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  1. Book: Ketsuekigaku yōgo jiten

    Hirai, Hisamaru

    2004  

    Title translation Terminology of hematology.
    Author's details [henshū Hirai Hisamaru, Chiba Shigeru]
    MeSH term(s) Hematology
    Language Japanese
    Size 462 p.
    Edition Kaitei 3-pan.
    Publisher Fuji Medikaru Suppan
    Publishing place Ōsaka-shi
    Document type Book
    ISBN 9784939048593 ; 4939048594
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book: Ketsueki no jiten

    Hirai, Hisamaru

    2004  

    Title translation Dictionary of hematology.
    Author's details henshū Hirai Hisamaru, Oshimi Kazuo, Sakata Yōichi
    MeSH term(s) Blood ; Hematology
    Language Japanese
    Size xi, 397 p. :, ill. ;, 22 cm.
    Edition Shohan.
    Publisher Asakura Shoten
    Publishing place Tōkyō
    Document type Book
    ISBN 9784254300765 ; 425430076X
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Book: Ketsuekigaku yōgo jiten

    Hirai, Hisamaru

    2001  

    Title translation Terminology of hematology.
    Author's details Hirai Hisamaru hen
    MeSH term(s) Hematology
    Language Japanese
    Size 389 p.
    Edition Kaiteiban.
    Publisher Fuji Medikaru Suppan
    Publishing place Ōsaka-shi
    Document type Book
    ISBN 9784939048128 ; 4939048128
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article: [Recent topics on leukemia: New molecular targeting therapy].

    Hirai, Hisamaru

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2003  Volume 92, Issue 6, Page(s) 1036–1042

    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antigens, CD/immunology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Division/drug effects ; Drug Design ; Histone Deacetylases/pharmacology ; Histone Deacetylases/therapeutic use ; Humans ; Leukemia/drug therapy ; Leukemia/pathology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/drug effects
    Chemical Substances Antibodies, Monoclonal ; Antigens, CD ; Antineoplastic Agents ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Histone Deacetylases (EC 3.5.1.98)
    Language Japanese
    Publishing date 2003-06-10
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: [Therapy of hematologic disorders with stem cell transplantation].

    Hirai, Hisamaru

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2002  Volume 91 Suppl, Page(s) 141–146

    MeSH term(s) Bone Marrow Transplantation ; Forecasting ; Graft vs Host Disease/prevention & control ; Graft vs Host Disease/therapy ; Hematologic Diseases/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/trends ; Humans ; Treatment Outcome
    Language Japanese
    Publishing date 2002-03-20
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 594: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Stem cells and regenerative medicine.

    Hirai, Hisamaru

    Human cell

    2003  Volume 15, Issue 4, Page(s) 190–198

    Abstract: Stem cells have been defined as clonogenic cells that undergo both self-renewal and differentiation to more committed progenitors and functionally specialized mature cells. Of late years, stem cells have been identified in a variety of tissues of an ... ...

    Abstract Stem cells have been defined as clonogenic cells that undergo both self-renewal and differentiation to more committed progenitors and functionally specialized mature cells. Of late years, stem cells have been identified in a variety of tissues of an adult body. Depending on the source, they have the potential to form one or more, or even all cell types of an organism. Stem cell research provided some outstanding contributions to our understanding of developmental biology and offered much hope for cell replacement therapies overcoming a variety of diseases. The establishment of human ES cell lines enabled us to generate all tissues we comprise. Recently, excitement has been evoked by the controversial evidence that adult stem cells have a much higher degree of developmental plasticity than previously imagined. More recently, the existence of multipotent somatic stem cells in bone marrow has been reported. Combined with these discoveries and achievements as well as the developing technologies, scientists are now trying to bring stem cell therapies to the clinic.
    MeSH term(s) Animals ; Cell Differentiation ; Cell- and Tissue-Based Therapy ; Embryo, Mammalian/cytology ; Humans ; Regeneration ; Stem Cell Transplantation ; Stem Cells ; Tissue Engineering
    Language English
    Publishing date 2003-07-30
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1111/j.1749-0774.2002.tb00115.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Molecular mechanisms of myelodysplastic syndrome.

    Hirai, Hisamaru

    Japanese journal of clinical oncology

    2003  Volume 33, Issue 4, Page(s) 153–160

    Abstract: Myelodysplastic syndrome (MDS) is a family of clonal disorders of hematopoietic stem cells that are characterized by ineffective hematopoiesis and susceptibility to acute myelogenous leukemias and are shown to be strikingly refractory to current ... ...

    Abstract Myelodysplastic syndrome (MDS) is a family of clonal disorders of hematopoietic stem cells that are characterized by ineffective hematopoiesis and susceptibility to acute myelogenous leukemias and are shown to be strikingly refractory to current therapeutic modalities. A substantial proportion of these complex diseases arises in the setting of exposures to environmental or occupational toxins, including cytotoxic therapy for a prior malignancy or other disorder. The conversion of a normal stem cell into a preleukemic and ultimately leukemic state is a multistep process requiring the accumulation of a number of genetic lesions. At the genomic level, MDS is typified by losses and translocations involving certain key gene segments, with disruption of the normal structure and function of genes that control the balance of proliferation and differentiation of hematopoietic precursors. More than half of the chromosomal abnormalities in MDS comprise deletions of chromosomes 5, 7, 11, 12, 13 and 20. This evidence suggests that as yet unidentified tumor-suppressor genes should have important roles in the molecular mechanisms of MDS. Further molecular approaches to such genetic lesions will identify the relevant tumor-suppressor genes. Over the past years, major signal transduction molecules have been identified and their genetic alterations have been extensively analyzed in both MDS and leukemias. These include receptors for growth factors, RAS signaling molecules, cell cycle regulators and transcription factors. Notable among them are transcription factors that regulate both proliferation and differentiation of hematopoietic stem cells. The disruption of the normal flow of the signal transduction pathways involving these molecules translates into ineffective multilineage hematopoiesis and bone marrow failure. Therefore, MDS provides a fertile testing ground on which we could study the molecular dissection implicated in the multistep leukemogenesis.
    MeSH term(s) Chromosome Aberrations ; Chromosome Deletion ; Genes, Tumor Suppressor/physiology ; Hematopoiesis ; Hematopoietic Stem Cells/pathology ; Humans ; Leukemia/etiology ; Myelodysplastic Syndromes/blood ; Myelodysplastic Syndromes/genetics ; Translocation, Genetic
    Language English
    Publishing date 2003-05-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyg037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1298: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Molecular pathogenesis of MDS.

    Hirai, Hisamaru

    International journal of hematology

    2003  Volume 76 Suppl 2, Page(s) 213–221

    Abstract: Myelodysplastic syndromes (MDS) are considered to be a family of clonal disorders of hematopoietic stem cells that are characterized by ineffective hematopoiesis and susceptibility to acute myelogenous leukemias, and are shown to be strikingly refractory ...

    Abstract Myelodysplastic syndromes (MDS) are considered to be a family of clonal disorders of hematopoietic stem cells that are characterized by ineffective hematopoiesis and susceptibility to acute myelogenous leukemias, and are shown to be strikingly refractory to current therapeutic modalities. A substantial proportion of these complex diseases arise in the setting of exposures to environmental or occupational toxins, including cytotoxic therapy for a prior malignancy or other disorder. The conversion of a normal stem cell into a preleukemic and ultimately leukemic state is a multistep process requiring the accumulation of a number of genetic lesions. On the genomic level, MDS is typified by losses and translocations involving certain key gene segments, with disruption of the normal structure and function of genes that control the balance of proliferation and differentiation of hematopoietic precursors. More than a half of the chromosomal abnormalities in MDS comprise deletions of chromosomes 5, 7, 11, 12, 13 and 20. This evidence suggests that as yet unidentified tumor suppressor genes should have important roles in the molecular mechanisms of MDS. Further molecular approaches to such genetic lesions will identify the relevant tumor suppressor genes. Over the past years, major signal transduction molecules were identified and their genetic alterations were extensively analyzed in MDS as well as leukemias. These include receptors for growth factors, RAS signaling molecules, cell cycle regulators, and transcription factors. Among them, notable is transcription factors that regulate both proliferation and differentiation of hematopoitic stem cells. The disruption of the normal flow of the signal transduction pathways involving these molecules translates into ineffective multilineage hematopoiesis and bone marrow failure. Therefore, MDS provides a fertile testing ground on which we could study the molecular dissection implicated in the multistep leukemogenesis.
    MeSH term(s) Cell Transformation, Neoplastic/genetics ; Chromosome Aberrations ; Humans ; Myelodysplastic Syndromes/etiology ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/pathology
    Language English
    Publishing date 2003-04-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0925-5710 ; 0917-1258
    ISSN (online) 1865-3774
    ISSN 0925-5710 ; 0917-1258
    DOI 10.1007/bf03165120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 269: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book: Ketsuekigaku yōgo jiten

    Hirai, Hisamaru

    1999  

    Title variant Hematological dictionary
    Author's details Hirai Hisamaru hen = Hematological dictionary / Hirai Hisamaru
    MeSH term(s) Hematologic Diseases
    Language Japanese ; English
    Size 317 p. :
    Edition Shohan.
    Publisher Fuji Medikaru Shuppan
    Publishing place Ōsaka-shi
    Document type Book
    Note Text in Japanese; entry terms also in English; index in English.
    ISBN 9784939048005 ; 4939048004
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Hakketsubyō no bunshi igaku

    Hirai, Hisamaru

    (New medikaru saiensu ; 23)

    1994  

    Title translation Molecular pathology of leukemia.
    Author's details Hirai Hisamaru hen
    Series title New medikaru saiensu ; 23
    MeSH term(s) Leukemia/physiopathology ; Chromosome Disorders/physiopathology
    Language Japanese
    Size 147 p. :, ill.
    Edition Shohan.
    Publisher Yōdosha
    Publishing place Tōkyō
    Document type Book
    ISBN 9784897065229 ; 4897065224
    Database Catalogue of the US National Library of Medicine (NLM)

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