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  1. Article ; Online: Bastos, J.C.S.; Kohn, L.K.; Fantinatti-Garboggini, F.; Padilla, M.A.; Flores, E.F.; da Silva, B.P.; de Menezes, C.B.A.; Arns, C.W. Antiviral Activity of Bacillus sp. Isolated from the Marine Sponge Petromica citrina against Bovine Viral Diarrhea Virus, a Surrogate Model of the Hepatitis C Virus. Viruses 2013, 5, 1219-1230.

    Juliana Cristina Santiago Bastos / Luciana Konecny Kohn / Fabiana Fantinatti-Garboggini / Marina Aiello Padilla / Eduardo Furtado Flores / Bárbara Pereira da Silva / Cláudia Beatriz Afonso de Menezes / Clarice Weis Arns

    Viruses, Vol 5, Iss 7, Pp 1682-

    2013  Volume 1683

    Abstract: The authors wish to add the following Acknowledgments and completed Table 1 to their paper published in Viruses [1], doi:10.3390/v5051219, website: http://www.mdpi.com/1999-4915/5/5/1219. ...

    Abstract The authors wish to add the following Acknowledgments and completed Table 1 to their paper published in Viruses [1], doi:10.3390/v5051219, website: http://www.mdpi.com/1999-4915/5/5/1219.
    Keywords n/a ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2013-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Biomarker Development: Bedside to Bench.

    Mishkin, Grace E / Kohn, Elise C

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 13, Page(s) 2722–2724

    Abstract: This commentary complements the report from Nixon and colleagues by addressing the critical definitions, assay and analytical quality control and interpretation, and resources available to advance similar fit-for-purpose biomarker development. See ... ...

    Abstract This commentary complements the report from Nixon and colleagues by addressing the critical definitions, assay and analytical quality control and interpretation, and resources available to advance similar fit-for-purpose biomarker development. See related articles by Nixon et al., p. 2771 and 2779.
    MeSH term(s) Bevacizumab ; Biomarkers ; Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Quality Control
    Chemical Substances Biomarkers ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2022-05-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-0750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Persistent azulene α-carbocations: synthesis from aldehydes, spectroscopic and crystallographic properties.

    Harabajiu, Catajina / Hann, Jodie L / Murfin, Lloyd C / Kociok-Köhn, Gabriele / Lewis, Simon E

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 4, Page(s) 858–866

    Abstract: The non-benzenoid aromatic system azulene is sufficiently nucleophilic at C1 that it can react with a protonated aldehyde to form an α-azulenyl alcohol. This in turn may be protonated and undergo loss of water to give an azulene α-carbocation. We report ... ...

    Abstract The non-benzenoid aromatic system azulene is sufficiently nucleophilic at C1 that it can react with a protonated aldehyde to form an α-azulenyl alcohol. This in turn may be protonated and undergo loss of water to give an azulene α-carbocation. We report the isolation of such azulenyl cations as salts with non-coordinating anions. The salts have been characterised by NMR, UV/Vis absorption and (in certain cases) X-ray crystallography. Reduction of representative salts to afford azulenyl(aryl) methylenes has been demonstrated.
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01695h
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  4. Article ; Online: Radical Ring Opening Polymerization of Cyclic Ketene Acetals Derived From d-Glucal.

    Hardy, Craig / Levere, Martin E / Kociok-Köhn, Gabriele / Buchard, Antoine

    ACS macro letters

    2023  Volume 12, Issue 11, Page(s) 1443–1449

    Abstract: A cyclic ketene acetal (CKA) derived from d-glucal was synthesized, and its polymerization using free radicals has been investigated. NMR analysis of the resulting polymers revealed the formation of polyacetal-polyester copolymers, with up to 78% of ... ...

    Abstract A cyclic ketene acetal (CKA) derived from d-glucal was synthesized, and its polymerization using free radicals has been investigated. NMR analysis of the resulting polymers revealed the formation of polyacetal-polyester copolymers, with up to 78% of ester linkages formed by radical ring-opening polymerization (rROP). Conversely, the polymerization of the monomer-saturated analogue only produced acetal linkages, demonstrating that the alkene functionality within the d-glucal pyranose ring is essential to promote ring-opening and ester formation, likely via the stabilization of an allyl radical. The thermal properties of the polymers were linked to the ratio of the ester and acetal linkages. Copolymerization with methyl methacrylate (MMA) afforded statistically PMMA-rich copolymers (66-98%) with linkages prone to hydrolytic degradation and decreased glass-transition temperatures. The retention of the pseudoglucal alkene function offers opportunities to functionalize further these bioderived (co)polymers.
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ISSN 2161-1653
    ISSN (online) 2161-1653
    DOI 10.1021/acsmacrolett.3c00397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Involvement of vulva in lichen sclerosus increases the risk of antidepressant and benzodiazepine prescriptions for psychiatric disorder diagnoses.

    Choi, Una E / Nicholson, Ryan C / Agrawal, Pranjal / Watts, Emelia / Kohn, Taylor P / Kohn, Jaden R / Clifton, Marisa

    International journal of impotence research

    2023  

    Abstract: While vulvar lichen sclerosus (VLS) causes intense pruritus, associated risks of mood disorders and prescription patterns and impact of concurrent sexual dysfunction are unknown. We queried TriNetX Diamond Network between 2009 and 2022, conducting three ... ...

    Abstract While vulvar lichen sclerosus (VLS) causes intense pruritus, associated risks of mood disorders and prescription patterns and impact of concurrent sexual dysfunction are unknown. We queried TriNetX Diamond Network between 2009 and 2022, conducting three comparisons after propensity-score matching for demographics and relevant comorbidities: (1) women with lichen sclerosus (LS) sparing the vulva vs. women with VLS; (2) VLS patients who received treatment within 6 months of diagnosis vs. patients who did not and (3) VLS patients with vs. without sexual dysfunction. Outcomes included new depressive episodes, anxiety disorder, major depressive disorder (MDD), and prescriptions of antidepressants or benzodiazepines. After matching, VLS was associated with increased depressive episode [risk ratio (RR) 1.39], anxiety disorder (RR 1.93), and MDD (RR 2.00) diagnoses compared to LS sparing the vulva. Next, VLS treatment was associated with decreased risk of depressive episode (RR 0.60) and anxiety disorder (RR 0.72). Finally, concurrent sexual dysfunction was associated with increased benzodiazepine (RR 3.50), vaginal estrogen (RR 6.20), antipruritic agents (RR 3.90), and topical anti-inflammatory (RR 2.61) prescriptions. In conclusion, vulvar involvement is associated with increased risk of antidepressant and benzodiazepine prescriptions, and diagnosis of depressive episode, anxiety disorder, or MDD.
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-023-00793-3
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  6. Article ; Online: The Need for a Modern Error Grid for Clinical Accuracy of Blood Glucose Monitors and Continuous Glucose Monitors.

    Tian, Tiffany / Aaron, Rachel E / Kohn, Michael A / Klonoff, David C

    Journal of diabetes science and technology

    2023  Volume 18, Issue 1, Page(s) 3–9

    MeSH term(s) Humans ; Blood Glucose ; Hypoglycemia ; Diabetes Mellitus, Type 1 ; Blood Glucose Self-Monitoring ; Reproducibility of Results
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Editorial
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/19322968231214281
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  7. Article: Biomechanical assessment of chronic liver injury using quantitative micro-elastography.

    Mowla, Alireza / Belford, Rose / Köhn-Gaone, Julia / Main, Nathan / Tirnitz-Parker, Janina E E / Yeoh, George C / Kennedy, Brendan F

    Biomedical optics express

    2022  Volume 13, Issue 9, Page(s) 5050–5066

    Abstract: Hepatocellular carcinoma is one of the most lethal cancers worldwide, causing almost 700,000 deaths annually. It mainly arises from cirrhosis, which, in turn, results from chronic injury to liver cells and corresponding fibrotic changes. Although it is ... ...

    Abstract Hepatocellular carcinoma is one of the most lethal cancers worldwide, causing almost 700,000 deaths annually. It mainly arises from cirrhosis, which, in turn, results from chronic injury to liver cells and corresponding fibrotic changes. Although it is known that chronic liver injury increases the elasticity of liver tissue, the role of increased elasticity of the microenvironment as a possible hepatocarcinogen is yet to be investigated. One reason for this is the paucity of imaging techniques capable of mapping the micro-scale elasticity variation in liver and correlating that with cancerous mechanisms on the cellular scale. The clinical techniques of ultrasound elastography and magnetic resonance elastography typically do not provide micro-scale resolution, while atomic force microscopy can only assess the elasticity of a limited number of cells. We propose quantitative micro-elastography (QME) for mapping the micro-scale elasticity of liver tissue into images known as micro-elastograms, and therefore, as a technique capable of correlating the micro-environment elasticity of tissue with cellular scale cancerous mechanisms in liver. We performed QME on 13 freshly excised healthy and diseased mouse livers and present micro-elastograms, together with co-registered histology, in four representative cases. Our results indicate a significant increase in the mean (×6.3) and standard deviation (×6.0) of elasticity caused by chronic liver injury and demonstrate that the onset and progression of pathological features such as fibrosis, hepatocyte damage, and immune cell infiltration correlate with localized variations in micro-elastograms.
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.467684
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  8. Article ; Online: Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data.

    Wu, C / Gunnarsson, E B / Myklebust, E M / Köhn-Luque, A / Tadele, D S / Enserink, J M / Frigessi, A / Foo, J / Leder, K

    ArXiv

    2023  

    Abstract: Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety of subpopulations with distinct therapeutic response characteristics. ... ...

    Abstract Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety of subpopulations with distinct therapeutic response characteristics. Characterizing this heterogeneity by determining the subpopulation structure within a tumor enables more precise and successful treatment strategies. In our prior work, we developed PhenoPop, a computational framework for unravelling the drug-response subpopulation structure within a tumor from bulk high-throughput drug screening data. However, the deterministic nature of the underlying models driving PhenoPop restricts the model fit and the information it can extract from the data. As an advancement, we propose a stochastic model based on the linear birth-death process to address this limitation. Our model can formulate a dynamic variance along the horizon of the experiment so that the model uses more information from the data to provide a more robust estimation. In addition, the newly proposed model can be readily adapted to situations where the experimental data exhibits a positive time correlation. We test our model on simulated data (
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
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  9. Article ; Online: Association of Time of Day with Delays in Antimicrobial Initiation among Ward Patients with Hospital-Onset Sepsis.

    Ginestra, Jennifer C / Kohn, Rachel / Hubbard, Rebecca A / Auriemma, Catherine L / Patel, Mitesh S / Anesi, George L / Kerlin, Meeta Prasad / Weissman, Gary E

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 9, Page(s) 1299–1308

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Sepsis/drug therapy ; Sepsis/complications ; Anti-Infective Agents ; Hospitalization ; Hospitals ; Hospital Mortality
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202302-160OC
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    Zs.A 5828: Show issues Location:
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  10. Article ; Online: Updated Management Guidelines for Adenosine Deaminase Deficiency.

    Grunebaum, Eyal / Booth, Claire / Cuvelier, Geoffrey D E / Loves, Robyn / Aiuti, Alessandro / Kohn, Donald B

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 6, Page(s) 1665–1675

    Abstract: Inherited defects in the adenosine deaminase (ADA) gene typically cause severe combined immunodeficiency. In addition to infections, ADA-deficient patients can present with neurodevelopmental, behavioral, hearing, skeletal, lung, heart, skin, kidney, ... ...

    Abstract Inherited defects in the adenosine deaminase (ADA) gene typically cause severe combined immunodeficiency. In addition to infections, ADA-deficient patients can present with neurodevelopmental, behavioral, hearing, skeletal, lung, heart, skin, kidney, urogenital, and liver abnormalities. Some patients also suffer from autoimmunity and malignancies. In recent years, there have been remarkable advances in the management of ADA deficiency. Most ADA-deficient patients can be identified by newborn screening for severe combined immunodeficiency, which facilitates early diagnosis and treatment of asymptomatic infants. Most patients benefit from enzyme replacement therapy (ERT). Allogeneic hematopoietic cell transplantation from an HLA-matched sibling donor or HLA-matched family member donor with no conditioning is currently the preferable treatment. When matched sibling donor or matched family member donor is not available, autologous ADA gene therapy with nonmyeloablative conditioning and ERT withdrawal, which is reported in recent studies to result in 100% overall survival and 90% to 95% engraftment, should be pursued. If gene therapy is not immediately available, ERT can be continued for a few years, although its excessive cost might be prohibitive. The recent improved outcome of hematopoietic cell transplantation using HLA-mismatched family-related donors or HLA-matched unrelated donors, after reduced-intensity conditioning, suggests that such procedures might also be considered rather than continuing ERT for prolonged periods. Long-term follow-up will further assist in determining the optimal treatment approach for ADA-deficient patients.
    MeSH term(s) Humans ; Infant ; Infant, Newborn ; Adenosine Deaminase/genetics ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/therapy ; Agammaglobulinemia/genetics ; Hematopoietic Stem Cell Transplantation/methods ; Severe Combined Immunodeficiency/diagnosis ; Severe Combined Immunodeficiency/genetics ; Severe Combined Immunodeficiency/therapy
    Chemical Substances Adenosine Deaminase (EC 3.5.4.4)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.01.032
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