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Article ; Online: Spatial and temporal variations of geochemical processes and toxicity of water, sediments, and suspended solids in Sibuti River Estuary, NW Borneo.

Gantayat, Rakesh Roshan / Mohan Viswanathan, Prasanna / Ramasamy, Nagarajan / Sabarathinam, Chidambaram

Environmental science and pollution research international

2023 Volume 30, Issue 40, Page(s) 92692–92719

Abstract: A comprehensive geochemical study was conducted in the Sibuti River estuary by considering water, suspended solids (SS), and sediment samples from 36 stations during southwest monsoon (SWM) and northeast monsoon (NEM). In this study, the distribution of ... ...

Abstract	A comprehensive geochemical study was conducted in the Sibuti River estuary by considering water, suspended solids (SS), and sediment samples from 36 stations during southwest monsoon (SWM) and northeast monsoon (NEM). In this study, the distribution of in situ parameters, major ions, nutrients, trace metals, and isotopes (δD, δ
MeSH term(s)	Estuaries ; Rivers/chemistry ; Water/analysis ; Borneo ; Cadmium/analysis ; Geologic Sediments/chemistry ; Environmental Monitoring ; Trace Elements/analysis ; Water Pollutants, Chemical/analysis ; Metals, Heavy/analysis
Chemical Substances	Water (059QF0KO0R) ; Cadmium (00BH33GNGH) ; Trace Elements ; Water Pollutants, Chemical ; Metals, Heavy
Language	English
Publishing date	2023-07-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-28596-5
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Article ; Online: Molecular mechanisms for thrombosis risk in Black people: a role in excess mortality from COVID-19.

Ramasamy, Roshan / Milne, Kate / Bell, Deanne / Stoneham, Simon / Chevassut, Timothy

British journal of haematology

2020 Volume 190, Issue 2, Page(s) e78–e80

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thrombosis
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16869
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Article ; Online: Comparison of mandibular buccal shelf bone characteristics between two facial types using cone beam computed tomography.

Ramasamy, Padmanathan / Sabrish, Sharanya / Pattabiraman, Vinod / Shivamurthy, Prashantha Govinakovi / Sagarkar, Roshan / Mathew, Silju

Indian journal of dental research : official publication of Indian Society for Dental Research

2022 Volume 33, Issue 3, Page(s) 277–281

Abstract: Background: Mandibular buccal shelf (MBS) offers good quality and quantity of bone for orthodontic bone screw (OBS) insertion. Despite several reports of treated patients, there are numerous variables in selecting the exact placement site for OBS ... ...

Abstract	Background: Mandibular buccal shelf (MBS) offers good quality and quantity of bone for orthodontic bone screw (OBS) insertion. Despite several reports of treated patients, there are numerous variables in selecting the exact placement site for OBS placement in the MBS. There are also anatomical variations in this area which must be considered. Objectives: This study aims to measure and compare the MBS bone characteristics for OBS placement using cone beam computed tomography (CBCT) between two different facial types. Materials and methods: Eighty CBCT samples were collected (40 samples of group A horizontal growers and 40 of group B vertical growers). Each CBCT image was reconstructed and oriented with CS 3D CBCT software. The cortical bone thickness, the slope of the MBS, and buccolingual inclination of mandibular second molar were measured and analysed. Result: Cortical bone thickness among horizontal growers was 5.23 ± 0.58 mm and among vertical growers was 4.85 ± 0.37 mm. The slope of MBS among horizontal growers was 60.83 ± 6.15 degrees and among vertical growers was 66.75 ± 6.27 degrees. In both the parameters there was a statistically significant difference between the groups. There was no significant difference between the groups for the buccolingual inclination of 2 Conclusion: Increased cortical bone thickness and the flatter slope of MBS at the 2
MeSH term(s)	Humans ; Cone-Beam Computed Tomography/methods ; Mandible/diagnostic imaging ; Mandible/surgery ; Face ; Molar ; Bone Screws
Language	English
Publishing date	2022-12-02
Publishing country	India
Document type	Journal Article
ZDB-ID	1354886-4
ISSN	1998-3603 ; 0970-9290
ISSN (online)	1998-3603
ISSN	0970-9290
DOI	10.4103/ijdr.ijdr_1201_21
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Article: Clinical Profile and Molecular Genetic Analysis of Prader - Willi Syndrome: A Single Center Experience.

Sridhar, Subbiah / Nazirudeen, Roshan / Ramasamy, Suresh / Natarajan, Vasanthiy / Thiagarajan, Kumanan / Karthika, Lakshmanan Nivethitha

Indian journal of endocrinology and metabolism

2022 Volume 26, Issue 4, Page(s) 384–388

Abstract: Aim: The prevalence of childhood and adolescent obesity is increasing worldwide as well as in India. Prader--Willi syndrome (PWS) is one of the most common causes of syndromic obesity with varied clinical manifestations across different lifespan. ... ...

Abstract	Aim: The prevalence of childhood and adolescent obesity is increasing worldwide as well as in India. Prader--Willi syndrome (PWS) is one of the most common causes of syndromic obesity with varied clinical manifestations across different lifespan. Herewith, we describe clinical and molecular characteristics of eight PWS who were diagnosed in an obesity clinic of tertiary care hospital. Materials and methods: Clinically suspected cases of PWS were screened between January 2014 and January 2022. Detailed history and clinical examination were done to look for typical features of PWS like characteristic facial appearance, short stature, obesity, hyperphagia, delayed puberty or hypogonadism, diabetes mellitus, developmental delay, cognitive dysfunction, learning disabilities or abnormal behavior. All were evaluated, with 75 g oral glucose tolerance tests (GTT), HbA1c, Free T4, TSH, LH, FSH, testosterone, and growth hormone level. Intelligent quotient (IQ) of each patient was assessed by a psychiatrist using Binet-Kamat test. Molecular confirmation of clinically suspected PWS was done by either Methylation-specific polymerase chain reaction (MS-PCR) or Fluorescence in situ Hybridization (FISH) methods. Results: Based on clinical and molecular characteristics, eight were diagnosed as PWS. Except one, all were male with characteristic facies, mean age of study cohort was 12 years and mean BMI of 44.58. Obesity, short stature, hyperphagia, hypotonia, and mild to moderate mental retardation were noted in entire (100%) PWS study population. All male PWS patients had cryptorchidism, which was bilateral in six patients and unilateral (right undescended testes) in one. Apart from obesity, short stature, other endocrine associations noted were diabetes mellitus in 50% and subclinical hypothyroidism in 37% of PWS. Molecular characteristics of PWS were confirmed by Methylation-specific PCR in seven and by FISH method in one. Conclusion: Prader-Willi syndrome should be kept in mind in case of childhood or adolescent obesity with short stature, hypotonia, cryptorchidism, and developmental delay or cognitive dysfunction. Judicious use of molecular diagnostic testing should be made in all clinically suspected cases. Early diagnosis and appropriate management of this complex disorder by a multidisciplinary team will improve the quality of life and treatment outcome.
Language	English
Publishing date	2022-09-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/ijem.ijem_122_22
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Article: Molecular mechanisms for thrombosis risk in Black people: a role in excess mortality from COVID-19

Ramasamy, Roshan / Milne, Kate / Bell, Deanne / Stoneham, Simon / Chevassut, Timothy

Br J Haematol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #327369
Database	COVID19

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Article ; Online: Molecular mechanisms for thrombosis risk in Black people

Ramasamy, Roshan / Milne, Kate / Bell, Deanne / Stoneham, Simon / Chevassut, Timothy

British Journal of Haematology

a role in excess mortality from COVID‐19

2020 Volume 190, Issue 2

Keywords	Hematology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16869
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Article ; Online: Molecular mechanisms for thrombosis risk in black people

Ramasamy, Roshan / Milne, Kate / Bell, Deanne / Stoneham, Simon / Chevassut, Timothy

a role in excess mortality from COVID-19

2020

Abstract: We read with great interest your recent article by Fogarty et al,[1] in particular their conclusion that differences in thrombotic risk may contribute to ethnic differences in mortality from Covid-19. This is particularly important in the UK, where age- ... ...

Abstract	We read with great interest your recent article by Fogarty et al,[1] in particular their conclusion that differences in thrombotic risk may contribute to ethnic differences in mortality from Covid-19. This is particularly important in the UK, where age- and sex-adjusted hospital death rates for Covid-19 are 2.17 higher for people with ethnicity recorded as black compared to white people, and 1.95 higher for those recorded as Asian.[3] This excess mortality is persists after adjustment for deprivation, body mass index (BMI), smoking and comorbidities,[3] and despite correction for region, rural/urban living, deprivation, household composition, socioeconomic status and health.[2] As yet uninvestigated factors such as thrombosis may contribute to the UK’s ethnic disparities in Covid-19. Similarly data from the USA shows that in 14 states, African-Americans represent 33% of hospitalisations for Covid-19, despite making up 14% of the catchment population.[4]
Keywords	R Medicine ; RB Pathology ; RB127 Manifestations of disease ; covid19
Language	English
Publishing date	2020-05-21
Publisher	Wiley
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Management of suspected paediatric meningitis: a multicentre prospective cohort study.

Ramasamy, Roshan / Willis, Louise / Kadambari, Seilesh / Kelly, Dominic F / Heath, Paul T / Nadel, Simon / Pollard, Andrew J / Sadarangani, Manish

Archives of disease in childhood

2018 Volume 103, Issue 12, Page(s) 1114–1118

Abstract: Objective: To quantify delays during management of children with suspected meningitis.: Design: Multicentre prospective cohort study.: Setting: Three UK tertiary paediatric centres; June 2011-June 2012 PATIENTS: 388 children aged <16 years ... ...

Abstract	Objective: To quantify delays during management of children with suspected meningitis. Design: Multicentre prospective cohort study. Setting: Three UK tertiary paediatric centres; June 2011-June 2012 PATIENTS: 388 children aged <16 years hospitalised with suspected meningitis or undergoing lumbar puncture (LP) during sepsis evaluation. Main outcome measures: Time of prehospital and in-hospital assessments, LP, antibiotic treatment and discharge; types of prehospital medical assessment and microbiological results. Data collected from hospital records and parental interview. Results: 220/388 (57%) children were seen by a medical professional prehospitalisation (143 by a general practitioner). Median times from initial hospital assessment to LP and antibiotic administration were 4.8 hours and 3.1 hours, respectively; 62% of children had their LP after antibiotic treatment. Median time to LP was shorter for children aged <3 months (3.0 hours) than those aged 3-23 months (6.2 hours, P<0.001) or age ≥2 years (20.3 hours, P<0.001). In meningitis of unknown cause, cerebrospinal fluid (CSF) PCR was performed for meningococcus in 7%, pneumococcus in 10% and enterovirus in 76%. When no pathogen was identified, hospital stay was longer if LP was performed after antibiotics (median 12.5 days vs 5.0 days, P=0.037). Conclusions: Most children had LP after antibiotics were administered, reducing yield from CSF culture, and PCRs were underused despite national recommendations. These deficiencies reduce the ability to exclude bacterial meningitis, increasing unnecessary hospital stay and antibiotic treatment.
MeSH term(s)	Adolescent ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Guideline Adherence/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Length of Stay/statistics & numerical data ; Linear Models ; Male ; Meningitis/cerebrospinal fluid ; Meningitis/diagnosis ; Meningitis/therapy ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/statistics & numerical data ; Prospective Studies ; Spinal Puncture ; Tertiary Care Centers ; Time-to-Treatment/standards ; Time-to-Treatment/statistics & numerical data ; United Kingdom
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2018-02-07
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2017-313913
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Article ; Online: Von Willebrand factor (vWF): marker of endothelial damage and thrombotic risk in COVID-19?

Ladikou, Eleni E / Sivaloganathan, Helena / Milne, Kate M / Arter, William E / Ramasamy, Roshan / Saad, Ramy / Stoneham, Simon M / Philips, Barbara / Eziefula, Alice C / Chevassut, Timothy

Clinical medicine (London, England)

2020 Volume 20, Issue 5, Page(s) e178–e182

Abstract: Background: COVID-19 infection is characterised, among other features, by a prothrombotic state with high rate of venous thromboembolism (VTE), D-dimer, and fibrinogen levels. Clinical observations have also highlighted that these patients have elevated ...

Abstract	Background: COVID-19 infection is characterised, among other features, by a prothrombotic state with high rate of venous thromboembolism (VTE), D-dimer, and fibrinogen levels. Clinical observations have also highlighted that these patients have elevated von Willebrand factor (vWF) and factor VIIIc. Methods: 24 consecutive COVID-19 positive patients were selected from the intensive care unit (ICU) or the high acuity ward of Brighton and Sussex University Hospitals NHS Trust. Results: The rate of VTE was 25% and mortality rate was 16.7%. Fibrinogen and D-Dimers were elevated, 7.9 (1.6) g/L and 2.4 (2.02) ug/ml respectively. Factor VIIIc and von vWF antigen levels were both extremely elevated at 279 (148) u/dL and 350 (131) % respectively, which are comparable to levels seen in ICU patients with severe sepsis. vWF levels were significantly higher in patients that died (p=0.017) and showed a positive correlation with age. There was a statistically significant association between COVID-19 disease and non-O blood group (p=0.02); 80% (4/5) of COVID-19 patients with VTE were blood group A. Conclusion: Very high levels of vWF and factor VIIIc are common in COVID-19 patients, comparable to levels in severely septic non-COVID ICU patients. This could contribute to the hypercoagulable state and increased VTE rate in COVID-19. Further studies are needed to evaluate the use of vWF for stratifying thrombotic risk in COVID-19 and to determine if elevated vWF is contributing to disease pathogenesis.
MeSH term(s)	Biomarkers/blood ; COVID-19 ; Cohort Studies ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/mortality ; Endothelium, Vascular/pathology ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Fibrinogen/metabolism ; Hospital Mortality/trends ; Hospitals, University ; Humans ; Intensive Care Units ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/mortality ; Risk Assessment ; Sampling Studies ; Severe Acute Respiratory Syndrome/blood ; Severe Acute Respiratory Syndrome/diagnosis ; Survival Rate ; United Kingdom ; Venous Thromboembolism/blood ; Venous Thromboembolism/etiology ; Venous Thromboembolism/mortality ; von Willebrand Factor/metabolism
Chemical Substances	Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; von Willebrand Factor ; Fibrinogen (9001-32-5)
Keywords	covid19
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.2020-0346
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Article: Von Willebrand factor (vWF): marker of endothelial damage and thrombotic risk in COVID-19?

Ladikou, Eleni E / Sivaloganathan, Helena / Milne, Kate M / Arter, William E / Ramasamy, Roshan / Saad, Ramy / Stoneham, Simon M / Philips, Barbara / Eziefula, Alice C / Chevassut, Timothy

Clin Med (Lond)

Abstract: BACKGROUND: COVID-19 infection is characterised, among other features, by a prothrombotic state with high rate of venous thromboembolism (VTE), D-dimer, and fibrinogen levels. Clinical observations have also highlighted that these patients have elevated ... ...

Abstract	BACKGROUND: COVID-19 infection is characterised, among other features, by a prothrombotic state with high rate of venous thromboembolism (VTE), D-dimer, and fibrinogen levels. Clinical observations have also highlighted that these patients have elevated von Willebrand factor (vWF) and factor VIIIc. METHODS: 24 consecutive COVID-19 positive patients were selected from the intensive care unit (ICU) or the high acuity ward of Brighton and Sussex University Hospitals NHS Trust. RESULTS: The rate of VTE was 25% and mortality rate was 16.7%. Fibrinogen and D-Dimers were elevated, 7.9 (1.6) g/L and 2.4 (2.02) ug/ml respectively. Factor VIIIc and von vWF antigen levels were both extremely elevated at 279 (148) u/dL and 350 (131) % respectively, which are comparable to levels seen in ICU patients with severe sepsis. vWF levels were significantly higher in patients that died (p=0.017) and showed a positive correlation with age. There was a statistically significant association between COVID-19 disease and non-O blood group (p=0.02); 80% (4/5) of COVID-19 patients with VTE were blood group A. CONCLUSION: Very high levels of vWF and factor VIIIc are common in COVID-19 patients, comparable to levels in severely septic non-COVID ICU patients. This could contribute to the hypercoagulable state and increased VTE rate in COVID-19. Further studies are needed to evaluate the use of vWF for stratifying thrombotic risk in COVID-19 and to determine if elevated vWF is contributing to disease pathogenesis.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #659698
Database	COVID19

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