Article ; Online: The role of hypoxia-inducible factors in breast cancer stem cell specification.
Pathology, research and practice
2023 Volume 243, Page(s) 154349
Abstract: Breast tumor is heterogeneous cancer with high morbidity and mortality rates, particularly in developing countries. Despite new efforts to reduce the breast cancer implications, the number of newly diagnosed cases is increasing worldwide. It is believed ... ...
Abstract | Breast tumor is heterogeneous cancer with high morbidity and mortality rates, particularly in developing countries. Despite new efforts to reduce the breast cancer implications, the number of newly diagnosed cases is increasing worldwide. It is believed that cancer stem cells (CSCs) are responsible for the implication of cancers including breast cancer. Although CSCs compose a small population in tumor bulks, they play a crucial role in tumor initiation, progression, metastasis, and chemotherapeutic resistance. These events are mediated by the hypoxia-inducible factor (HIF) pathway which regulates the transcription of genes involved in CSC maintenance and tumorigenesis. In this review, we discussed the mechanisms by which hypoxia- or chemotherapy-induced HIFs promote breast CSC specification. |
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MeSH term(s) | Humans ; Female ; Breast Neoplasms/pathology ; Hypoxia/metabolism ; Carcinogenesis/metabolism ; Neoplastic Stem Cells/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Cell Line, Tumor ; Cell Hypoxia |
Chemical Substances | Hypoxia-Inducible Factor 1, alpha Subunit |
Language | English |
Publishing date | 2023-01-30 |
Publishing country | Germany |
Document type | Journal Article ; Review |
ZDB-ID | 391889-0 |
ISSN | 1618-0631 ; 0344-0338 |
ISSN (online) | 1618-0631 |
ISSN | 0344-0338 |
DOI | 10.1016/j.prp.2023.154349 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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