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  1. Article ; Online: Optical and scintillation properties of hybrid manganese(II) bromides with formamidinium and acetamidinium cations.

    Fateev, Sergey A / Kozhevnikova, Vladislava Y / Kuznetsov, Kirill M / Belikova, Daria E / Khrustalev, Victor N / Goodilin, Eugene A / Tarasov, Alexey B

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 6, Page(s) 2722–2730

    Abstract: In recent years, hybrid manganese(II) halides (HMHs) have attracted wide attention due to their impressive optical properties, low toxicity, and facile synthetic processibility. Being effective reabsorption-free phosphors, these compounds demonstrate the ...

    Abstract In recent years, hybrid manganese(II) halides (HMHs) have attracted wide attention due to their impressive optical properties, low toxicity, and facile synthetic processibility. Being effective reabsorption-free phosphors, these compounds demonstrate the potential to be used as low-cost solution-processable scintillators. However, most of the HMHs studied to date contain bulk organic cations and, as a result, are characterized by low density and low X-ray stopping power. For this reason, we studied manganese(II) bromides with compact organic cations such as formamidinium (FA
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03452f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress.

    Qu, Jia-Hua / Chakir, Khalid / Tarasov, Kirill V / Riordon, Daniel R / Perino, Maria Grazia / Silvester, Allwin Jennifa / Lakatta, Edward G

    eLife

    2024  Volume 12

    Abstract: Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge ...

    Abstract Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) which included overexpression of a large number of proteins. Here, we conducted an unbiased phosphoproteomics analysis in order to determine the role of altered protein phosphorylation in the adaptive heart performance and protection profile of adult TGAC8 left ventricle (LV) at 3-4 months of age, and integrated the phosphoproteome with transcriptome and proteome. Based on differentially regulated phosphoproteins by genotype, numerous stress-response pathways within reprogrammed TGAC8 LV, including PKA, PI3K, and AMPK signaling pathways, predicted upstream regulators (e.g. PDPK1, PAK1, and PTK2B), and downstream functions (e.g. cell viability, protein quality control), and metabolism were enriched. In addition to PKA, numerous other kinases and phosphatases were hyper-phosphorylated in TGAC8 vs. WT. Hyper-phosphorylated transcriptional factors in TGAC8 were associated with increased mRNA transcription, immune responses, and metabolic pathways. Combination of the phosphoproteome with its proteome and with the previously published TGAC8 transcriptome enabled the elucidation of cardiac performance and adaptive protection profiles coordinately regulated at post-translational modification (PTM) (phosphorylation), translational, and transcriptional levels. Many stress-response signaling pathways, i.e., PI3K/AKT, ERK/MAPK, and ubiquitin labeling, were consistently enriched and activated in the TGAC8 LV at transcriptional, translational, and PTM levels. Thus, reprogramming of the cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress. We identified numerous pathways/function predictions via gene sets, phosphopeptides, and phosphoproteins, which may point to potential novel therapeutic targets to enhance heart adaptivity, maintaining heart performance while avoiding cardiac dysfunction.
    MeSH term(s) Adult ; Humans ; Proteome ; Adenylyl Cyclases/genetics ; Transcriptome ; Resilience, Psychological ; Phosphatidylinositol 3-Kinases ; Phosphoproteins/genetics ; 3-Phosphoinositide-Dependent Protein Kinases
    Chemical Substances Proteome ; Adenylyl Cyclases (EC 4.6.1.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphoproteins ; PDPK1 protein, human (EC 2.7.11.1) ; 3-Phosphoinositide-Dependent Protein Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88732
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  3. Article ; Online: Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice.

    Qu, Jia-Hua / Tarasov, Kirill V / Tarasova, Yelena S / Chakir, Khalid / Lakatta, Edward G

    Fortune journal of health sciences

    2023  Volume 6, Issue 3, Page(s) 332–356

    Abstract: Advancing age is the most important risk factor for cardiovascular diseases (CVDs). Two types of cells, within the heart pacemaker, sinoatrial node (SAN), and within the left ventricle (LV), control two crucial characteristics of heart function, heart ... ...

    Abstract Advancing age is the most important risk factor for cardiovascular diseases (CVDs). Two types of cells, within the heart pacemaker, sinoatrial node (SAN), and within the left ventricle (LV), control two crucial characteristics of heart function, heart beat rate and contraction strength. As age advances, the heart's structure becomes remodeled, and SAN and LV cell functions deteriorate, thus increasing the risk for CVDs. However, the different molecular features of age-associated changes in SAN and LV cells have never been compared in omics scale in the context of aging. We applied deep RNA sequencing to four groups of samples, young LV, old LV, young SAN and old SAN, followed by numerous bioinformatic analyses. In addition to profiling the differences in gene expression patterns between the two heart chambers (LV vs. SAN), we also identified the chamber-specific concordant or discordant age-associated changes in: (1) genes linked to energy production related to cardiomyocyte contraction, (2) genes related to post-transcriptional processing, (3) genes involved in KEGG longevity regulating pathway, (4) prolongevity and antilongevity genes recorded and curated in the GenAge database, and (5) CVD marker genes. Our bioinformatic analysis also predicted the regulation activities and mapped the expression of upstream regulators including transcription regulators and post-transcriptional regulator miRNAs. This comprehensive analysis promotes our understanding of regulation of heart functions and will enable discovery of gene-specific therapeutic targets of CVDs in advanced age.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ISSN 2644-2906
    ISSN (online) 2644-2906
    DOI 10.26502/fjhs.134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: EFFECT OF FARMING TECHNOLOGIES INTENSIFICATION ON WHEAT YIELD IN THE DRY STEPPE OF SIBERIA

    Kirill O. Tarasov / Elena V. Ponkina / Aliya B. Nugumanova

    Siberian Journal of Life Sciences and Agriculture, Vol 14, Iss 2, Pp 401-

    AN ANALYSIS BASED ON THE METHOD OF PROPENSITY SCORE MATCHING

    2022  Volume 426

    Abstract: The study examines the effect of crop production technology intensification on wheat yield under drought conditions. The causal effect of fertilizers and herbicides usage was quantified based on a dataset of reports from 196 farms located in the Kulunda ... ...

    Abstract The study examines the effect of crop production technology intensification on wheat yield under drought conditions. The causal effect of fertilizers and herbicides usage was quantified based on a dataset of reports from 196 farms located in the Kulunda Steppe in Altai Krai. To quantify causal effects, the various methods were tested – Two Means Comparison tests and Linear regression. Due to the not experimental nature of the data, Propensity Score Matching was used to balance the sample based on the main indicative signs (covariates). We refined the effects of crop technologies intensification based on the balanced sample. The results showed that, according to all considered methods, intensification of agriculture even in the dry climatic conditions resulted in the expected growth of wheat yield. The average causal effect of intensive farming was +2.02 dt/ha. The results also showed that it is possible to obtain more correct estimates of causal effects based on balanced samples. Using simple approaches like Two Means Comparison methods lead to underestimation or overestimation. Finally, we highlighted some limitations and peculiarities of the Propensity Score Matching method. However, the Propensity Score Matching can be considered a good and prospective tool for developing digital services in agricultural analytics.
    Keywords causal effect ; two means comparison ; propensity score matching ; wheat yield ; intensive farming ; steppe ; siberia ; Agriculture ; S ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Science and Innovation Center Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Modification of Some Structural and Functional Parameters of Living Culture of

    Cepoi, Liliana / Zinicovscaia, Inga / Chiriac, Tatiana / Rudi, Ludmila / Yushin, Nikita / Grozdov, Dmitrii / Tasca, Ion / Kravchenko, Elena / Tarasov, Kirill

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Selenium nanoparticles are attracting the attention of researchers due to their multiple applications, including medicine. The biosynthesis of selenium nanoparticles has become particularly important due to the environmentally friendly character of the ... ...

    Abstract Selenium nanoparticles are attracting the attention of researchers due to their multiple applications, including medicine. The biosynthesis of selenium nanoparticles has become particularly important due to the environmentally friendly character of the process and special properties of the obtained particles. The possibility of performing the biosynthesis of selenium nanoparticles via the living culture of
    Language English
    Publishing date 2023-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16020852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cytobacillus pseudoceanisediminis sp. nov., A Novel Facultative Methylotrophic Bacterium with High Heavy Metal Resistance Isolated from the Deep Underground Saline Spring

    Tarasov, Kirill / Yakhnenko, Alena / Zarubin, Mikhail / Gangapshev, Albert / Potekhina, Natalia V. / Avtukh, Alexander N. / Kravchenko, Elena

    Curr Microbiol. 2023 Jan., v. 80, no. 1 p.31-31

    2023  

    Abstract: In this study, we present the characterization of the BNO1ᵀ bacterial strain isolated from the deep subsurface saline spring at the Baksan Neutrino Observatory INR RAS (Kabardino-Balkaria, Russia). The complete genome sequence of the strain BNO1ᵀ is 5, ... ...

    Abstract In this study, we present the characterization of the BNO1ᵀ bacterial strain isolated from the deep subsurface saline spring at the Baksan Neutrino Observatory INR RAS (Kabardino-Balkaria, Russia). The complete genome sequence of the strain BNO1ᵀ is 5,347,902 bp, with a GC content 41 and 49%. The cell wall peptidoglycan contains meso-diaminopimelic acid. The major isoprenoid quinone is MK-7 and the polar lipids are diphosphatidylglycerol, phosphatidylglycerol, and phosphatidylethanolamine. The major fatty acids are anteiso-C₁₅:₀ (23.34%), iso-C₁₅:₀ (20.10%), C₁₆:₀ (11.96%), iso-C₁₆:₀ (10.88%), and anteiso-C₁₇:₀ (10.79%). The 16S rRNA gene sequence clearly demarcated the strain as belonging to Cytobacillus genera. Based on the phylogenetic analysis, ANI (average nucleotide identity) and dDDH (digital DNA-DNA hybridization) assessments we propose to assign the strain BNO1ᵀ and other related strains to new species and to name it Cytobacillus pseudoceanisediminis sp. nov. (The values of ANI and dDDH between BNO1ᵀ and Cytobacillus oceanisediminis CGMCC 1.10115 ᵀ are 80.65% and 24.7%, respectively; values of ANI and dDDH between BNO1ᵀ and Cytobacillus firmus NCTC 10335 ᵀ are 89% and 38%, respectively). Genomic analysis of strain BNO1ᵀ revealed pathways for C1 compounds oxidation and two pathways for C1 compounds assimilation: serine and ribulose monophosphate pathways. In addition, strain BNO1ᵀ contains a plasmid (342,541 bp) coding multiple genes involved in heavy metal ion balance. Moreover, heavy metal toxicity testing confirmed the high potential of the strain BNO1ᵀ as a source of metal resistance genes and enzymes. The type strain is BNO1ᵀ (= BIM B-1921 ᵀ = VKM B-3664 ᵀ).
    Keywords Russia ; bacteria ; cell walls ; genomics ; heavy metals ; isoprenoids ; metal tolerance ; new species ; nucleic acid hybridization ; nucleotide sequences ; oxidation ; peptidoglycans ; phosphatidylethanolamines ; phylogeny ; plasmids ; quinones ; ribulose ; serine ; spring ; toxicity
    Language English
    Dates of publication 2023-01
    Size p. 31.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-03141-8
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome.

    Qu, Jia-Hua / Tarasov, Kirill V / Chakir, Khalid / Tarasova, Yelena S / Riordon, Daniel R / Lakatta, Edward G

    Cells

    2022  Volume 11, Issue 21

    Abstract: ... ...

    Abstract Rationale
    MeSH term(s) Mice ; Animals ; Proteomics ; 14-3-3 Proteins/metabolism ; Mitochondria/metabolism ; Heart ; Immunoprecipitation
    Chemical Substances 14-3-3 Proteins
    Language English
    Publishing date 2022-11-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11213496
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  8. Article ; Online: Cytobacillus pseudoceanisediminis sp. nov., A Novel Facultative Methylotrophic Bacterium with High Heavy Metal Resistance Isolated from the Deep Underground Saline Spring.

    Tarasov, Kirill / Yakhnenko, Alena / Zarubin, Mikhail / Gangapshev, Albert / Potekhina, Natalia V / Avtukh, Alexander N / Kravchenko, Elena

    Current microbiology

    2022  Volume 80, Issue 1, Page(s) 31

    Abstract: In this study, we present the characterization of the ... ...

    Abstract In this study, we present the characterization of the BNO1
    MeSH term(s) RNA, Ribosomal, 16S/genetics ; Phylogeny ; Metals, Heavy ; DNA
    Chemical Substances RNA, Ribosomal, 16S ; Metals, Heavy ; DNA (9007-49-2)
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-022-03141-8
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  9. Article ; Online: Profiling of Yeast Lipids by Shotgun Lipidomics.

    Klose, Christian / Tarasov, Kirill

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1361, Page(s) 309–324

    Abstract: Lipidomics is a rapidly growing technology for identification and quantification of a variety of cellular lipid molecules. Following the successful development and application of functional genomic technologies in yeast Saccharomyces cerevisiae, we ... ...

    Abstract Lipidomics is a rapidly growing technology for identification and quantification of a variety of cellular lipid molecules. Following the successful development and application of functional genomic technologies in yeast Saccharomyces cerevisiae, we witness a recent expansion of lipidomics applications in this model organism. The applications include detailed characterization of the yeast lipidome as well as screening for perturbed lipid phenotypes across hundreds of yeast gene deletion mutants. In this chapter, we describe sample handling, mass spectrometry, and bioinformatics methods developed for yeast lipidomics studies.
    MeSH term(s) Computational Biology/methods ; Lipid Metabolism/genetics ; Lipids/biosynthesis ; Lipids/genetics ; Mass Spectrometry/methods ; Saccharomyces cerevisiae/genetics
    Chemical Substances Lipids
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3079-1_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Randomized Clinical Trial of Surgical Versus Percutaneous Versus Hybrid Multivessel Coronary Revascularization: 3 Years' Follow-Up.

    Ganyukov, Vladimir I / Kochergin, Nikita A / Shilov, Aleksandr A / Tarasov, Roman S / Skupien, Jan / Kozyrin, Kirill A / Barbarash, Olga L / Musialek, Piotr

    JACC. Cardiovascular interventions

    2021  Volume 14, Issue 10, Page(s) 1163–1165

    MeSH term(s) Coronary Artery Bypass ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Follow-Up Studies ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Letter ; Randomized Controlled Trial
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2021.02.037
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