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  1. Article ; Online: Precision intervention for prostate cancer: Re-evaluating who is at risk.

    Papachristodoulou, Alexandros / Abate-Shen, Cory

    Cancer letters

    2022  Volume 538, Page(s) 215709

    Abstract: The vast majority of new prostate cancer diagnoses are low-grade tumors that are monitored by active surveillance rather than undergoing immediate treatment. However, a subset of men will progress to advanced prostate cancer which may result in lethality, ...

    Abstract The vast majority of new prostate cancer diagnoses are low-grade tumors that are monitored by active surveillance rather than undergoing immediate treatment. However, a subset of men will progress to advanced prostate cancer which may result in lethality, and these men are likely to benefit from early intervention to prevent or delay such progression. For this high-risk group, which includes aged men, men of African descent, and those with a hereditary predisposition to prostate cancer, informed risk stratification can be the cornerstone of clinical decision making and treatment intervention. In this review, we discuss the importance of a precision intervention approach that considers the cumulative risk for a given patient or population to develop prostate cancer or to progress to lethal disease, with particular focus on the interplay of major determinants of high-risk disease.
    MeSH term(s) Aged ; Clinical Decision-Making ; Genetic Predisposition to Disease ; Humans ; Male ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-04-29
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2022.215709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Modeling metastasis in mice: a closer look.

    Giacobbe, Arianna / Abate-Shen, Cory

    Trends in cancer

    2021  Volume 7, Issue 10, Page(s) 916–929

    Abstract: Unraveling the multifaceted cellular and physiological processes associated with metastasis is best achieved by using in vivo models that recapitulate the requisite tumor cell-intrinsic and -extrinsic mechanisms at the organismal level. We discuss the ... ...

    Abstract Unraveling the multifaceted cellular and physiological processes associated with metastasis is best achieved by using in vivo models that recapitulate the requisite tumor cell-intrinsic and -extrinsic mechanisms at the organismal level. We discuss the current status of mouse models of metastasis. We consider how mouse models can refine our understanding of the underlying biological and molecular processes that promote metastasis, and we envisage how the application of new technologies will further enhance investigations of metastasis at single-cell resolution in the context of the whole organism. Our view is that investigations based on state-of-the-art mouse models can propel a holistic understanding of the biology of metastasis, which will ultimately lead to the discovery of new therapeutic opportunities.
    MeSH term(s) Animals ; Disease Models, Animal ; Mice ; Neoplasms
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Establishment of the LNCaP Cell Line - The Dawn of an Era for Prostate Cancer Research.

    Abate-Shen, Cory / Nunes de Almeida, Francisca

    Cancer research

    2022  Volume 82, Issue 9, Page(s) 1689–1691

    Abstract: Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating ... ...

    Abstract Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigenesis, metastasis, and drug response, particularly in the context of androgen receptor signaling. Here, we present major highlights from a wealth of literature that has exploited LNCaP cells and their derivatives to inform on prostate cancer progression and androgen response for improving the treatment of patients with prostate cancer. See related article by Horoszewicz and colleagues, Cancer Res 1983;43:1809-18.
    MeSH term(s) Androgens ; Cell Line ; Cell Transformation, Neoplastic ; Humans ; Male ; Prostate/pathology ; Prostatic Neoplasms/pathology
    Chemical Substances Androgens
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-1065
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  4. Article ; Online: Prostate Cancer Metastasis - Fueled by Fat?

    Abate-Shen, Cory

    The New England journal of medicine

    2018  Volume 378, Issue 17, Page(s) 1643–1645

    MeSH term(s) Humans ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms
    Language English
    Publishing date 2018-04-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr1800808
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  5. Article ; Online: B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer.

    Wang, Jingqiang / Kobayashi, Takashi / Floc'h, Nicolas / Kinkade, Carolyn Waugh / Aytes, Alvaro / Dankort, David / Lefebvre, Celine / Mitrofanova, Antonina / Cardiff, Robert D / McMahon, Martin / Califano, Andrea / Shen, Michael M / Abate-Shen, Cory

    Cancer research

    2012  Volume 72, Issue 18, Page(s) 4765–4776

    Abstract: ... signaling pathways in these prostate tumors cooperate to upregulate c-Myc. Accordingly, therapeutic treatments ... with rapamycin and PD0325901 to target these pathways, respectively, attenuate c-Myc levels and reduce tumor and ... metastatic burden. Together, our findings suggest a generalized therapeutic approach to target c-Myc ...

    Abstract Both the PI3K → Akt → mTOR and mitogen-activated protein kinase (MAPK) signaling pathways are often deregulated in prostate tumors with poor prognosis. Here we describe a new genetically engineered mouse model of prostate cancer in which PI3K-Akt-mTOR signaling is activated by inducible disruption of PTEN, and extracellular signal-regulated kinase 1/2 (ERK1/2) MAPK signaling is activated by inducible expression of a BRAF(V600E) oncogene. These tissue-specific compound mutant mice develop lethal prostate tumors that are inherently resistant to castration. These tumors bypass cellular senescence and disseminate to lymph nodes, bone marrow, and lungs where they form overt metastases in approximately 30% of the cases. Activation of PI3K → Akt → mTOR and MAPK signaling pathways in these prostate tumors cooperate to upregulate c-Myc. Accordingly, therapeutic treatments with rapamycin and PD0325901 to target these pathways, respectively, attenuate c-Myc levels and reduce tumor and metastatic burden. Together, our findings suggest a generalized therapeutic approach to target c-Myc activation in prostate cancer by combinatorial targeting of the PI3K → Akt → mTOR and ERK1/2 MAPK signaling pathways.
    MeSH term(s) Animals ; Blotting, Western ; Disease Models, Animal ; Enzyme Activation/physiology ; Gene Expression Profiling ; Immunoprecipitation ; Male ; Mice ; PTEN Phosphohydrolase/metabolism ; Prostatic Neoplasms/metabolism ; Proto-Oncogene Proteins B-raf/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Signal Transduction/physiology
    Chemical Substances Myc protein, mouse ; Proto-Oncogene Proteins c-myc ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67)
    Language English
    Publishing date 2012-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-12-0820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: What approaches are needed to understand human development and disease?

    Sozen, Berna / Flavell, Richard A / Lamming, Dudley W / Silver, Debra L / Parrinello, Simona / Abate-Shen, Cory / Michor, Franziska / Sankaran, Vijay G

    Developmental cell

    2023  Volume 58, Issue 24, Page(s) 2822–2825

    Abstract: Researchers are leveraging what we have learned from model organisms to understand if the same principles arise in human physiology, development, and disease. In this collection of Voices, we asked researchers from different fields to discuss what tools ... ...

    Abstract Researchers are leveraging what we have learned from model organisms to understand if the same principles arise in human physiology, development, and disease. In this collection of Voices, we asked researchers from different fields to discuss what tools and insights they are using to answer fundamental questions in human biology.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2023.11.026
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  7. Article ; Online: Genetically Engineered Mouse Models of Prostate Cancer in the Postgenomic Era.

    Arriaga, Juan M / Abate-Shen, Cory

    Cold Spring Harbor perspectives in medicine

    2019  Volume 9, Issue 2

    Abstract: Recent genomic sequencing analyses have unveiled the spectrum of genomic alterations that occur in primary and advanced prostate cancer, raising the question of whether the corresponding genes are functionally relevant for prostate tumorigenesis, and ... ...

    Abstract Recent genomic sequencing analyses have unveiled the spectrum of genomic alterations that occur in primary and advanced prostate cancer, raising the question of whether the corresponding genes are functionally relevant for prostate tumorigenesis, and whether such functions are associated with particular disease stages. In this review, we describe genetically engineered mouse models (GEMMs) of prostate cancer, focusing on those that model genomic alterations known to occur in human prostate cancer. We consider whether the phenotypes of GEMMs based on gain or loss of function of the relevant genes provide reliable counterparts to study the predicted consequences of the corresponding genomic alterations as occur in human prostate cancer, and we discuss exceptions in which the GEMMs do not fully emulate the expected phenotypes. Last, we highlight future directions for the generation of new GEMMs of prostate cancer and consider how we can use GEMMs most effectively to decipher the biological and molecular mechanisms of disease progression, as well as to tackle clinically relevant questions.
    MeSH term(s) Adenocarcinoma/genetics ; Animals ; Disease Models, Animal ; Disease Progression ; Genetic Engineering/methods ; Humans ; Male ; Mice ; Neoplasm Invasiveness ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/genetics
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2019-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a030528
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  8. Article ; Online: Correction: In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis.

    Arriaga, Juan M / Ronaldson-Bouchard, Kacey / Picech, Florencia / Nunes de Almeida, Francisca / Afari, Stephanie / Chhouri, Houssein / Vunjak-Novakovic, Gordana / Abate-Shen, Cory

    Oncogene

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-03031-2
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  9. Article ; Online: In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis.

    Arriaga, Juan M / Ronaldson-Bouchard, Kacey / Picech, Florencia / Nunes de Almeida, Francisca / Afari, Stephanie / Chhouri, Houssein / Vunjak-Novakovic, Gordana / Abate-Shen, Cory

    Oncogene

    2024  Volume 43, Issue 17, Page(s) 1303–1315

    Abstract: Most cancer deaths are due to metastatic dissemination to distant organs. Bone is the most frequently affected organ in metastatic prostate cancer and a major cause of prostate cancer deaths. Yet, our partial understanding of the molecular factors that ... ...

    Abstract Most cancer deaths are due to metastatic dissemination to distant organs. Bone is the most frequently affected organ in metastatic prostate cancer and a major cause of prostate cancer deaths. Yet, our partial understanding of the molecular factors that drive bone metastasis has been a limiting factor for developing preventative and therapeutic strategies to improve patient survival and well-being. Although recent studies have uncovered molecular alterations that occur in prostate cancer metastasis, their functional relevance for bone metastasis is not well understood. Using genome-wide CRISPR activation and inhibition screens we have identified multiple drivers and suppressors of prostate cancer metastasis. Through functional validation, including an innovative organ-on-a-chip invasion platform for studying bone tropism, our study identifies the transcriptional modulator CITED2 as a novel driver of prostate cancer bone metastasis and uncovers multiple new potential molecular targets for bone metastatic disease.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-024-02995-5
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  10. Article ; Online: Editor's Note: Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model.

    Floc'h, Nicola / Kinkade, Carolyn Waugh / Kobayashi, Takashi / Aytes, Alvaro / Lefebvre, Celine / Mitrofanova, Antonina / Cardiff, Robert D / Califano, Andrea / Shen, Michael M / Abate-Shen, Cory

    Cancer research

    2023  Volume 83, Issue 7, Page(s) 1160

    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-0516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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