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  1. Book ; Online ; E-Book: Medical management of type 1 diabetes

    Low Wang, Cecilia C. / Shah, Avni C.

    2016  

    Title variant Medical management of type one diabetes
    Author's details [edited by] Cecilia C. Low Wang, MD, FACP; Avni C. Shah, MD
    Keywords Diabetes Mellitus, Type 1
    Language English
    Size 1 Online-Ressource (143 Seiten), Illustrationen, Diagramme
    Edition Seventh edition
    Publisher American Diabetes Association
    Publishing place Arlington, VA
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019616245
    ISBN 978-1-58040-677-2 ; 9781580406307 ; 1-58040-677-7 ; 1580406300
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Continuous Glucose Monitoring for Prediabetes: What Are the Best Metrics?

    Zahalka, Salwa J / Galindo, Rodolfo J / Shah, Viral N / Low Wang, Cecilia C

    Journal of diabetes science and technology

    2024  , Page(s) 19322968241242487

    Abstract: Background: Continuous glucose monitoring (CGM) has transformed the care of type 1 and type 2 diabetes, and there is potential for CGM to also become influential in prediabetes identification and management. However, to date, we do not have any ... ...

    Abstract Background: Continuous glucose monitoring (CGM) has transformed the care of type 1 and type 2 diabetes, and there is potential for CGM to also become influential in prediabetes identification and management. However, to date, we do not have any consensus guidelines or high-quality evidence to guide CGM goals and metrics for use in prediabetes.
    Methods: We searched PubMed for all English-language articles on CGM use in nonpregnant adults with prediabetes published by November 1, 2023. We excluded any articles that included subjects with type 1 diabetes or who were known to be at risk for type 1 diabetes due to positive islet autoantibodies.
    Results: Based on the limited data available, we suggest possible CGM metrics to be used for individuals with prediabetes. We also explore the role that glycemic variability (GV) plays in the transition from normoglycemia to prediabetes.
    Conclusions: Glycemic variability indices beyond the standard deviation and coefficient of variation are emerging as prominent identifiers of early dysglycemia. One GV index in particular, the mean amplitude of glycemic excursion (MAGE), may play a key future role in CGM metrics for prediabetes and is highlighted in this review.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/19322968241242487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Macrovascular Complications.

    McRae, Michael / Low Wang, Cecilia C

    Primary care

    2022  Volume 49, Issue 2, Page(s) 255–273

    Abstract: ... to a statin and low-dose aspirin. ...

    Abstract Because macrovascular complications of diabetes are the leading cause of mortality and decreased quality of life for individuals with diabetes, prevention and risk reduction are paramount. Besides lifestyle management, contemporary therapies can significantly reduce risk for cardiovascular events in diabetes. For primary prevention, most individuals should be on statin therapy, whereas those at high atherosclerotic cardiovascular disease risk should also be on glucagon-like peptide 1 receptor agonists (GLP1RA) or sodium/glucose cotransporter-2 inhibitors (SGLT2i) at any hemoglobin A1c. For secondary prevention, addition of GLP1RA or SGLT2i, PCKS9i, rivaroxaban, and/or icosapent ethyl should be considered in addition to a statin and low-dose aspirin.
    MeSH term(s) Cardiovascular Diseases/drug therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Quality of Life ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604005-6
    ISSN 1558-299X ; 0095-4543
    ISSN (online) 1558-299X
    ISSN 0095-4543
    DOI 10.1016/j.pop.2021.11.012
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  4. Article ; Online: Advances in the management of type 2 diabetes in adults.

    Galindo, Rodolfo J / Trujillo, Jennifer M / Low Wang, Cecilia C / McCoy, Rozalina G

    BMJ medicine

    2023  Volume 2, Issue 1, Page(s) e000372

    Abstract: Type 2 diabetes is a chronic and progressive cardiometabolic disorder that affects more than 10% of adults worldwide and is a major cause of morbidity, mortality, disability, and high costs. Over the past decade, the pattern of management of diabetes has ...

    Abstract Type 2 diabetes is a chronic and progressive cardiometabolic disorder that affects more than 10% of adults worldwide and is a major cause of morbidity, mortality, disability, and high costs. Over the past decade, the pattern of management of diabetes has shifted from a predominantly glucose centric approach, focused on lowering levels of haemoglobin A
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-0413
    ISSN (online) 2754-0413
    DOI 10.1136/bmjmed-2022-000372
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  5. Article: Safety and Efficacy of Insulins in Critically Ill Patients Receiving Continuous Enteral Nutrition.

    Ni, Kevin / Hawkins, R Matthew / Smyth, Heather L / Seggelke, Stacey A / Gibbs, Joanna / Lindsay, Mark C / Kaizer, Laura K / Low Wang, Cecilia C

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2024  Volume 30, Issue 4, Page(s) 367–371

    Abstract: Objective: There is a relative lack of consensus regarding the optimal management of hyperglycemia in patients receiving continuous enteral nutrition (EN), with or without a diagnosis of diabetes.: Methods: This retrospective study examined 475 ... ...

    Abstract Objective: There is a relative lack of consensus regarding the optimal management of hyperglycemia in patients receiving continuous enteral nutrition (EN), with or without a diagnosis of diabetes.
    Methods: This retrospective study examined 475 patients (303 with known diabetes) hospitalized in critical care setting units in 2019 in a single center who received continuous EN. Rates of hypoglycemia, hyperglycemia, and glucose levels within the target range (70-180 mg/dL) were compared between patients with and without diabetes, and among patients treated with intermediate-acting (IA) biphasic neutral protamine Hagedorn 70/30, long-acting (LA) insulin, or rapid-acting insulin only.
    Results: Among those with type 2 diabetes mellitus, IA and LA insulin regimens were associated with a significantly higher proportion of patient-days in the target glucose range and fewer hyperglycemic days. Level 1 (<70 mg/dL) and level 2 (<54 mg/dL) hypoglycemia occurred rarely, and there were no significant differences in level 2 hypoglycemia frequency across the different insulin regimens.
    Conclusion: Administration of IA and LA insulin can be safe and effective for those receiving insulin doses for EN-related hyperglycemia.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/adverse effects ; Retrospective Studies ; Enteral Nutrition ; Critical Illness/therapy ; Blood Glucose ; Insulin/adverse effects ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemia/drug therapy ; Insulin, Long-Acting/therapeutic use ; Hyperglycemia/drug therapy ; Hyperglycemia/prevention & control ; Hyperglycemia/chemically induced ; Glucose/therapeutic use ; Insulin, Isophane/adverse effects
    Chemical Substances Hypoglycemic Agents ; Blood Glucose ; Insulin ; Insulin, Long-Acting ; Glucose (IY9XDZ35W2) ; Insulin, Isophane (53027-39-7)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2024.01.009
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  6. Article ; Online: A simple modeling framework for prediction in the human glucose-insulin system.

    Sirlanci, Melike / Levine, Matthew E / Low Wang, Cecilia C / Albers, David J / Stuart, Andrew M

    Chaos (Woodbury, N.Y.)

    2023  Volume 33, Issue 7

    Abstract: ... low BG levels. Such predictions have potential use for glycemic management as part of control systems ...

    Abstract Forecasting blood glucose (BG) levels with routinely collected data is useful for glycemic management. BG dynamics are nonlinear, complex, and nonstationary, which can be represented by nonlinear models. However, the sparsity of routinely collected data creates parameter identifiability issues when high-fidelity complex models are used, thereby resulting in inaccurate forecasts. One can use models with reduced physiological fidelity for robust and accurate parameter estimation and forecasting with sparse data. For this purpose, we approximate the nonlinear dynamics of BG regulation by a linear stochastic differential equation: we develop a linear stochastic model, which can be specialized to different settings: type 2 diabetes mellitus (T2DM) and intensive care unit (ICU), with different choices of appropriate model functions. The model includes deterministic terms quantifying glucose removal from the bloodstream through the glycemic regulation system and representing the effect of nutrition and externally delivered insulin. The stochastic term encapsulates the BG oscillations. The model output is in the form of an expected value accompanied by a band around this value. The model parameters are estimated patient-specifically, leading to personalized models. The forecasts consist of values for BG mean and variation, quantifying possible high and low BG levels. Such predictions have potential use for glycemic management as part of control systems. We present experimental results on parameter estimation and forecasting in T2DM and ICU settings. We compare the model's predictive capability with two different nonlinear models built for T2DM and ICU contexts to have a sense of the level of prediction achieved by this model.
    MeSH term(s) Humans ; Glucose ; Diabetes Mellitus, Type 2 ; Blood Glucose ; Insulin ; Nonlinear Dynamics
    Chemical Substances Glucose (IY9XDZ35W2) ; Blood Glucose ; Insulin
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0146808
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  7. Article: Digital Health and Shared Decision-Making in Diabetes Care - A Survey Initiative in Patients and Clinicians.

    Mubeen, Faiza / Low Wang, Cecilia C / Al Maradni, Ahmad / Shivaswamy, Vijay / Sadhu, Archana R

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2023  Volume 29, Issue 7, Page(s) 538–545

    Abstract: Objective: To assess the landscape of digital health resources in the United States, better understand the impact of the digital health on shared decision-making, and identify potential barriers and opportunities for progress in the care of persons with ...

    Abstract Objective: To assess the landscape of digital health resources in the United States, better understand the impact of the digital health on shared decision-making, and identify potential barriers and opportunities for progress in the care of persons with diabetes.
    Methods: The study consisted of two phases: A qualitative phase in which one-on-one interviews were conducted virtually with 34 physicians (endocrinologists {Endos}: n = 15; primary care physicians {PCPs}: n = 19) between February 11, 2021 and February 18, 2021, and a quantitative phase in which two online, email-based surveys in the English language were conducted between April 16, 2021 and May 17, 2021: one with healthcare professionals (HCP) (n = 403: n = 200 Endos and n = 203 PCPs), and one with persons with diabetes (n = 517: patients with type 1 diabetes, n = 257; patients with type 2 diabetes, n = 260).
    Results: Diabetes digital health tools were found to be helpful in shared decision-making, but leading barriers include cost, coverage, and lack of time by healthcare professionals. Among diabetes digital health tools, continuous glucose monitoring (CGM) systems were used most commonly and viewed as most effective in improving quality of life and facilitating shared decision-making. Strategies for increasing use of diabetes digital health resources included lower cost, integration into electronic health records, and increased simplicity of tools.
    Conclusion: This study revealed that both Endos and PCPs feel that diabetes digital health tools have an overall positive impact. Integration with telemedicine and simpler, lower cost tools with increased patient access can further facilitate shared decision-making and improved diabetes care and quality of life.
    MeSH term(s) Humans ; United States ; Diabetes Mellitus, Type 2/therapy ; Quality of Life ; Blood Glucose Self-Monitoring ; Blood Glucose ; Physicians
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2023.04.012
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  8. Article: Insulin Resistance in a Hospitalized COVID-19 Patient: A Case Review.

    Seggelke, Stacey A / Ingram, Claire C / Crawley, Svitlana / Low Wang, Cecilia C

    Clinical diabetes : a publication of the American Diabetes Association

    2021  Volume 39, Issue 2, Page(s) 228–232

    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1025953-3
    ISSN 0891-8929
    ISSN 0891-8929
    DOI 10.2337/cd20-0036
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  9. Article: Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic Review.

    Brooks, Danielle / Schulman-Rosenbaum, Rifka / Griff, Megan / Lester, Janice / Low Wang, Cecilia C

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2022  Volume 28, Issue 11, Page(s) 1166–1177

    Abstract: Objective: Optimal glucocorticoid-induced hyperglycemia (GCIH) management is unclear. The COVID-19 pandemic has made this issue more prominent because dexamethasone became the standard of care in patients needing respiratory support. This systematic ... ...

    Abstract Objective: Optimal glucocorticoid-induced hyperglycemia (GCIH) management is unclear. The COVID-19 pandemic has made this issue more prominent because dexamethasone became the standard of care in patients needing respiratory support. This systematic review aimed to describe the management of GCIH and summarize available management strategies for dexamethasone-associated hyperglycemia in patients with COVID-19.
    Methods: A systematic review was conducted using the PubMed/MEDLINE, Cochrane Library, Embase, and Web of Science databases with results from 2011 through January 2022. Keywords included synonyms for "steroid-induced diabetes" or "steroid-induced hyperglycemia." Randomized controlled trials (RCTs) were included for review of GCIH management. All studies focusing on dexamethasone-associated hyperglycemia in COVID-19 were included regardless of study quality.
    Results: Initial search for non-COVID GCIH identified 1230 references. After screening and review, 33 articles were included in the non-COVID section of this systematic review. Initial search for COVID-19-related management of dexamethasone-associated hyperglycemia in COVID-19 identified 63 references, whereas 7 of these were included in the COVID-19 section. RCTs of management strategies were scarce, did not use standard definitions for hyperglycemia, evaluated a variety of treatment strategies with varying primary end points, and were generally not found to be effective except for Neutral Protamine Hagedorn insulin added to basal-bolus regimens.
    Conclusion: Few RCTs are available evaluating GCIH management. Further studies are needed to support the formulation of clinical guidelines for GCIH especially given the widespread use of dexamethasone during the COVID-19 pandemic.
    MeSH term(s) Humans ; Glucocorticoids/adverse effects ; COVID-19/drug therapy ; Hyperglycemia/chemically induced ; Hyperglycemia/therapy ; Dexamethasone/adverse effects ; Steroids/adverse effects
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL) ; Steroids
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2022.07.014
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  10. Article ; Online: Rosiglitazone improves insulin resistance but does not improve exercise capacity in individuals with impaired glucose tolerance: A randomized clinical study.

    Abushamat, Layla A / Schauer, Irene E / Low Wang, Cecilia C / Mitchell, Stacey / Herlache, Leah / Bridenstine, Mark / Durbin, Roy / Snell-Bergeon, Janet K / Regensteiner, Judith G / Reusch, Jane Eb

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2024  Volume 72, Issue 3, Page(s) 294–304

    Abstract: ... endpoints (coronary artery calcium (CAC) volume and density and C-reactive protein (CRP)) were measured ...

    Abstract Dysmetabolic states, such as type 2 diabetes (T2D), characterized by insulin resistance (IR), are associated with fatty liver, increased cardiovascular disease (CVD) risk, and decreased functional exercise capacity (FEC). Rosiglitazone (RO) improves exercise capacity and IR in T2D. However, the effects of RO on FEC and other markers of CVD risk in prediabetes are unknown. We hypothesized that insulin sensitization with RO would improve exercise capacity and markers of CVD risk in participants with impaired glucose tolerance (IGT). Exercise performance (peak oxygen consumption and oxygen uptake kinetics), IR (homeostasis model assessment of IR and quantitative insulin sensitivity check index), and surrogate cardiovascular endpoints (coronary artery calcium (CAC) volume and density and C-reactive protein (CRP)) were measured in participants with IGT after 12 and 18 months of RO or placebo (PL). RO did not significantly improve exercise capacity. Glycemic measures and IR were significantly lower in people on RO compared to PL at 18 months. CAC volume progression was not different between PL and RO groups. RO did not improve exercise capacity during an 18-month intervention despite improved IR and glycemia in people with IGT. Future studies should explore why effects on FEC with RO occur in T2D but not IGT. Understanding these questions may help in targeting therapeutic approaches in T2D and IGT.
    MeSH term(s) Humans ; Insulin Resistance ; Glucose Intolerance/drug therapy ; Rosiglitazone/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Exercise Tolerance ; Glucose Tolerance Test ; Blood Glucose/metabolism ; Cardiovascular Diseases/complications
    Chemical Substances Rosiglitazone (05V02F2KDG) ; Blood Glucose
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1177/10815589231225183
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