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Article ; Online: Subclinical Thrombotic Events as a Mechanism for Troponin Release?

Laufer, Eduard M / Hofstra, Leonard

Journal of the American College of Cardiology

2018 Volume 71, Issue 9, Page(s) 1056

MeSH term(s)	Chest Pain ; Humans ; Thrombosis ; Troponin I ; Troponin T
Chemical Substances	Troponin I ; Troponin T
Language	English
Publishing date	2018-03-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2017.11.073
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Five-year results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement-the ARISE Study and ARISE Registry Data.

Horke, Alexander / Tudorache, Igor / Laufer, Günther / Andreas, Martin / Pomar, Jose Luis / Pereda, Daniel / Quintana, Eduard / Sitges, Marta / Meyns, Bart / Rega, Filip / Hazekamp, Mark / Cesnjevar, Robert / Schmiady, Martin Oliver / Pepper, John / Rosendahl, Ulrich / Lichtenberg, Artur / Stadnik, Dmytro / Jashari, Ramadan / Boethig, Dietmar /

Bobylev, Dmitry / Avsar, Murat / Ruhparwar, Arjang / Haverich, Axel / Cebotari, Serghei / Sarikouch, Samir

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2024 Volume 65, Issue 4

Abstract: Objectives: Decellularized aortic homografts (DAH) were introduced as a new option for aortic valve replacement for young patients.: Methods: A prospective, EU-funded, single-arm, multicentre study in 8 centres evaluating non-cryopreserved DAH for ... ...

Abstract	Objectives: Decellularized aortic homografts (DAH) were introduced as a new option for aortic valve replacement for young patients. Methods: A prospective, EU-funded, single-arm, multicentre study in 8 centres evaluating non-cryopreserved DAH for aortic valve replacement. Results: A total of 144 patients (99 male) were prospectively enrolled in the ARISE Trial between October 2015 and October 2018 with a median age of 30.4 years [interquartile range (IQR) 15.9-55.1]; 45% had undergone previous cardiac operations, with 19% having 2 or more previous procedures. The mean implanted DAH diameter was 22.6 mm (standard deviation 2.4). The median operation duration was 312 min (IQR 234-417), the median cardiopulmonary bypass time was 154 min (IQR 118-212) and the median cross-clamp time 121 min (IQR 93-150). No postoperative bypass grafting or renal replacement therapy were required. Two early deaths occurred, 1 due to a LCA thrombus on day 3 and 1 due ventricular arrhythmia 5 h postoperation. There were 3 late deaths, 1 death due to endocarditis 4 months postoperatively and 2 unrelated deaths after 5 and 7 years due to cancer and Morbus Wegener resulting in a total mortality of 3.47%. After a median follow-up of 5.9 years [IQR 5.1-6.4, mean 5.5 years. (standard deviation 1.3) max. 7.6 years], the primary efficacy end-points peak gradient with median 11.0 mmHg (IQR 7.8-17.6) and regurgitation of median 0.5 (IQR 0-0.5) of grade 0-3 were excellent. At 5 years, freedom from death/reoperation/endocarditis/bleeding/thromboembolism were 97.9%/93.5%/96.4%/99.2%/99.3%, respectively. Conclusions: The 5-year results of the prospective multicentre ARISE trial continue to show DAH to be safe for aortic valve replacement with excellent haemodynamics.
MeSH term(s)	Adult ; Humans ; Male ; Allografts/surgery ; Aortic Valve/surgery ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/surgery ; Endocarditis/surgery ; Follow-Up Studies ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/methods ; Prospective Studies ; Reoperation ; Routinely Collected Health Data ; Female ; Adolescent ; Young Adult ; Middle Aged
Language	English
Publishing date	2024-03-27
Publishing country	Germany
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezae121
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Article ; Online: An armored heart in constrictive pericarditis.

Velthuis, Sebastiaan / Laufer, Eduard M / Hofstra, Leonard / Winkens, Mark H M

Journal of the American College of Cardiology

2009 Volume 53, Issue 11, Page(s) 972

MeSH term(s)	Aged ; Fatal Outcome ; Heart Rupture, Post-Infarction/complications ; Humans ; Male ; Myocardial Infarction/complications ; Myocardium/pathology ; Pericarditis, Constrictive/diagnostic imaging ; Pericarditis, Constrictive/etiology ; Pericarditis, Constrictive/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2009-03-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2008.11.045
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Molecular imaging of macrophage cell death for the assessment of plaque vulnerability.

Laufer, Eduard M / Winkens, Mark H M / Narula, Jagat / Hofstra, Leonard

Arteriosclerosis, thrombosis, and vascular biology

2009 Volume 29, Issue 7, Page(s) 1031–1038

Abstract: The ability to identify atherosclerotic plaques that are prone to rupture, also called vulnerable plaques, may provide a major step forward in the recognition of patients that have a high risk of developing acute myocardial infarction. Current clinical ... ...

Abstract	The ability to identify atherosclerotic plaques that are prone to rupture, also called vulnerable plaques, may provide a major step forward in the recognition of patients that have a high risk of developing acute myocardial infarction. Current clinical risk profiling algorithms, such as the Framingham and Procam risk scores, have reasonable predictive value in the assessment of the 10 year risk. These clinical risk profiling scores typically classify patients into low risk (10-year risk, less than 5%), intermediate risk (5% to 20% risk), and high risk (greater than 20%). The challenge to imagers is to identify the risk that is beyond 2% yearly risk. Molecular imaging may help identify plaque inflammation and apoptosis of inflammatory cells, which are obligatory components of the plaque instability. These processes offer specific biological targets that can potentially be exploited to obtain biological information on atherosclerosis development in the individual patient.
MeSH term(s)	Animals ; Annexin A5 ; Apoptosis ; Atherosclerosis/diagnosis ; Atherosclerosis/pathology ; Biosensing Techniques/methods ; Carotid Artery Diseases/diagnosis ; Carotid Artery Diseases/pathology ; Contrast Media ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/pathology ; Diagnostic Imaging/methods ; Humans ; In Situ Nick-End Labeling ; Macrophages/pathology ; Mice ; Rabbits ; Radioisotopes
Chemical Substances	Annexin A5 ; Contrast Media ; Radioisotopes
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.108.165522
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Zs.A 1705: Show issues

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Article ; Online: Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease.

Cell and tissue banking

2023 Volume 25, Issue 1, Page(s) 55–66

Abstract: For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve replacement (PVR) in congenital heart disease. More recently, decellularized pulmonary homografts (DPH) ... ...

Abstract	For decades, bovine jugular vein conduits (BJV) and classic cryopreserved homografts have been the two most widely used options for pulmonary valve replacement (PVR) in congenital heart disease. More recently, decellularized pulmonary homografts (DPH) have provided an alternative avenue for PVR. Matched comparison of patients who received DPH for PVR with patients who received bovine jugular vein conduits (BJV) considering patient age group, type of heart defect, and previous procedures. 319 DPH patients were matched to 319 BJV patients; the mean age of BJV patients was 15.3 (SD 9.5) years versus 19.1 (12.4) years in DPH patients (p = 0.001). The mean conduit diameter was 24.5 (3.5) mm for DPH and 20.3 (2.5) mm for BJV (p < 0.001). There was no difference in survival rates between the two groups after 10 years (97.0 vs. 98.1%, p = 0.45). The rate of freedom from endocarditis was significantly lower for BJV patients (87.1 vs. 96.5%, p = 0.006). Freedom from explantation was significantly lower for BJV at 10 years (81.7 vs. 95.5%, p = 0.001) as well as freedom from any significant degeneration at 10 years (39.6 vs. 65.4%, p < 0.001). 140 Patients, matched for age, heart defect type, prior procedures, and conduit sizes of 20-22 mm (± 2 mm), were compared separately; mean age BJV 8.7 (4.9) and DPH 9.5 (7.3) years (p = n.s.). DPH showed 20% higher freedom from explantation and degeneration in this subgroup (p = 0.232). Decellularized pulmonary homografts exhibit superior 10-year results to bovine jugular vein conduits in PVR.
MeSH term(s)	Humans ; Cattle ; Animals ; Infant ; Adolescent ; Child ; Pulmonary Valve/transplantation ; Jugular Veins/transplantation ; Treatment Outcome ; Heart Defects, Congenital/surgery ; Allografts ; Retrospective Studies
Language	English
Publishing date	2023-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170897-6
ISSN	1573-6814 ; 1389-9333
ISSN (online)	1573-6814
ISSN	1389-9333
DOI	10.1007/s10561-023-10082-4
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Zs.A 5972: Show issues

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Article: Grading Systems for Canine Urothelial Carcinoma of the Bladder: A Comparative Overview.

Brambilla, Eleonora / Govoni, Veronica M / Cavalca, Alexandre Matheus Baesso / Laufer-Amorim, Renée / Fonseca-Alves, Carlos Eduardo / Grieco, Valeria

Animals : an open access journal from MDPI

2022 Volume 12, Issue 11

Abstract: The relationship between tumor morphology and clinical behavior is a key point in oncology. In this scenario, pathologists and clinicians play a pivotal role in the identification and testing of reliable grading systems based on standardized parameters ... ...

Abstract	The relationship between tumor morphology and clinical behavior is a key point in oncology. In this scenario, pathologists and clinicians play a pivotal role in the identification and testing of reliable grading systems based on standardized parameters to predict patient prognosis. Dogs with bladder urothelial carcinoma (BUC) were recently proposed as a "large animal" model for the study of human BUCs due to the similar morphology and metastasis locations. BUC grading systems are consolidated in human medicine, while in veterinary medicine, the BUC grading systems that have been proposed for canine tumors are not yet applied in routine diagnostics. These latter systems have been proposed, decade by decade, over the last thirty years, and the reason for their scarce application is mainly related to a lack of specific cutoff values and studies assessing their prognostic relevance. However, for any prognostic study, reliable grading is necessary. The aim of the present article was to give an overview of the BUC grading systems available in both human and veterinary pathology and provide an extensive description and a critical evaluation to support veterinary researchers in the choice of possible grading systems to apply in future studies on canine BUCs.
Language	English
Publishing date	2022-06-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12111455
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Article ; Online: Finding the optimal dose reduction and iterative reconstruction level for coronary calcium scoring.

Willemink, Martin J / den Harder, Annemarie M / Foppen, Wouter / Schilham, Arnold M R / Rienks, Rienk / Laufer, Eduard M / Nieman, Koen / de Jong, Pim A / Budde, Ricardo P J / Nathoe, Hendrik M / Leiner, Tim

Journal of cardiovascular computed tomography

2016 Volume 10, Issue 1, Page(s) 69–75

Abstract: Objective: To assess the maximally achievable computed tomography (CT) dose reduction for coronary artery calcium (CAC) scoring with iterative reconstruction (IR) by using phantom-experiments and a systematical within-patient study.: Methods: Our ... ...

Abstract	Objective: To assess the maximally achievable computed tomography (CT) dose reduction for coronary artery calcium (CAC) scoring with iterative reconstruction (IR) by using phantom-experiments and a systematical within-patient study. Methods: Our local institutional review-board approved this study and informed consent was obtained from all participants. A phantom and patient study were conducted with 30 patients (23 men, median age 55.0 (52.0-56.0) years) who underwent 256-slice electrocardiogram-triggered CAC-scoring at four dose levels (routine, 60%, 40%, and 20%-dose) in a single session. Tube-voltage was 120 kVp, tube-current was lowered to achieve stated dose levels. Data were reconstructed with filtered back-projection (FBP) and three IR levels. Agatston, volume and mass scores were determined with validated software and compared using Wilcoxon signed ranks-tests. Subsequently, patient reclassification was analyzed. Results: The phantom study showed that Agatston scores remained nearly stable with FBP between routine-dose and 40%-dose and increased substantially at lower dose. Twenty-three patients (77%) had coronary calcifications. For Agatston scoring, one 40%-dose and six 20%-dose FBP reconstructions were not interpretable due to noise. In contrast, with IR all reconstructions were interpretable. Median Agatston scores increased with FBP from 26.1 (5.2-192.2) at routine-dose to 60.5 (11.6-251.7) at 20% dose. However, IR lowered Agatston scores to 22.9 (5.9-195.5) at 20%-dose and strong IR (level 7) with Agatston reclassifications in 15%. Conclusion: IR allows for CAC-scoring radiation dose reductions of up to 80% resulting in effective doses between 0.15 and 0.18 mSv. At these dose-levels, reclassification-rates remain within 15% if the highest IR-level is applied.
MeSH term(s)	Algorithms ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Dose-Response Relationship, Radiation ; Female ; Humans ; Male ; Middle Aged ; Radiation Dosage ; Radiation Exposure/analysis ; Radiation Exposure/prevention & control ; Radiation Protection/methods ; Radiographic Image Enhancement/methods ; Radiographic Image Interpretation, Computer-Assisted/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Signal-To-Noise Ratio ; Tomography, X-Ray Computed/methods ; Vascular Calcification/diagnostic imaging
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2015.08.004
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Zs.A 6761: Show issues

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Article ; Online: Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas.

Cardoso de Almeida Moreira, Andrea Regina / Franzoni, Mayara Simão / Dos Anjos, Denner Santos / César-Jark, Paulo / Nóbrega, Juliano / Laufer-Amorim, Renée / Valsecchi Henriques, Marina / Neto, Osmar Pinto / Fonseca-Alves, Carlos Eduardo

Veterinary sciences

2023 Volume 10, Issue 5

Abstract: ... evaluated tumor size (T), nodal involvement (N), distant metastasis (M), and histological grading criteria ...

Abstract	Soft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affecting approximately 20% of patients. Although this tumor set is vital in veterinary medicine, no previous unified staging system or mitotic count has been associated with patient prognosis. Therefore, this study proposed a new clinicopathological staging method and evaluated a cut-off value for mitosis related to the survival of dogs affected by STS. This study included 105 dogs affected by STS, treated only with surgery, and a complete follow-up evaluation. The new clinicopathological staging system evaluated tumor size (T), nodal involvement (N), distant metastasis (M), and histological grading criteria (G) to categorize the tumor stage into four groups (stages I, II, III, and IV). The proposed tumor staging system was able to differentiate patients' prognoses, with dogs with stage IV disease experiencing the lowest survival time and dogs with stage I disease having the highest survival time (
Language	English
Publishing date	2023-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci10050327
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Article ; Online: Diagnostic evaluation and treatment strategy in patients with suspected prosthetic heart valve dysfunction: The incremental value of MDCT.

Suchá, Dominika / Symersky, Petr / van den Brink, Renee B A / Tanis, Wilco / Laufer, Eduard M / Meijs, Matthijs F L / Habets, Jesse / de Mol, Bas A J M / Mali, Willem P Th M / Chamuleau, Steven A J / van Herwerden, Lex A / Budde, Ricardo P J

Journal of cardiovascular computed tomography

2016 Volume 10, Issue 5, Page(s) 398–406

Abstract: Background: In patients with suspected prosthetic heart valve (PHV) dysfunction, routine evaluation echocardiography and fluoroscopy may provide unsatisfactory results for identifying the cause of dysfunction. This study assessed the value of MDCT as a ... ...

Abstract	Background: In patients with suspected prosthetic heart valve (PHV) dysfunction, routine evaluation echocardiography and fluoroscopy may provide unsatisfactory results for identifying the cause of dysfunction. This study assessed the value of MDCT as a routine, complementary imaging modality in suspected PHV-dysfunction for diagnosing the cause of PHV dysfunction and proposing a treatment strategy. Methods: Patients with suspected PHV dysfunction were prospectively recruited. All patients underwent routine diagnostic work-up (TTE, TEE ± fluoroscopy) and additional MDCT imaging. An expert panel reviewed all cases and assessed the diagnosis and treatment strategy, first based on routine evaluation only, second with additional MDCT information. Results: Forty-two patients were included with suspected PHV obstruction (n = 30) and PHV regurgitation (n = 12). The addition of MDCT showed incremental value to routine evaluation in 26/30 (87%) cases for detecting the specific cause of PHV obstruction and in 7/12 (58%) regurgitation cases for assessment of complications and surgical planning. The addition of MDCT resulted in treatment strategy change in 8/30 (27%) patients with suspected obstruction and 3/12 (25%) patients with regurgitation. Conclusion: In addition to echocardiography and fluoroscopy, MDCT may identify the cause of PHV dysfunction and alter the treatment strategy.
MeSH term(s)	Adult ; Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/physiopathology ; Aortic Valve/surgery ; Cardiac-Gated Imaging Techniques ; Cross-Sectional Studies ; Echocardiography, Doppler, Color ; Electrocardiography ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Hemodynamics ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve/surgery ; Multidetector Computed Tomography ; Netherlands ; Predictive Value of Tests ; Prospective Studies ; Prosthesis Failure ; Reoperation ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2016.07.008
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Article ; Online: 5-Year results from the prospective European multi-centre study on decellularized homografts for pulmonary valve replacement ESPOIR Trial and ESPOIR Registry data.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2022 Volume 62, Issue 5

Abstract: Objectives: Early results from the prospective ESPOIR Trial have indicated excellent results for pulmonary valve replacement using decellularized pulmonary homografts (DPH).: Methods: A 5-year analysis of ESPOIR Trial patients was performed to ... ...

Abstract	Objectives: Early results from the prospective ESPOIR Trial have indicated excellent results for pulmonary valve replacement using decellularized pulmonary homografts (DPH). Methods: A 5-year analysis of ESPOIR Trial patients was performed to provide an insight into the midterm DPH performance. ESPOIR Trial and Registry patients were matched with cryopreserved homografts (CH) patients considering patient age, type of heart defect and previous procedures to present the overall experience with DPH. Results: A total of 121 patients (59 female) were prospectively enrolled (8/2014-12/2016), median age 16.5 years (interquartile range 11.2-29.8), and median DPH diameter 24 mm. One death (73 year-old) occurred during a median follow-up of 5.9 years (5.4-6.4), in addition to 2 perioperative deaths resulting in an overall mortality rate of 2.5%. One case of endocarditis in 637 patient-years was noticed, resulting in an incidence of 0.15% per patient-year. At 5 years, the mean peak gradient was 19.9 mmHg (9.9), mean regurgitation 0.9 (0.6, grade 0-3) and freedom from explantation/any reintervention 97.5% (1.5). The combined DPH cohort, n = 319, comprising both Trial and Registry data, showed significantly better freedom from explantation for DPH 95.5% (standard deviation 1.7) than CH 83.0% (2.8) (P < 0.001) and less structural valve degeneration at 10 years when matched to 319 CH patients [DPH 65.5% (standard deviation 4.4) and CH 47.3% (3.7), P = 0.11]. Conclusions: The 5-year data of the prospective ESPOIR Trial show excellent performance for DPH and low rates of adverse events. ESPOIR Registry data up to 15 years, including a matched comparison with CH, demonstrated statistically significant better freedom from explantation.
MeSH term(s)	Humans ; Female ; Adolescent ; Aged ; Pulmonary Valve/transplantation ; Prospective Studies ; Treatment Outcome ; Registries ; Allografts/surgery ; Heart Valve Prosthesis/adverse effects ; Heart Valve Prosthesis Implantation/methods ; Aortic Valve/surgery ; Follow-Up Studies
Language	English
Publishing date	2022-04-16
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezac219
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