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Article: Novel Insights into Understanding the Molecular Dialogues between Bipolaroxin and the Gα and Gβ Subunits of the Wheat Heterotrimeric G-Protein during Host-Pathogen Interaction.

Malviya, Deepti / Singh, Udai B / Dehury, Budheswar / Singh, Prakash / Kumar, Manoj / Singh, Shailendra / Chaurasia, Anurag / Yadav, Manoj Kumar / Shankar, Raja / Roy, Manish / Rai, Jai P / Mukherjee, Arup K / Solanki, Ishwar Singh / Kumar, Arun / Kumar, Sunil / Singh, Harsh V

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: Spot blotch disease of wheat, caused by the ... ...

Abstract	Spot blotch disease of wheat, caused by the fungus
Language	English
Publishing date	2022-09-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11091754
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Article: Novel Insights into Understanding the Molecular Dialogues between Bipolaroxin and the Gα and Gβ Subunits of the Wheat Heterotrimeric G-Protein during Host–Pathogen Interaction

Malviya, Deepti / Singh, Udai B. / Dehury, Budheswar / Singh, Prakash / Kumar, Manoj / Singh, Shailendra / Chaurasia, Anurag / Yadav, Manoj Kumar / Shankar, Raja / Roy, Manish / Rai, Jai P. / Mukherjee, Arup K. / Solanki, Ishwar Singh / Kumar, Arun / Kumar, Sunil / Singh, Harsh V.

Antioxidants. 2022 Sept. 05, v. 11, no. 9

2022

Abstract: ... we have developed the three-dimensional structure of G-protein alpha subunit from Triticum aestivum ... Molecular docking studies were performed using the active site of the modeled G-protein alpha and cryo-EM ... revealed that six H-bonds are mainly formed by Glu29, Ser30, Lys32, and Ala177 of G-alpha with Bipolaroxin ...

Abstract	Spot blotch disease of wheat, caused by the fungus Bipolaris sorokiniana (Sacc.) Shoem., produces several toxins which interact with the plants and thereby increase the blightening of the wheat leaves, and Bipolaroxin is one of them. There is an urgent need to decipher the molecular interaction between wheat and the toxin Bipolaroxin for in-depth understanding of host–pathogen interactions. In the present study, we have developed the three-dimensional structure of G-protein alpha subunit from Triticum aestivum. Molecular docking studies were performed using the active site of the modeled G-protein alpha and cryo-EM structure of beta subunit from T. aestivum and ‘Bipolaroxin’. The study of protein–ligand interactions revealed that six H-bonds are mainly formed by Glu29, Ser30, Lys32, and Ala177 of G-alpha with Bipolaroxin. In the beta subunit, the residues of the core beta strand domain participate in the ligand interaction where Lys256, Phe306, and Leu352 formed seven H-bonds with the ligand Bipolaroxin. All-atoms molecular dynamics (MD) simulation studies were conducted for G-alpha and -beta subunit and Bipolaroxin complexes to explore the stability, conformational flexibility, and dynamic behavior of the complex system. In planta studies clearly indicated that application of Bipolaroxin significantly impacted the physio-biochemical pathways in wheat and led to the blightening of leaves in susceptible cultivars as compared to resistant ones. Further, it interacted with the Gα and Gβ subunits of G-protein, phenylpropanoid, and MAPK pathways, which is clearly supported by the qPCR results. This study gives deeper insights into understanding the molecular dialogues between Bipolaroxin and the Gα and Gβ subunits of the wheat heterotrimeric G-protein during host–pathogen interaction.
Keywords	Bipolaris sorokiniana ; Triticum aestivum ; active sites ; cultivars ; fungi ; heterotrimeric GTP-binding proteins ; host-pathogen relationships ; ligands ; molecular dynamics ; toxins ; wheat
Language	English
Dates of publication	2022-0905
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11091754
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Public Key Cryptosystem Technique Elliptic Curve Cryptography with Generator g for Image Encryption

Vinod Kumar Yadav / Dr. A.K. Malviya / D.L. Gupta / Satyendra Singh / Ganesh Chandra

International Journal of Computer Technology and Applications , Vol 03, Iss 01, Pp 298-

2012 Volume 302

Abstract: ... the help of an algorithm ‘Elliptic CurveCryptography with generator g for ImageEncryption’. ECC is ...

Abstract	This paper present goal of cryptography is thesecure communication through insecure channelswith the help of an algorithm ‘Elliptic CurveCryptography with generator g for ImageEncryption’. ECC is an efficient technique oftransmitting the image securely. It has been shownthough the image encryption by ECC to transmitsthe image secretly and efficiently recovers the sameat the receiver end. The scheme comprises of theimportant algorithms namely encryption algorithmis used to create every 2-D image pixels of theoriginal image into the ECC points in a finiteabelian group over m GF(2 ) or E a b m ( , ).2TheseECC points convert into cipher image pixels atsender side and decryption algorithm is used to getoriginal image within a very short time with a highlevel of security at the receiver side.
Keywords	Security ; Elliptic Curve Cryptography (ECC) ; The Generator g ; RGB color Model ; image encryption algorithm at sender side process and Image decryption algorithm at Receiver side process. ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	006
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Technopark Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cocos nucifera Husk Biomass as an Effective Adsorbent for Industrial Wastewater Removal: Harnessing the Power of Nature.

Sharma, Rishav / Awasthi, Rajendra / Malviya, Rishabha

Recent advances in food, nutrition & agriculture

2024

Abstract: ... However, the dye removal efficacy decreased after reaching a specific dosage of 0.6 g/L. A concentration of 0.05 g ...

Abstract	Background: Rapid industrialization has polluted waterways, threatened aquatic ecosystems and endangered human health. To solve this problem, sustainable industrial practices and innovative water treatment technology must be implemented to ensure clean and safe water for future generations. Methods: This study aimed to investigate the adsorbent capacity of Cocos nucifera husk for ineffective removal of methylene blue (MB), a cationic dye abundantly found in industrial effluent. Adsorption capacity is measured using parameters such as dye elimination percentage and polymer dosage. The Langmuir and Freundlich isotherms, adsorption kinetics (pseudo-first, pseudo-second, and second order), and intraparticle diffusion were determined to better understand the adsorption process. Results: The increased dosage of cellulose fiber results in the availability of a greater number of adsorption sites and an increased surface area. However, the dye removal efficacy decreased after reaching a specific dosage of 0.6 g/L. A concentration of 0.05 g/L was most effective in eliminating Methylene blue (MB). The value of the separation factor (0.99) suggested a favorable adsorption isotherm. The reciprocal of the heterogeneity factor (-1.469) demonstrated the concentration-independent adsorption behavior of Fiber. Freundlich and Langmuir's isotherm model showed that the pseudo-second-order kinetic model demonstrated the highest level of correlation with the experimental data about the mechanism of adsorption. The Methylene blue (MB) adsorption is not limited by the intraparticle diffusion and adsorption is influenced by surface area and concentration variation of fiber as well as solvent concentration, as evidenced by low R2 value and the fact that the intraparticle diffusion plot does not intersect with the origin. Conclusion: The study concludes that Cocos nucifera husk can be effectively used for the treatment of wastewater.
Language	English
Publishing date	2024-03-14
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2772-5758
ISSN (online)	2772-5758
DOI	10.2174/012772574X288759240305065156
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Article ; Online: Functional and radiological outcomes of periacetabular osteotomy for hip dysplasia in patients under fifty years using a minimally invasive approach-a single surgeon series with a minimum follow up of two years.

Sunil Kumar, Karadi Hari / Bhargava, Kartik / Stamp, Gregory / Malviya, Ajay

International orthopaedics

2024 Volume 48, Issue 5, Page(s) 1225–1231

Abstract: Purpose: We conducted a retrospective analysis of prospectively collected data to evaluate (1) the extent of surgical correction following minimally invasive periacetabular osteotomy, (2) improvements in functional outcomes and any potential predictors ... ...

Abstract	Purpose: We conducted a retrospective analysis of prospectively collected data to evaluate (1) the extent of surgical correction following minimally invasive periacetabular osteotomy, (2) improvements in functional outcomes and any potential predictors for favourable outcome, and (3) complications after minimally invasive periacetabular osteotomy. Methods: A total of 352 minimally invasive periacetabular osteotomy procedures were performed on 312 hip dysplasia patients between 2013 and 2020. Radiological parameters such as lateral centre edge angle, acetabular index, and Tönnis grade of arthritis were calculated. Patients also completed a range of patient reported outcome measures. Wilcoxon signed-rank tests were performed to assess for differences between patient reported outcome measures and radiological outcomes across the follow-up periods. Univariate linear regression and logistic regression were used to assess for predictors of change in functional outcome. Results: Patients had a significant correction in mean lateral centre edge angle from 17.2° to 35.3° (p < 0.001) and mean acetabular index from 13.2° to - 0.82°. At one year follow-up all patient reported outcome measures were significantly greater than their baseline measurements and this improvement was maintained at two years. Changes in patient reported outcome measures were independent of radiological parameters such as change in the lateral centre edge angle and acetabular index, pre-operative Tönnis grade, and patient factors such as age and sex. A total of 5.11% of patients developed post-operative complications, with four requiring posterior column fixation. Four patients (1.12%) needed a total hip replacement. Conclusion: Minimally invasive periacetabular osteotomy is a safe procedure that provides significant functional outcome improvements following surgery at six months which is maintained at two years. More than three-fourths of patients achieved improvement of iHOT-12 score beyond the minimal clinically important difference and more than half of the patients achieved substantial clinical benefit for iHOT-12 score.
MeSH term(s)	Humans ; Hip Dislocation/surgery ; Follow-Up Studies ; Retrospective Studies ; Treatment Outcome ; Hip Dislocation, Congenital/surgery ; Acetabulum/diagnostic imaging ; Acetabulum/surgery ; Osteotomy/adverse effects ; Osteotomy/methods ; Surgeons
Language	English
Publishing date	2024-02-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-024-06094-8
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Article: A robust heterogeneous chiral phosphoric acid enables multi decagram scale production of optically active

Maestro, Aitor / Malviya, Bhanwar K / Auer, Gerald / Ötvös, Sándor B / Kappe, C Oliver

Green chemistry : an international journal and green chemistry resource : GC

2024 Volume 26, Issue 8, Page(s) 4593–4599

Abstract: Asymmetric organocatalysis has been recognized as one of the "top 10 emerging technologies" in chemistry by IUPAC in 2019. Its potential to make chemical processes more sustainable is promising, but there are still challenges that need to be addressed. ... ...

Abstract	Asymmetric organocatalysis has been recognized as one of the "top 10 emerging technologies" in chemistry by IUPAC in 2019. Its potential to make chemical processes more sustainable is promising, but there are still challenges that need to be addressed. Developing new and reliable enantioselective processes for reproducing batch reactions on a large scale requires a combination of chemical and technical solutions. In this manuscript, we combine a robust immobilized chiral phosphoric acid with a new packed-bed reactor design. This combination allows scaling up of the enantioselective addition of thiols to imines from a few milligrams to a multi-decagram scale in a continuous flow process without physical or chemical degradation of the catalyst.
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d4gc00019f
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Article: Probiotics as modulators of gut-brain axis for cognitive development.

Kumar, Akash / Sivamaruthi, Bhagavathi Sundaram / Dey, Swarnima / Kumar, Yogesh / Malviya, Rishabha / Prajapati, Bhupendra G / Chaiyasut, Chaiyavat

Frontiers in pharmacology

2024 Volume 15, Page(s) 1348297

Abstract: Various microbial communities reside in the gastrointestinal tract of humans and play an important role in immunity, digestion, drug metabolism, intestinal integrity, and protection from pathogens. Recent studies have revealed that the gut microbiota (GM) ...

Abstract	Various microbial communities reside in the gastrointestinal tract of humans and play an important role in immunity, digestion, drug metabolism, intestinal integrity, and protection from pathogens. Recent studies have revealed that the gut microbiota (GM) is involved in communication with the brain, through a bidirectional communication network known as the gut-brain axis. This communication involves humoral, immunological, endocrine, and neural pathways. Gut dysbiosis negatively impacts these communication pathways, leading to neurological complications and cognitive deficits. Both pre-clinical and clinical studies have demonstrated that probiotics can restore healthy GM, reduce intestinal pH, and reduce inflammation and pathogenic microbes in the gut. Additionally, probiotics improve cell-to-cell signaling and increase blood-brain-derived neurotrophic factors. Probiotics emerge as a potential approach for preventing and managing neurological complications and cognitive deficits. Despite these promising findings, the safety concerns and possible risks of probiotic usage must be closely monitored and addressed. This review article provides a brief overview of the role and significance of probiotics in cognitive health.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1348297
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Article ; Online: Applications of Bioengineered Polymer in the Field of Nano-Based Drug Delivery.

Mishra, Sudhanshu / Shah, Harshil / Patel, Artiben / Tripathi, Shivendra Mani / Malviya, Rishabha / Prajapati, Bhupendra G

ACS omega

2023 Volume 9, Issue 1, Page(s) 81–96

Abstract: The most favored route of drug administration is oral administration; however, several factors, including poor solubility, low bioavailability, and degradation, in the severe gastrointestinal environment frequently compromise the effectiveness of drugs ... ...

Abstract	The most favored route of drug administration is oral administration; however, several factors, including poor solubility, low bioavailability, and degradation, in the severe gastrointestinal environment frequently compromise the effectiveness of drugs taken orally. Bioengineered polymers have been developed to overcome these difficulties and enhance the delivery of therapeutic agents. Polymeric nanoparticles, including carbon dots, fullerenes, and quantum dots, have emerged as crucial components in this context. They provide a novel way to deliver various therapeutic materials, including proteins, vaccine antigens, and medications, precisely to the locations where they are supposed to have an effect. The promise of this integrated strategy, which combines nanoparticles with bioengineered polymers, is to address the drawbacks of conventional oral medication delivery such as poor solubility, low bioavailability, and early degradation. In recent years, we have seen substantially increased interest in bioengineered polymers because of their distinctive qualities, such as biocompatibility, biodegradability, and flexible physicochemical characteristics. The different bioengineered polymers, such as chitosan, alginate, and poly(lactic-
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c07356
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Article ; Online: Role of Peptides in Diagnostics.

Pandey, Shashank / Malviya, Gaurav / Chottova Dvorakova, Magdalena

International journal of molecular sciences

2021 Volume 22, Issue 16

Abstract: The specificity of a diagnostic assay depends upon the purity of the biomolecules used as a probe. To get specific and accurate information of a disease, the use of synthetic peptides in diagnostics have increased in the last few decades, because of ... ...

Abstract	The specificity of a diagnostic assay depends upon the purity of the biomolecules used as a probe. To get specific and accurate information of a disease, the use of synthetic peptides in diagnostics have increased in the last few decades, because of their high purity profile and ability to get modified chemically. The discovered peptide probes are used either in imaging diagnostics or in non-imaging diagnostics. In non-imaging diagnostics, techniques such as Enzyme-Linked Immunosorbent Assay (ELISA), lateral flow devices (i.e., point-of-care testing), or microarray or LC-MS/MS are used for direct analysis of biofluids. Among all, peptide-based ELISA is considered to be the most preferred technology platform. Similarly, peptides can also be used as probes for imaging techniques, such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET). The role of radiolabeled peptides, such as somatostatin receptors, interleukin 2 receptor, prostate specific membrane antigen, αβ3 integrin receptor, gastrin-releasing peptide, chemokine receptor 4, and urokinase-type plasminogen receptor, are well established tools for targeted molecular imaging ortumor receptor imaging. Low molecular weight peptides allow a rapid clearance from the blood and result in favorable target-to-non-target ratios. It also displays a good tissue penetration and non-immunogenicity. The only drawback of using peptides is their potential low metabolic stability. In this review article, we have discussed and evaluated the role of peptides in imaging and non-imaging diagnostics. The most popular non-imaging and imaging diagnostic platforms are discussed, categorized, and ranked, as per their scientific contribution on PUBMED. Moreover, the applicability of peptide-based diagnostics in deadly diseases, mainly COVID-19 and cancer, is also discussed in detail.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing/methods ; Databases, Factual ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Peptides/analysis ; Positron-Emission Tomography/methods ; Receptors, Somatostatin ; SARS-CoV-2/isolation & purification ; Tandem Mass Spectrometry/methods ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Peptides ; Receptors, Somatostatin
Language	English
Publishing date	2021-08-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22168828
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Article: Disabilities in leprosy--The new concepts.

Malviya, G N

Indian journal of leprosy

2014 Volume 86, Issue 3, Page(s) 121–127

Abstract: The concept of disabilities has undergone changes in recent years and disability is no longer a mere physical dysfunction. It includes activity limitations, stigma, discrimination, and social participation restrictions. In addition to the presence of an ... ...

Abstract	The concept of disabilities has undergone changes in recent years and disability is no longer a mere physical dysfunction. It includes activity limitations, stigma, discrimination, and social participation restrictions. In addition to the presence of an illness or impairment, the understanding of disability now explores the relationship between disease/illness/impairment, the persons functioning within daily activities/social roles, and the social, cultural, and physical environments that enable or limit an individual's ability to participate fully in his or her community and daily lives. International Classification of Functioning Disability and Health (ICF) has recognized several dimensions of disability viz., body structure and function (and impairment thereof), activity (and activity restrictions) and participation (and participation restrictions). It also recognizes the role of physical and social environmental factors in affecting disability outcomes and has shifted the focus from the cause of disability to its effect, thereby emphasizing the role of the environment (physical, cultural, social, political) rather than focusing on disability as a 'medical' or 'biological' dysfunction. There is not much information available about these relationships in leprosy related disabilities. Studies are required in different patient groups having different socio-cultural background to develop a better understanding of these issues. Accordingly the need for services can be worked out for rehabilitation of the patients released from the treatment and "Cure".
MeSH term(s)	Disability Evaluation ; Disabled Persons ; Humans ; Leprosy/diagnosis ; Leprosy/physiopathology ; Leprosy/rehabilitation
Language	English
Publishing date	2014-07
Publishing country	India
Document type	Journal Article
ZDB-ID	605804-8
ISSN	0254-9395
ISSN	0254-9395
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