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  1. Book ; Online ; E-Book: Frontiers in pharmacology of neurotransmitters

    Bansal, Puneet Kumar / Deb, Pran Kishore

    2020  

    Abstract: Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the ... ...

    Author's details Puneet Kumar, Pran Kishore Deb, editors
    Abstract Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This is the first book to provide a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.
    Keywords Pharmaceutical technology
    Subject code 615.19
    Language English
    Size 1 online resource (XX, 721 p. 196 illus., 101 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer
    Publishing place Gateway East, Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-3556-6 ; 981-15-3555-8 ; 978-981-15-3556-7 ; 978-981-15-3555-0
    DOI 10.1007/978-981-15-3556-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Animal models of neurological disorders

    Bansal, Puneet Kumar / Deshmukh, Rahul

    principle and working procedure for animal models of neurological disorders

    2017  

    Author's details Puneet Kumar Bansal, Rahul Deshmukh editors
    Keywords Medicine ; Neurosciences ; Pharmacology ; Animal models in research ; Neurobiology
    Subject code 612.8
    Language English
    Size 1 Online-Ressource (xviii, 343 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019616996
    ISBN 978-981-10-5981-0 ; 9789811059803 ; 981-10-5981-0 ; 9811059802
    DOI 10.1007/978-981-10-5981-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: DFT Struggles to Predict the Energy Landscape for Iron Pyridine Diimine-Catalyzed [2 + 2] Cycloaddition of Alkenes: Insights into the Problem and Alternative Solutions.

    Kumar, Nikunj / Gupta, Puneet

    The journal of physical chemistry. A

    2024  

    Abstract: In recent years, noninnocent pyridine diimine (PDI) complexes featuring first-row transition metals have emerged as prominent catalysts, demonstrating efficacy in a diverse range of vital organometallic transformations. However, the inherent complexity ... ...

    Abstract In recent years, noninnocent pyridine diimine (PDI) complexes featuring first-row transition metals have emerged as prominent catalysts, demonstrating efficacy in a diverse range of vital organometallic transformations. However, the inherent complexity of the fundamental reactivity paradigm in these systems arises from the presence of a noninnocent ligand and the multispin feasibility of 3d metals. While density functional theory (DFT) has been widely used to unravel mechanistic insights, its limitations as a single-reference method can potentially misrepresent spin-state energetics, compromising our understanding of these intricate systems. In this study, we employ extensive high-level
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c08325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The durability of vaccine-induced protection: an overview.

    Vashishtha, Vipin M / Kumar, Puneet

    Expert review of vaccines

    2024  Volume 23, Issue 1, Page(s) 389–408

    Abstract: Introduction: Current vaccines vary widely in both their efficacy against infection and disease, and the durability of the efficacy. Some vaccines provide practically lifelong protection with a single dose, while others provide only limited protection ... ...

    Abstract Introduction: Current vaccines vary widely in both their efficacy against infection and disease, and the durability of the efficacy. Some vaccines provide practically lifelong protection with a single dose, while others provide only limited protection following annual boosters. What variables make vaccine-induced immune responses last? Can breakthroughs in these factors and technologies help us produce vaccines with better protection and fewer doses? The durability of vaccine-induced protection is now a hot area in vaccinology research, especially after COVID-19 vaccines lost their luster. It has fueled discussion on the eventual utility of existing vaccines to society and bolstered the anti-vaxxer camp. To sustain public trust in vaccines, lasting vaccines must be developed.
    Areas covered: This review summarizes licensed vaccines' protection. It analyses immunological principles and vaccine and vaccinee parameters that determine longevity of antibodies. The review concludes with challenges and the way forward to improve vaccine durability.
    Expert opinion: Despite enormous advances, we still lack essential markers and reliable correlates of lasting protection. Most research has focused on humoral immune responses, but we must also focus on innate, mucosal, and cellular responses - their assessment, correlates, determinants, and novel adjuvants. Suitable vaccine designs and platforms for durable immunity must be found.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Immunity, Cellular ; Vaccines ; Adjuvants, Immunologic ; Immunization, Secondary ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Vaccines ; Adjuvants, Immunologic ; Antibodies, Viral
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2024.2331065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Atypical Neuroimaging Features of Herpes Simplex Virus-2 Encephalitis.

    Meena, Ankit Kumar / Choudhary, Puneet Kumar / Wander, Arvinder / Madaan, Priyanka

    Indian journal of pediatrics

    2024  

    Language English
    Publishing date 2024-02-23
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-024-05082-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Optical coherence tomography image based eye disease detection using deep convolutional neural network.

    Puneet / Kumar, Rakesh / Gupta, Meenu

    Health information science and systems

    2022  Volume 10, Issue 1, Page(s) 13

    Abstract: Over the past few decades, health care industries and medical practitioners faced a lot of obstacles to diagnosing medical-related problems due to inadequate technology and availability of equipment. In the present era, computer science technologies such ...

    Abstract Over the past few decades, health care industries and medical practitioners faced a lot of obstacles to diagnosing medical-related problems due to inadequate technology and availability of equipment. In the present era, computer science technologies such as IoT, Cloud Computing, Artificial Intelligence and its allied techniques, etc. play a crucial role in the identification of medical diseases, especially in the domain of Ophthalmology. Despite this, ophthalmologists have to perform the various disease diagnosis task manually which is time-consuming and the chances of error are also very high because some of the abnormalities of eye diseases possess the same symptoms. Furthermore, multiple autonomous systems also exist to categorize the diseases but their prediction rate does not accomplish state-of-art accuracy. In the proposed approach by implementing the concept of Attention, Transfer Learning with the Deep Convolution Neural Network, the model accomplished an accuracy of 97.79% and 95.6% on the training and testing data respectively. This autonomous model efficiently classifies the various oscular disorders namely Choroidal Neovascularization, Diabetic Macular Edema, Drusen from the Optical Coherence Tomography images. It may provide a realistic solution to the healthcare sector to bring down the ophthalmologist burden in the screening of Diabetic Retinopathy.
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697647-X
    ISSN 2047-2501
    ISSN 2047-2501
    DOI 10.1007/s13755-022-00182-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Conjunctival Involvement in Infants as an Unusual Symptom of Omicron XBB.1.16 Driven Surge.

    Vashishtha, Vipin M / Kumar, Puneet

    Indian pediatrics

    2023  Volume 60, Issue 10, Page(s) 861–862

    Abstract: We describe clinical characteristics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected children during the XBB.1.16 variant-driven surge in April, 2023 in India. A signi-ficantly higher positivity rate in young infants than in ... ...

    Abstract We describe clinical characteristics of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected children during the XBB.1.16 variant-driven surge in April, 2023 in India. A signi-ficantly higher positivity rate in young infants than in older children (37.4% vs 13.3%; P<0.001), and a predominance of respiratory symptoms were noticed. Notably, non-purulent con-junctivitis was found in 36.8% of SARS-CoV-2 positive infants. All recovered with symptomatic treatment as outpatients.
    MeSH term(s) Child ; Humans ; Infant ; COVID-19/epidemiology ; India/epidemiology ; SARS-CoV-2 ; Conjunctival Neoplasms/epidemiology
    Language English
    Publishing date 2023-10-11
    Publishing country India
    Document type Letter
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 859: Show issues Location:
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  8. Article ; Online: The salience of the motor domain in the risk of psychosis.

    Verma, Vishal / Soni, Puneet Kumar / Nebhinani, Naresh

    The lancet. Psychiatry

    2023  Volume 10, Issue 5, Page(s) 314–315

    MeSH term(s) Humans ; Psychotic Disorders ; Motivation
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Letter ; Comment
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(23)00070-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Self-inhibition of HER2 and HER3 at fever temperatures may prevent their hetero-dimerization.

    Singh, Puneet Kumar / Stan, Razvan C

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–4

    Abstract: HER2 and HER3 receptors dimerize into potent pro-oncogenic complexes involved in various aggressive and recurrent tumors. The role of febrile temperatures on the formation of HER2:HER3 complexes is unknown. To this end, molecular dynamics simulations of ... ...

    Abstract HER2 and HER3 receptors dimerize into potent pro-oncogenic complexes involved in various aggressive and recurrent tumors. The role of febrile temperatures on the formation of HER2:HER3 complexes is unknown. To this end, molecular dynamics simulations of HER2 and HER3 were performed in the 37 °C-40 °C range. HER2 and ligand-free HER32 display inactive conformers that cannot form complexes at 40 °C, while maintaining their extended conformations able to dimerize in the 37 °C-39 °C range. Thermal therapy at particular fever points may complement existing therapy options for HER2-relevant cancers.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2227700
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  10. Article ; Online: Recurring Outbreaks of Circulating Vaccine-derived Polioviruses: Implications for Global Poliovirus Immunization Strategy.

    Vashishtha, Vipin M / Kumar, Puneet

    Indian pediatrics

    2023  Volume 60, Issue 6, Page(s) 437–441

    Abstract: The incidence of polio has decreased by more than 99.9% and currently, only two countries are endemic for wild poliovirus. However, increasing outbreaks of circulating vaccine-derived poliovirus globally in the last few years, with the latest ones in ... ...

    Abstract The incidence of polio has decreased by more than 99.9% and currently, only two countries are endemic for wild poliovirus. However, increasing outbreaks of circulating vaccine-derived poliovirus globally in the last few years, with the latest ones in high-income, exclusive inactivated polio virus vaccine (IPV)-using countries have brought out a new dimension to the end game of polio eradication. The inability of the current IPV to induce efficient mucosal immunity in the intestine is likely to be one of the key reasons behind the silent transmission of the polio virus in these countries. New challenges demand concerted global efforts with renewed vigor to cross the last mile. We need to aggressively cover up areas of under-vaccination and continue large-scale genomic surveillance. Further, the availability of a novel oral polio vaccine (nOPV2), and the likely availability of Sabin IPV and a more refined IPV with mucosal adjuvant in the near future is likely to go a long way in achieving this remarkable feat.
    MeSH term(s) Humans ; Disease Outbreaks/prevention & control ; Global Health ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Poliovirus ; Poliovirus Vaccine, Inactivated ; Poliovirus Vaccine, Oral/adverse effects ; Vaccination
    Chemical Substances Poliovirus Vaccine, Inactivated ; Poliovirus Vaccine, Oral
    Language English
    Publishing date 2023-03-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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