja, Mohummad Hassan Raza / Khakwani, Muhammad Mussab / Khakwani, Minahil / Jamil, Bushra

    JPMA. The Journal of the Pakistan Medical Association

    2024  Volume 74, Issue 3, Page(s) 544–548

    Abstract: In the past two decades, Pakistan has faced multiple human immunodeficiency virus outbreaks, with Larkana appearing to be the hub of such outbreaks. While the previous Larkana outbreaks happened in high-risk populations, the alarming outbreak in 2019 ... ...

    Abstract In the past two decades, Pakistan has faced multiple human immunodeficiency virus outbreaks, with Larkana appearing to be the hub of such outbreaks. While the previous Larkana outbreaks happened in high-risk populations, the alarming outbreak in 2019 occurred in a low-risk paediatric population, raising several concerning questions. Human immunodeficiency virus infections spilling into the general population is indicative of a steady increase in the number of cases, and the failure of control strategies to stem the concentrated epidemic from evolving. Although several causative factors have been identified from previous outbreaks, the one that occurred in 2019 may have been influenced by an additional, hitherto unexplored factor; child sexual abuse. The current narrative review was planned to summarise human immunodeficiency virus risk factors and causes identified in previous Larkana epidemics, to explore potential reasons for the outbreaks in children, and to discuss possible steps needed for stemming human immunodeficiency virus outbreaks in Pakistan.
    MeSH term(s) Child ; Humans ; HIV ; Pakistan/epidemiology ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Disease Outbreaks/prevention & control ; Risk Factors
    Language English
    Publishing date 2024-04-09
    Publishing country Pakistan
    Document type Review ; Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.9042
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  7. Article: LUSPATERCEPT - A better strategy for thalassemia?

    Patel, Mustafa Saleem / Raza, Imran Mansoor / Hassan, Syeda Zuhaa

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71, Issue 8, Page(s) 2107

    MeSH term(s) Activin Receptors, Type II ; Humans ; Immunoglobulin Fc Fragments ; Recombinant Fusion Proteins ; Thalassemia/drug therapy ; beta-Thalassemia
    Chemical Substances Immunoglobulin Fc Fragments ; Recombinant Fusion Proteins ; luspatercept (AQK7UBA1LS) ; Activin Receptors, Type II (EC 2.7.11.30)
    Language English
    Publishing date 2021-08-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.773
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  8. Article ; Online: Synthesis and discovery of potential tyrosinase inhibitor of new coumarin-based thiophenyl-pyrazolylthiazole nuclei: In vitro evaluation, cytotoxicity, kinetic, and computational studies.

    Hosseini Nasab, Narges / Raza, Hussain / Eom, Young Seok / Hassan, Mubashir / Kloczkowski, Andrzej / Kim, Song Ja

    Chemical biology & drug design

    2023  Volume 101, Issue 6, Page(s) 1262–1272

    Abstract: A well-known key enzyme in melanogenesis and hyperpigmentation is tyrosinase. The present study introduces a novel series of thiophenyl-pyrazolylthiazole-coumarin hybrids (6a-6h) as tyrosinase inhibitors. The in-vitro tyrosinase inhibition results ... ...

    Abstract A well-known key enzyme in melanogenesis and hyperpigmentation is tyrosinase. The present study introduces a novel series of thiophenyl-pyrazolylthiazole-coumarin hybrids (6a-6h) as tyrosinase inhibitors. The in-vitro tyrosinase inhibition results indicated that all compounds have strong tyrosinase inhibitory activity, particularly compound 6g (IC
    MeSH term(s) Molecular Structure ; Molecular Docking Simulation ; Monophenol Monooxygenase/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Coumarins/pharmacology ; Structure-Activity Relationship ; Melanins ; Agaricales
    Chemical Substances Monophenol Monooxygenase (EC 1.14.18.1) ; Enzyme Inhibitors ; Coumarins ; Melanins
    Language English
    Publishing date 2023-02-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2216600-2
    ISSN 1747-0285 ; 1747-0277
    ISSN (online) 1747-0285
    ISSN 1747-0277
    DOI 10.1111/cbdd.14209
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  9. Article ; Online: Leveraging collaborative learning for improved heart failure care: insights from Argentina.

    Raja, Mohummad Hassan Raza / Ahmad, Tariq / Samad, Zainab

    International journal for quality in health care : journal of the International Society for Quality in Health Care

    2023  Volume 35, Issue 3

    MeSH term(s) Humans ; Argentina ; Interdisciplinary Placement ; Heart Failure/therapy
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1194150-9
    ISSN 1464-3677 ; 1353-4505
    ISSN (online) 1464-3677
    ISSN 1353-4505
    DOI 10.1093/intqhc/mzad067
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  10. Article ; Online: Design and synthesis of thiadiazole-oxadiazole-acetamide derivatives: Elastase inhibition, cytotoxicity, kinetic mechanism, and computational studies.

    Hosseini Nasab, Narges / Raza, Hussain / Eom, Young Seok / Hassan, Mubashir / Kloczkowski, Andrzej / Kim, Song Ja

    Bioorganic & medicinal chemistry

    2023  Volume 86, Page(s) 117292

    Abstract: Considering the biological significance of 1,3,4-thiadiazole/oxadiazole heterocyclic scaffolds, a novel series of 1,3,4-thiadiazole-1,3,4-oxadiazole-acetamide derivatives (7a-j) was designed and synthesized using molecular hybridization. The inhibitory ... ...

    Abstract Considering the biological significance of 1,3,4-thiadiazole/oxadiazole heterocyclic scaffolds, a novel series of 1,3,4-thiadiazole-1,3,4-oxadiazole-acetamide derivatives (7a-j) was designed and synthesized using molecular hybridization. The inhibitory effects of the target compounds on elastase were evaluated, and all of these molecules were found to be potent inhibitors compared to the standard reference oleanolic acid. Compound 7f exhibited the excellent inhibitory activity (IC
    MeSH term(s) Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Pancreatic Elastase ; Oxadiazoles/chemistry ; Kinetics ; Oleanolic Acid ; Thiadiazoles/chemistry ; Melanoma ; Amides ; Acetamides/pharmacology ; Molecular Structure
    Chemical Substances 1,3,4-thiadiazole (14IAC3GH7G) ; Pancreatic Elastase (EC 3.4.21.36) ; Oxadiazoles ; Oleanolic Acid (6SMK8R7TGJ) ; Thiadiazoles ; Amides ; Acetamides
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2023.117292
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