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The Journal of comparative medicine and veterinary archives
2022 Volume 19, Issue 3, Page(s) 208–209
| Language | English |
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| Publishing date | 2022-10-24 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Methods in molecular biology (Clifton, N.J.)
2018 Volume 1792, Page(s) 117–128
Abstract: Over the past 10 years next generation sequencing (NGS) approaches deciphered a large number of genomes from a wide variety of tumor types. However, despite most relevant findings, this technology has not yet been implemented into standard diagnostic ... ...
| Abstract | Over the past 10 years next generation sequencing (NGS) approaches deciphered a large number of genomes from a wide variety of tumor types. However, despite most relevant findings, this technology has not yet been implemented into standard diagnostic workflows. Broad access to NGS technology is still limited, sequencing/analysis times exceed clinically relevant timeframes and despite huge cuts, costs remain significant. We proposed a custom-tailored gene panel, which focuses on a selected number of relevant genes and developed a clinically oriented NGS targeted sequencing approach for the molecular characterization of Multiple Myeloma (MM) tumors, allowing the description of the tumor genetic heterogeneity and its changes under selective pressure of antitumor therapy, in a more cost effective and faster turnaround timeframe. |
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| MeSH term(s) | Biopsy ; Data Analysis ; Gene Library ; Genetic Testing/methods ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/genetics ; Reproducibility of Results |
| Language | English |
| Publishing date | 2018-06-22 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1940-6029 |
| ISSN (online) | 1940-6029 |
| DOI | 10.1007/978-1-4939-7865-6_8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Cancer medicine
2020 Volume 9, Issue 9, Page(s) 2989–2996
Abstract: ... refractory multiple myeloma (RRMM), with carfilzomib administered twice weekly at 56 mg/m ...
| Abstract | Combination of carfilzomib with dexamethasone (Kd) is approved for use in relapsed and/or refractory multiple myeloma (RRMM), with carfilzomib administered twice weekly at 56 mg/m |
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| MeSH term(s) | Aged ; Clinical Trials, Phase III as Topic ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Resistance, Neoplasm/drug effects ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Multicenter Studies as Topic ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Oligopeptides/therapeutic use ; Prognosis ; Randomized Controlled Trials as Topic ; Salvage Therapy ; Survival Rate |
| Chemical Substances | Oligopeptides ; carfilzomib (72X6E3J5AR) |
| Language | English |
| Publishing date | 2020-02-28 |
| Publishing country | United States |
| Document type | Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2045-7634 |
| ISSN (online) | 2045-7634 |
| DOI | 10.1002/cam4.2945 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2021 Volume 374, Issue 6575, Page(s) 1586–1593
Abstract: The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongoing ... ...
| Abstract | The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral therapeutics are an important part of the healthcare response to countering the ongoing threat presented by COVID-19. Here, we report the discovery and characterization of PF-07321332, an orally bioavailable SARS-CoV-2 main protease inhibitor with in vitro pan-human coronavirus antiviral activity and excellent off-target selectivity and in vivo safety profiles. PF-07321332 has demonstrated oral activity in a mouse-adapted SARS-CoV-2 model and has achieved oral plasma concentrations exceeding the in vitro antiviral cell potency in a phase 1 clinical trial in healthy human participants. |
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| MeSH term(s) | Administration, Oral ; Animals ; COVID-19/drug therapy ; COVID-19/virology ; Clinical Trials, Phase I as Topic ; Coronavirus/drug effects ; Disease Models, Animal ; Drug Therapy, Combination ; Humans ; Lactams/administration & dosage ; Lactams/pharmacokinetics ; Lactams/pharmacology ; Lactams/therapeutic use ; Leucine/administration & dosage ; Leucine/pharmacokinetics ; Leucine/pharmacology ; Leucine/therapeutic use ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Nitriles/administration & dosage ; Nitriles/pharmacokinetics ; Nitriles/pharmacology ; Nitriles/therapeutic use ; Proline/administration & dosage ; Proline/pharmacokinetics ; Proline/pharmacology ; Proline/therapeutic use ; Randomized Controlled Trials as Topic ; Ritonavir/administration & dosage ; Ritonavir/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Viral Protease Inhibitors/administration & dosage ; Viral Protease Inhibitors/pharmacokinetics ; Viral Protease Inhibitors/pharmacology ; Viral Protease Inhibitors/therapeutic use ; Virus Replication/drug effects |
| Chemical Substances | Lactams ; Nitriles ; Viral Protease Inhibitors ; nirmatrelvir (7R9A5P7H32) ; Proline (9DLQ4CIU6V) ; Leucine (GMW67QNF9C) ; Ritonavir (O3J8G9O825) |
| Language | English |
| Publishing date | 2021-11-02 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 128410-1 |
| ISSN | 1095-9203 ; 0036-8075 |
| ISSN (online) | 1095-9203 |
| ISSN | 0036-8075 |
| DOI | 10.1126/science.abl4784 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 27: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MG 77: Show issues |
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2020 Volume 42, Issue 3, Page(s) 333–353
Abstract: ... complex causing tuberculosis, M. leprae and M. lepromatosis causing leprosy, and atypical mycobacteria, or ... non-tuberculous mycobacteria (NTM), responsible for a wide range of diseases. Among the NTMs, M. ulcerans is responsible ... for the neglected tropical skin disease Buruli ulcer (BU). Most pathogenic mycobacteria, including M. leprae, evade ...
| Abstract | Mycobacterial pathogens can be categorized into three broad groups: Mycobacterium tuberculosis complex causing tuberculosis, M. leprae and M. lepromatosis causing leprosy, and atypical mycobacteria, or non-tuberculous mycobacteria (NTM), responsible for a wide range of diseases. Among the NTMs, M. ulcerans is responsible for the neglected tropical skin disease Buruli ulcer (BU). Most pathogenic mycobacteria, including M. leprae, evade effector mechanisms of the humoral immune system by hiding and replicating inside host cells and are furthermore excellent modulators of host immune responses. In contrast, M. ulcerans replicates predominantly extracellularly, sheltered from host immune responses through the cytotoxic and immunosuppressive effects of mycolactone, a macrolide produced by the bacteria. In the year 2018, 208,613 new cases of leprosy and 2713 new cases of BU were reported to WHO, figures which are notoriously skewed by vast underreporting of these diseases. |
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| MeSH term(s) | Buruli Ulcer ; Humans ; Mycobacterium ; Mycobacterium ulcerans ; Skin |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-02-25 |
| Publishing country | Germany |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2316828-6 |
| ISSN | 1863-2300 ; 1863-2297 |
| ISSN (online) | 1863-2300 |
| ISSN | 1863-2297 |
| DOI | 10.1007/s00281-020-00790-4 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1425: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2021 Volume 39, Issue 30, Page(s) 3410–3411
| Language | English |
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| Publishing date | 2021-09-02 |
| Publishing country | United States |
| Document type | Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Letter ; Comment |
| ZDB-ID | 604914-x |
| ISSN | 1527-7755 ; 0732-183X |
| ISSN (online) | 1527-7755 |
| ISSN | 0732-183X |
| DOI | 10.1200/JCO.21.01587 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1847: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 650: Show issues |
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The European physical journal. C, Particles and fields
2022 Volume 82, Issue 7, Page(s) 618
Abstract: DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a ... ...
| Abstract | DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 |
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| Language | English |
| Publishing date | 2022-07-16 |
| Publishing country | France |
| Document type | Journal Article |
| ZDB-ID | 1459069-4 |
| ISSN | 1434-6052 ; 1434-6044 |
| ISSN (online) | 1434-6052 |
| ISSN | 1434-6044 |
| DOI | 10.1140/epjc/s10052-022-10549-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Bulletin of earthquake engineering
2021 Volume 20, Issue 14, Page(s) 7707–7712
Abstract: The Samos Island (Aegean Sea) Earthquake occurred on 30 October 2020. It produced a tsunami that impacted coastal communities, ground shaking that was locally amplified in some areas and that led to collapse of structures with 118 fatalities in both ... ...
| Abstract | The Samos Island (Aegean Sea) Earthquake occurred on 30 October 2020. It produced a tsunami that impacted coastal communities, ground shaking that was locally amplified in some areas and that led to collapse of structures with 118 fatalities in both Greece and Turkey, and wide-ranging geotechnical effects including rockfalls, landsliding, and liquefaction. As a result of the global COVID-19 pandemic, the reconnaissance of this event did not involve the deployment of international teams, as would be typical for an event of this size. Instead, following initial deployments of separate Greek and Turkish teams, the reconnaissance and documentation efforts were managed in a coordinated manner with the assistance of international partners. This coordination ultimately produced a multi-agency joint report published on the 2-month anniversary of the earthquake, and this special issue. This paper provides an overview of the reconnaissance activities undertaken to document the effects of this important event and summarizes key lessons spanning topic areas from seismology to emergency response. |
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| Language | English |
| Publishing date | 2021-08-28 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2098452-2 |
| ISSN | 1573-1456 ; 1570-761X |
| ISSN (online) | 1573-1456 |
| ISSN | 1570-761X |
| DOI | 10.1007/s10518-021-01212-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
2020 Volume 33, Issue 3, Page(s) 351–372
Abstract: ... for adults (≥16 years) with severe obesity (body mass index ≥35 kg m: Methods: Four data sources were ...
| Abstract | Introduction: The aim of this project was to systematically review UK evidence on the effectiveness of long-term (≥12 months) weight management services (WMSs) for weight loss and weight maintenance for adults (≥16 years) with severe obesity (body mass index ≥35 kg m Methods: Four data sources were searched from 1999 to October 2018. Results: Our searches identified 20 studies, mostly noncomparative studies: 10 primary care interventions, nine in secondary care specialist weight management clinics and one commercial setting intervention. A programme including a phase of low energy formula diet (810-833 kcal day Conclusions: There is a persistent and clear need for guidance on long-term weight data collection and reporting methods to allow comparisons across studies and services for participants with severe obesity. Data could also include quality of life, clinical outcomes, adverse events, costs and economic outcomes. A randomised trial comparison of National Health Service Tier 3 services with commercial WMSs would be of value. |
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| MeSH term(s) | Adolescent ; Adult ; Bariatrics/methods ; Bariatrics/statistics & numerical data ; Behavior Therapy/methods ; Body Mass Index ; Diet, Reducing/methods ; Female ; Humans ; Male ; Middle Aged ; Obesity, Morbid/physiopathology ; Obesity, Morbid/therapy ; State Medicine/statistics & numerical data ; Treatment Outcome ; United Kingdom ; Weight Reduction Programs/methods ; Weight Reduction Programs/statistics & numerical data ; Young Adult |
| Language | English |
| Publishing date | 2020-02-06 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review |
| ZDB-ID | 645183-4 |
| ISSN | 1365-277X ; 0952-3871 ; 1465-8178 |
| ISSN (online) | 1365-277X |
| ISSN | 0952-3871 ; 1465-8178 |
| DOI | 10.1111/jhn.12732 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2551: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2021 Volume 12, Issue 1, Page(s) 5236
Abstract: ... structure of the cytochrome bd oxidase from M. tuberculosis at 2.5 Å. In conjunction with atomistic ... of the cytochrome bd oxidase from M. tuberculosis will form the basis for the design of highly specific drugs to act ...
| Abstract | New drugs are urgently needed to combat the global TB epidemic. Targeting simultaneously multiple respiratory enzyme complexes of Mycobacterium tuberculosis is regarded as one of the most effective treatment options to shorten drug administration regimes, and reduce the opportunity for the emergence of drug resistance. During infection and proliferation, the cytochrome bd oxidase plays a crucial role for mycobacterial pathophysiology by maintaining aerobic respiration at limited oxygen concentrations. Here, we present the cryo-EM structure of the cytochrome bd oxidase from M. tuberculosis at 2.5 Å. In conjunction with atomistic molecular dynamics (MD) simulation studies we discovered a previously unknown MK-9-binding site, as well as a unique disulfide bond within the Q-loop domain that defines an inactive conformation of the canonical quinol oxidation site in Actinobacteria. Our detailed insights into the long-sought atomic framework of the cytochrome bd oxidase from M. tuberculosis will form the basis for the design of highly specific drugs to act on this enzyme. |
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| MeSH term(s) | Bacterial Proteins/chemistry ; Binding Sites ; Cryoelectron Microscopy ; Cytochrome b Group/chemistry ; Cytochrome d Group/chemistry ; Electron Transport Chain Complex Proteins/chemistry ; Molecular Dynamics Simulation ; Mycobacterium tuberculosis/enzymology ; Oxidoreductases/chemistry ; Protein Conformation ; Protein Subunits ; Vitamin K 2/analogs & derivatives ; Vitamin K 2/chemistry |
| Chemical Substances | Bacterial Proteins ; Cytochrome b Group ; Electron Transport Chain Complex Proteins ; Protein Subunits ; Vitamin K 2 (11032-49-8) ; menaquinone 9 (523-39-7) ; Cytochrome d Group (9035-36-3) ; Oxidoreductases (EC 1.-) |
| Language | English |
| Publishing date | 2021-09-02 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-021-25537-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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