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  1. Article ; Online: Revisiting Limitations of Present Models in Microsurgery Training: Presentation of a Novel Model.

    Retchkiman, Meir / Doucet, Ophelie / Dimitropoulos, Georgios / Lussier, Bertrand / Danino, Michel Alain

    Plastic and reconstructive surgery

    2023  Volume 152, Issue 2, Page(s) 373e–375e

    MeSH term(s) Humans ; Microsurgery ; Clinical Competence ; Internship and Residency ; Simulation Training
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Letter
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000010426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Tree-Based Diffusion Schr\"odinger Bridge with Applications to Wasserstein Barycenters

    Noble, Maxence / De Bortoli, Valentin / Doucet, Arnaud / Durmus, Alain

    2023  

    Abstract: Multi-marginal Optimal Transport (mOT), a generalization of OT, aims at minimizing the integral of a cost function with respect to a distribution with some prescribed marginals. In this paper, we consider an entropic version of mOT with a tree-structured ...

    Abstract Multi-marginal Optimal Transport (mOT), a generalization of OT, aims at minimizing the integral of a cost function with respect to a distribution with some prescribed marginals. In this paper, we consider an entropic version of mOT with a tree-structured quadratic cost, i.e., a function that can be written as a sum of pairwise cost functions between the nodes of a tree. To address this problem, we develop Tree-based Diffusion Schr\"odinger Bridge (TreeDSB), an extension of the Diffusion Schr\"odinger Bridge (DSB) algorithm. TreeDSB corresponds to a dynamic and continuous state-space counterpart of the multimarginal Sinkhorn algorithm. A notable use case of our methodology is to compute Wasserstein barycenters which can be recast as the solution of a mOT problem on a star-shaped tree. We demonstrate that our methodology can be applied in high-dimensional settings such as image interpolation and Bayesian fusion.
    Keywords Statistics - Machine Learning ; Computer Science - Machine Learning ; Mathematics - Probability
    Publishing date 2023-05-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Les Dialium de la région guinéo-congolaise (synthèse bibliographique)

    Gael Bibang Bengono / Alain Souza / Félicien Tosso / Robin Doucet / Aurore Richel / Jean-Louis Doucet

    Biotechnologie, Agronomie, Société et Environnement, Vol 25, Iss 3, Pp 172-

    2021  Volume 191

    Abstract: The Dialium of the Guinean-Congolese region. A review Introduction. The present study provides a synthesis of current knowledge on the genus Dialium (Fabaceae, Dialioideae), focusing on the species of the Guinean-Congolese region. In particular, it ... ...

    Abstract The Dialium of the Guinean-Congolese region. A review Introduction. The present study provides a synthesis of current knowledge on the genus Dialium (Fabaceae, Dialioideae), focusing on the species of the Guinean-Congolese region. In particular, it examines the possibility of sustainably using the wood and sawing co-products of Dialium species in order to reduce the pressure on other hardwood species whose populations are declining. Literature. Although there is no consensus among botanists, the Dialium genus is known to include 44 species, 22 of which are endemic to the Guinean-Congolese region. The differences between species are sometimes tenuous, and descriptions are based on a limited number of individuals. Species living in rainforests have balanced population structures. Apart from their mode of dispersal, which is zoochorous, ecological knowledge of Dialium species is very incomplete. The lack of data on population dynamics is particularly problematic in the context of sustainable forest management. The physical, mechanical and biochemical properties of the wood of these plants have only been characterized for a limited number of species. Conclusions. By proposing a key for determining the Dialium species of the Guinean-Congolese region, this article has attempted to clarify the taxonomy, while raising the need for further genetic studies. In Central Africa, some species of the genus Dialium are locally abundant and seem to regenerate well. They offer many prospects for development because their wood is very durable and could contain molecules of interest. Future research should focus primarily on the demographic dynamics of these species and the properties of their wood.
    Keywords taxonomy ; phylogeny ; ecology ; wood ; metabolites ; pharmacology ; Biotechnology ; TP248.13-248.65 ; Environmental sciences ; GE1-350
    Subject code 590
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Presses Agronomiques de Gembloux
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: GDF15 mediates renal cell plasticity in response to potassium depletion in mice.

    Lasaad, Samia / Walter, Christine / Rafael, Chloé / Morla, Luciana / Doucet, Alain / Picard, Nicolas / Blanchard, Anne / Fromes, Yves / Matot, Béatrice / Crambert, Gilles / Cheval, Lydie

    Acta physiologica (Oxford, England)

    2023  Volume 239, Issue 2, Page(s) e14046

    Abstract: Objective: To understand the mechanisms involved in the response to a low-K: Methods: Male mice of different genotypes (WT, GDF15-KO, and HKA2-KO) were fed an LK diet for different periods of time. We analyzed GDF15 levels, metabolic and ... ...

    Abstract Objective: To understand the mechanisms involved in the response to a low-K
    Methods: Male mice of different genotypes (WT, GDF15-KO, and HKA2-KO) were fed an LK diet for different periods of time. We analyzed GDF15 levels, metabolic and physiological parameters, and the cellular composition of collecting ducts.
    Results: Mice fed an LK diet showed a 2-4-fold increase in plasma and urine GDF15 levels. Compared to WT mice, GDF15-KO mice rapidly developed hypokalemia due to impaired renal adaptation. This is related to their 1/ inability to increase the number of type A intercalated cells (AIC) and 2/ absence of upregulation of H,K-ATPase type 2 (HKA2), the two processes responsible for K
    Conclusions: In this study, we showed that GDF15 and HKA2 are linked and play a central role in the response to K
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.14046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Newly Developed Chemically Defined Serum-Free Medium Suitable for Human Primary Keratinocyte Culture and Tissue Engineering Applications.

    Ghio, Sergio Cortez / Barbier, Martin A / Doucet, Emilie J / Debbah, Imad / Safoine, Meryem / Le-Bel, Gaëtan / Cartier, Andréanne / Jolibois, Emilie / Morissette, Amélie / Larouche, Danielle / Fradette, Julie / Guérin, Sylvain L / Garnier, Alain / Germain, Lucie

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: In our experience, keratinocytes cultured in feeder-free conditions and in commercially available defined and serum-free media cannot be as efficiently massively expanded as their counterparts grown in conventional bovine serum-containing medium, nor can ...

    Abstract In our experience, keratinocytes cultured in feeder-free conditions and in commercially available defined and serum-free media cannot be as efficiently massively expanded as their counterparts grown in conventional bovine serum-containing medium, nor can they properly form a stratified epidermis in a skin substitute model. We thus tested a new chemically defined serum-free medium, which we developed for massive human primary keratinocyte expansion and skin substitute production. Our medium, named Surge Serum-Free Medium (Surge SFM), was developed to be used alongside a feeder layer. It supports the growth of keratinocytes freshly isolated from a skin biopsy and cryopreserved primary keratinocytes in cultured monolayers over multiple passages. We also show that keratin-19-positive epithelial stem cells are retained through serial passaging in Surge SFM cultures. Transcriptomic analyses suggest that gene expression is similar between keratinocytes cultured with either Surge SFM or the conventional serum-containing medium. Additionally, Surge SFM can be used to produce bilayered self-assembled skin substitutes histologically similar to those produced using serum-containing medium. Furthermore, these substitutes were grafted onto athymic mice and persisted for up to six months. In conclusion, our new chemically defined serum-free keratinocyte culture medium shows great promise for basic research and clinical applications.
    MeSH term(s) Animals ; Mice ; Humans ; Tissue Engineering ; Keratinocytes/metabolism ; Skin/metabolism ; Epidermis/metabolism ; Epidermal Cells ; Culture Media, Serum-Free/pharmacology ; Cells, Cultured
    Chemical Substances Culture Media, Serum-Free
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [No title information]

    Samson, Ségolène / Jego, Alain / Kadri, Nadir / Doucet, Jean / Zulfiqar, Abrar-Ahmad

    Soins. Gerontologie

    2017  Volume 22, Issue 127, Page(s) 45–46

    Title translation 29. Hyperparathyroïdie primitive chez le sujet âgé.
    Language French
    Publishing date 2017-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
    DOI 10.1016/j.sger.2017.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Patient Safety Culture Bundle for CEOs and Senior Leaders.

    Armutlu, Markirit / Davis, Donna / Doucet, Alain / Down, Annette / Schierbeck, Dale / Stevens, Polly

    Healthcare quarterly (Toronto, Ont.)

    2020  Volume 22, Issue SP, Page(s) 82–95

    Abstract: Senior healthcare leaders are the difference makers as key influencers in ushering in an organizational culture committed to patient safety. Although leaders at all levels are champions of transformation, leaders at the "top" have a unique opportunity - ... ...

    Abstract Senior healthcare leaders are the difference makers as key influencers in ushering in an organizational culture committed to patient safety. Although leaders at all levels are champions of transformation, leaders at the "top" have a unique opportunity - and a responsibility - to foster a culture that supports an organization on its journey to zero harm. Through a literature review of more than 60 resources and validation with thought leaders, national and provincial partners have developed a patient safety culture bundle for CEOs and senior healthcare leaders. The bundle is based on a set of evidence-based practices that must be applied collectively to establish and sustain a culture of quality and safety in order to deliver safe care.
    MeSH term(s) Evidence-Based Practice ; Humans ; Leadership ; Medical Errors/prevention & control ; Organizational Culture ; Patient Safety ; Safety Management/organization & administration
    Language English
    Publishing date 2020-02-07
    Publishing country Canada
    Document type Journal Article
    ISSN 1710-2774
    ISSN 1710-2774
    DOI 10.12927/hcq.2020.26044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Highlighting a New Morphospecies within the Dialium Genus Using Leaves and Wood Traits

    Robin Doucet / Gaël Bibang Bengono / Marius Ruwet / Isabelle Van De Vreken / Brieuc Lecart / Jean-Louis Doucet / Juan Antonio Fernandez Pierna / Philippe Lejeune / Benoit Jourez / Alain Souza / Aurore Richel

    Forests, Vol 13, Iss 8, p

    2022  Volume 1339

    Abstract: During inventories of lesser-known timber species in eastern Gabon, a new Dialium morphospecies was discovered. To discriminate it from the two other 2–5 leaflets Dialium species, 25 leaf traits were measured on 45 trees (16 Dialium pachyphyllum , 14 ... ...

    Abstract During inventories of lesser-known timber species in eastern Gabon, a new Dialium morphospecies was discovered. To discriminate it from the two other 2–5 leaflets Dialium species, 25 leaf traits were measured on 45 trees (16 Dialium pachyphyllum , 14 Dialium lopense , 15 Dialium sp. nov.). Nine wood chemical traits, as well as infrared spectra, were also examined on harvestable trees (four Dialium pachyphyllum and four Dialium sp. nov.). This study revealed seven discriminant leaf traits that allowed to create a field identification key. Nine significant differences (five in sapwood and four in heartwood) in terms of wood composition were highlighted. The use of the PLS-DA technique on FT-IR wood spectra allowed to accurately identify the new morphospecies. These results provide strong support for describing a new species in this genus. Implications for sustainable management of its populations are also discussed.
    Keywords new species ; leaves ; morphology ; wood ; properties ; chemical composition ; Plant ecology ; QK900-989
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Highlighting a New Morphospecies within the Dialium Genus Using Leaves and Wood Traits

    Doucet, Robin / Bibang Bengono, Gaël / Ruwet, Marius / Van De Vreken, Isabelle / Lecart, Brieuc / Doucet, Jean-Louis / Fernandez Pierna, Juan Antonio / Lejeune, Philippe / Jourez, Benoit / Souza, Alain / Richel, Aurore

    Forests. 2022 Aug. 22, v. 13, no. 8

    2022  

    Abstract: During inventories of lesser-known timber species in eastern Gabon, a new Dialium morphospecies was discovered. To discriminate it from the two other 2–5 leaflets Dialium species, 25 leaf traits were measured on 45 trees (16 Dialium pachyphyllum, 14 ... ...

    Abstract During inventories of lesser-known timber species in eastern Gabon, a new Dialium morphospecies was discovered. To discriminate it from the two other 2–5 leaflets Dialium species, 25 leaf traits were measured on 45 trees (16 Dialium pachyphyllum, 14 Dialium lopense, 15 Dialium sp. nov.). Nine wood chemical traits, as well as infrared spectra, were also examined on harvestable trees (four Dialium pachyphyllum and four Dialium sp. nov.). This study revealed seven discriminant leaf traits that allowed to create a field identification key. Nine significant differences (five in sapwood and four in heartwood) in terms of wood composition were highlighted. The use of the PLS-DA technique on FT-IR wood spectra allowed to accurately identify the new morphospecies. These results provide strong support for describing a new species in this genus. Implications for sustainable management of its populations are also discussed.
    Keywords Dialium ; heartwood ; leaves ; morphospecies ; new species ; sapwood ; taxonomic keys ; wood ; Gabon
    Language English
    Dates of publication 2022-0822
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f13081339
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: A Newly Developed Chemically Defined Serum-Free Medium Suitable for Human Primary Keratinocyte Culture and Tissue Engineering Applications

    Sergio Cortez Ghio / Martin A. Barbier / Emilie J. Doucet / Imad Debbah / Meryem Safoine / Gaëtan Le-Bel / Andréanne Cartier / Emilie Jolibois / Amélie Morissette / Danielle Larouche / Julie Fradette / Sylvain L. Guérin / Alain Garnier / Lucie Germain

    International Journal of Molecular Sciences, Vol 24, Iss 1821, p

    2023  Volume 1821

    Abstract: In our experience, keratinocytes cultured in feeder-free conditions and in commercially available defined and serum-free media cannot be as efficiently massively expanded as their counterparts grown in conventional bovine serum-containing medium, nor can ...

    Abstract In our experience, keratinocytes cultured in feeder-free conditions and in commercially available defined and serum-free media cannot be as efficiently massively expanded as their counterparts grown in conventional bovine serum-containing medium, nor can they properly form a stratified epidermis in a skin substitute model. We thus tested a new chemically defined serum-free medium, which we developed for massive human primary keratinocyte expansion and skin substitute production. Our medium, named Surge Serum-Free Medium (Surge SFM), was developed to be used alongside a feeder layer. It supports the growth of keratinocytes freshly isolated from a skin biopsy and cryopreserved primary keratinocytes in cultured monolayers over multiple passages. We also show that keratin-19-positive epithelial stem cells are retained through serial passaging in Surge SFM cultures. Transcriptomic analyses suggest that gene expression is similar between keratinocytes cultured with either Surge SFM or the conventional serum-containing medium. Additionally, Surge SFM can be used to produce bilayered self-assembled skin substitutes histologically similar to those produced using serum-containing medium. Furthermore, these substitutes were grafted onto athymic mice and persisted for up to six months. In conclusion, our new chemically defined serum-free keratinocyte culture medium shows great promise for basic research and clinical applications.
    Keywords cell culture ; tissue engineering ; defined medium ; stem cells ; skin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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