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  1. Book: Genetic variants in periodontal health and disease

    Dumitrescu, Alexandrina L. / Kobayashi, Junya

    2010  

    Author's details Alexandrina L. Dumitrescu ; Junya Kobayashi
    Keywords Periodontitis / genetics ; Genetic Predisposition to Disease
    Language English
    Size XIII, 135 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    Note Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT017026087
    ISBN 978-3-642-00679-1 ; 3-642-00679-5 ; 9783642006807 ; 3642006809
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4597 order for loan Magazin

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  2. Article ; Online: Senescence-Associated Heterochromatin Foci Suppress γ-H2AX Focus Formation Induced by Radiation Exposure.

    Oizumi, Takashi / Suzuki, Tomoya / Kobayashi, Junya / Nakamura, Asako J

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: DNA damage is induced by both endogenous and exogenous factors. Repair of DNA double-strand break (DSB), a serious damage that threatens genome stability, decreases with senescence. However, the molecular mechanisms underlying the decline in DNA repair ... ...

    Abstract DNA damage is induced by both endogenous and exogenous factors. Repair of DNA double-strand break (DSB), a serious damage that threatens genome stability, decreases with senescence. However, the molecular mechanisms underlying the decline in DNA repair capacity during senescence remain unclear. We performed immunofluorescence staining for phosphorylated histone H2AX (γ-H2AX) in normal human fetal lung fibroblasts and human skin fibroblasts of different ages after chronic irradiation (total dose, 1 Gy; dose rate, 1 Gy/day) to investigate the effect of cellular senescence and organismal aging on DSB repair. Accumulation of DSBs was observed with cellular senescence and organismal aging, probably caused by delayed DSB repair. Importantly, the formation of γ-H2AX foci, an early event in DSB repair, is delayed with cellular senescence and organismal aging. These results suggest that the delay in γ-H2AX focus formation might delay the overall DSB repair. Interestingly, immediate γ-H2AX foci formation was suppressed in cells with senescence-associated heterochromatin foci (SAHF). To investigate the relationship between the γ-H2AX focus formation and SAHF, we used LiCl to relax the SAHFs, followed by irradiation. We demonstrated that LiCl rescued the delayed γ-H2AX foci formation associated with cellular senescence. This indicates that SAHF interferes with γ-H2AX focus formation and inhibits DSB repair in radiation-induced DSB. Our results suggest that therapeutic targeting of SAHFs have potential to resolve DSB repair dysfunction associated with cellular senescence.
    MeSH term(s) Humans ; Histones/metabolism ; Heterochromatin ; DNA Repair ; DNA Damage ; Radiation Exposure
    Chemical Substances Histones ; Heterochromatin
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063355
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  3. Article ; Online: Design of a new self-assembling antioxidant nanomedicine to ameliorate oxidative stress in zebrafish embryos.

    Shashni, Babita / Tamaoki, Junya / Kobayashi, Makoto / Nagasaki, Yukio

    Acta biomaterialia

    2023  Volume 159, Page(s) 367–381

    Abstract: Oxidative stress, which is a persistent state of elevated reactive oxygen species (ROS), is implicated in the pathogeneses of several diseases, making antioxidant-based therapeutics the aptest intervention. Nevertheless, the clinical failure of ... ...

    Abstract Oxidative stress, which is a persistent state of elevated reactive oxygen species (ROS), is implicated in the pathogeneses of several diseases, making antioxidant-based therapeutics the aptest intervention. Nevertheless, the clinical failure of conventional low-molecular-weight (LMW) antioxidants in oxidative stress-related diseases to yield favorable therapeutic outcomes and an increased mortality rate attributable to their poor pharmacokinetic characteristics, necessitates the development of alternative therapeutics. In light of this, we designed and synthesized a new amphiphilic polymer functionalized with a clinically safe base polymer of poly(styrene-co-maleic anhydride) copolymer conjugated with the LMW pleiotropic antioxidant TEMPO (a potent antioxidant) and biocompatible poly(ethylene glycol) (TEMPO-installed PSMA-g-PEG), which self-assembles into nano-sized micelles (SMAPo
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Reactive Oxygen Species ; Zebrafish ; Nanomedicine ; Oxidative Stress ; Polymers ; Polyethylene Glycols
    Chemical Substances Antioxidants ; tempol (U78ZX2F65X) ; poly(styrene-co-maleic anhydride) ; Reactive Oxygen Species ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.01.012
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  4. Article ; Online: Effects of carbonated beverages on sustained swallowing behavior changes in older inpatients.

    Morishita, Motoyoshi / Sota, Junya / Kobayashi, Mariko

    Physiology & behavior

    2023  Volume 265, Page(s) 114172

    Abstract: Sensory stimulation, including stimulation with carbonated liquids, has been known to influence swallowing activity. The aim of this study is to determine the effect of sustained changes in the swallowing behavior of hospitalized patients without ... ...

    Abstract Sensory stimulation, including stimulation with carbonated liquids, has been known to influence swallowing activity. The aim of this study is to determine the effect of sustained changes in the swallowing behavior of hospitalized patients without dysphagia using the cervical auscultatory recordings of swallowing sounds. The study participants were hospitalized older adults without dysphagia. The participants were asked to initially swallow water and then a carbonated beverage. The sustained effects of the carbonated beverage in relation to swallowing movements were evaluated by measuring the swallowing sounds at the following time periods: (1) immediately and (2) at 1 to 9 min with intervals of 2 min after swallowing the carbonated beverage. The swallowing sounds before and after swallowing the same volume of water were also measured and compared on a different day. Analysis was performed to calculate the time from a sound signal to the beginning of the swallowing sound. Significant shortening of the swallowing sound time of the late pharyngeal phase was observed up to 7 min after swallowing the carbonated beverage, except during the 3 min after swallowing. Shortening of the whole swallowing sound time was observed only immediately after swallowing the carbonated beverage. Regarding the shortening of the acoustic signal in the late pharyngeal period, the effect of cerebral excitability changes due to carbonic acid stimulation was considered.
    MeSH term(s) Humans ; Aged ; Deglutition/physiology ; Deglutition Disorders/etiology ; Inpatients ; Carbonated Beverages/adverse effects ; Pharynx/physiology ; Beverages
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2023.114172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 747: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Analysis method of cellular stress caused by intermediate dose-rate irradiation using a cell lysate array technique.

    Morishima, Nobuhiro / Ogata, Hiromitsu / Magae, Junji / Ito, Yoshihiro / Kobayashi, Junya

    Genes to cells : devoted to molecular & cellular mechanisms

    2023  Volume 28, Issue 4, Page(s) 288–306

    Abstract: Ionizing radiation damages DNA and may lead to the development of cancer. Irradiation also generates reactive oxygen species (ROS) which cause damage to various biological molecules. Relatively low dose-rate irradiation causes less damage. However, the ... ...

    Abstract Ionizing radiation damages DNA and may lead to the development of cancer. Irradiation also generates reactive oxygen species (ROS) which cause damage to various biological molecules. Relatively low dose-rate irradiation causes less damage. However, the damage and its effects on cell fate are difficult to evaluate. To develop a method to analyze the damage and accompanying changes in physiology in cells irradiated by γ-rays at a relatively low dose-rate, we used the protein array technique to quantify marker proteins involved in the stress response and the regulation of cell growth and death. This method enabled efficient analyses of many replicates of experimental data on cell lysate samples. We detected relatively small changes in the levels of these proteins in the irradiated cells. Changes in protein levels suggested ROS production and DNA damage as well as cell cycle retardation and the progression of cellular senescence. Thus, our approach shows promise for analyzing the biological effects of relatively low dose-rate irradiation.
    MeSH term(s) Reactive Oxygen Species/metabolism ; Gamma Rays ; DNA Damage ; Cellular Senescence/genetics ; Cell Differentiation
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.13011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4539: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Structural analysis of polyglycerol fatty acid ester-coenzyme Q10 aggregates in solution.

    Iwase, Hiroki / Kobayashi, Junya / Kasama, Yuuki / Fujii, Wataru / Nanbu, Hironobu

    Food research international (Ottawa, Ont.)

    2023  Volume 175, Page(s) 113741

    Abstract: Polyglycerol fatty acid esters (PGFEs) are common food additives. PGFE-based formulations exhibit high structural stability, however, the stability mechanism of the micellar structures has not been yet elucidated. In this study, nanostructural analysis ... ...

    Abstract Polyglycerol fatty acid esters (PGFEs) are common food additives. PGFE-based formulations exhibit high structural stability, however, the stability mechanism of the micellar structures has not been yet elucidated. In this study, nanostructural analysis was performed using small-angle neutron and X-ray scattering (SANS and SAXS) measurements to reveal the mechanism of the structural stability of PGFE-coenzyme Q10 (CoQ10) mixtures as a CoQ10 formulation. Pure PGFE formed multilamellar vesicles, whereas PGFE-CoQ10 formed spherical micelles. Furthermore, when the amount of added water increased, the PGFE-CoQ10 micellar size and the amount of water in the micelles remained unchanged. A model-fitting analysis of the SANS results suggested that the CoQ10 molecules were introduced between the surfactants, forming a palisade-type structure. The high structural stability of the PGFE-CoQ10 micelles was attributed to two factors: proper spreading of the hydrophilic head chains and inhibition of the change of the amount of water inside the micelles by the PGFE heads and quinone ring of CoQ10. This indicates that PGFE-CoQ10 can function in water while maintaining the micellar structure formed in the storage solution. The findings of this study are important for the safety and nano-hazard aspects of PGFE-CoQ10 formulations.
    MeSH term(s) Micelles ; Scattering, Small Angle ; X-Ray Diffraction ; Fatty Acids/chemistry ; Esters/chemistry ; Water
    Chemical Substances polyglycerol (25618-55-7) ; coenzyme Q10 (EJ27X76M46) ; Micelles ; Fatty Acids ; Esters ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-11-25
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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  7. Article ; Online: Effects of carbonated beverages on sustained swallowing behavior changes in older inpatients

    Morishita, Motoyoshi / Sota, Junya / Kobayashi, Mariko

    Physiology & Behavior. 2023 June, v. 265 p.114172-

    2023  

    Abstract: Sensory stimulation, including stimulation with carbonated liquids, has been known to influence swallowing activity. The aim of this study is to determine the effect of sustained changes in the swallowing behavior of hospitalized patients without ... ...

    Abstract Sensory stimulation, including stimulation with carbonated liquids, has been known to influence swallowing activity. The aim of this study is to determine the effect of sustained changes in the swallowing behavior of hospitalized patients without dysphagia using the cervical auscultatory recordings of swallowing sounds. The study participants were hospitalized older adults without dysphagia. The participants were asked to initially swallow water and then a carbonated beverage. The sustained effects of the carbonated beverage in relation to swallowing movements were evaluated by measuring the swallowing sounds at the following time periods: (1) immediately and (2) at 1 to 9 min with intervals of 2 min after swallowing the carbonated beverage. The swallowing sounds before and after swallowing the same volume of water were also measured and compared on a different day. Analysis was performed to calculate the time from a sound signal to the beginning of the swallowing sound. Significant shortening of the swallowing sound time of the late pharyngeal phase was observed up to 7 min after swallowing the carbonated beverage, except during the 3 min after swallowing. Shortening of the whole swallowing sound time was observed only immediately after swallowing the carbonated beverage. Regarding the shortening of the acoustic signal in the late pharyngeal period, the effect of cerebral excitability changes due to carbonic acid stimulation was considered.
    Keywords acoustics ; behavior ; carbonated beverages ; carbonic acid ; dysphagia ; pharynx ; physiology ; Swallowing behavior ; Sustained effect ; Swallowing sound ; Sensory stimulation
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2023.114172
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 74/401: Show issues

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  8. Article ; Online: Soy-Derived Equol Induces Antioxidant Activity in Zebrafish in an Nrf2-Independent Manner.

    Watanabe, Asami / Muraki, Kyoji / Tamaoki, Junya / Kobayashi, Makoto

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Antioxidant effects of soy-derived isoflavones are predicted to be mediated by the Keap1-Nrf2 pathway. Recently, we constructed an assay system to evaluate the antioxidant effects of dietary phytochemicals in zebrafish and revealed a relationship between ...

    Abstract Antioxidant effects of soy-derived isoflavones are predicted to be mediated by the Keap1-Nrf2 pathway. Recently, we constructed an assay system to evaluate the antioxidant effects of dietary phytochemicals in zebrafish and revealed a relationship between these effects and the Keap1-Nrf2 pathway. In this study, we used this system to examine the antioxidant effects of seven isoflavones. Among those seven, equol showed strong antioxidant effects when arsenite was used as an oxidative stressor. The antioxidant effect of equol was also shown in Nrf2-mutant zebrafish
    MeSH term(s) Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Equol/pharmacology ; GA-Binding Protein Transcription Factor ; Isoflavones/pharmacology ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Larva/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Zebrafish/genetics
    Chemical Substances Antioxidants ; GA-Binding Protein Transcription Factor ; Isoflavones ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Equol (531-95-3)
    Language English
    Publishing date 2022-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23095243
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  9. Article ; Online: Aspiration pneumonia associated with achalasia

    Yuri Ono / Hiroyuki Kobayashi / Kazuya Nagasaki / Hiroyuki Ariga / Junya Kashimura

    Journal of General and Family Medicine, Vol 23, Iss 3, Pp 195-

    2022  Volume 196

    Keywords achalasia ; aspiration pneumonia ; dysphagia ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Aspiration pneumonia associated with achalasia.

    Ono, Yuri / Kobayashi, Hiroyuki / Nagasaki, Kazuya / Ariga, Hiroyuki / Kashimura, Junya

    Journal of general and family medicine

    2022  Volume 23, Issue 3, Page(s) 195–196

    Abstract: In this case, a chest computed tomography scan of a young patient with pneumonia revealed esophageal obstruction, which led to the diagnosis of aspiration pneumonia due to achalasia. This report highlights achalasia and other gastrointestinal ... ...

    Abstract In this case, a chest computed tomography scan of a young patient with pneumonia revealed esophageal obstruction, which led to the diagnosis of aspiration pneumonia due to achalasia. This report highlights achalasia and other gastrointestinal obstructions as one of the causes of aspiration pneumonia.
    Language English
    Publishing date 2022-02-03
    Publishing country Japan
    Document type Case Reports
    ISSN 2189-7948
    ISSN (online) 2189-7948
    DOI 10.1002/jgf2.524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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