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  1. Article: Radiation Safety and External Radiation Exposure Rate of Patients Receiving I-131 Therapy for Hyperthyroidism and Remnant Ablation as Outpatient: An Institutional Experience.

    Bhatia, Nisha / Dhingra, Vandana K / Mittal, Pulkit / Saini, Sunil

    World journal of nuclear medicine

    2023  Volume 22, Issue 3, Page(s) 203–207

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2023-09-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2911903-0
    ISSN 1607-3312 ; 1450-1147
    ISSN (online) 1607-3312
    ISSN 1450-1147
    DOI 10.1055/s-0043-1771285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Insights into amyloid precursor protein target through PPI network analysis.

    Grewal, Annu / Sheokand, Deepak / Chauhan, Raveena / Saini, Vandana / Kumar, Ajit

    Bioinformation

    2024  Volume 20, Issue 2, Page(s) 140–145

    Abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide with therapeutic lacunae till date. The beta-amyloid (Aβ) accumulation triggers AD pathogenesis, though clinical trials lowering Aβ have not altered disease outcomes suggesting other ... ...

    Abstract Alzheimer's disease (AD) is the leading cause of dementia worldwide with therapeutic lacunae till date. The beta-amyloid (Aβ) accumulation triggers AD pathogenesis, though clinical trials lowering Aβ have not altered disease outcomes suggesting other interacting factors to be identified for drug design of AD. Therefore, it is of interest to identify potential hub proteins interlinked with disease-driving pathways using a network-based approach for AD therapeutic designing. Literature mining was done to identify proteins implicated in AD etiology. Protein-protein interactions (PPIs) were retrieved from the STRING database and merged into a single network using Cytoscape 3.10.1. The hub proteins involved in AD etiology were predicted based on the topological algorithms of CytoHubba. Six major proteins, with STRING database identifiers - APP, BACE1, PSEN1, MAPT, APOE4 and TREM2, were identified to be involved in AD pathogenesis. The merged network of PPIs of these proteins contained 51 nodes and 211 edges, as predicted by Analyzer module of Cytoscape. The Amyloid precursor protein (APP) emerged as the highest-scoring hub protein across multiple centrality measures and topological algorithms. Thus, current data provides evidence to support the ongoing investigation of APP's multifaceted functions and therapeutic potential for AD.
    Language English
    Publishing date 2024-02-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/973206300200140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Minimally invasive endoscopic management of tubercular tenosynovitis of the anterior tibial tendon.

    Khurana, Ankit / Kumar, Nitin / Bansal, Himanshu / Saini, Jitender / Singh, Jujhar / Chugh, Vandana

    Journal of clinical orthopaedics and trauma

    2024  Volume 50, Page(s) 102359

    Abstract: The incidence of tubercular tenosynovitis around the foot and ankle is rare even in endemic areas. We present an unusual case involving the isolated tubercular tenosynovitis of the Anterior Tibial tendon, which was successfully managed through a ... ...

    Abstract The incidence of tubercular tenosynovitis around the foot and ankle is rare even in endemic areas. We present an unusual case involving the isolated tubercular tenosynovitis of the Anterior Tibial tendon, which was successfully managed through a combination of medical treatment and endoscopic intervention. Our patient, a 30-year-old female, sought medical attention due to a gradually worsening painful swelling localized to the anterior aspect of her left ankle. Diagnostic imaging, specifically Magnetic Resonance Imaging (MRI), revealed alterations in signal intensity within the Anterior Tibial tendon. Importantly, the infection had not spread to involve the ankle joint. We performed both diagnostic and therapeutic tenosynovectomy endoscopically and subsequently sent the tissue for histopathological examination. The histopathological findings revealed the presence of histiocytic granulomas containing Langhans' giant cells, which strongly suggested a tuberculosis infection. Consequently, we initiated anti-tubercular chemotherapy as the treatment approach. Our patient exhibited a positive response to the treatment, and after one year, she experienced complete resolution of the disease. This case underscores the importance of maintaining a high level of clinical suspicion for tuberculosis, especially in endemic areas, when encountering unusual presentations.
    Level of evidence: V.
    Language English
    Publishing date 2024-02-06
    Publishing country India
    Document type Case Reports
    ZDB-ID 2596956-0
    ISSN 2213-3445 ; 0976-5662
    ISSN (online) 2213-3445
    ISSN 0976-5662
    DOI 10.1016/j.jcot.2024.102359
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  4. Article: Molecular docking analysis of marine phytochemicals with BACE-1.

    Sheokand, Deepak / Grewal, Annu / Kumar, Pawan / Chauhan, Raveena / Saini, Vandana / Kumar, Ajit

    Bioinformation

    2024  Volume 20, Issue 2, Page(s) 151–155

    Abstract: Alzheimer's disease (AD), a debilitating neurodegenerative condition, is characterized by progressive cognitive decline brought about by the deposition of amyloid beta (Aβ) plaques in the brain initiates downstream neuronal dysfunction and death in AD ... ...

    Abstract Alzheimer's disease (AD), a debilitating neurodegenerative condition, is characterized by progressive cognitive decline brought about by the deposition of amyloid beta (Aβ) plaques in the brain initiates downstream neuronal dysfunction and death in AD pathogenesis. The β-secretase (BACE-1) enzyme plays a crucial role in generating Aβ from amyloid precursor protein (APP). Hence, we report the virtual screening of marine phytochemicals as BACE-1 inhibitors. 2583 compounds, retrieved from Comprehensive Marine Natural Product Database (CMNPD), were primarily screened for drug-likeliness and blood-brain barrier permeability using admetSAR 2.0 and
    Language English
    Publishing date 2024-02-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2203786-X
    ISSN 0973-2063
    ISSN 0973-2063
    DOI 10.6026/973206300200151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparative Analysis between Reid’s Colposcopic Index and Swede’s Score for Detection of Premalignant Lesions of Cervix

    Smriti Pandey / Vandana Saini / Keya Kalra

    Journal of Clinical and Diagnostic Research, Vol 17, Iss 4, Pp QC10-QC

    A Prospective Study

    2023  Volume 14

    Abstract: Introduction: Colposcopy is an effective tool to detect premalignant lesions of the cervix. It is an observer-dependent technique; hence, various colposcopic-based scoring systems have been employed to minimise interobserver variations. Aim: To compare ... ...

    Abstract Introduction: Colposcopy is an effective tool to detect premalignant lesions of the cervix. It is an observer-dependent technique; hence, various colposcopic-based scoring systems have been employed to minimise interobserver variations. Aim: To compare Reid’s Colposcopic Index (RCI) and Swede’s score for the detection of premalignant lesions of the cervix and compare it with colposcopic directed biopsy and histopathology. Materials and Methods: In this prospective observational study conducted at a tertiary care hospital in Delhi, India, between August 2019 to April 2020, 100 women of the reproductive age group were recruited. Pap (Papanicolaou) smear and colposcopy were done for all the patients. Scoring of colposcopic lesions was done according to Reid’s and Swede’s scoring system. In women with RCI or Swedes score ≥3, biopsy of the cervix for histopathology was carried out. Data was recorded and statistically analysed using Statistical Package for the Social Sciences (SPSS) software. Pearson and spearmen correlation coefficient was used for correlation of RCI and Swede’s score. Results: Mean age of women was 43.89±8.2 years. A positive correlation was found between RCI and Swedes score as the correlation coefficient was 0.995 and p-value<0.001. Sensitivity was better with Swede’s scoring system as compared to RCI for predicting Cervical Intraepithelial Neoplasia (CIN)-I lesions. However, for predicting CIN-II and CIN-III lesions sensitivity with both the scoring system was comparable. The sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of RCI at a cut-off score of 5 was 54.54%, 87.17%, 54.54%, and 87.1% for CIN-I, for CIN-II was 100%, 86.67%, 45.45%, and 100%. CIN-III was 100%, 82.1%, 22.7%, and 100%. Similarly, the sensitivity, specificity, PPV, and NPV of Swedes score at a cut-off score of 5 was 59%, 84.6%, 52%, and 88% for CIN-I, for CIN-II was 100%, 83.33%, 40%, and 100%. And that for CIN-III was 100%, 78.94%, 20% and 100%. Conclusion: Both scoring systems ...
    Keywords cervical biopsy ; colposcopy ; premalignant cervical lesion ; reid’s colposcopic index ; swede’s score ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Clinical side-effects based drug repositioning for anti-epileptic activity.

    Kumar, Pawan / Sheokand, Deepak / Grewal, Annu / Saini, Vandana / Kumar, Ajit

    Journal of biomolecular structure & dynamics

    2023  Volume 42, Issue 3, Page(s) 1443–1454

    Abstract: Several generations of anti-epileptic drugs (AEDs) are available but have several associated side effects apart from a limited success rate. Drug repositioning strategies have gained importance in the last two decades owing to lower failure rates and ... ...

    Abstract Several generations of anti-epileptic drugs (AEDs) are available but have several associated side effects apart from a limited success rate. Drug repositioning strategies have gained importance in the last two decades owing to lower failure rates and economic burden. Drugs with similar side effect profiles may share a common mechanism of action and thus can be linked to other disease treatments. The present study was carried out to identify the newly approved drug candidate(s) as AEDs using clinical side-effects drug repositioning strategy. The clinical side effect similarity of drugs available in the SIDER v4.1 database was estimated against common side effects of 5 major marketed AEDs, using the 'dplyr' package library in the R. Further drugs were filtered based on Blood Brain Barrier permeability prediction and FDA-approval status. Molecular docking studies were performed for selected 26 hits (drugs) against previously identified epilepsy target receptors: Voltage-gated sodium channel α2 (Nav1.2), GABA receptor α1-β1 (GABAr α1-β1), and Voltage-gated calcium channel α-1 G (Cav3.1). Only 2 drugs (Ziprasidone and Paroxetine) showed better binding affinities against studied epilepsy receptors Nav1.2, GABAr α1-β1, and Cav3.1, than their corresponding standard AEDs, i.e. Carbamazepine, Clonazepam, and Pregabalin, respectively. Ziprasidone reportedly showed seizure-like symptoms in ∼3% of patients and was hence omitted from further study. The MDS study of docked complexes of Paroxetine with selected epilepsy target receptors showed stable RMSD values and better interaction energies. The study reveals Paroxetine as a potential candidate to be repurposed for 1st line epileptic seizure medication.Communicated by Ramaswamy H. Sarma.
    MeSH term(s) Humans ; Drug Repositioning ; Molecular Docking Simulation ; Paroxetine/therapeutic use ; Anticonvulsants/pharmacology ; Epilepsy/drug therapy ; Piperazines ; Thiazoles
    Chemical Substances ziprasidone (6UKA5VEJ6X) ; Paroxetine (41VRH5220H) ; Anticonvulsants ; Piperazines ; Thiazoles
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2199874
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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  7. Article: Protective Efficacy of Multiple Epitope-Based Vaccine against

    Nandi, Abhijit / Manisha / Solanki, Vandana / Tiwari, Vishvanath / Sajjanar, Basavaraj / Sankar, Muthu / Saini, Mohini / Shrivastava, Sameer / Bhure, S K / Ghosh, Srikant

    Vaccines

    2023  Volume 11, Issue 4

    Abstract: ... Hyalomma ... ...

    Abstract Hyalomma anatolicum
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11040881
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  8. Article ; Online: Air travel in COVID-19 pandemic

    Saini, Vandana / Saini, Narendra

    Journal of Patient Safety and Infection Control

    2020  Volume 8, Issue 1, Page(s) 29

    Keywords covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ISSN 2214-207X
    DOI 10.4103/jpsic.jpsic_12_20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery.

    Kumar, Virender / Garg, Vandana / Saini, Nakul / Aggarwal, Navidha / Kumar, Harsh / Kumar, Davinder / Chopra, Hitesh / Kamal, Mohammad Amjad / Dureja, Harish

    Current pharmaceutical biotechnology

    2024  

    Abstract: Background: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of ... ...

    Abstract Background: A nanoemulsion is a colloidal system of small droplets dispersed in another liquid. It has attracted considerable attention due to its unique properties and various applications. Throughout this review, we provide an overview of nanoemulsions and how they can be applied to various applications such as drug delivery, food applications, and pesticide formulations.
    Objective: This updated review aims to comprehensively overview nanoemulsions and their applications as a versatile platform for drug delivery, food applications, and pesticide formulations.
    Methods: Research relevant scientific literature across various databases, including PubMed, Scopus, and Web of Science. Suitable keywords for this purpose include "nanoemulsion," "drug delivery," and "food applications." Ensure the search criteria include recent publications to ensure current knowledge is included.
    Results: Several benefits have been demonstrated in the delivery of drugs using nanoemulsions, including improved solubility, increased bioavailability, and controlled delivery. Nanoemulsions have improved some bioactive compounds in food applications, including vitamins and antioxidants. At the same time, pesticide formulations based on nanoemulsions have also improved solubility, shelf life, and effectiveness.
    Conclusion: The versatility of nanoemulsions makes them ideal for drug delivery, food, and pesticide formulation applications. These products are highly soluble, bioavailable, and targeted, providing significant advantages. More research and development are required to implement nanoemulsion-based products on a commercial scale.
    Language English
    Publishing date 2024-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010267771240211124950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
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  10. Article: A Low-Prevalence Single-Nucleotide Polymorphism in the Sensor Kinase PhoR in

    Waturuocha, Uchenna Watson / Krishna, M S / Malhotra, Vandana / Dixit, Narendra M / Saini, Deepak Kumar

    Frontiers in microbiology

    2021  Volume 12, Page(s) 724482

    Abstract: The genome sequencing ... ...

    Abstract The genome sequencing of
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.724482
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