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Article: Robotic intracorporeal orthotopic neobladder in the supine Trendelenburg position: a stepwise approach.

Bhattu, Amit S / Ritch, Chad R / Jahromi, Mona / Banerjee, Indraneel / Gonzalgo, Mark L

2021 Volume 28, Issue 4, Page(s) 10794–10798

Abstract: Robotic radical cystectomy with urinary diversion has become increasingly utilized for the surgical management of bladder cancer. Orthotopic neobladder reconstruction is still performed worldwide primarily via an extracorporeal approach because of the ... ...

Abstract	Robotic radical cystectomy with urinary diversion has become increasingly utilized for the surgical management of bladder cancer. Orthotopic neobladder reconstruction is still performed worldwide primarily via an extracorporeal approach because of the difficulty associated with robotic intracorporeal reconstruction. The objective of this article is to demonstrate a stepwise approach for robotic intracorporeal neobladder in a standardized manner that adheres to the principles of open surgery.
MeSH term(s)	Cystectomy ; Head-Down Tilt ; Humans ; Robotic Surgical Procedures ; Surgically-Created Structures ; Treatment Outcome ; Urinary Bladder Neoplasms/surgery ; Urinary Diversion
Language	English
Publishing date	2021-08-11
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2064475-9
ISSN	1195-9479
ISSN	1195-9479
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Article ; Online: Overactive bladder and urgency urinary incontinence in men undergoing artificial urinary sphincter placement.

Jahromi, Mona S / Engle, Kyrra / Furlong, Daniel / Guevara Méndez, Alejandra / Gomez, Christopher S

Neurourology and urodynamics

2020 Volume 39, Issue 5, Page(s) 1489–1493

Abstract: Purpose: To assess persistent and de novo rates of overactive bladder (OAB) and urgency urinary incontinence (UUI) in patients with incontinence after prostate treatment (IPT) focusing on differences between surgical intervention vs radiation.: ... ...

Abstract	Purpose: To assess persistent and de novo rates of overactive bladder (OAB) and urgency urinary incontinence (UUI) in patients with incontinence after prostate treatment (IPT) focusing on differences between surgical intervention vs radiation. Methods: We performed a retrospective review of 79 patients who underwent primary artificial urinary sphincter (AUS) placement and activation from a single surgeon between February 2012 and November 2017. Four patients with neurogenic bladder were excluded and two with insufficient follow-up. The primary outcome measures were persistent OAB, persistent UUI, and pad usage before and after AUS placement. Results: After activation of the AUS, 67% of non-radiated patients had resolution of urgency incontinence vs only 31% of the radiated patients (P = .096). After activation of the AUS, resolution of OAB symptoms was more common in the non-radiated group. We found 53% of the non-radiated group vs only 22% of the radiated group had resolution of their urinary urgency (P = .045). Previous history of radiation was a risk factor for OAB after implantation of AUS (odds ratio [OR], 3.63; P = .010). Postoperative oral medical pharmacotherapy for OAB was higher in those with previous radiation vs those without prior radiation (66.7% vs 25.7%, P = .001). A history of OAB or UUI did not affect social continence after AUS placement. Conclusion: Radiation is a risk for continued OAB after AUS activation. Appropriate counseling is necessary pre- and postoperatively to manage patient expectations and provide additional medical therapies. Mixed urinary incontinence or OAB symptoms should not exclude patients from undergoing AUS placement.
MeSH term(s)	Aged ; Humans ; Male ; Middle Aged ; Prostate/surgery ; Prostatectomy/adverse effects ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome ; Urinary Bladder, Overactive/etiology ; Urinary Bladder, Overactive/surgery ; Urinary Incontinence, Urge/etiology ; Urinary Incontinence, Urge/surgery ; Urinary Sphincter, Artificial
Language	English
Publishing date	2020-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.24378
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Zs.A 1828: Show issues

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Article ; Online: Molecular strategy for the direct detection and identification of the most common fungal community in cerumen specimens by multiplex PCR.

Jabrodini, Ahmad / Sohrabizdeh, Maryam / Aboutalebian, Shima / Hashemi, Seyed Basir / Zomorodian, Kamiar / Alirezaie, Arefeh / Rasti Jahromi, Mona / Shamsdin, Seyedeh Neda / Motamedi, Marjan

Journal of medical microbiology

2023 Volume 72, Issue 8

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Humans ; Multiplex Polymerase Chain Reaction ; Otomycosis ; Mycobiome ; Cerumen ; Reproducibility of Results ; Candida ; DNA Primers ; Penicillium
Chemical Substances	DNA Primers
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001746
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Zs.A 634: Show issues

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Article ; Online: UTIs in patients with neurogenic bladder.

Jahromi, Mona S / Mure, Amanda / Gomez, Christopher S

Current urology reports

2014 Volume 15, Issue 9, Page(s) 433

Abstract: Urinary tract infections (UTI) remain one of the most prevalent and frustrating morbidities for neurogenic bladder patients, and death attributed to urosepsis in the spinal cord injury (SCI) patient is higher when compared to the general population. Risk ...

Abstract	Urinary tract infections (UTI) remain one of the most prevalent and frustrating morbidities for neurogenic bladder patients, and death attributed to urosepsis in the spinal cord injury (SCI) patient is higher when compared to the general population. Risk factors include urinary stasis, high bladder pressures, bladder stones, and catheter use. While classic symptoms of UTI include dysuria, increased frequency and urgency, neurogenic bladder patients present differently with increased spasticity, autonomic dysreflexia, urinary incontinence, and vague pains. Multiple modalities have been assessed for prevention including catheter type, oral supplements, bladder irrigation, detrusor injections and prophylactic antimicrobials. Of these, bladder inoculation with E. coli HU2117, irrigation with iAluRil(®), detrusor injections, and weekly prophylaxis with alternating antibiotics appear to have a positive reduction in UTI but require further study. Ultimately, treatment for symptomatic UTI should account for the varied flora and possible antibiotic resistances including relying on urine cultures to guide antibiotic therapy.
MeSH term(s)	Administration, Intravesical ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents, Urinary/therapeutic use ; Antibiotic Prophylaxis/methods ; Antioxidants/therapeutic use ; Ascorbic Acid/therapeutic use ; Botulinum Toxins, Type A/therapeutic use ; Catheter-Related Infections/drug therapy ; Catheter-Related Infections/prevention & control ; Escherichia coli ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/etiology ; Escherichia coli Infections/prevention & control ; Humans ; Immunotherapy, Active/methods ; Mannose/therapeutic use ; Methenamine/therapeutic use ; Multiple Sclerosis/complications ; Neuromuscular Agents/therapeutic use ; Proanthocyanidins/therapeutic use ; Probiotics/therapeutic use ; Recurrence ; Spinal Cord Injuries/complications ; Urinary Bladder, Neurogenic/complications ; Urinary Bladder, Neurogenic/drug therapy ; Urinary Catheterization/methods ; Urinary Catheters ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/etiology ; Urinary Tract Infections/prevention & control
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents, Urinary ; Antioxidants ; Neuromuscular Agents ; Proanthocyanidins ; proanthocyanidin (18206-61-6) ; Botulinum Toxins, Type A (EC 3.4.24.69) ; Methenamine (J50OIX95QV) ; Mannose (PHA4727WTP) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2014-08-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057354-6
ISSN	1534-6285 ; 1527-2737
ISSN (online)	1534-6285
ISSN	1527-2737
DOI	10.1007/s11934-014-0433-2
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Article ; Online: Pediatric Kidney Transplantation Outcomes in Children with Primary Urological Abnormalities Versus Nonurological Abnormalities: Long-Term Results.

Jahromi, Mona S / Velasquez, Maria C / Blachman-Braun, Ruben / Gosalbez, Rafael / Castellan, Miguel / Labbie, Andrew / Ciancio, Gaetano / Chandar, Jayanthi / Alam, Alireza

The Journal of urology

2019 Volume 203, Issue 2, Page(s) 406–412

Abstract: Purpose: We assessed renal function, graft survival rates and the risk of graft loss in children based on etiology with a focus on differences between urological causes from congenital anomalies of the kidney and urinary tract vs other causes of end ... ...

Abstract	Purpose: We assessed renal function, graft survival rates and the risk of graft loss in children based on etiology with a focus on differences between urological causes from congenital anomalies of the kidney and urinary tract vs other causes of end stage kidney disease. Materials and methods: A retrospective chart review was performed including patients younger than 18 years who underwent kidney transplantation at our institution from December 1984 to November 2010 with the last followup recorded in March 2018. Patient clinical characteristics, demographics and end stage kidney disease etiology were recorded. Patients were divided into the 2 groups of urological (congenital anomalies of the kidney and urinary tract) vs nonurological based on end stage kidney disease etiology, and survival analysis was performed. Results: Of 112 kidney transplant cases 90 (80.4%) were associated with nonurological causes and 22 (19.6%) with urological causes. Median (IQR) patient age at transplantation was 12 (7-15) years. Median graft survival time was not statistically different according to end stage kidney disease etiology (nonurological 12 years 95% CI 10.01-13.99 vs urological 16 years 95% CI 7.59-24.41, p=0.532). There was a significant risk of graft loss in patients with urinary tract infections after transplantation (HR 3.15, 95% CI 1.59-6.25, p=0.001). Conclusions: Children requiring transplantation due to urological causes have no disadvantage in graft survival compared to children with end stage kidney disease with other causes. Patients with urinary tract infection after transplantation had a higher rate of graft loss.
MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Male ; Postoperative Complications/epidemiology ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Urinary Tract/abnormalities ; Urinary Tract/surgery
Language	English
Publishing date	2019-09-05
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000000528
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Article: The Situation of Chemokine Ligands and Receptors Gene Expression, Following the Oral Administration of Drug Mannuronic Acid in Rheumatoid Arthritis Patients.

Aslani, Mona / Ahmadzadeh, Arman / Rezaieyazdi, Zahra / Mortazavi-Jahromi, Seyed S / Barati, Anis / Hosseini, Mostafa / Mirshafiey, Abbas

Recent patents on inflammation & allergy drug discovery

2019 Volume 14, Issue 1, Page(s) 69–77

Abstract: Background: Regarding the leukocytes infiltration into the synovium of Rheumatoid Arthritis (RA) patients is mostly mediated by chemokine ligands and receptors, and following the efficient and motivating results of international Phase III clinical trial ...

Abstract	Background: Regarding the leukocytes infiltration into the synovium of Rheumatoid Arthritis (RA) patients is mostly mediated by chemokine ligands and receptors, and following the efficient and motivating results of international Phase III clinical trial of β-D-Mannuronic acid (M2000) patented EP067919 (2017), as a novel anti-inflammatory drug, in patients with RA, the present research was designed. Objectives: This study aimed to assess the oral administration effects of this new drug on gene expression of some chemokine receptors and ligands, including CXCR4, CXCR3, CCR2, CCR5 and CCL2/MCP-1 in PBMCs of patients with active form of RA. Methods: Twelve patients suffering from RA, with inadequate response to conventional drugs were selected (Clinical trial identifier IRCT2017100213739N10) and 1000mg/day of M2000 was orally administrated to them for 12 weeks. The mRNA expression of target molecules was then evaluated in PBMCs of the patients before and after treatment with M2000 using real-time PCR and was compared to healthy controls. Patents related to this study were also reviewed. Results: The results showed that M2000 was able to significantly down-regulate the mRNA expression of CXCR4, CCR2 and CCL2/MCP-1 in the PBMCs of the RA patients. It should be noted that the gene expression situation of the target molecules was in coordinate with the clinical and paraclinical assessments in the patients. Conclusion: Taken together, the results of this investigation revealed the part of molecular and immunological mechanisms of drug Mannuronic acid (M2000) in the treatment of RA, based on chemokine ligands and receptors mediated processes.
MeSH term(s)	Administration, Oral ; Adolescent ; Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Chemokines/metabolism ; Female ; Gene Expression Regulation/drug effects ; Hexuronic Acids/administration & dosage ; Hexuronic Acids/pharmacology ; Humans ; Leukocytes, Mononuclear/drug effects ; Male ; Middle Aged ; Patents as Topic ; Receptors, Chemokine/genetics ; Young Adult
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Chemokines ; Hexuronic Acids ; Receptors, Chemokine ; mannuronic acid (980IT47Y34)
Language	English
Publishing date	2019-11-15
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1872-213X
ISSN	1872-213X
DOI	10.2174/1872213X13666191114111822
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Article ; Online: Partial protection of Sinopharm vaccine against SARS COV2 during recent outbreak in Bahrain.

Jahromi, Mohamed / Al Sheikh, Mona Hmoud

Microbial pathogenesis

2021 Volume 158, Page(s) 105086

Abstract: ... due to lack of its potential to detect recent variations in the protein structure of spike(S) protein ...

Abstract	Background: In order to impart immunity against SARS COV 2 in the community, the oil rich countries of the Gulf Cooperation Council (GCC) provided citizens and expatriates with free vaccination. Different types of vaccination brands were utilized for this purpose. The purpose of this study is to determine the efficacy of the different types of vaccinations used. Methods: This is an observational analytical case study of one Bahraini family who were vaccinated with 1st, 2nd or no dose. Results: Out of 22 double dose recipients of SARS COV2 vaccine, 20 were infected. Those 20 were vaccinated against SARS COV 2 using Sinopharm, the rest (2) were in direct contact with the source but were vaccinated against SARS COV 2 using other type of vaccine. Out of 26 single dose recipients of Sinopharm vaccine, 23 were infected. The other three were not in direct contact with the infected source. Social gathering has been the main source of transmission. The infection has been mild with headache, chest pain. From 20 cases with double dose vaccinations only one had a lung infection and needed hospitalization. Out of 23 cases with single dose vaccinations 10 were hospitalized due to lung infections. All family members who were not vaccinated were infected, three were hospitalized one of which was deceased due to diabetes mellitus complications. Conlcusion: Sinopharm provides partial protection against SARS COV 2 infection. That might be due to lack of its potential to detect recent variations in the protein structure of spike(S) protein of virus.
MeSH term(s)	Bahrain/epidemiology ; COVID-19 ; COVID-19 Vaccines ; Disease Outbreaks ; Humans ; RNA, Viral ; SARS-CoV-2 ; Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Viral ; Vaccines
Language	English
Publishing date	2021-07-11
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2021.105086
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Article: Partial protection of Sinopharm vaccine against SARS COV2 during recent outbreak in Bahrain

Jahromi, Mohamed / Al Sheikh, Mona Hmoud

Microbial pathogenesis. 2021 Sept., v. 158

2021

Abstract: ... of spike(S) protein of virus. ...

Abstract	In order to impart immunity against SARS COV 2 in the community, the oil rich countries of the Gulf Cooperation Council (GCC) provided citizens and expatriates with free vaccination. Different types of vaccination brands were utilized for this purpose. The purpose of this study is to determine the efficacy of the different types of vaccinations used.This is an observational analytical case study of one Bahraini family who were vaccinated with 1st, 2nd or no dose.Out of 22 double dose recipients of SARS COV2 vaccine, 20 were infected. Those 20 were vaccinated against SARS COV 2 using Sinopharm, the rest (2) were in direct contact with the source but were vaccinated against SARS COV 2 using other type of vaccine. Out of 26 single dose recipients of Sinopharm vaccine, 23 were infected. The other three were not in direct contact with the infected source. Social gathering has been the main source of transmission. The infection has been mild with headache, chest pain. From 20 cases with double dose vaccinations only one had a lung infection and needed hospitalization. Out of 23 cases with single dose vaccinations 10 were hospitalized due to lung infections. All family members who were not vaccinated were infected, three were hospitalized one of which was deceased due to diabetes mellitus complications.Sinopharm provides partial protection against SARS COV 2 infection. That might be due to lack of its potential to detect recent variations in the protein structure of spike(S) protein of virus.
Keywords	case studies ; chest ; diabetes mellitus ; direct contact ; headache ; immunity ; lungs ; oils ; pathogenesis ; protein structure ; vaccination ; vaccines ; viruses ; Bahrain
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2021.105086
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Article ; Online: Copy Number Alterations and Methylation in Ewing's Sarcoma.

Jahromi, Mona S / Jones, Kevin B / Schiffman, Joshua D

Sarcoma

2011 Volume 2011, Page(s) 362173

Abstract: Ewing's sarcoma is the second most common bone malignancy affecting children and young adults. The prognosis is especially poor in metastatic or relapsed disease. The cell of origin remains elusive, but the EWS-FLI1 fusion oncoprotein is present in the ... ...

Abstract	Ewing's sarcoma is the second most common bone malignancy affecting children and young adults. The prognosis is especially poor in metastatic or relapsed disease. The cell of origin remains elusive, but the EWS-FLI1 fusion oncoprotein is present in the majority of cases. The understanding of the molecular basis of Ewing's sarcoma continues to progress slowly. EWS-FLI1 affects gene expression, but other factors must also be at work such as mutations, gene copy number alterations, and promoter methylation. This paper explores in depth two molecular aspects of Ewing's sarcoma: copy number alterations (CNAs) and methylation. While CNAs consistently have been reported in Ewing's sarcoma, their clinical significance has been variable, most likely due to small sample size and tumor heterogeneity. Methylation is thought to be important in oncogenesis and balanced karyotype cancers such as Ewing's, yet it has received only minimal attention in prior studies. Future CNA and methylation studies will help to understand the molecular basis of this disease.
Language	English
Publishing date	2011-03-15
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1338527-6
ISSN	1369-1643 ; 1357-714X
ISSN (online)	1369-1643
ISSN	1357-714X
DOI	10.1155/2011/362173
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Article ; Online: The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients.

Mortazavi-Jahromi, Seyed Shahabeddin / Ahmadzadeh, Arman / Rezaieyazdi, Zahra / Aslani, Mona / Omidian, Saiedeh / Mirshafiey, Abbas

Immunopharmacology and immunotoxicology

2020 Volume 42, Issue 3, Page(s) 228–236

Abstract: Context: ...

Abstract	Context:
MeSH term(s)	Adolescent ; Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Cytokines/blood ; Female ; Hexuronic Acids/therapeutic use ; Humans ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-6/blood ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; MicroRNAs/genetics ; Middle Aged ; NF-kappa B/genetics ; Treatment Outcome ; Tumor Necrosis Factor-alpha/blood ; Young Adult
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Cytokines ; Hexuronic Acids ; IL6 protein, human ; Interleukin-6 ; Intracellular Signaling Peptides and Proteins ; MIRN146 microRNA, human ; MicroRNAs ; NF-kappa B ; TNF protein, human ; Tifab protein, human ; Tumor Necrosis Factor-alpha ; mannuronic acid (980IT47Y34) ; IRAK1 protein, human (EC 2.7.11.1) ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2020-03-29
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2020.1742734
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