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Article ; Online: T

Webb, Bridgette / Manninger, Martin / Leoni, Marlene / Widek, Thomas / Dobrovnik, Martin / Scherr, Daniel / Stollberger, Rudolf / Schwark, Thorsten

International journal of legal medicine

2019 Volume 134, Issue 2, Page(s) 679–690

Abstract: ... fundamental findings related to intramyocardial variability and temporal stability of T ...

Abstract	Diagnosis of ischaemia-related sudden cardiac death in the absence of microscopic and macroscopic ischaemic lesions remains a challenge for medical examiners. Medical imaging techniques increasingly provide support in post-mortem examinations by detecting and documenting internal findings prior to autopsy. Previous studies have characterised MR relaxation times to investigate post-mortem signs of myocardial infarction in forensic cohorts. In this prospective study based on an ex situ porcine heart model, we report fundamental findings related to intramyocardial variability and temporal stability of T
MeSH term(s)	Animals ; Autopsy ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/pathology ; Disease Models, Animal ; Heart/diagnostic imaging ; Magnetic Resonance Imaging ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/pathology ; Myocardium/pathology ; Prospective Studies ; Swine
Language	English
Publishing date	2019-12-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1055109-8
ISSN	1437-1596 ; 0937-9827
ISSN (online)	1437-1596
ISSN	0937-9827
DOI	10.1007/s00414-019-02211-0
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Article ; Online: In vivo T

O'Reilly, Thomas / Webb, Andrew G

Magnetic resonance in medicine

2021 Volume 87, Issue 2, Page(s) 884–895

Abstract: Purpose: Low-field (B: Methods: Using 3D turbo spin echo readouts, T: Results: The average T ... Conclusions: For tissues except for CSF, the measured T ...

Abstract	Purpose: Low-field (B Methods: Using 3D turbo spin echo readouts, T Results: The average T Conclusions: For tissues except for CSF, the measured T
MeSH term(s)	Brain/diagnostic imaging ; Healthy Volunteers ; Humans ; Lipids ; Magnetic Resonance Imaging ; Muscle, Skeletal/diagnostic imaging
Chemical Substances	Lipids
Language	English
Publishing date	2021-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29009
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Article ; Online: Twisted pair transmission line coil - a flexible, self-decoupled and robust element for 7 T MRI.

Vliem, Jules / Xiao, Ying / Wenz, Daniel / Xin, Lijing / Teeuwise, Wouter / Ruytenberg, Thomas / Webb, Andrew / Zivkovic, Irena

Magnetic resonance imaging

2024 Volume 108, Page(s) 146–160

Abstract: ... as a transceive element for 7 T MRI in terms of physical flexibility, robustness to shape deformations, and ...

Abstract	Objective: This study evaluates the performance of a twisted pair transmission line coil as a transceive element for 7 T MRI in terms of physical flexibility, robustness to shape deformations, and interelement decoupling. Methods: Each coil element was created by shaping a twisted pair of wires into a circle. One wire was interrupted at the top, while the other was interrupted at the bottom, and connected to the matching circuit. Electromagnetic simulations were conducted to determine the optimal number of twists per length (in terms of B₁ Results: Increasing the number of twists per length resulted in a more physically robust coil. Poynting vector streamline visualisation showed that the twisted pair coil concentrated most of the energy in the near field. The twisted pair coil exhibited comparable B₁ Discussion: The findings highlight the robustness of the twisted pair coil, showcasing its stability under shape variations. This coil holds great potential as a flexible RF coil for various imaging applications using multiple-element arrays, benefiting from its inherent decoupling.
MeSH term(s)	Equipment Design ; Magnetic Resonance Imaging/methods ; Radio Waves ; Phantoms, Imaging
Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2024.02.007
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Article ; Online: Measurement of T

Damen, Mariska / van Leeuwen, Maarten / Webb, Andrew / Klomp, Dennis / de Castro, Catalina Arteaga

Magma (New York, N.Y.)

2019 Volume 32, Issue 6, Page(s) 703–708

Abstract: Objective: To determine T: Materials and methods: Twenty-six healthy subjects were scanned ... with a 7 T MR system using eight parallel transceiver antennas, each with two additional receive loops ... A Look-Locker sequence was used to obtain images for T: Results: The age range of the included ...

Abstract	Objective: To determine T Materials and methods: Twenty-six healthy subjects were scanned with a 7 T MR system using eight parallel transceiver antennas, each with two additional receive loops. A Look-Locker sequence was used to obtain images for T Results: The age range of the included subjects was 21-72 years. Average T Conclusion: T
MeSH term(s)	Adult ; Aged ; Algorithms ; Equipment Design ; Healthy Volunteers ; Humans ; Image Enhancement/methods ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/instrumentation ; Middle Aged ; Pancreas/diagnostic imaging ; Young Adult
Language	English
Publishing date	2019-07-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1160826-2
ISSN	1352-8661 ; 0968-5243
ISSN (online)	1352-8661
ISSN	0968-5243
DOI	10.1007/s10334-019-00768-w
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Article ; Online: Neurosurgical Implant Safety in 7 T MRI: A Scoping Review.

Shaffer, Annabelle / Weisbaum, David / Naik, Anant / Anderson, Aaron / Wszalek, Tracey / Cohen, Mark / Sutton, Brad / Webb, Andrew / Damon, Bruce / Arnold, Paul M

Journal of magnetic resonance imaging : JMRI

2022 Volume 57, Issue 3, Page(s) 661–669

Abstract: The use of 7 Tesla (T) magnetic resonance imaging (MRI) is expanding across neurosurgical and ... neurologic specialties. However, few neurosurgical-related implants have been tested for safety at 7 T ... To assess the current state of neurosurgical implant safety at 7 T, a systematic search was performed using ...

Abstract	The use of 7 Tesla (T) magnetic resonance imaging (MRI) is expanding across neurosurgical and neurologic specialties. However, few neurosurgical-related implants have been tested for safety at 7 T, limiting its use in patients with cranial fixation, shunt placements, and other implants. Implant safety can be determined via the American Society for Testing Materials International (ASTM) guidelines. To assess the current state of neurosurgical implant safety at 7 T, a systematic search was performed using PubMed, MEDLINE, Web of Knowledge, and citation matching. Studies written in English that included at least one neurosurgical implant and at least one safety outcome were included. Data were extracted for implant studied, implant composition, deflection angle, torque, temperature change, and ASTM guidelines followed. PRISMA reporting guidelines for scoping reviews were followed. Overall, 18 studies consisting of 45 unique implants were included. Implants included cranial fixation devices, aneurysm clips, spinal rods, pedicle screws, ventriculoperitoneal (VP) shunts, deep brain stimulation devices, and electroencephalogram (EEG) caps and electrodes. Cranial fixation devices, deep brain stimulation devices, spinal rods, and pedicle screws are likely 7 T MRI compatible based on outcomes reported. Aneurysm clips and EEG devices had variable safety outcomes. The VP shunts studied lost functionality after 7 T MRI exposure. We identified several implants that are likely compatible with 7 T MRI. Given the growth in 7 T imaging and expansion of the technology, neurosurgical implants should be constructed with the aforementioned considerations. Caution must be taken with all implants, especially aneurysm clips, programmable VP shunts, and EEG recording devices. It is also noteworthy that several implant testing reports did not report following ASTM standards. This scoping review seeks to concisely summarize all neurosurgical-related implants that have been tested for safety in 7 T MRI. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.
MeSH term(s)	Humans ; Aneurysm ; Magnetic Resonance Imaging/adverse effects ; Magnetic Resonance Imaging/methods ; Prostheses and Implants
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28449
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Article ; Online: Recognizing the complexities of co-prescriptions and life-style factors in opioid agonist treatment: A response from Eleni Domzaridou, Matthew J. Carr, Tim Millar, Roger T. Webb and Darren M. Ashcroft.

Domzaridou, Eleni / Carr, Matthew J / Millar, Tim / Webb, Roger T / Ashcroft, Darren M

Addiction (Abingdon, England)

2024 Volume 119, Issue 5, Page(s) 967–968

MeSH term(s)	Humans ; Analgesics, Opioid/therapeutic use ; Prescriptions ; Drug Overdose/drug therapy ; Benzodiazepines ; Retrospective Studies
Chemical Substances	Analgesics, Opioid ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Letter
ZDB-ID	1141051-6
ISSN	1360-0443 ; 0965-2140
ISSN (online)	1360-0443
ISSN	0965-2140
DOI	10.1111/add.16447
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Article ; Online: Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.

Benede, Ntombi / Tincho, Marius B / Walters, Avril / Subbiah, Vennesa / Ngomti, Amkele / Baguma, Richard / Butters, Claire / Hahnle, Lina / Mennen, Mathilda / Skelem, Sango / Adriaanse, Marguerite / Facey-Thomas, Heidi / Scott, Christiaan / Day, Jonathan / Spracklen, Timothy F / van Graan, Strauss / Balla, Sashkia R / Moyo-Gwete, Thandeka / Moore, Penny L /

MacGinty, Rae / Botha, Maresa / Workman, Lesley / Johnson, Marina / Goldblatt, David / Zar, Heather J / Ntusi, Ntobeko A B / Zühlke, Liesl / Webb, Kate / Riou, Catherine / Burgers, Wendy A / Keeton, Roanne S

iScience

2023 Volume 27, Issue 1, Page(s) 108728

Abstract: ... specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropositive or ...

Abstract	SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on SARS-CoV-2 antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropositive or seronegative for SARS-CoV-2. SARS-CoV-2-specific CD4
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.108728
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Article ; Online: Elevated phosphodiester and T

Hooijmans, M T / Niks, E H / Burakiewicz, J / Verschuuren, J J G M / Webb, A G / Kan, H E

NMR in biomedicine

2017 Volume 30, Issue 1

Abstract: Quantitative MRI and MRS are increasingly important as non-invasive outcome measures in therapy development for Duchenne muscular dystrophy (DMD). Many studies have focussed on individual measures such as fat fraction and metabolite levels in relation to ...

Abstract	Quantitative MRI and MRS are increasingly important as non-invasive outcome measures in therapy development for Duchenne muscular dystrophy (DMD). Many studies have focussed on individual measures such as fat fraction and metabolite levels in relation to age and functionality, but much less attention has been given to how these indices relate to each other. Here, we assessed spatially resolved metabolic changes in leg muscles of DMD patients, and classified muscles according to the degree of fat replacement compared with healthy controls. Quantitative MRI (three-point Dixon and multi-spin echo without fat suppression and a tri-exponential fit) and 2D-CSI
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1000976-0
ISSN	1099-1492 ; 0952-3480
ISSN (online)	1099-1492
ISSN	0952-3480
DOI	10.1002/nbm.3667
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Article ; Online: Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging.

Silva-Cayetano, Alyssa / Fra-Bido, Sigrid / Robert, Philippe A / Innocentin, Silvia / Burton, Alice R / Watson, Emily M / Lee, Jia Le / Webb, Louise M C / Foster, William S / McKenzie, Ross C J / Bignon, Alexandre / Vanderleyden, Ine / Alterauge, Dominik / Lemos, Julia P / Carr, Edward J / Hill, Danika L / Cinti, Isabella / Balabanian, Karl / Baumjohann, Dirk /

Espeli, Marion / Meyer-Hermann, Michael / Denton, Alice E / Linterman, Michelle A

Nature immunology

2023 Volume 24, Issue 7, Page(s) 1124–1137

Abstract: ... and dark zones. In aged mice, there is CXCR4-mediated mislocalization of T follicular helper (T ...

Abstract	The magnitude and quality of the germinal center (GC) response decline with age, resulting in poor vaccine-induced immunity in older individuals. A functional GC requires the co-ordination of multiple cell types across time and space, in particular across its two functionally distinct compartments: the light and dark zones. In aged mice, there is CXCR4-mediated mislocalization of T follicular helper (T
MeSH term(s)	Animals ; Mice ; T-Lymphocytes, Helper-Inducer ; B-Lymphocytes ; T Follicular Helper Cells ; Germinal Center ; Aging ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01519-9
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Article ; Online: A vision of 14 T MR for fundamental and clinical science.

Bates, Steve / Dumoulin, Serge O / Folkers, Paul J M / Formisano, Elia / Goebel, Rainer / Haghnejad, Aidin / Helmich, Rick C / Klomp, Dennis / van der Kolk, Anja G / Li, Yi / Nederveen, Aart / Norris, David G / Petridou, Natalia / Roell, Stefan / Scheenen, Tom W J / Schoonheim, Menno M / Voogt, Ingmar / Webb, Andrew

Magma (New York, N.Y.)

2023 Volume 36, Issue 2, Page(s) 211–225

Abstract: Objective: We outline our vision for a 14 Tesla MR system. This comprises a novel whole-body magnet design utilizing high temperature superconductor; a console and associated electronic equipment; an optimized radiofrequency coil setup for proton ... ...

Abstract	Objective: We outline our vision for a 14 Tesla MR system. This comprises a novel whole-body magnet design utilizing high temperature superconductor; a console and associated electronic equipment; an optimized radiofrequency coil setup for proton measurement in the brain, which also has a local shim capability; and a high-performance gradient set. Research fields: The 14 Tesla system can be considered a 'mesocope': a device capable of measuring on biologically relevant scales. In neuroscience the increased spatial resolution will anatomically resolve all layers of the cortex, cerebellum, subcortical structures, and inner nuclei. Spectroscopic imaging will simultaneously measure excitatory and inhibitory activity, characterizing the excitation/inhibition balance of neural circuits. In medical research (including brain disorders) we will visualize fine-grained patterns of structural abnormalities and relate these changes to functional and molecular changes. The significantly increased spectral resolution will make it possible to detect (dynamic changes in) individual metabolites associated with pathological pathways including molecular interactions and dynamic disease processes. Conclusions: The 14 Tesla system will offer new perspectives in neuroscience and fundamental research. We anticipate that this initiative will usher in a new era of ultra-high-field MR.
MeSH term(s)	Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Head ; Diffusion Magnetic Resonance Imaging ; Radio Waves
Language	English
Publishing date	2023-04-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1160826-2
ISSN	1352-8661 ; 0968-5243
ISSN (online)	1352-8661
ISSN	0968-5243
DOI	10.1007/s10334-023-01081-3
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