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  1. Article ; Online: Routes to momentary self-esteem in adolescence: Links with interpersonal perceptions of liking and personality metaperceptions within social interactions.

    Bleckmann, Eva / Nestler, Steffen / Wagner, Jenny

    Journal of personality

    2023  

    Abstract: ... preceding personality metaperceptions (i.e., meta-accuracy and meta-positivity) extended these sociometer ...

    Abstract Objective: This study provides insights into the perceptual processes contributing to positive social experiences and momentary self-esteem in adolescents' initial social interactions.
    Background: A person's self-esteem is shaped by their social experiences. However, little is known about which interpersonal perceptions are linked to momentary self-esteem within social interactions. Identifying two key interpersonal perceptions, we examined differential associations between an individual's meta-liking and other-perceptions of liking by interaction partners with momentary self-esteem. Further, we investigated how preceding personality metaperceptions (i.e., meta-accuracy and meta-positivity) extended these sociometer processes.
    Method: The current study used round-robin data from N = 296 adolescents participating in a virtual group interaction. Social accuracy modeling was used to estimate meta-accuracy and meta-positivity of personality metaperceptions, and path models were used to test associations with interpersonal perceptions of liking and momentary self-esteem.
    Results: Two main findings emerged: First, meta-liking was consistently related to higher momentary self-esteem, whereas other-perceptions of liking were not. Second, meta-positivity of personality metaperceptions was linked to higher meta-liking and indirectly contributed to higher momentary self-esteem through meta-liking.
    Conclusion: These findings highlight the importance of considering different interpersonal perceptions to understand social interaction experiences.
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 420745-2
    ISSN 1467-6494 ; 0022-3506
    ISSN (online) 1467-6494
    ISSN 0022-3506
    DOI 10.1111/jopy.12883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Molecular neuropharmacology

    Nestler, Eric J. / Hyman, Steven E. / Malenka, Robert C.

    a foundation for clinical neuroscience

    2009  

    Author's details Eric J. Nestler ; Steven E. Hyman ; Robert C. Malenka
    Keywords Central Nervous System Agents / pharmacology ; Central Nervous System / drug effects ; Central Nervous System / physiology ; Neuropharmakologie ; Molekularpharmakologie
    Subject Nervensystem
    Language English
    Size XIV, 498 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher McGraw-Hill Medical
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015494762
    ISBN 978-0-07-148127-4 ; 0-07-148127-3
    Database Catalogue ZB MED Medicine, Health

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  3. Article: A Long-Term Comparative Analysis of Endovascular Coiling and Clipping for Ruptured Cerebral Aneurysms: An Individual Patient-Level Meta-Analysis Assessing Rerupture Rates.

    Wach, Johannes / Vychopen, Martin / Güresir, Agi / Guranda, Alexandru / Nestler, Ulf / Güresir, Erdem

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061778
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  4. Article ; Online: Supercharging collaboration for bipolar research-Breakthrough discoveries for thriving with bipolar disorder (BD

    Altimus, C M / Baxi, E G / Frye, M A / Nestler, E J / Pham, D L / Burdick, K E

    Bipolar disorders

    2023  Volume 25, Issue 8, Page(s) 619–623

    MeSH term(s) Humans ; Bipolar Disorder/therapy ; Biomedical Research
    Language English
    Publishing date 2023-12-21
    Publishing country Denmark
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: In reply.

    Nestler, E J

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2014  Volume 15, Issue 3, Page(s) 174–175

    Language English
    Publishing date 2014-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/BF03341945
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  6. Article: The Case of Double Supervision: A Resident's Perspective on Common Problems in Psychotherapy Supervision.

    Nestler, E J

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2014  Volume 14, Issue 3, Page(s) 129–136

    Abstract: The author, while in psychiatric residency training (PGY-3), presented an individual psychotherapy patient to two clinical supervisors, who acted formally as consultants, over a six-month course of treatment. There were fundamental differences of opinion ...

    Abstract The author, while in psychiatric residency training (PGY-3), presented an individual psychotherapy patient to two clinical supervisors, who acted formally as consultants, over a six-month course of treatment. There were fundamental differences of opinion between the supervisors concerning the psychotherapy. In addition, during a case conference, another senior psychiatrist acting as discussant offered a third and generally divergent view of the patient's psychopathology and treatment. The results emphasize the extent to which residents may receive inconsistent and contradictory advice from their clinical supervisors and raise important questions concerning the proper role and practice of psychotherapy supervision in residency training.
    Language English
    Publishing date 2014-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/BF03341284
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  7. Article ; Online: Mesolimbic Neural Response Dynamics Predict Future Individual Alcohol Drinking in Mice.

    Montgomery, Sarah E / Li, Long / Russo, Scott J / Calipari, Erin S / Nestler, Eric J / Morel, Carole / Han, Ming-Hu

    Biological psychiatry

    2023  Volume 95, Issue 10, Page(s) 951–962

    Abstract: Background: Individual variability in response to rewarding stimuli is a striking but understudied phenomenon. The mesolimbic dopamine system is critical in encoding the reinforcing properties of both natural reward and alcohol; however, how innate or ... ...

    Abstract Background: Individual variability in response to rewarding stimuli is a striking but understudied phenomenon. The mesolimbic dopamine system is critical in encoding the reinforcing properties of both natural reward and alcohol; however, how innate or baseline differences in the response dynamics of this circuit define individual behavior and shape future vulnerability to alcohol remain unknown.
    Methods: Using naturalistic behavioral assays, a voluntary alcohol drinking paradigm, in vivo fiber photometry, in vivo electrophysiology, and chemogenetics, we investigated how differences in mesolimbic neural circuit activity contribute to the individual variability seen in reward processing and, by proxy, alcohol drinking.
    Results: We first characterized heterogeneous behavioral and neural responses to natural reward and defined how these baseline responses predicted future individual alcohol-drinking phenotypes in male mice. We then determined spontaneous ventral tegmental area dopamine neuron firing profiles associated with responses to natural reward that predicted alcohol drinking. Using a dual chemogenetic approach, we mimicked specific mesolimbic dopamine neuron firing activity before or during voluntary alcohol drinking to link unique neurophysiological profiles to individual phenotype. We show that hyperdopaminergic individuals exhibit a lower neuronal response to both natural reward and alcohol that predicts lower levels of alcohol consumption in the future.
    Conclusions: These findings reveal unique, circuit-specific neural signatures that predict future individual vulnerability or resistance to alcohol and expand the current knowledge base on how some individuals are able to titrate their alcohol consumption whereas others go on to engage in unhealthy alcohol-drinking behaviors.
    MeSH term(s) Animals ; Alcohol Drinking/physiopathology ; Alcohol Drinking/genetics ; Male ; Reward ; Ventral Tegmental Area/drug effects ; Mice ; Dopaminergic Neurons/physiology ; Dopaminergic Neurons/drug effects ; Mice, Inbred C57BL ; Limbic System/physiopathology ; Ethanol/pharmacology ; Ethanol/administration & dosage
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2023.11.019
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    Zs.A 720: Show issues Location:
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  8. Book: Molecular neuropharmacology

    Nestler, Eric J. / Hyman, Steven E. / Malenka, Robert C.

    foundation for clinical neuroscience

    2001  

    Author's details Eric J. Nestler ; Steven E. Hyman ; Robert C. Malenka
    Keywords Central Nervous System Agents / pharmacology ; Central Nervous System / drug effects ; Central Nervous System / physiology ; Central Nervous System Diseases / drug therapy ; Neuropharmakologie ; Molekularpharmakologie
    Subject Nervensystem
    Language English
    Size XVI, 539 S. : Ill., graph. Darst.
    Publisher McGraw-Hill
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013435240
    ISBN 0-8385-6379-1 ; 978-0-8385-6379-3
    Database Catalogue ZB MED Medicine, Health

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  9. Article: Distal Flow Diversion with Anti-Thrombotically Coated and Bare Metal Low-Profile Flow Diverters-A Comparison.

    Schüngel, Marie-Sophie / Hoffmann, Karl-Titus / Weber, Erik / Maybaum, Jens / Bailis, Nikolaos / Scheer, Maximilian / Nestler, Ulf / Schob, Stefan

    Journal of clinical medicine

    2023  Volume 12, Issue 7

    Abstract: Background and purpose: The establishment of low-profile flow diverting stents (FDS), for example, the Silk Vista Baby (SVB) and the p48MW, facilitated endovascular treatment of peripheral cerebral aneurysms. This study therefore aims to compare the ... ...

    Abstract Background and purpose: The establishment of low-profile flow diverting stents (FDS), for example, the Silk Vista Baby (SVB) and the p48MW, facilitated endovascular treatment of peripheral cerebral aneurysms. This study therefore aims to compare the performance and outcomes of the SVB with those of the p48MW HPC, with a special focus on hemodynamic aspects of peripheral segments and bifurcations.
    Materials and methods: The study cohort comprises 108 patients, who were either treated with the SVB or the p48MW HPC between June 2018 and April 2021.
    Results: Sixty patients received a SVB and forty-eight patients a p48MW HPC. The SVB was used predominantly in the AcomA-complex, and the p48MW HPC in the MCA bifurcation. Immediately after implantation, significant hemodynamic downgrading (OKM A2-A3, B1-B3, C3) was achieved in 60% in the SVB group vs. 75.1% in the p48MW HPC group. At the second follow-up, after an average of 8.8 and 10.9 months, respectively, OKM D1 was observed in 64.4% of the SVB group vs. 27.3% in the p48MW HPC group. Only 1.7% vs. 6.8% of the aneurysms remained morphologically unaltered (OKM A1). Adverse events with persisting neurologic sequalae at last follow-up were largely comparable in both groups (5.0% vs. 4.2%).
    Conclusion: Immediately after implantation, the p48MW HPC had a more profound hemodynamic impact than the SVB; however, early complete occlusions were achieved in a greater proportion of lesions after implantation of the uncoated SVB.
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12072700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Improved Analysis of Prostate Cancer: VIM3, ATG7 and P53 Form a Complex and Activate miRNA 371a-3p.

    Nohl, Elena K / Behring, Jasmin / Kameri, Ersen / Köditz, Barbara / Nestler, Tim / Heidenreich, Axel / VON Brandenstein, Melanie

    Anticancer research

    2023  Volume 43, Issue 6, Page(s) 2407–2416

    Abstract: Background/aim: It is not possible to differentiate prostate carcinomas sufficiently to ensure that every patient receives the right therapy. New molecular markers are needed. Our objective was to identify a complex consisting of vimentin variant 3 ( ... ...

    Abstract Background/aim: It is not possible to differentiate prostate carcinomas sufficiently to ensure that every patient receives the right therapy. New molecular markers are needed. Our objective was to identify a complex consisting of vimentin variant 3 (VIM3), autophagy-related protein 7 (ATG7) and tumor protein p53 (TP53) in prostate cancer cells and its effect on microRNA (miR)-371a-3p.
    Materials and methods: Prostate cancer cell lines (PC3, DU145, LNCaP) and the benign prostatic hyperplasia cell line BPH-1 were cultured in growth medium for 24 h, then stimulated with endothelin 1 (EDN1) (50 nM) and withaferin A (2 nM) for 24 h. Cell extracts were then analyzed by western blot. The localization of VIM3, ATG7 and TP53 in the nucleus was demonstrated with immunofluorescence staining and complex formation was demonstrated by immunoprecipitation. Cancer cell migration was analyzed with a scratch assay and agarose drop analysis. The binding of the complex to the promoter of pri-miR-371a-3p was analyzed with a non-radioactive electrophoretic mobility shift assay. VIM3 knockdown using small interfering RNA and quantitative real-time polymerase chain reaction for miR-371a-3p were performed.
    Results: The complex was present in the nucleus of prostate cancer cells and in the BPH-1 cell line. EDN1 increased the levels of the complex partners and cell migration, whereas withaferin A reduced the levels of the complex partners and migration. The complex bound to the promoter of pri-miR-371a-3p and might be involved in its transcription. Transfection with miR-371a-3p increased migration of prostate cancer cells. VIM3 knockdown reduced miR-371a-3p expression.
    Conclusion: The VIM3-ATG7-P53 complex, with its stimulatory effect on miR-371a-3p, may have the potential to be a marker for improved differentiation between prostate carcinomas, allowing tailored therapy.
    MeSH term(s) Humans ; Male ; Autophagy-Related Protein 7/metabolism ; Carcinoma ; Cell Line, Tumor ; Cell Proliferation ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Prostatic Hyperplasia ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Tumor Suppressor Protein p53/genetics ; Vimentin/genetics
    Chemical Substances ATG7 protein, human (EC 6.2.1.45) ; Autophagy-Related Protein 7 (EC 6.2.1.45) ; MicroRNAs ; Tumor Suppressor Protein p53 ; TP53 protein, human ; Vimentin ; MIRN371 microRNA, human
    Language English
    Publishing date 2023-05-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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