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Article: Willow leaves as a cobalt supplement for weaned lambs

Walker, B. / Stoate, C. / Kendall, N. R.

2022 Volume 264, Issue -, Page(s) 105047

Language	English
Document type	Article
ZDB-ID	2226176-X
ISSN	1871-1413
Database	Current Contents Nutrition, Environment, Agriculture

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Article: Willow leaves as a cobalt supplement for weaned lambs

Walker, B. / Stoate, C / Kendall, N.R.

Livestock science. 2022 Oct., v. 264

2022

Abstract: Cobalt is an essential trace element in sheep for the synthesis of vitamin B12 in the rumen to support growth and prevent clinical deficiencies (Pine). Willow (Salix spp.) leaves contain a high concentration of cobalt (∼6 times the requirement of lambs). ...

Abstract	Cobalt is an essential trace element in sheep for the synthesis of vitamin B12 in the rumen to support growth and prevent clinical deficiencies (Pine). Willow (Salix spp.) leaves contain a high concentration of cobalt (∼6 times the requirement of lambs). The aim of this study was to determine the efficacy of supplementary willow leaves in improving plasma vitamin B12 status of sheep. Weaned lambs (n=24) on ad libitum grass were randomly allocated to one of three groups: Willow (offered up to 300 g of fresh willow leaves per lamb each day); Drench (2.8mg oral cobalt sulphate heptahydrate drench on day 0); Control (received no treatment). Plasma B12 concentration was evaluated for all lambs using blood samples taken on days 0 and 14. Values for plasma B12 concentration were log transformed prior to statistical analysis. At day 14 the mean (± s.d.) concentrations, on the log₁₀ scale, were 3.00 (±0.155) pmol/L, 2.61 (±0.146) pmol/L and 2.55 (±0.214) pmol/L for Willow, Drench and Control, respectively. The corresponding back transformed means were 990 pmol/L, 407 pmol/L, 351 pmol/L, respectively. The value for the Willow treatment was significantly higher than each of the other treatments, which did not differ significantly. Supplementary willow can be used by producers to improve vitamin B12 status in lambs.
Keywords	Salix ; cobalt ; cobalt sulfate ; grasses ; statistical analysis ; vitamin B12
Language	English
Dates of publication	2022-10
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2226176-X
ISSN	1878-0490 ; 1871-1413
ISSN (online)	1878-0490
ISSN	1871-1413
DOI	10.1016/j.livsci.2022.105047
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ixazomib with cyclophosphamide and dexamethasone in relapsed or refractory myeloma: MUKeight phase II randomised controlled trial results.

Auner, Holger W / Brown, Sarah R / Walker, Katrina / Kendall, Jessica / Dawkins, Bryony / Meads, David / Morgan, Gareth J / Kaiser, Martin F / Cook, Mark / Roberts, Sadie / Parrish, Christopher / Cook, Gordon

Blood cancer journal

2022 Volume 12, Issue 4, Page(s) 52

Abstract: The all-oral combination of ixazomib, cyclophosphamide, and dexamethasone (ICD) is well tolerated and effective in newly diagnosed and relapsed multiple myeloma (MM). We carried out MUKeight, a randomised, controlled, open, parallel group, multi-centre ... ...

Abstract	The all-oral combination of ixazomib, cyclophosphamide, and dexamethasone (ICD) is well tolerated and effective in newly diagnosed and relapsed multiple myeloma (MM). We carried out MUKeight, a randomised, controlled, open, parallel group, multi-centre phase II trial in patients with relapsed MM after prior treatment with thalidomide, lenalidomide, and a proteasome inhibitor (ISRCTN58227268), with the primary objective to test whether ICD has improved clinical activity compared to cyclophosphamide and dexamethasone (CD) in terms of progression-free survival (PFS). Between January 2016 and December 2018, 112 participants were randomised between ICD (n = 58) and CD (n = 54) in 33 UK centres. Patients had a median age of 70 years and had received a median of four prior lines of therapy. 74% were classed as frail. Median PFS in the ICD arm was 5.6 months, compared to 6.7 months with CD (hazard ratio (HR) = 1.21, 80% CI 0.9-1.6, p = 0.3634). Response rates and overall survival were not significantly different between ICD and CD. Dose modifications or omissions, and serious adverse events (SAEs), occurred more often in the ICD arm. In summary, the addition of ixazomib to cyclophosphamide and dexamethasone did not improve outcomes in the comparatively frail patients enroled in the MUKeight trial.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Boron Compounds ; Cyclophosphamide/adverse effects ; Dexamethasone ; Glycine/analogs & derivatives ; Humans ; Multiple Myeloma
Chemical Substances	Boron Compounds ; ixazomib (71050168A2) ; Dexamethasone (7S5I7G3JQL) ; Cyclophosphamide (8N3DW7272P) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-022-00626-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of the SARS-CoV-2 Pandemic on Emergency Department Presentations in an Integrated Health System.

Walker, Laura E / Heaton, Heather A / Monroe, Ryan J / Reichard, R Ross / Kendall, Monica / Mullan, Aidan F / Goyal, Deepi G

Mayo Clinic proceedings

2020 Volume 95, Issue 11, Page(s) 2395–2407

Abstract: Objective: To quantify the impact of the severe acute respiratory syndrome coronavirus 2 pandemic on emergency department volumes and patient presentations and evaluate changes in community mortality for the purpose of characterizing new patterns of ... ...

Abstract	Objective: To quantify the impact of the severe acute respiratory syndrome coronavirus 2 pandemic on emergency department volumes and patient presentations and evaluate changes in community mortality for the purpose of characterizing new patterns of emergency care use. Patients and methods: This is an observational cross-sectional study using electronic health records for emergency department visits in an integrated multihospital system with academic and community practices across 4 states for visits between March 17 and April 21, 2019, and February 9 and April 21, 2020. We compared numbers and proportions of common and critical chief symptoms and diagnoses, triage assessments, throughput, disposition, and selected hospital lengths of stay and out-of-hospital deaths. Results: In the period of interest, emergency department visits decreased by nearly 50% (35037 to 18646). Total numbers of patients with myocardial infarctions, stroke, appendicitis, and cholecystitis diagnosed decreased. The percentage of visits for mental health symptoms increased. There was an increase in deaths, driven by out-of-hospital mortality. Conclusion: Fewer patients presenting with acute and time-sensitive diagnoses suggests that patients are deferring care. This may be further supported by an increase in out-of-hospital mortality. Understanding which patients are deferring care and why will allow us to develop outreach strategies and ensure that those in need of rapid assessment and treatment will do so, preventing downstream morbidity and mortality.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections ; Cross-Sectional Studies ; Delivery of Health Care, Integrated/trends ; Emergency Service, Hospital/trends ; Facilities and Services Utilization/trends ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Mortality/trends ; Pandemics ; Pneumonia, Viral ; United States ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-09-19
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2020.09.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of the SARS-CoV-2 Pandemic on Emergency Department Presentations in an Integrated Health System

Walker, Laura E. / Heaton, Heather A. / Monroe, Ryan J. / Reichard, R. Ross / Kendall, Monica / Mullan, Aidan F. / Goyal, Deepi G.

Mayo Clinic Proceedings

2020 Volume 95, Issue 11, Page(s) 2395–2407

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2020.09.019
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differences in Gaze Fixation Location and Duration Between Resident and Fellowship Sonographers Interpreting a Focused Assessment With Sonography in Trauma.

Bell, Colin R / Szulewski, Adam / Walker, Melanie / McKaigney, Conor / Ross, Graeme / Rang, Louise / Newbigging, Joseph / Kendall, John

AEM education and training

2020 Volume 5, Issue 1, Page(s) 28–36

Abstract: Objectives: We quantified the gaze fixation duration of resident and fellowship sonographers interpreting a prerecorded focused assessment with sonography in trauma (FAST). We hypothesized that all sonographers would fixate on each relevant anatomic ... ...

Abstract	Objectives: We quantified the gaze fixation duration of resident and fellowship sonographers interpreting a prerecorded focused assessment with sonography in trauma (FAST). We hypothesized that all sonographers would fixate on each relevant anatomic relationship but that the duration of fixation would differ. Methods: We conducted a cross-sectional study collecting and analyzing the gaze fixations of a convenience sample of current resident and fellowship sonographers. All sonographers viewed a standardized FAST video, and their gaze fixations were recorded using a Tobii X3-120 eye-tracking bar. Gaze fixations over nine anatomic regions of interest (ROIs) were identified. These were assessed for normality and analyzed using the Wilcoxon rank sum test at an alpha of 0.05 and Bonferroni correction p value of <0.0034. The chi-square test and Pearson's correlation were performed to assess statistical association. Results: The gaze fixation recordings of 24 resident and eight fellowship sonographers were suitable for analysis. Fourteen of the 24 resident sonographers viewed all ROIs in the FAST, whereas all eight fellowship sonographers viewed each of the nine relevant ROIs. Five ROIs were identified over which at least one resident sonographer did not have a gaze fixation. No statistically significant difference was identified between groups. Resident sonographers gaze fixated over the left upper quadrant (LUQ) splenorenal interface for a median (interquartile range) of 10.64 (9.73-11.60) seconds. The fellowship group viewed the same ROI for 8.43 (6.64-8.95) seconds (p < 0.003). All participants viewed this ROI. No other ROIs had a statistical difference. Conclusion: Five ROIs were identified that were not visually interrogated by all resident sonographers. Only 14 of 24 resident sonographers visually interrogated every area in the FAST, whereas all fellowship sonographers interrogated every ROI. A statistically significant difference was found in gaze fixation duration between resident and fellowship sonographers in one ROI. Further study is required for gaze fixation assessment to become a tool for the interpretation component of point-of-care ultrasound.
Language	English
Publishing date	2020-02-28
Publishing country	United States
Document type	Journal Article
ISSN	2472-5390
ISSN (online)	2472-5390
DOI	10.1002/aet2.10439
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Novel Technical Protocol for Improved Capture of the Genicular Nerves by Radiofrequency Ablation.

Conger, Aaron / Cushman, Daniel M / Walker, Kortnie / Petersen, Russell / Walega, David R / Kendall, Richard / McCormick, Zachary L

Pain medicine (Malden, Mass.)

2019 Volume 20, Issue 11, Page(s) 2208–2212

Abstract: Background: Fluoroscopically guided cooled genicular nerve radiofrequency ablation (RFA) is an increasingly performed procedure for chronic, refractory knee pain due to osteoarthritis. Traditionally, partial sensory denervation has been accomplished ... ...

Abstract	Background: Fluoroscopically guided cooled genicular nerve radiofrequency ablation (RFA) is an increasingly performed procedure for chronic, refractory knee pain due to osteoarthritis. Traditionally, partial sensory denervation has been accomplished through ablation of the superomedial, superolateral, and inferomedial genicular nerves. However, recent cadaveric studies have demonstrated additional sensory nerves and significant anatomic variation that impact current protocols. Objective: We describe an updated cooled genicular nerve radiofrequency ablation protocol that accounts for varied nerve location of the superomedial, superolateral, and inferomedial genicular nerves, as well as capture of the terminal articular branches of the nerves to the vastus intermedius, vastus lateralis, and vastus medialis. Furthermore, we describe an adjusted technique for inferomedial genicular nerve capture that mitigates the risk of pes anserine tendon injury. Design: Technical report and brief literature review. Methods: Cadaveric studies relating to the sensory innervation of the anterior knee joint were reviewed, and a more accurate and comprehensive cooled genicular nerve radiofrequency ablation (CRFA) protocol is proposed. Conclusions: Based on recent, rigorous anatomic dissections of the knee, the proposed genicular nerve CRFA protocol will provide more complete sensory denervation and potentially improve clinical outcomes. Prospective studies will be needed to confirm the hypothesis that this protocol will result in improved effectiveness and safety of genicular nerve RFA.
MeSH term(s)	Catheter Ablation/methods ; Chronic Pain/surgery ; Dissection/methods ; Humans ; Knee Joint/innervation ; Knee Joint/surgery ; Osteoarthritis, Knee/surgery ; Prospective Studies
Language	English
Publishing date	2019-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pnz124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 167 Changes in Patterns of Community Mortality during the SARS-CoV-2 Pandemic

Walker, L.E. / Heaton, H.A. / Mullan, A.F. / Reichard, R.R. / Monroe, R.J. / Kendall, M. / Goyal, D.G.

Annals of Emergency Medicine

2020 Volume 76, Issue 4, Page(s) S65

Keywords	Emergency Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2020.09.179
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 4 Impact of the SARS-CoV-2 Pandemic on Emergency Department Presentations in an Integrated Health System

Walker, L.E. / Heaton, H.A. / Monroe, R.J. / Reichard, R.R. / Kendall, M. / Mullan, A.F. / Goyal, D.G.

Annals of Emergency Medicine

2020 Volume 76, Issue 4, Page(s) S2–S3

Keywords	Emergency Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2020.09.014
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Article: Molecular mechanisms of cognitive dysfunction following traumatic brain injury.

Walker, Kendall R / Tesco, Giuseppina

Frontiers in aging neuroscience

2013 Volume 5, Page(s) 29

Abstract: Traumatic brain injury (TBI) results in significant disability due to cognitive deficits particularly in attention, learning and memory, and higher-order executive functions. The role of TBI in chronic neurodegeneration and the development of ... ...

Abstract	Traumatic brain injury (TBI) results in significant disability due to cognitive deficits particularly in attention, learning and memory, and higher-order executive functions. The role of TBI in chronic neurodegeneration and the development of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and most recently chronic traumatic encephalopathy (CTE) is of particular importance. However, despite significant effort very few therapeutic options exist to prevent or reverse cognitive impairment following TBI. In this review, we present experimental evidence of the known secondary injury mechanisms which contribute to neuronal cell loss, axonal injury, and synaptic dysfunction and hence cognitive impairment both acutely and chronically following TBI. In particular we focus on the mechanisms linking TBI to the development of two forms of dementia: AD and CTE. We provide evidence of potential molecular mechanisms involved in modulating Aβ and Tau following TBI and provide evidence of the role of these mechanisms in AD pathology. Additionally we propose a mechanism by which Aβ generated as a direct result of TBI is capable of exacerbating secondary injury mechanisms thereby establishing a neurotoxic cascade that leads to chronic neurodegeneration.
Language	English
Publishing date	2013-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2013.00029
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