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  1. Article ; Online: Multistate Mumps Outbreak Originating from Asymptomatic Transmission at a Nebraska Wedding - Six States, August-October 2019.

    Donahue, Matthew / Hendrickson, Blake / Julian, Derek / Hill, Nicholas / Rother, Julie / Koirala, Samir / Clayton, Joshua L / Safranek, Thomas / Buss, Bryan

    MMWR. Morbidity and mortality weekly report

    2020  Volume 69, Issue 22, Page(s) 666–669

    Abstract: In August 2019, 30 attendees at a Nebraska wedding developed mumps after being exposed to one asymptomatic index patient who was fully vaccinated according to Advisory Committee on Immunization Practices (ACIP) recommendations (1), resulting in a ... ...

    Abstract In August 2019, 30 attendees at a Nebraska wedding developed mumps after being exposed to one asymptomatic index patient who was fully vaccinated according to Advisory Committee on Immunization Practices (ACIP) recommendations (1), resulting in a multistate outbreak. A public health investigation and response revealed epidemiologic links that extended from the index patient through secondary, tertiary, and quaternary patients and culminated in a measles-mumps-rubella (MMR) booster vaccination campaign in the local community where approximately half of the patients resided.
    MeSH term(s) Adolescent ; Adult ; Asymptomatic Diseases ; Child ; Disease Outbreaks ; Female ; Humans ; Immunization Schedule ; Male ; Marriage ; Measles-Mumps-Rubella Vaccine/administration & dosage ; Middle Aged ; Mumps/epidemiology ; Mumps/prevention & control ; Mumps/transmission ; Nebraska/epidemiology ; United States/epidemiology ; Young Adult
    Chemical Substances Measles-Mumps-Rubella Vaccine
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm6922a2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Molecular markers of tumor progression in melanoma.

    Rother, Joshua / Jones, Dan

    Current genomics

    2009  Volume 10, Issue 4, Page(s) 231–239

    Abstract: Malignant melanoma represents one of the most aggressive malignancies but outcome is highly variable with early tumor lesions having an excellent prognosis following resection. We review here the data on identification of genes involved in the ... ...

    Abstract Malignant melanoma represents one of the most aggressive malignancies but outcome is highly variable with early tumor lesions having an excellent prognosis following resection. We review here the data on identification of genes involved in the progression of melanoma as a result of expression array studies, genomic profiling, and genetic models. We focus on the role of tumor suppressors involved in cell cycle function, DNA repair, and genome maintenance. Highlighted are the roles of loss of p16 in promoting neoplasia in cooperation with deregulated MAPK signaling, and the role of loss of the RASSF1A protein in promoting chromosomal instability. The interactions between point mutation in growth signaling molecules and epigenetic changes in genes involved in DNA repair and cell division are discussed.
    Language English
    Publishing date 2009-11-02
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2033677-9
    ISSN 1875-5488 ; 1389-2029
    ISSN (online) 1875-5488
    ISSN 1389-2029
    DOI 10.2174/138920209788488526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erratum to: Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers.

    Wei, Chongjuan / Peng, Bo / Han, Younghun / Chen, Wei V / Rother, Joshua / Tomlinson, Gail E / Richard Boland, C / Chaussabel, Damien / Frazier, Marsha L / Amos, Christopher I

    Familial cancer

    2015  Volume 14, Issue 2, Page(s) 307

    Language English
    Publishing date 2015-06
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-015-9801-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6099: Show issues Location:
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  4. Article ; Online: Reduced fire severity offers near-term buffer to climate-driven declines in conifer resilience across the western United States.

    Davis, Kimberley T / Robles, Marcos D / Kemp, Kerry B / Higuera, Philip E / Chapman, Teresa / Metlen, Kerry L / Peeler, Jamie L / Rodman, Kyle C / Woolley, Travis / Addington, Robert N / Buma, Brian J / Cansler, C Alina / Case, Michael J / Collins, Brandon M / Coop, Jonathan D / Dobrowski, Solomon Z / Gill, Nathan S / Haffey, Collin / Harris, Lucas B /
    Harvey, Brian J / Haugo, Ryan D / Hurteau, Matthew D / Kulakowski, Dominik / Littlefield, Caitlin E / McCauley, Lisa A / Povak, Nicholas / Shive, Kristen L / Smith, Edward / Stevens, Jens T / Stevens-Rumann, Camille S / Taylor, Alan H / Tepley, Alan J / Young, Derek J N / Andrus, Robert A / Battaglia, Mike A / Berkey, Julia K / Busby, Sebastian U / Carlson, Amanda R / Chambers, Marin E / Dodson, Erich Kyle / Donato, Daniel C / Downing, William M / Fornwalt, Paula J / Halofsky, Joshua S / Hoffman, Ashley / Holz, Andrés / Iniguez, Jose M / Krawchuk, Meg A / Kreider, Mark R / Larson, Andrew J / Meigs, Garrett W / Roccaforte, John Paul / Rother, Monica T / Safford, Hugh / Schaedel, Michael / Sibold, Jason S / Singleton, Megan P / Turner, Monica G / Urza, Alexandra K / Clark-Wolf, Kyra D / Yocom, Larissa / Fontaine, Joseph B / Campbell, John L

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 11, Page(s) e2208120120

    Abstract: Increasing fire severity and warmer, drier postfire conditions are making forests in the western United States (West) vulnerable to ecological transformation. Yet, the relative importance of and interactions between these drivers of forest change remain ... ...

    Abstract Increasing fire severity and warmer, drier postfire conditions are making forests in the western United States (West) vulnerable to ecological transformation. Yet, the relative importance of and interactions between these drivers of forest change remain unresolved, particularly over upcoming decades. Here, we assess how the interactive impacts of changing climate and wildfire activity influenced conifer regeneration after 334 wildfires, using a dataset of postfire conifer regeneration from 10,230 field plots. Our findings highlight declining regeneration capacity across the West over the past four decades for the eight dominant conifer species studied. Postfire regeneration is sensitive to high-severity fire, which limits seed availability, and postfire climate, which influences seedling establishment. In the near-term, projected differences in recruitment probability between low- and high-severity fire scenarios were larger than projected climate change impacts for most species, suggesting that reductions in fire severity, and resultant impacts on seed availability, could partially offset expected climate-driven declines in postfire regeneration. Across 40 to 42% of the study area, we project postfire conifer regeneration to be likely following low-severity but not high-severity fire under future climate scenarios (2031 to 2050). However, increasingly warm, dry climate conditions are projected to eventually outweigh the influence of fire severity and seed availability. The percent of the study area considered unlikely to experience conifer regeneration, regardless of fire severity, increased from 5% in 1981 to 2000 to 26 to 31% by mid-century, highlighting a limited time window over which management actions that reduce fire severity may effectively support postfire conifer regeneration.
    MeSH term(s) Fires ; Wildfires ; Climate ; Climate Change ; Tracheophyta
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2208120120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  5. Article ; Online: Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers.

    Wei, Chongjuan / Peng, Bo / Han, Younghun / Chen, Wei V / Rother, Joshua / Tomlinson, Gail E / Boland, C Richard / Chaussabel, Damien / Chaussabel, Marc / Frazier, Marsha L / Amos, Christopher I

    Familial cancer

    2015  Volume 14, Issue 2, Page(s) 297–306

    Abstract: We studied a large family that presented a strong familial susceptibility to multiple early onset cancers including prostate, breast, colon, and several other uncommon cancers. Through targeted gene, linkage, and whole genome sequencing analyses, we show ...

    Abstract We studied a large family that presented a strong familial susceptibility to multiple early onset cancers including prostate, breast, colon, and several other uncommon cancers. Through targeted gene, linkage, and whole genome sequencing analyses, we show that the presence of a variant in the regulatory region of HNRNPA0 associated with elevated cancer incidence in this family (Hazard ratio = 7.20, p = 0.0004). Whole genome sequencing identified a second rare protein changing mutation of WIF1 that interacted with the HNRNPA0 variant resulting in extremely high risk for cancer in carriers of mutations in both genes (p = 1.98 × 10(-13)). Analysis of downstream targets of the mutations in these two genes showed that the HNRNPA0 mutation affected expression patterns in the PI3 kinase and ERK/MAPK signaling pathways, while the WIF1 variant influenced expression of genes that play a role in NAD biosynthesis. This is a first report of variation in HNRNPA0 influencing common cancers or of a striking interaction between rare variants coexisting in an extended pedigree and jointly affecting cancer risk.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Genetic Linkage ; Genetic Predisposition to Disease ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Repressor Proteins/genetics
    Chemical Substances Adaptor Proteins, Signal Transducing ; HNRNPA0 protein, human ; Heterogeneous-Nuclear Ribonucleoproteins ; Repressor Proteins ; WIF1 protein, human
    Language English
    Publishing date 2015-02-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-014-9758-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6099: Show issues Location:
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  6. Article ; Online: Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis.

    Wang, Wei-Lien / Hornick, Jason L / Mallipeddi, Raj / Zelger, Bettina G / Rother, Joshua D / Yang, Dan / Lev, Dina C / Trent, Jonathan C / Prieto, Victor G / Brenn, Thomas / Robson, Alistair / Calonje, Eduardo / Lazar, Alexander J F

    The American Journal of dermatopathology

    2009  Volume 31, Issue 3, Page(s) 297–300

    Abstract: Gastrointestinal stromal tumors (GISTs) rarely metastasize to the skin. We describe 5 patients with GIST with subcutaneous and cutaneous metastases. The mean age at metastasis was 54 years (range 30-68 years) with a male predominance (4:1). Primary ... ...

    Abstract Gastrointestinal stromal tumors (GISTs) rarely metastasize to the skin. We describe 5 patients with GIST with subcutaneous and cutaneous metastases. The mean age at metastasis was 54 years (range 30-68 years) with a male predominance (4:1). Primary tumors occurred in the stomach (n = 3), small bowel (n = 1), and abdomen, not otherwise specified (n = 1). The average time from primary tumor resection to the resection of skin metastases was 59 months (range 11-155 months). The metastases occurred in the scalp (n = 2), cheek (n = 1), and abdomen (n = 2) with 3 patients presenting with solitary nodules and 2 patients with multiple nodules. The average size was 2 cm (range 0.6-4 cm). Histologically, 2 cases were spindled and 3 cases demonstrated mixed epithelioid and spindle cell morphology. All were confirmed to have CD117 reactivity. KIT genotyping was performed in 4 of 5 cases. Two cases harbored a mutation in exon 11, and the remaining 2 cases were wild type in exons 9, 11, 13, and 17. All 5 patients had multiple concurrent or subsequent abdominal and/or hepatic metastases. In 4 patients with an average follow-up of 32 months (range 6-75 months), after the resection of the metastases, 2 were alive with disease and 2 died of disease. Cutaneous metastases seem to be a late complication of GIST, but their presence does not necessarily herald a rapid demise of the patient.
    MeSH term(s) Adult ; Aged ; DNA Mutational Analysis ; Exons ; Female ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/immunology ; Gastrointestinal Stromal Tumors/mortality ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mutation ; Proto-Oncogene Proteins c-kit/analysis ; Proto-Oncogene Proteins c-kit/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/immunology ; Skin Neoplasms/mortality ; Skin Neoplasms/secondary ; Skin Neoplasms/surgery ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/immunology ; Soft Tissue Neoplasms/mortality ; Soft Tissue Neoplasms/secondary ; Soft Tissue Neoplasms/surgery ; Subcutaneous Tissue/immunology ; Subcutaneous Tissue/pathology ; Subcutaneous Tissue/surgery ; Time Factors ; Treatment Outcome
    Chemical Substances Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2009-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0b013e31818acb1a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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