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Article ; Online: Comparing the effect of assessment-simulation-animation-based against traditional education on nursing students' anxiety and self-efficacy in maternity clinical practicum.

Yeh, Ching-Hsueh / Yang, Ya-Ping

2024 Volume 76, Page(s) 103932

Abstract: Background: The clinical practicum is the practical course that causes the most anxiety in nursing undergraduates. Although high-fidelity simulation education has been demonstrated to boost nursing students' self-efficacy and decrease anxiety in patient ...

Abstract	Background: The clinical practicum is the practical course that causes the most anxiety in nursing undergraduates. Although high-fidelity simulation education has been demonstrated to boost nursing students' self-efficacy and decrease anxiety in patient care, it is also associated with excessive psychological stress. Assessment-simulation-animation-based (ASA-based) education has been developed to solve the drawbacks of simulation-based education while preserving positive learning outcomes. Objectives: To compare the effects of ASA-based education and traditional education in reducing anxiety and improving self-efficacy of junior nursing students in their maternity clinical practicum. Design: This study used a two-group pre-post quasi-experimental design. The comparison group was studied first followed by the experimental group. Settings: Department of Nursing and affiliated medical center at a medical university in southern Taiwan. Participants: We enrolled 114 junior nursing students from two different class years. Methods: A convenience sample of junior nursing students was used in this study, with 55 in the experimental group and 59 in the comparison group. The intervention included online ASA-based education videos with pamphlets and was conducted three days a week for five weeks encompassing the maternity nursing clinical practicum. We developed and applied the Clinical Situation Anxiety Scale (CS-AS) and Clinical Situation Self-Efficacy Scale (CS-SES) before and after the intervention. Qualitative feedback was assessed after the intervention. Data were collected from both the comparison and experimental groups during the fall and spring terms of both the 2019-2020 and 2020-2021 academic years. Results: Compared with the comparison group, the total CS-AS and CS-SES scores significantly improved from before to after the intervention in the experimental group. The students responded to the intervention by demonstrating clinical consistency, knowing what to do and how to do it and more confidently practicing health education. Conclusion: Our results suggest that ASA-based education with videos and pamphlets contributed to reducing anxiety and increasing self-efficacy in nursing students during their maternity clinical practicum.
MeSH term(s)	Humans ; Female ; Pregnancy ; Education, Nursing, Baccalaureate/methods ; Students, Nursing/psychology ; Self Efficacy ; Preceptorship ; Anxiety/psychology ; Clinical Competence
Language	English
Publishing date	2024-02-29
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2058575-5
ISSN	1873-5223 ; 1471-5953
ISSN (online)	1873-5223
ISSN	1471-5953
DOI	10.1016/j.nepr.2024.103932
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Article: Erythrodermic mycosis fungoides: A case report.

Xu, Wu-Bing / Zhang, Ya-Ping / Zhou, Su-Ping / Bai, Hao-Yang

World journal of clinical cases

2023 Volume 12, Issue 1, Page(s) 130–135

Abstract: Background: Mycosis fungoides is the most common primary cutaneous T-cell lymphoma, whereas generalized erythroderma is rare. In this report, we describe a case of mycosis fungoides with generalized erythroderma using complete clinical data and [18F] ... ...

Abstract	Background: Mycosis fungoides is the most common primary cutaneous T-cell lymphoma, whereas generalized erythroderma is rare. In this report, we describe a case of mycosis fungoides with generalized erythroderma using complete clinical data and [18F]fluoroDglucose positron emission tomography/computed tomography (18F-FDG PET/CT) images. Case summary: Systemic skin redness with desquamation for three years confirmed mycosis fungoides within one month. The patient underwent left axillary lymphadenectomy biopsy; pathological biopsy suggested abnormal T-cell lesions consistent with mycosis fungoides involving lymph nodes. The patient received methotrexate, 5 mg twice weekly, as part of their chemotherapy regimen. Patients January half after discharge, no obvious cause of high fever, left axillary lymph nodes with red heat pain, and rupture entered our hospital for treatment. Conclusion: The 18F-FDG PET/CT is essential for early diagnosis and timely treatment.
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v12.i1.130
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Article: The functional role of cellular senescence during vascular calcification in chronic kidney disease.

Fang, Ya-Ping / Zhao, Yu / Huang, Jia-Yi / Yang, Xin / Liu, Yan / Zhang, Xiao-Liang

Frontiers in endocrinology

2024 Volume 15, Page(s) 1330942

Abstract: Vascular calcification (VC) has emerged as a key predictor of cardiovascular events in patients with chronic kidney disease (CKD). In recent years, an expanding body of research has put forth the concept of accelerated vascular aging among CKD patients, ... ...

Abstract	Vascular calcification (VC) has emerged as a key predictor of cardiovascular events in patients with chronic kidney disease (CKD). In recent years, an expanding body of research has put forth the concept of accelerated vascular aging among CKD patients, highlighting the significance of vascular cells senescence in the process of VC. Within the milieu of uremia, senescent vascular endothelial cells (VECs) release extracellular microvesicles (MV) that promote vascular smooth muscle cells (VSMCs) senescence, thereby triggering the subsequent osteogenic phenotypic switch and ultimately contributing to the VC process. In addition, senescent vascular progenitor or stem cells with diminished ability to differentiate into VECs and VSMCS, compromise the repair of vascular integrity, on the other hand, release a cascade of molecules associated with senescence, collectively known as the senescence-associated secretory phenotype (SASP), perpetuating the senescence phenomenon. Furthermore, SASP triggers the recruitment of monocytes and macrophages, as well as adjacent VECs and VSMCs into a pro-adhesive and pro-inflammatory senescent state. This pro-inflammatory microenvironment niche not only impacts the functionality of immune cells but also influences the differentiation of myeloid immune cells, thereby amplifying the reduced ability to effectively clear senescent cells of senescent macrophages, promoted calcification of VSMCs. The objective of this paper is to provide a comprehensive review of the contribution of vascular cell senescence to the emergence and advancement of VC. Gaining a comprehensive understanding of the involvement of cellular senescence within the vessel wall is pivotal, especially when it comes to its intersection with VC. This knowledge is essential for advancing groundbreaking anti-aging therapies, aiming to effectively mitigate cardiovascular diseases.
MeSH term(s)	Humans ; Endothelial Cells ; Muscle, Smooth, Vascular ; Cellular Senescence/genetics ; Vascular Calcification/etiology ; Renal Insufficiency, Chronic/complications
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1330942
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Article: GETdb: A comprehensive database for genetic and evolutionary features of drug targets.

Zhang, Qi / He, Yang / Lu, Ya-Ping / Wei, Qi-Hao / Zhang, Hong-Yu / Quan, Yuan

Computational and structural biotechnology journal

2024 Volume 23, Page(s) 1429–1438

Abstract: The development of an innovative drug is complex and time-consuming, and the drug target identification is one of the critical steps in drug discovery process. Effective and accurate identification of drug targets can accelerate the drug development ... ...

Abstract	The development of an innovative drug is complex and time-consuming, and the drug target identification is one of the critical steps in drug discovery process. Effective and accurate identification of drug targets can accelerate the drug development process. According to previous research, evolutionary and genetic information of genes has been found to facilitate the identification of approved drug targets. In addition, allosteric proteins have great potential as targets due to their structural diversity. However, this information that could facilitate target identification has not been collated in existing drug target databases. Here, we construct a comprehensive drug target database named Genetic and Evolutionary features of drug Targets database (GETdb, http://zhanglab.hzau.edu.cn/GETdb/page/index.jsp). This database not only integrates and standardizes data from dozens of commonly used drug and target databases, but also innovatively includes the genetic and evolutionary information of targets. Moreover, this database features an effective allosteric protein prediction model. GETdb contains approximately 4000 targets and over 29,000 drugs, and is a user-friendly database for searching, browsing and downloading data to facilitate the development of novel targets.
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2694435-2
ISSN	2001-0370
ISSN	2001-0370
DOI	10.1016/j.csbj.2024.04.006
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Article ; Online: Novel Archaeal Histamine Oxidase from

Hou, Jing / Li, Xin-Xin / Sun, Yu / Li, Yang / Yang, Xiao-Yan / Sun, Ya-Ping / Cui, Heng-Lin

Journal of agricultural and food chemistry

2024 Volume 72, Issue 12, Page(s) 6519–6525

Abstract: Histamine, found abundantly in salt-fermented foods, poses a risk of food poisoning. ...

Abstract	Histamine, found abundantly in salt-fermented foods, poses a risk of food poisoning.
MeSH term(s)	Animals ; Histamine/metabolism ; Oxidoreductases ; Archaea/metabolism ; Sodium Chloride ; Biogenic Amines/metabolism ; Food Safety
Chemical Substances	Histamine (820484N8I3) ; Oxidoreductases (EC 1.-) ; Sodium Chloride (451W47IQ8X) ; Biogenic Amines
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.4c00695
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Article ; Online: [Research progress of novel functional materials in extraction of algal toxins].

Fang, Min / Wu, Ya-Ping / Zhang, Wen-Min / Zhang, Lan / Yang, Zhen-Quan

Se pu = Chinese journal of chromatography

2024 Volume 42, Issue 3, Page(s) 225–233

Abstract: Algal toxins are secondary metabolites produced by harmful algae; these metabolites are characterized with strong toxicity, diverse structure and bioaccumulation. Aquatic organisms that feed on harmful algae can accumulate algal toxins in their bodies, ... ...

Abstract	Algal toxins are secondary metabolites produced by harmful algae; these metabolites are characterized with strong toxicity, diverse structure and bioaccumulation. Aquatic organisms that feed on harmful algae can accumulate algal toxins in their bodies, and the consumption of these organisms by humans can cause symptoms of paralysis, diarrhea, and even death. The onset of poisoning can occur within as little as 30 min; in many cases, no suitable antidote for algal toxins is available. Thus, algal toxins present significant threats to human health, the aquaculture industry, and aquatic ecosystems. Because the potential risks of algal toxins are a critical issue, these toxins have become a research hotspot. The water environment and various types of aquatic products should be monitored and analyzed to ensure their safety. However, because of possible matrix effects and the low content of algal toxins in actual samples, an efficient pretreatment method is necessary prior to instrumental analyses. Efficient sample pretreatment techniques can not only reduce or eliminate interferences from the sample matrix during analysis but also enrich the target analytes to meet the detection limit of the analytical instrument, thereby ensuring the sensitivity and accuracy of the detection method. In recent years, sample pretreatment techniques such as solid-phase extraction (SPE), solid-phase microextraction (SPME), magnetic SPE (MSPE), dispersive SPE (DSPE), and pipette tip-based SPE (PT-SPE) have gained wide attention in the field of algal-toxin separation and analysis. The performance of these pretreatment techniques largely depends on the characteristics of the extraction materials. Given the diverse physicochemical properties of algal toxins, including their different molecular sizes, hydrophobicity/hydrophilicity, and charges, the design and preparation of materials suitable for algal-toxin extraction is an essential undertaking. The optimal extraction material should be capable of reversible algal-toxin adsorption and preferably possess a porous structure with a large surface area to allow for high recovery rates and good interfacial contact with the toxins. Additionally, the extraction material should exhibit good chemical stability in the sample solution and elution solvent within the working pH range; otherwise, it may dissolve or lose its functional groups. Many research efforts have sought to develop novel adsorbent materials with these properties in the separation and analysis of algal toxins, focusing on carbon-based materials, metal organic frameworks (MOFs), covalent organic frameworks (COFs), molecularly imprinted polymers (MIPs), and their functionalized counterparts. Carbon-based materials, MOFs, and COFs have advantages such as large surface areas and abundant adsorption sites. These extraction materials are widely used in the separation and analysis of target substances in complex environmental, biological, and food samples owing to their excellent performance and unique microstructure. They are also the main adsorbents used for the extraction of algal toxins. These extraction materials play an essential role in the extraction of algal toxins, but they also present a number of limitations: (1) Carbon-based materials, MOFs, and COFs have relatively poor selective-adsorption ability towards target substances; (2) Most MOFs are unstable in aqueous solutions and challenging to apply during extraction from water-based sample solutions; (3) COFs mainly consist of lightweight elements, rendering them difficult to completely separate from sample solutions using centrifugal force, which limits their application range; (4) Although MIPs have good selectivity, issues such as template-molecule loss, slow mass-transfer rates, and low adsorption capacity must be addressed. Therefore, the design and preparation of novel functionalized extraction materials specifically tailored for algal toxins and studies on new composite extraction materials are highly desirable. This article collects representative literature from domestic and international research on algal-toxin analysis over the past decade, summarizes the relevant findings, categorizes the applications of novel functional materials in algal-toxin-extraction processes, and provides an outlook on their future development prospects.
MeSH term(s)	Humans ; Ecosystem ; Adsorption ; Aquaculture ; Carbon ; Water ; Solid Phase Extraction
Chemical Substances	Carbon (7440-44-0) ; Water (059QF0KO0R)
Language	Chinese
Publishing date	2024-03-18
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1872-2059
ISSN (online)	1872-2059
DOI	10.3724/SP.J.1123.2023.10006
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Article ; Online: Carbon-TiO

Dong, Xiuli / Liu, Yamin / Adcock, Audrey F / Sheriff, Kirkland / Liang, Weixiong / Yang, Liju / Sun, Ya-Ping

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Carbon-semiconductor hybrid quantum dots are classical carbon dots with core carbon nanoparticles doped with a selected nanoscale semiconductor. Specifically, on those with the nanoscale ... ...

Abstract	Carbon-semiconductor hybrid quantum dots are classical carbon dots with core carbon nanoparticles doped with a selected nanoscale semiconductor. Specifically, on those with the nanoscale TiO
MeSH term(s)	Quantum Dots ; Carbon/pharmacology ; Anti-Bacterial Agents/pharmacology ; Gram-Negative Bacteria ; Gram-Positive Bacteria
Chemical Substances	Carbon (7440-44-0) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042196
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Article ; Online: Identification of a novel growth-associated promoter for biphasic expression of heterogenous proteins in

Shen, Qi / Cui, Jie / Wang, Yang / Hu, Zhong-Ce / Xue, Ya-Ping / Zheng, Yu-Guo

Applied and environmental microbiology

2024 Volume 90, Issue 2, Page(s) e0174023

Abstract: ... Pichia ... ...

Abstract	Pichia pastoris
MeSH term(s)	Methanol/metabolism ; Pichia/genetics ; Pichia/metabolism ; Gene Expression Regulation, Fungal ; Promoter Regions, Genetic ; Recombinant Proteins/metabolism ; Saccharomycetales
Chemical Substances	Methanol (Y4S76JWI15) ; Recombinant Proteins
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.01740-23
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Article ; Online: Evaluation of a concise fall risk stratification among older adults with cataracts in day surgery settings: A historically controlled study.

Wang, Ya-Ping / Dai, Can / Ou-Yang, Ping / Zhao, Yan-Hua / Xu, Dan

Japan journal of nursing science : JJNS

2023 Volume 21, Issue 2, Page(s) e12579

Abstract: Aim: This study aimed to evaluate the use of a concise fall risk stratification in assessing and predicting falls compared with the Morse Falls Scale among older adults with cataracts in day surgery settings.: Methods: A historically controlled study ...

Abstract	Aim: This study aimed to evaluate the use of a concise fall risk stratification in assessing and predicting falls compared with the Morse Falls Scale among older adults with cataracts in day surgery settings. Methods: A historically controlled study conducted from July 2020 to June 2022 was used in a municipal ophthalmic hospital in China. The concise fall risk stratification which directly graded fall risk by multifactorial judgment was used during the intervention period, while the Morse Falls Scale which graded fall risk by scale scores was used during the control period. The fall risk levels, fall assessment time, fall rates, fall-related injuries, predictive validity, and patient satisfaction with day surgery care were extracted. Propensity score matching was performed to balance baselines. Results: After matching, 4132 patients were included in the final analysis. Compared with the control group, the intervention group had significantly higher assessment results for fall risk level, a significantly shorter (by 48.15%) fall assessment time, and higher patient satisfaction. There were no differences in fall rates and fall-related injuries. Compared with the Morse Falls Scale, the concise fall risk stratification had higher sensitivity and negative predictive validity, and lower specificity and positive predictive validity, while the area under curve did not differ significantly. Conclusion: The use of the concise fall risk stratification reduced fall assessment time, improved patient satisfaction, and is unlikely to impact falls with an overall predictive performance comparable to that of the Morse Falls Scale for older cataract adults in day surgery settings.
MeSH term(s)	Humans ; Aged ; Ambulatory Surgical Procedures ; Historically Controlled Study ; Risk Assessment/methods ; Cataract
Language	English
Publishing date	2023-12-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2156618-5
ISSN	1742-7924 ; 1742-7932
ISSN (online)	1742-7924
ISSN	1742-7932
DOI	10.1111/jjns.12579
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Article ; Online: Effects of Advance Care Planning on End-of-Life Indicators for Nursing Home Residents-An Experimental Study with a Retrospective Chart Review.

Lo, Yu-Tai / Wang, Jin-Jy / Yang, Yi-Ching / Yu, Chiu-Yen / Chang, Chia-Ming / Yang, Ya-Ping

Geriatrics (Basel, Switzerland)

2024 Volume 9, Issue 2

Abstract: Advance care planning (ACP) has the potential to improve the outcomes of end-of-life care for residents in nursing homes. The aim of this study was to determine whether an ACP program was beneficial for nursing home residents by assessing end-of-life ... ...

Abstract	Advance care planning (ACP) has the potential to improve the outcomes of end-of-life care for residents in nursing homes. The aim of this study was to determine whether an ACP program was beneficial for nursing home residents by assessing end-of-life indicators. An experimental study with a retrospective chart review was conducted. In total, 37 residents in the intervention group participated in an institutional advance care planning program for 1 year, and their chart data over 1 year were collected following the completion of the program; 33 residents in the control group had died within 1 year before the start date of program, and their chart data were reviewed retrospectively. Chi-square and
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ISSN	2308-3417
ISSN (online)	2308-3417
DOI	10.3390/geriatrics9020042
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