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  1. Book: Diagnostic nuclear medicine

    Allen-Auerbach, Martin / Schiepers, Christiaan

    with 32 tables

    (Medical radiology : diagnostic imaging)

    2006  

    Author's details Christiaan Schiepers (ed.). With contrib. by M. Allen-Auerbach
    Series title Medical radiology : diagnostic imaging
    Keywords Nuclear Medicine ; Diagnostic Imaging ; Radionuclide Imaging ; Nuklearmedizin ; Radiologische Diagnostik
    Subject Diagnostische Radiologie ; Strahlendiagnostik ; Nuklearmedizinische Diagnostik
    Language English
    Size X, 355 S. : zahlr. Ill., graph. Darst., 28 cm
    Edition 2., rev. ed.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT015023035
    ISBN 978-3-540-42309-6 ; 3-540-42309-5
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Online: Diagnostic Nuclear Medicine

    Baert, A. L. / Sartor, K. / Schiepers, Christiaan

    2006  

    Author's details edited by A. L. Baert, K. Sartor, Christiaan Schiepers
    Keywords Internal medicine ; Nuclear medicine ; Oncology ; Radiology, Medical
    Language English
    Edition 2nd Revised Edition
    Publisher Springer-Verlag Berlin Heidelberg
    Publishing place Berlin, Heidelberg
    Document type Book ; Online
    HBZ-ID TT050387737
    ISBN 978-3-540-42309-6 ; 978-3-540-30005-2 ; 3-540-42309-5 ; 3-540-30005-8
    DOI 10.1007/3-540-30005-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Diagnostic nuclear medicine

    Becker, Wolfgang / Schiepers, Christiaan

    with 36 tables

    (Medical radiology)

    2000  

    Author's details C. Schiepers (ed.). With contributions by W. Becker
    Series title Medical radiology
    Keywords Nuclear Medicine ; Diagnostic Imaging ; Radionuclide Imaging ; Radiologische Diagnostik ; Nuklearmedizin
    Subject Nuklearmedizinische Diagnostik ; Diagnostische Radiologie ; Strahlendiagnostik
    Language English
    Size X, 294 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT011262700
    ISBN 3-540-63467-3 ; 978-3-540-63467-6
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Positron emission tomography: a coming of age?

    Schiepers, Christiaan

    European journal of internal medicine

    2004  Volume 15, Issue 3, Page(s) 143–146

    Language English
    Publishing date 2004-06
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2004.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: PET/CT in Colorectal Cancer.

    Schiepers, Christiaan

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2003  Volume 44, Issue 11, Page(s) 1804–1805

    MeSH term(s) Colorectal Neoplasms/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Tomography, Emission-Computed ; Tomography, X-Ray Computed
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2003-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 328: Show issues

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  6. Article ; Online: Molecular imaging in oncology: the acceptance of PET/CT and the emergence of MR/PET imaging.

    Schiepers, Christiaan / Dahlbom, Magnus

    European radiology

    2010  Volume 21, Issue 3, Page(s) 548–554

    Abstract: In the last decade, PET-only systems have been phased out and replaced with PET-CT systems. This merger of a functional and anatomical imaging modality turned out to be extremely useful in clinical practice. Currently, PET-CT is a major diagnostic tool ... ...

    Abstract In the last decade, PET-only systems have been phased out and replaced with PET-CT systems. This merger of a functional and anatomical imaging modality turned out to be extremely useful in clinical practice. Currently, PET-CT is a major diagnostic tool in oncology. At the dawn of the merger of MRI and PET, another breakthrough in clinical imaging is expected. The combination of these imaging modalities is challenging, but has particular features such as imaging biological processes at the same time in specific body locations.
    MeSH term(s) Humans ; Magnetic Resonance Imaging/trends ; Medical Oncology/trends ; Molecular Imaging/trends ; Neoplasms/diagnosis ; Positron-Emission Tomography/trends ; Practice Patterns, Physicians'/trends ; Subtraction Technique/trends ; Tomography, X-Ray Computed/trends
    Language English
    Publishing date 2010-12-21
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-010-2033-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dynamic PET/CT with 11C-acetate in prostate cancer.

    Schiepers, Christiaan / Huang, Sung-Cheng / Dahlbom, Magnus

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2013  Volume 54, Issue 2, Page(s) 326

    MeSH term(s) Acetates ; Carbon ; Humans ; Magnetic Resonance Imaging ; Male ; Multimodal Imaging ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Tomography, X-Ray Computed
    Chemical Substances Acetates ; Carbon (7440-44-0)
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.112.112532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 328: Show issues

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  8. Article ; Online: Molecular mechanisms of bone 18F-NaF deposition.

    Czernin, Johannes / Satyamurthy, Nagichettiar / Schiepers, Christiaan

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2010  Volume 51, Issue 12, Page(s) 1826–1829

    Abstract: There is renewed interest in (18)F-NaF bone imaging with PET or PET/CT. The current brief discussion focuses on the molecular mechanisms of (18)F-NaF deposition in bone and presents model-based approaches to quantifying bone perfusion and metabolism in ... ...

    Abstract There is renewed interest in (18)F-NaF bone imaging with PET or PET/CT. The current brief discussion focuses on the molecular mechanisms of (18)F-NaF deposition in bone and presents model-based approaches to quantifying bone perfusion and metabolism in the context of preclinical and clinical applications of bone imaging with PET.
    MeSH term(s) Animals ; Bone Diseases/diagnostic imaging ; Bone Neoplasms/diagnostic imaging ; Bone and Bones/diagnostic imaging ; Bone and Bones/metabolism ; Cyclotrons ; Drug Compounding ; Fluorine Radioisotopes/pharmacokinetics ; Humans ; Mice ; Models, Biological ; Positron-Emission Tomography ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacokinetics ; Rats ; Sodium Fluoride/chemical synthesis ; Sodium Fluoride/pharmacokinetics
    Chemical Substances Fluorine Radioisotopes ; Radiopharmaceuticals ; Sodium Fluoride (8ZYQ1474W7)
    Language English
    Publishing date 2010-11-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.110.077933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Brain tumors.

    Herholz, Karl / Langen, Karl-Josef / Schiepers, Christiaan / Mountz, James M

    Seminars in nuclear medicine

    2012  Volume 42, Issue 6, Page(s) 356–370

    Abstract: This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting ... ...

    Abstract This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from nonmalignant lesions. Amino acid tracers including (11)C-methionine, (18)F-fluoroethyltyrosine, and (18)F-L-3,4-dihydroxyphenylalanine provide high sensitivity, which is most useful for detecting recurrent or residual gliomas, including most low-grade gliomas. They also play an increasing role for planning and monitoring of therapy. (18)F-fluorothymidine can only be used in tumors with absent or broken blood-brain barrier and has potential for tumor grading and monitoring of therapy. Ligands for somatostatin receptors are of particular interest in pituitary adenomas and meningiomas. Tracers to image neovascularization, hypoxia, and phospholipid synthesis are under investigation for potential clinical use. All methods provide the maximum of information when used with image registration and fusion display with contrast-enhanced magnetic resonance imaging scans. Integration of PET and magnetic resonance imaging with stereotactic neuronavigation systems allows the targeting of stereotactic biopsies to obtain a more accurate histologic diagnosis and better planning of conformal and stereotactic radiotherapy.
    MeSH term(s) Animals ; Brain Neoplasms/complications ; Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Humans ; Nuclear Medicine ; Opportunistic Infections ; Radiopharmaceuticals ; Treatment Outcome
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2012-09-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2012.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: ¹⁸F-FLT    and ¹⁸F-FDOPA PET kinetics in recurrent brain tumors.

    Wardak, Mirwais / Schiepers, Christiaan / Cloughesy, Timothy F / Dahlbom, Magnus / Phelps, Michael E / Huang, Sung-Cheng

    European journal of nuclear medicine and molecular imaging

    2014  Volume 41, Issue 6, Page(s) 1199–1209

    Abstract: Purpose: In this study, kinetic parameters of the cellular proliferation tracer (18)F-3'-deoxy-3'-fluoro-L-thymidine (FLT) and the amino acid probe 3,4-dihydroxy-6-(18)F-fluoro-L-phenylalanine (FDOPA) were measured before and early after the start of ... ...

    Abstract Purpose: In this study, kinetic parameters of the cellular proliferation tracer (18)F-3'-deoxy-3'-fluoro-L-thymidine (FLT) and the amino acid probe 3,4-dihydroxy-6-(18)F-fluoro-L-phenylalanine (FDOPA) were measured before and early after the start of therapy, and were used to predict the overall survival (OS) of patients with recurrent malignant glioma using multiple linear regression (MLR) analysis.
    Methods: High-grade recurrent brain tumors in 21 patients (11 men and 10 women, age range 26 - 76 years) were investigated. Each patient had three dynamic PET studies with each probe: at baseline and after 2 and 6 weeks from the start of treatment. Treatment consisted of biweekly cycles of bevacizumab (an angiogenesis inhibitor) and irinotecan (a chemotherapeutic agent). For each study, about 3.5 mCi of FLT (or FDOPA) was administered intravenously and dynamic PET images were acquired for 1 h (or 35 min for FDOPA). A total of 126 PET scans were analyzed. A three-compartment, two-tissue model was applied to estimate tumor FLT and FDOPA kinetic rate constants using a metabolite- and partial volume-corrected input function. MLR analysis was used to model OS as a function of FLT and FDOPA kinetic parameters for each of the three studies as well as their relative changes between studies. An exhaustive search of MLR models using three or fewer predictor variables was performed to find the best models.
    Results: Kinetic parameters from FLT were more predictive of OS than those from FDOPA. The three-predictor MLR model derived using information from both probes (adjusted R(2) = 0.83) fitted the OS data better than that derived using information from FDOPA alone (adjusted R(2) = 0.41), but was only marginally different from that derived using information from FLT alone (adjusted R(2) = 0.82). Standardized uptake values (either from FLT alone, FDOPA alone, or both together) gave inferior predictive results (best adjusted R(2) = 0.25).
    Conclusion: For recurrent malignant glioma treated with bevacizumab and irinotecan, FLT kinetic parameters obtained early after the start of treatment (absolute values and their associated changes) can provide sufficient information to predict OS with reasonable confidence using MLR. The slight increase in accuracy for predicting OS with a combination of FLT and FDOPA PET information may not warrant the additional acquisition of FDOPA PET for therapy monitoring in patients with recurrent glioma.
    MeSH term(s) Adult ; Aged ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Bevacizumab ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Data Interpretation, Statistical ; Dideoxynucleosides/pharmacokinetics ; Dihydroxyphenylalanine/analogs & derivatives ; Dihydroxyphenylalanine/pharmacokinetics ; Female ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Humans ; Irinotecan ; Kinetics ; Male ; Middle Aged ; Models, Biological ; Positron-Emission Tomography ; Radiopharmaceuticals/pharmacokinetics ; Recurrence ; Tissue Distribution
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal, Humanized ; Dideoxynucleosides ; Radiopharmaceuticals ; fluorodopa F 18 (2C598205QX) ; Bevacizumab (2S9ZZM9Q9V) ; Dihydroxyphenylalanine (63-84-3) ; Irinotecan (7673326042) ; alovudine (PG53R0DWDQ) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2014-03-07
    Publishing country Germany
    Document type Comparative Study ; Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-013-2678-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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