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  1. Article ; Online: Traumatic Herniation of Vastus Lateralis Muscle Through a Defect in the Iliotibial Band Fascia.

    Ge, Shuliang / Agrawal, Sachin

    American journal of physical medicine & rehabilitation

    2023  Volume 102, Issue 10, Page(s) e146

    MeSH term(s) Humans ; Quadriceps Muscle ; Fascia ; Muscle, Skeletal ; Fascia Lata
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.100: Show issues Location:
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  2. Article: The Leukemoid Reaction in Severe Alcoholic Hepatitis: A Case Report.

    Reddy, Siva / Agrawal, Sachin / Kumar, Sunil / Acharya, Sourya

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54039

    Abstract: Alcoholic hepatitis (AH) is a clinicopathologic illness caused by excessive alcohol abuse and is a precursor of cirrhosis. The leukemoid reaction (LR) is characterized by a strikingly raised granulocyte count of 40,000-50,000 cells/ ... ...

    Abstract Alcoholic hepatitis (AH) is a clinicopathologic illness caused by excessive alcohol abuse and is a precursor of cirrhosis. The leukemoid reaction (LR) is characterized by a strikingly raised granulocyte count of 40,000-50,000 cells/mm
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Comprehensive Review of the Immunomodulatory Effects of Vitamin D in Sepsis.

    Ahuja, Abhinav / Agrawal, Sachin / Acharya, Sourya / Kumar, Sunil

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53678

    Abstract: Sepsis remains a critical global health challenge characterised by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. This review examines the immunomodulatory effects of Vitamin D in sepsis, focusing on ... ...

    Abstract Sepsis remains a critical global health challenge characterised by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. This review examines the immunomodulatory effects of Vitamin D in sepsis, focusing on its regulation of immune cell function, modulation of cytokine production, and enhancement of antimicrobial responses. While the potential of Vitamin D as an adjunctive therapy in sepsis management is evident, challenges such as variability in Vitamin D status, uncertainties regarding optimal dosages and patient heterogeneity, and potential adverse effects require careful consideration. The review highlights the implications for future research and clinical practice, emphasising the need for standardised measurement protocols, elucidation of optimal supplementation strategies, and integration of Vitamin D assessments into routine care. Despite the complexities, Vitamin D emerges as a promising avenue for personalised interventions in sepsis, necessitating ongoing research collaboration and evidence-based guidelines to harness its full therapeutic potential and improve clinical outcomes.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diagnosis and Treatment of Ankylosing Spondylitis.

    Agrawal, Parv / Tote, Sachin / Sapkale, Bhagyesh

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52559

    Abstract: Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the axial bone and sacroiliac joints. Its etiology is complicated and involves genetic variables, demographic factors (age of onset, gender, ethnicity, family history), ... ...

    Abstract Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the axial bone and sacroiliac joints. Its etiology is complicated and involves genetic variables, demographic factors (age of onset, gender, ethnicity, family history), and environmental variables. It typically manifests in males in their third decade. Galen is credited with first recognizing it, according to historical traditions, but it was not until the 19th century that specific diagnostic criteria were developed. The human leukocyte antigen B27 (HLA-B27) variation, around 20% of the genetic risk, is currently the most significant gene associated with AS susceptibility. Over 100 genes have been connected to AS susceptibility. Clinical signs of AS include stiffness and inflammation in the back, eye inflammation, aortitis (inflammation of the aorta), and spinal ankylosis that impacts posture and fatigue. The dagger sign and sacroiliitis on radiographs, in particular, are crucial for diagnosis. Early inflammatory alterations can be found using modern diagnostic tools such as MRI, and the HLA-B27 gene can help confirm the diagnosis. Overall, 80-95% of people with AS have the HLA-B27 marker. Furthermore, although non-specific, elevated inflammatory markers, such as C-reactive protein and erythrocyte sedimentation rate, offer supporting evidence. Over time, treatment paradigms have seen significant change. First-line treatments such as non-steroidal anti-inflammatory drugs are no longer the only options, even though disease-modifying anti-rheumatic drugs and biologics, especially tumor necrosis factor blockers, have been developed. Physical therapy, which emphasizes consistent exercise, stretches, and posture maintenance, is extremely helpful in managing AS. Surgical interventions can be required in extreme situations. The significance of the interleukin 23/17 axis in the disease cascade has been demonstrated by recent research. Furthermore, a deeper comprehension of the genetic landscape, mainly the functions of non-HLA-B27 loci, may open the door for more specialized therapies. Early diagnosis and interdisciplinary therapies can improve patient outcomes and quality of life as our understanding of AS grows.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Enteric Fever Presenting With Complete Heart Block (CHB): A Rare Case of Reversible Arrhythmia.

    Dhondge, Rushikesh H / Acharya, Sourya / Kumar, Sunil / Agrawal, Sachin / Nimkar, Shubham V

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56121

    Abstract: Salmonella ... ...

    Abstract Salmonella enterica
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56121
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  6. Article ; Online: A new theoretical framework of shopping motives and channel preference behaviour in the digital era

    Agrawal, Durgesh Kumar / Gupta, Sachin

    International Journal of Consumer Studies. 2023 Jan., v. 47, no. 1 p.400-418

    2023  

    Abstract: The unprecedented dissemination of digital technology has changed people's psychology including their shopping behaviour in the last two decades. Smartphone led digital applications and advancements have disrupted consumers' shopping processes, purchase ... ...

    Abstract The unprecedented dissemination of digital technology has changed people's psychology including their shopping behaviour in the last two decades. Smartphone led digital applications and advancements have disrupted consumers' shopping processes, purchase decisions, and priorities as well as increased their exposure, aspirations and expectations inevitably. Therefore, it is imperative to examine the relevance of various elements of shopping motives holistically. Therefore, the present study aims to develop a new theoretical framework based on significant elements of shopping motives for physical products in the digital technology era. For this purpose, an exploratory study, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and structural equation modelling (SEM) were used. EFA generated five latent factors by grouping 18 independent variables. CFA validated latent factor construct and measured model fit. SEM visualized the path analysis and portrayed the pattern of relations between latent factors into a single factor structural model (consumer shopping motives framework). Results show that consumers' shopping priorities are changing as 3 conventional variables (‘role‐playing’, ‘status and authority’, and ‘pleasure of bargaining’) became obsolete and 3 new (‘anywhere and any‐time shopping’, ‘safe and secure digital transaction’, and ‘unbiased reviews and ratings”) came into existence prominently. The format and perspective of ‘fun, entertainment and recreation’ ‘social interaction and communication’, and ‘exposure to new and latest trends' have been changing. Consumers are becoming more technology‐dependent in their shopping processes and purchase decisions. The validation of the framework on channel preference behaviour revealed that consumers largely prefer offline channels for the fulfilment of risk‐free and social sub‐motives, and online channels for convenience sub‐motive. Therefore, broad structural change and clarity, specification of priorities, a shift in the format and perspective of few elements of shopping motives, intrinsic passion for the use of digital technology and web service in the shopping journey, and simplification of antecedents for growing popularity of multi‐channel shopping paradigm are the key novelty of this study.
    Keywords Internet ; equations ; factor analysis ; mobile telephones ; models ; path analysis ; psychology ; recreation ; social behavior
    Language English
    Dates of publication 2023-01
    Size p. 400-418.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2045189-1
    ISSN 1470-6423
    ISSN 1470-6423
    DOI 10.1111/ijcs.12818
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 6399: Show issues

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  7. Article: Unraveling Neurological Shades: Vitamin D Toxication and Central Pontine Myelinolysis Exposed.

    Ahuja, Abhinav / Agrawal, Sachin / Daiya, Varun / Batra, Nitish / Agarwal, Aaditi

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53806

    Abstract: This case report is about a middle-aged female who presented with complaints of pain in the abdomen with intractable vomiting for three months, pain and weakness in bilateral lower limbs for two months, and irritability for three days. She was previously ...

    Abstract This case report is about a middle-aged female who presented with complaints of pain in the abdomen with intractable vomiting for three months, pain and weakness in bilateral lower limbs for two months, and irritability for three days. She was previously treated for lumbar disc bulge and severe narrowing of the spinal cord whose treatment also included vitamin D supplements. After taking high doses of a vitamin D supplement daily for approximately four months, it resulted in vitamin D toxicity. The sodium level of the patient was in the normal range throughout the treatment. Her magnetic resonance imaging brain revealed features of central pontine myelinolysis. The development of central pontine myelinolysis due to vitamin D toxicity, with normal sodium levels, makes this a rare case for discussion.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Monkeypox: The Re-emerging Terror.

    Sapkal, Anuja / Agrawal, Sachin

    Cureus

    2022  Volume 14, Issue 8, Page(s) e28597

    Abstract: Monkeypox is a zoonotic Orthopoxvirus called human Monkeypox. It has symptoms that resemble or are pretty similar to smallpox. Monkeypox virus belongs to the genus Orthopoxvirus, which also includes cowpox, vaccinia, and variola viruses. The World Health ...

    Abstract Monkeypox is a zoonotic Orthopoxvirus called human Monkeypox. It has symptoms that resemble or are pretty similar to smallpox. Monkeypox virus belongs to the genus Orthopoxvirus, which also includes cowpox, vaccinia, and variola viruses. The World Health Organization confirmed in 1970 that the primary virus is the Orthopoxvirus infecting humans after smallpox elimination. Clinically distinguishing the condition from varicella and smallpox is challenging for a clinician. Although the mortality rate of this disease is low, new tests are being tried and studied, which are required for a more accurate and quick diagnosis because the lab diagnosis is the key to the detection of illness and its monitoring. The illness or the virus is endemic to parts of western and central Africa. Surveillance in underdeveloped rural regions is challenging but manageable with evidence-based techniques and training materials for public health professionals. However, as in the present scenario, the disease is having a worldwide outbreak in various countries, and recently India detected its first case on 15 July 2022 in New Delhi. The widespread disease is due to trading exotic pets and international travel. Since smallpox vaccinations are not administered to people regularly, epidemiological studies are required. New medications and vaccines provide hope for treating and preventing Monkeypox; however, further study is required before they can be used effectively. Also, there is a requirement for advanced scientific studies in the etiology, epidemiology, and biological structure of the virus in the endemic zones to know and halt the spread of infection to humans.
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.28597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Migraine and Neuromodulation: A Literature Review.

    Tiwari, Varun / Agrawal, Sachin

    Cureus

    2022  Volume 14, Issue 11, Page(s) e31223

    Abstract: Migraine is not only known to be one of the most common causes of a headache around the globe but is also the leading neurologic cause of disability worldwide. Migraine has significant social and economic effects. It not only hampers patients' quality of ...

    Abstract Migraine is not only known to be one of the most common causes of a headache around the globe but is also the leading neurologic cause of disability worldwide. Migraine has significant social and economic effects. It not only hampers patients' quality of life but also hampers work, public conduct, and family life. Migraine is one of the leading causes of morbidity in the world, so effective management is critical. Currently, medical management is the mainstay remedial approach for migraine, but with time, non-pharmacological approaches, especially neuromodulation, are gaining popularity with a shred of solid backing evidence. Neuromodulation is the process in which specific devices are used to excite the central nervous system or peripheral nervous system with electric or magnetic, or any other form of energy to regulate the abnormal behavior of neural pathways that have occurred due to the disease process. Neuromodulation devices as approved by Food and Drug Administration include non-invasive Vagus nerve stimulators, single-pulse transcranial magnetic stimulators, and transcutaneous supraorbital neurostimulators. The purpose of this study is to summarize the information about the advances relating to neuromodulation concerning managing and preventing migraine. This Narrative review article is prepared after analyzing various research papers and publications on PubMed and Google Scholar. This article holds brief information on understanding neuromodulation, its mechanism, its implication in managing migraine, and its different modalities with their mechanism of action and contraindications. These neuromodulation techniques can certainly be used to deal with acute migraine attacks and inhibit their progression to chronic illness. Research is required on the application of neuromodulation in the early diagnosis of migraine, which is what we still lack as a whole medical fraternity.
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.31223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author's reply.

    Sen, Alok / Mehta, Sonali / Sule, Ashita / More, Amruta / Shetty, Sachin / Singh, Jayanti / Tripathi, Shubhi / Agrawal, Rupesh / Talwar, Dinesh

    Retina (Philadelphia, Pa.)

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000004070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1724: Show issues Location:
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