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  1. Article ; Online: Functional vagal paraganglioma developing 15 years after resection of a retroperitoneal paraganglioma.

    Kojima, Fumiya / Ohno, Kazuchika / Fushimi, Naoki / Takahashi, Ryosuke / Tasaki, Akihisa / Asakage, Takahiro

    Auris, nasus, larynx

    2024  Volume 51, Issue 3, Page(s) 425–428

    Abstract: The patient, a 40-year-old woman, was diagnosed as having a functional right vagal paraganglioma (PGL) 15 years after undergoing resection for a retroperitoneal PGL. ...

    Abstract The patient, a 40-year-old woman, was diagnosed as having a functional right vagal paraganglioma (PGL) 15 years after undergoing resection for a retroperitoneal PGL.
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Oncological Risk of Colonic Stents Used as Bridge to Surgery for Left-Side Malignant Colonic Obstructions.

    Yamada, Takeshi / Matsuda, Akihisa / Takahashi, Goro / Yoshida, Hiroshi

    Annals of surgical oncology

    2022  Volume 29, Issue 5, Page(s) 2759–2760

    MeSH term(s) Colonic Neoplasms/surgery ; Colorectal Neoplasms/surgery ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/pathology ; Intestinal Obstruction/surgery ; Stents ; Treatment Outcome
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-11274-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Discordant responses of bone formation and absorption markers in Japanese infants with vitamin D deficiency: a comprehensive matched case-control study.

    Takahashi, Keigo / Ikeda, Kazushige / Hara-Isono, Kaori / Nitta, Akihisa / Nagano, Nobuhiko / Arimitsu, Takeshi

    JBMR plus

    2024  Volume 8, Issue 5, Page(s) ziae033

    Abstract: Vitamin D deficiency during infancy has been associated with increased bone turnover rate and bone mineral loss. However, few studies have examined bone turnover markers (BTMs) for both bone formation and resorption in infants with vitamin D deficiency. ... ...

    Abstract Vitamin D deficiency during infancy has been associated with increased bone turnover rate and bone mineral loss. However, few studies have examined bone turnover markers (BTMs) for both bone formation and resorption in infants with vitamin D deficiency. Here, we analyzed serum concentrations of 25OHD, intact parathormone (iPTH), and BTMs including total alkaline phosphatase (ALP), tartrate-resistant acid phosphatase isoform 5b (TRACP-5b), and serum type I collagen N-telopeptide (NTx) as well as basic clinical characteristics of 456 infants (626 samples) aged less than 12 mo born at Saitama City Hospital, Japan (latitude 35.9° North) between January 2021 and December 2022. One hundred sixteen infants (147 samples) were classified as having vitamin D deficiency (25OHD < 12.0 ng/mL), and 340 infants (479 samples) had sufficient vitamin D levels (25OHD ≥ 12.0 ng/mL). In addition to 25OHD and ALP, both TRACP-5b and sNTx were measured in 331 infants (418 samples), while 90 infants (105 samples) had only TRACP-5b measured and 101 infants (103 samples) had only sNTx measured. Statistical comparison of 104 subjects each in the vitamin D deficiency and sufficiency groups after matching for the background characteristics revealed that the vitamin D deficiency group had significantly higher levels of ALP and iPTH compared with the sufficiency group (
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1093/jbmrpl/ziae033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-term outcomes between self-expandable metallic stent and transanal decompression tube for malignant large bowel obstruction: A multicenter retrospective study and meta-analysis.

    Matsuda, Akihisa / Yamada, Takeshi / Yokoyama, Yasuyuki / Takahashi, Goro / Yoshida, Hiroshi

    Annals of gastroenterological surgery

    2023  Volume 7, Issue 4, Page(s) 583–593

    Abstract: Aim: To compare the oncological outcomes between self-expandable metallic stent (SEMS) as a bridge to surgery and transanal decompression tube (TDT) placement for malignant large bowel obstruction (MLBO).: Methods: A total of 287 MLBO patients who ... ...

    Abstract Aim: To compare the oncological outcomes between self-expandable metallic stent (SEMS) as a bridge to surgery and transanal decompression tube (TDT) placement for malignant large bowel obstruction (MLBO).
    Methods: A total of 287 MLBO patients who underwent SEMS (
    Results: Postoperative complications of Clavien-Dindo grade ≥II and ≥III occurred frequently in the TDT group compared with the SEMS group (
    Conclusion: Our study demonstrated that SEMS placement had no inferiority regarding long-term outcomes, including OS and DFS, compared with TDT placement. Considering the short-term benefits of SEMS placement, this could be a preferable preoperative decompression method for MLBO.
    Language English
    Publishing date 2023-02-20
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Afterglow Properties and Trap-Depth Control in ZrO

    Aimi, Akihisa / Takahashi, Hiroaki / Fujimoto, Kenjiro

    Inorganic chemistry

    2020  Volume 59, Issue 23, Page(s) 16865–16871

    Abstract: ... Ti-doped ... ...

    Abstract Ti-doped ZrO
    Language English
    Publishing date 2020-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.0c01578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Incidence of Pancreatic Injury and Pancreatitis in Patients Treated With Immune Checkpoint Inhibitors.

    Hori, Yasuki / Naitoh, Itaru / Naiki-Ito, Aya / Kawai, Tatsuya / Yoshida, Michihiro / Kato, Akihisa / Kachi, Kenta / Sahashi, Hidenori / Adachi, Akihisa / Toyohara, Tadashi / Kito, Yusuke / Yamamoto, Tatsuhito / Takahashi, Satoru / Kataoka, Hiromi

    Clinical and translational gastroenterology

    2024  Volume 15, Issue 4, Page(s) e00667

    Abstract: Introduction: Immune checkpoint inhibitors (ICIs) are being increasingly used to treat advanced malignancies. ICI-induced pancreatic injury (ICI-PI), which is an immune-related adverse event that may be a risk factor of ICI-associated pancreatitis, is ... ...

    Abstract Introduction: Immune checkpoint inhibitors (ICIs) are being increasingly used to treat advanced malignancies. ICI-induced pancreatic injury (ICI-PI), which is an immune-related adverse event that may be a risk factor of ICI-associated pancreatitis, is not well documented in the literature.
    Methods: Consecutive patients who received ICIs for advanced malignancies from August 2015 through October 2022 were analyzed for the incidence of ICI-PI based on the Common Terminology Criteria for Adverse Events and ICI-associated pancreatitis. The imaging, clinical, and pathological findings of ICI-associated pancreatitis were also assessed.
    Results: This study enrolled 843 patients. In multivariable analyses, dual or simultaneous immunotherapy and ≥10 cycles of ICI administration were significant predictive factors for all grades of pancreatic injury, including grade ≥3. Notably, patients who received simultaneous immunotherapy exhibited a higher incidence of grade ≥3 pancreatic injuries compared with those receiving asynchronous immunotherapy in univariable analysis ( P = 0.032). One-fifth of the patients (16/70) with grade ≥3 pancreatic injuries had imaging evidence of pancreatitis similar to mild acute pancreatitis. ICI-associated pancreatitis was observed in 5.7% (48/843) of patients, including 1.8% (15/843) with moderate-to-severe pancreatitis (grade ≥2). Symptomatic cases (0.36%, 3/843) were treated with steroids with favorable outcomes. Immunohistochemistry for CD4 and CD8 revealed greater infiltration of CD8 + than CD4 + lymphocytes.
    Discussion: Simultaneous immunotherapy and dual immunotherapy are risk factors of ICI-PI. Although most patients diagnosed with ICI-PI and ICI-associated pancreatitis were asymptomatic and had a low mortality likelihood, long-term outcomes, including endocrine and exocrine function, should be carefully monitored.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Male ; Female ; Middle Aged ; Incidence ; Pancreatitis/chemically induced ; Pancreatitis/epidemiology ; Pancreatitis/immunology ; Aged ; Risk Factors ; Retrospective Studies ; Adult ; Neoplasms/drug therapy ; Pancreas/pathology ; Pancreas/immunology ; Pancreas/diagnostic imaging ; Aged, 80 and over
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Gastric metastasis of breast cancer treated as primary gastric cancer due to difficulty in differentiating primary and metastatic cancer:a case report].

    Nukui, Takayuki / Minowa, Akihisa / Mizushima, Takashi / Urakabe, Kenji / Okayama, Kohei / Suzuki, Taketo / Suzuki, Yuta / Haneda, Kenichi / Takahashi, Satoru / Okumura, Fumihiro

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2024  Volume 121, Issue 2, Page(s) 117–126

    Abstract: A female patient in her 50s who underwent chemotherapy for left primary breast cancer presented with cancerous pleurisy and disseminated intravascular coagulation. Esophagogastroduodenoscopy and liver biopsy revealed gastric and liver cancer. ... ...

    Abstract A female patient in her 50s who underwent chemotherapy for left primary breast cancer presented with cancerous pleurisy and disseminated intravascular coagulation. Esophagogastroduodenoscopy and liver biopsy revealed gastric and liver cancer. Distinguishing between primary and metastatic cancer by pathological findings is difficult using hematoxylin and eosin staining. We diagnosed and treated simultaneous primary breast cancer (ER-positive) and gastric cancer with liver metastasis (ER-negative), based on differences in estrogen receptor expression. The patient lived for 10 months with chemotherapy. After death, an autopsy was performed because the endoscopic results were atypical for primary gastric cancer, and additional immunohistochemical studies indicated gastric metastasis of breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Stomach Neoplasms/diagnosis ; Biopsy
    Language Japanese
    Publishing date 2024-02-10
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.121.117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 477: Show issues

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  8. Article ; Online: Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 Apc

    Suzuki, Kenshi / Tsuruoka, Chizuru / Morioka, Takamitsu / Seo, Hitomi / Ogawa, Mari / Kambe, Ryosuke / Imaoka, Tatsuhiko / Kakinuma, Shizuko / Takahashi, Akihisa

    Life sciences in space research

    2024  Volume 41, Page(s) 202–209

    Abstract: Explorations of the Moon and Mars are planned as future manned space missions, during which humans will be exposed to both radiation and microgravity. We do not, however, know the health effects for such combined exposures. In a ground-based experiment, ... ...

    Abstract Explorations of the Moon and Mars are planned as future manned space missions, during which humans will be exposed to both radiation and microgravity. We do not, however, know the health effects for such combined exposures. In a ground-based experiment, we evaluated the combined effects of radiation and simulated microgravity on tumorigenesis by performing X-irradiation and tail suspension in C3B6F1 Apc
    MeSH term(s) Animals ; Mice ; Weightlessness Simulation ; Intestinal Neoplasms/pathology ; Intestinal Neoplasms/etiology ; Carcinogenesis/radiation effects ; Mice, Inbred C57BL ; Hindlimb Suspension ; Male ; X-Rays ; Disease Models, Animal ; Female ; Intestine, Small/radiation effects ; Intestine, Small/pathology ; Thymus Gland/radiation effects ; Thymus Gland/pathology ; Neoplasms, Radiation-Induced/pathology ; Neoplasms, Radiation-Induced/etiology
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2214-5532
    ISSN (online) 2214-5532
    DOI 10.1016/j.lssr.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Advanced Interferometry with 3-D Structured Illumination Reveals the Surface Fine Structure of Complex Biospecimens.

    Matsuzaki, Takahisa / Kawamura, Ryuzo / Yamamoto, Akihisa / Takahashi, Hozumi / Fujii, Mai / Togo, Shodai / Yoneyama, Yosuke / Hakuno, Fumihiko / Takahashi, Shin-Ichiro / Suganuma, Masami / Nakabayashi, Seiichiro / Sharma, Shivani / Gimzewski, James K / Yoshikawa, Hiroshi Y

    The journal of physical chemistry letters

    2024  Volume 15, Issue 4, Page(s) 1097–1104

    Abstract: Interference reflection microscopy (IRM) is a powerful, label-free technique to visualize the surface structure of biospecimens. However, stray light outside a focal plane obscures the surface fine structures beyond the diffraction limit ( ...

    Abstract Interference reflection microscopy (IRM) is a powerful, label-free technique to visualize the surface structure of biospecimens. However, stray light outside a focal plane obscures the surface fine structures beyond the diffraction limit (
    MeSH term(s) Lighting ; Microscopy, Interference/methods ; Interferometry ; Microtubules ; Proteins
    Chemical Substances Proteins
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A new type of simulated partial gravity apparatus for rats based on a pully-spring system.

    Zhang, Shenke / Adachi, Takuya / Zhang, Shengli / Yoshida, Yukari / Takahashi, Akihisa

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 965656

    Abstract: The return to the Moon and the landing on Mars has emphasized the need for greater attention to the effects of partial gravity on human health. Here, we sought to devise a new type of simulated partial gravity apparatus that could more efficiently and ... ...

    Abstract The return to the Moon and the landing on Mars has emphasized the need for greater attention to the effects of partial gravity on human health. Here, we sought to devise a new type of simulated partial gravity apparatus that could more efficiently and accurately provide a partial gravity environment for rat hindlimbs. The new apparatus uses a pulley system and tail suspension to create the simulated partial gravity of the rat's hind limbs by varying the weight in a balance container attached to the pulley system. An experiment was designed to verify the reliability and stability of the new apparatus. In this experiment, 25 seven-week-old male Wistar Hannover rats were randomly divided into five groups (
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.965656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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