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  1. Article ; Online: Expanding the Tuberculosis Cascade of Care to Treat Undiagnosed and Subclinical Tuberculosis in High-Burden Settings.

    O'Donnell, Max / Mathema, Barun

    American journal of respiratory and critical care medicine

    2021  Volume 205, Issue 2, Page(s) 149–151

    MeSH term(s) Humans ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202111-2528ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Drug resistant

    Schami, Alyssa / Islam, M Nurul / Wall, Matthew / Hicks, Amberlee / Meredith, Reagan / Kreiswirth, Barry / Mathema, Barun / Belisle, John T / Torrelles, Jordi B

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Mycobacterium tuberculosis: Author summary: Tuberculosis (TB) is a leading cause of death due to an infectious organism and is caused by the ... ...

    Abstract Mycobacterium tuberculosis
    Author summary: Tuberculosis (TB) is a leading cause of death due to an infectious organism and is caused by the bacteria
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.10.588986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Operational Research on the Treatment of Drug-Resistant Tuberculosis: Exciting Results That Need to Be Protected.

    O'Donnell, Max / Mathema, Barun

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 1, Page(s) 11–13

    MeSH term(s) Diarylquinolines ; Humans ; Nitroimidazoles ; Operations Research ; Oxazoles ; Prospective Studies ; Tuberculosis, Multidrug-Resistant/drug therapy
    Chemical Substances Diarylquinolines ; Nitroimidazoles ; OPC-67683 ; Oxazoles ; bedaquiline (78846I289Y)
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202007-2974ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y.

    Bobba, Suhas / Chauhan, Kuldeep S / Akter, Sadia / Das, Shibali / Mittal, Ekansh / Mathema, Barun / Philips, Jennifer A / Khader, Shabaana A

    PLoS pathogens

    2024  Volume 20, Issue 4, Page(s) e1012137

    Abstract: Interleukin-1 (IL-1) signaling is essential for controlling virulent Mycobacterium tuberculosis (Mtb) infection since antagonism of this pathway leads to exacerbated pathology and increased susceptibility. In contrast, the triggering of type I interferon ...

    Abstract Interleukin-1 (IL-1) signaling is essential for controlling virulent Mycobacterium tuberculosis (Mtb) infection since antagonism of this pathway leads to exacerbated pathology and increased susceptibility. In contrast, the triggering of type I interferon (IFN) signaling is associated with the progression of tuberculosis (TB) disease and linked with negative regulation of IL-1 signaling. However, mice lacking IL-1 signaling can control Mtb infection if infected with an Mtb strain carrying the rifampin-resistance conferring mutation H445Y in its RNA polymerase β subunit (rpoB-H445Y Mtb). The mechanisms that govern protection in the absence of IL-1 signaling during rpoB-H445Y Mtb infection are unknown. In this study, we show that in the absence of IL-1 signaling, type I IFN signaling controls rpoB-H445Y Mtb replication, lung pathology, and excessive myeloid cell infiltration. Additionally, type I IFN is produced predominantly by monocytes and recruited macrophages and acts on LysM-expressing cells to drive protection through nitric oxide (NO) production to restrict intracellular rpoB-H445Y Mtb. These findings reveal an unexpected protective role for type I IFN signaling in compensating for deficiencies in IL-1 pathways during rpoB-H445Y Mtb infection.
    MeSH term(s) Mycobacterium tuberculosis ; Interferon Type I/metabolism ; Animals ; Mice ; Rifampin/pharmacology ; Signal Transduction ; DNA-Directed RNA Polymerases/metabolism ; DNA-Directed RNA Polymerases/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Mutation ; Mice, Inbred C57BL ; Drug Resistance, Bacterial/genetics ; Tuberculosis/microbiology ; Tuberculosis/immunology ; Tuberculosis/genetics ; Mice, Knockout
    Chemical Substances Interferon Type I ; Rifampin (VJT6J7R4TR) ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; Bacterial Proteins ; rpoB protein, Mycobacterium tuberculosis
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012137
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  5. Article ; Online: Connecting the dots: understanding how human mobility shapes TB epidemics.

    Brown, Tyler S / Robinson, D Ashley / Buckee, Caroline O / Mathema, Barun

    Trends in microbiology

    2022  Volume 30, Issue 11, Page(s) 1036–1044

    Abstract: Tuberculosis (TB) remains a leading infectious cause of death worldwide. Reducing TB infections and TB-related deaths rests ultimately on stopping forward transmission from infectious to susceptible individuals. Critical to this effort is understanding ... ...

    Abstract Tuberculosis (TB) remains a leading infectious cause of death worldwide. Reducing TB infections and TB-related deaths rests ultimately on stopping forward transmission from infectious to susceptible individuals. Critical to this effort is understanding how human host mobility shapes the transmission and dispersal of new or existing strains of Mycobacterium tuberculosis (Mtb). Important questions remain unanswered. What kinds of mobility, over what temporal and spatial scales, facilitate TB transmission? How do human mobility patterns influence the dispersal of novel Mtb strains, including emergent drug-resistant strains? This review summarizes the current state of knowledge on mobility and TB epidemic dynamics, using examples from three topic areas, including inference of genetic and spatial clustering of infections, delineating source-sink dynamics, and mapping the dispersal of novel TB strains, to examine scientific questions and methodological issues within this topic. We also review new data sources for measuring human mobility, including mobile phone-associated movement data, and discuss important limitations on their use in TB epidemiology.
    MeSH term(s) Antitubercular Agents/therapeutic use ; Epidemics ; Humans ; Mycobacterium tuberculosis/genetics ; Tuberculosis/epidemiology ; Tuberculosis/microbiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2022.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3738: Show issues Location:
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  6. Article: Signatures of transmission in within-host

    Walter, Katharine S / Cohen, Ted / Mathema, Barun / Colijn, Caroline / Sobkowiak, Benjamin / Comas, Iñaki / Goig, Galo A / Croda, Julio / Andrews, Jason R

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: Because : Methods: To evaluate the transmission information present in within-host : Findings: We found moderate levels of minority variation present in : Interpretation: Within-host : Funding: NIAID: 5K01AI173385. ...

    Abstract Background: Because
    Methods: To evaluate the transmission information present in within-host
    Findings: We found moderate levels of minority variation present in
    Interpretation: Within-host
    Funding: NIAID: 5K01AI173385.
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.28.23300451
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  7. Article ; Online: Impact of active surveillance and decolonization strategies for methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit.

    Gollerkeri, Sonia / Oliver, Caroline / Maria, Messina / Green, Daniel A / Wu, Fann / Paul, Anshu A / Hill-Ricciuti, Alexandra / Mathema, Barun / Sahni, Rakesh / Saiman, Lisa

    Journal of perinatology : official journal of the California Perinatal Association

    2024  

    Abstract: Objective: To assess the impact of active surveillance and decolonization strategies on methicillin-resistant Staphylococcus aureus (MRSA) infection rates in a NICU.: Study design: MRSA infection rates were compared before (2014-2016) and during ( ... ...

    Abstract Objective: To assess the impact of active surveillance and decolonization strategies on methicillin-resistant Staphylococcus aureus (MRSA) infection rates in a NICU.
    Study design: MRSA infection rates were compared before (2014-2016) and during (2017-2022) an active surveillance program. Eligible infants were decolonized with chlorohexidine gluconate (CHG) bathing and/or topical mupirocin. Successful decolonization and rates of recolonization were assessed.
    Results: Fifty-two (0.57%) of 9 100 hospitalized infants had invasive MRSA infections from 2014 to 2022; infection rates declined non-significantly. During the 6-year surveillance program, the risk of infection was 16.9-times [CI
    Conclusions: MRSA infection rates did not significantly decline in association with an active surveillance and decolonization program. Alternatives to mupirocin and CHG are needed to facilitate decolonization.
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-024-01902-w
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  8. Article ; Online: Corrigendum to "Rifampicin resistance mutations in the rpoB gene of Enterococcus faecalis affect the production of cytokines by host macrophages" Cytokine 151 (2022) 155788.

    Urusova, Darya V / Merriman, Joseph A / Gupta, Ananya / Chen, Liang / Mathema, Barun / Caparon, Michael G / Khader, Shabaana A

    Cytokine

    2022  Volume 152, Page(s) 155845

    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2022.155845
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  9. Article ; Online: The epidemiology, transmission, diagnosis, and management of drug-resistant tuberculosis-lessons from the South African experience.

    Naidoo, Kogieleum / Perumal, Rubeshan / Cox, Helen / Mathema, Barun / Loveday, Marian / Ismail, Nazir / Omar, Shaheed Vally / Georghiou, Sophia B / Daftary, Amrita / O'Donnell, Max / Ndjeka, Norbert

    The Lancet. Infectious diseases

    2024  

    Abstract: Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts, particularly in Africa where the disease remains out of control. The dogma that DR-TB epidemics are fueled by unchecked rates of acquired resistance in inadequately ... ...

    Abstract Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts, particularly in Africa where the disease remains out of control. The dogma that DR-TB epidemics are fueled by unchecked rates of acquired resistance in inadequately treated or non-adherent individuals is no longer valid in most high DR-TB burden settings, where community transmission is now widespread. A large burden of DR-TB in Africa remains undiagnosed due to inadequate access to diagnostic tools that simultaneously detect tuberculosis and screen for resistance. Furthermore, acquisition of drug resistance to new and repurposed drugs, for which diagnostic solutions are not yet available, presents a major challenge for the implementation of novel, all-oral, shortened (6-9 months) treatment. Structural challenges including poverty, stigma, and social distress disrupt engagement in care, promote poor treatment outcomes, and reduce the quality of life for people with DR-TB. We reflect on the lessons learnt from the South African experience in implementing state-of-the-art advances in diagnostic solutions, deploying recent innovations in pharmacotherapeutic approaches for rapid cure, understanding local transmission dynamics and implementing interventions to curtail DR-TB transmission, and in mitigating the catastrophic socioeconomic costs of DR-TB. We also highlight globally relevant and locally responsive research priorities for achieving DR-TB control in South Africa.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00144-0
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  10. Article ; Online: Emergence and evolution of drug-resistant Mycobacterium tuberculosis in eastern China: A six-year prospective study.

    Wang, Luqi / Chen, Bin / Zhou, Hui / Mathema, Barun / Chen, Liang / Li, Xiangchen / Lu, Yewei / Liu, Zhengwei / Wang, Xiaomeng / Wang, Weibing

    Genomics

    2023  Volume 115, Issue 3, Page(s) 110640

    Abstract: Understanding the emergence and evolution of drug resistance can inform public health intervention to combat tuberculosis (TB). In this prospective molecular epidemiological surveillance study from 2015 to 2021 in eastern China, we prospectively ... ...

    Abstract Understanding the emergence and evolution of drug resistance can inform public health intervention to combat tuberculosis (TB). In this prospective molecular epidemiological surveillance study from 2015 to 2021 in eastern China, we prospectively collected whole-genome sequencing and epidemiological data on TB patients. We dissect the ordering of drug resistance mutation acquisition for nine commonly used anti-TB drugs, and we found that the katG S315T mutation first appeared around 1959, followed by rpoB S450L (1969), rpsL L43A (1972), embB M306V (1978), rrs 1401 (1981), fabG1 (1982), pncA (1985) and folC (1988) mutations. GyrA gene mutations appeared after the year of 2000. We observed that the first expansion of Mycobacterium tuberculosis (M.tb) resistance population among eastern China appeared after the introduction of isoniazid, streptomycin and para-amino salicylic acid, and the second expansion after the ethambutol, rifampicin, pyrazinamide, ethionamide and aminoglycosides. We speculate these two expansions are linked with population shift historically. By geospatial analysis, we found drug-resistant isolates migrated within eastern China. With epidemiological data of clonal strains, we observed some strains can evolve continuously in individuals and transmit readily in a population. In conclusion, this study mirrored the emergence and evolution of drug-resistant M.tb in eastern China were linked to the sequence and timing of introduction of anti-TB drugs, and multiple factors may contribute to the resistant population enlarged. To resolve the epidemic of drug-resistant TB, it requires applying anti-TB drugs carefully and/or identifying resistant patients timely to prevent them from developing high-level resistance and transmitting to others.
    MeSH term(s) Humans ; Mycobacterium tuberculosis/genetics ; Prospective Studies ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/microbiology ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; China ; Mutation ; Drug Resistance, Multiple, Bacterial/genetics ; Bacterial Proteins/genetics
    Chemical Substances Antitubercular Agents ; Bacterial Proteins
    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2023.110640
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