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Article ; Online: The Death of Actively Dying.

Noch, Evan K

2020 Volume 23, Issue 9, Page(s) 1149

MeSH term(s)	Attitude to Death ; Death ; Humans ; Terminal Care
Language	English
Publishing date	2020-06-08
Publishing country	United States
Document type	Letter
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2020.0152
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Article ; Online: Til Neglect Do Us Part.

Noch, Evan K

JAMA neurology

2018 Volume 75, Issue 7, Page(s) 785–786

MeSH term(s)	Aged ; Female ; Humans ; Male ; Marriage ; Perceptual Disorders/rehabilitation ; Spouses ; Stroke Rehabilitation
Language	English
Publishing date	2018-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2018.1185
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Article ; Online: Right Brain: Home is where the heart is.

Noch, Evan K

Neurology

2016 Volume 87, Issue 24, Page(s) e288–e289

Language	English
Publishing date	2016-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000003436
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Article ; Online: Metabolic partitioning in the brain and its hijacking by glioblastoma.

de Ruiter Swain, Jed / Michalopoulou, Evdokia / Noch, Evan K / Lukey, Michael J / Van Aelst, Linda

Genes & development

2023 Volume 37, Issue 15-16, Page(s) 681–702

Abstract: The different cell types in the brain have highly specialized roles with unique metabolic requirements. Normal brain function requires the coordinated partitioning of metabolic pathways between these cells, such as in the neuron-astrocyte glutamate- ... ...

Abstract	The different cell types in the brain have highly specialized roles with unique metabolic requirements. Normal brain function requires the coordinated partitioning of metabolic pathways between these cells, such as in the neuron-astrocyte glutamate-glutamine cycle. An emerging theme in glioblastoma (GBM) biology is that malignant cells integrate into or "hijack" brain metabolism, co-opting neurons and glia for the supply of nutrients and recycling of waste products. Moreover, GBM cells communicate via signaling metabolites in the tumor microenvironment to promote tumor growth and induce immune suppression. Recent findings in this field point toward new therapeutic strategies to target the metabolic exchange processes that fuel tumorigenesis and suppress the anticancer immune response in GBM. Here, we provide an overview of the intercellular division of metabolic labor that occurs in both the normal brain and the GBM tumor microenvironment and then discuss the implications of these interactions for GBM therapy.
MeSH term(s)	Humans ; Glioblastoma ; Brain ; Neuroglia ; Astrocytes ; Neurons ; Tumor Microenvironment
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.350693.123
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Article: Qualitative feasibility study of the mobile app Destroke for clinical stroke monitoring based on the NIH stroke scale.

Noch, Evan K / Pham, Dan / Kitago, Tomoko / Wuennemann, Marissa / Wortman-Jutt, Susan / Falo, M Cristina

Heliyon

2023 Volume 9, Issue 8, Page(s) e18393

Abstract: Background: Stroke is a leading cause of severe disability in the United States, but there is no effective method for patients to accurately detect the signs of stroke at home. We developed a mobile app, Destroke, that allows remote performance of a ... ...

Abstract	Background: Stroke is a leading cause of severe disability in the United States, but there is no effective method for patients to accurately detect the signs of stroke at home. We developed a mobile app, Destroke, that allows remote performance of a modified NIH stroke scale (NIHSS) by patients. Aims: To assess the feasibility of a mobile app for stroke monitoring and education by patients with a history of stroke. Materials and methods: We enrolled 25 patients with a history of stroke in a prospective open-label study to evaluate the feasibility of the Destroke app in patients with stroke. Nineteen patients completed all study assessments, with a median time from stroke onset to enrollment of 5.6 years (range 0.1-12 years). We designed a modified NIHSS that assessed 12 out of 16 tasks on the NIHSS. Patients completed this test eight times over a 28-day period. We conducted pre-study surveys that assessed demographic information, stroke and cardiovascular history, baseline NIHSS, and experience using mobile technologies, and mid- and post-study surveys that assessed patient satisfaction on app usage and confidence in stroke detection. Results: Ten men and nine women participated in this study (median age of 64 (33-76)), representing ten US states and Washington D.C. Median baseline NIHSS was 0 (0-4). 15 patients reported using health apps. On a 5-point Likert scale, patients rated the app as 4.2 on being able to understand and use the app and 4.3 on using the app when instructed by their doctor. For eight patients with poor confidence in detecting the signs of a stroke before the study, six showed higher confidence after the study. Conclusions: The use of an at-home stroke monitoring app is feasible by patients with a history of stroke and improves confidence in detecting the signs of stroke.
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18393
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Article: Impact of COVID-19 Pandemic on Physician-Scientist Trainees to Faculty One Year into the Pandemic.

Obradovic, Aleksandar / Toubat, Omar / Chen, Nathan W / Siebert, Aisha / Jansen, Carey / Christophers, Briana / Leveille, Etienne / Noch, Evan / Kwan, Jennifer M

Research square

2023

Abstract: Purpose: Physician-scientists play a crucial role in advancing biomedical sciences. Proportionally fewer physicians are actively engaged in scientific pursuits, attributed to attrition in the training and retention pipeline. This national study ... ...

Abstract	Purpose: Physician-scientists play a crucial role in advancing biomedical sciences. Proportionally fewer physicians are actively engaged in scientific pursuits, attributed to attrition in the training and retention pipeline. This national study evaluated the ongoing and longer-term impact of the COVID-19 pandemic on research productivity for physician-scientists at all levels of training. Methods: A survey of medical students, graduate students, and residents/fellows/junior faculty (RFJF) was conducted from April to August 2021 to assess the impact of COVID-19 on individual stress, productivity, and optimism. Multivariate regression analyses were performed to identify associated variables and unsupervised variable clustering techniques were employed to identify highly correlated responses. Results: A total 677 respondents completed the survey, representing different stages of physician-scientist training. Respondents report high levels of stress (medical students: 85%, graduate students: 63%, RFJF: 85%) attributed to impaired productivity concerns, concern about health of family and friends, impact on personal health and impairment in training or career development. Many cited impaired productivity (medical students: 65% graduate students: 79%, RFJF: 78%) associated with pandemic impacts on training, labs closures and loss of facility/resource access, and social isolation. Optimism levels were low (medical students: 37%, graduate students: 38% and RFJF: 39%) with females less likely to be optimistic and more likely to report concerns of long-term effects of COVID-19. Optimism about the future was correlated with not worrying about the long-term effects of COVID-19. Since the COVID-19 pandemic, all respondents reported increased prioritization of time with family/friends (67%) and personal health (62%) over career (25%) and research (24%). Conclusions: This national survey highlights the significant and protracted impact of the COVID-19 pandemic on stress levels, productivity, and optimism among physician-scientists and trainees. These findings underscore the urgent need for tailored support, including mental health, academic, and career development assistance for this biomedical workforce.
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3478814/v1
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Article ; Online: Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production.

Noch, Evan K / Palma, Laura / Yim, Isaiah / Bullen, Nayah / Barnett, Daniel / Walsh, Alexander / Bhinder, Bhavneet / Benedetti, Elisa / Krumsiek, Jan / Gurvitch, Justin / Khwaja, Sumaiyah / Atlas, Daphne / Elemento, Olivier / Cantley, Lewis C

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 8, Page(s) e2317343121

Abstract: Glucose and amino acid metabolism are critical for glioblastoma (GBM) growth, but little is known about the specific metabolic alterations in GBM that are targetable with FDA-approved compounds. To investigate tumor metabolism signatures unique to GBM, ... ...

Abstract	Glucose and amino acid metabolism are critical for glioblastoma (GBM) growth, but little is known about the specific metabolic alterations in GBM that are targetable with FDA-approved compounds. To investigate tumor metabolism signatures unique to GBM, we interrogated The Cancer Genome Atlas for alterations in glucose and amino acid signatures in GBM relative to other human cancers and found that GBM exhibits the highest levels of cysteine and methionine pathway gene expression of 32 human cancers. Treatment of patient-derived GBM cells with the FDA-approved single cysteine compound N-acetylcysteine (NAC) reduced GBM cell growth and mitochondrial oxygen consumption, which was worsened by glucose starvation. Normal brain cells and other cancer cells showed no response to NAC. Mechanistic experiments revealed that cysteine compounds induce rapid mitochondrial H
MeSH term(s)	Humans ; Mice ; Animals ; Hydrogen Peroxide ; Peroxides ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Proteomics ; Acetylcysteine/pharmacology ; Glucose ; Cell Line, Tumor ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Peroxides ; Acetylcysteine (WYQ7N0BPYC) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2317343121
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Article ; Online: Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.

Noch, Evan K / Yim, Isaiah / Milner, Teresa A / Cantley, Lewis C

The Journal of comparative neurology

2020 Volume 529, Issue 2, Page(s) 434–449

Abstract: Phosphatidylinositol-4,5-bisphosphate (PI-4,5- ... ...

Abstract	Phosphatidylinositol-4,5-bisphosphate (PI-4,5-P
MeSH term(s)	Animals ; Brain/embryology ; Brain/growth & development ; Brain/metabolism ; Brain Chemistry/physiology ; Female ; Humans ; Macaca ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphatidylinositol Phosphates/analysis ; Phosphatidylinositol Phosphates/biosynthesis ; Phosphotransferases (Alcohol Group Acceptor)/analysis ; Phosphotransferases (Alcohol Group Acceptor)/biosynthesis
Chemical Substances	Phosphatidylinositol Phosphates ; phosphatidylinositol 5-phosphate ; PI5P4Kbeta protein, mouse (EC 2.7.1.-) ; PIP4K2A protein, human (EC 2.7.1.-) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-)
Language	English
Publishing date	2020-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3086-7
ISSN	1096-9861 ; 0021-9967 ; 0092-7317
ISSN (online)	1096-9861
ISSN	0021-9967 ; 0092-7317
DOI	10.1002/cne.24956
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Article: A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center.

Noch, Evan K / Sait, Sameer F / Farooq, Shama / Trippett, Tanya M / Miller, Alexandra M

Neuro-oncology practice

2021 Volume 8, Issue 3, Page(s) 325–336

Abstract: Background: Extraneural metastasis of glioma is a rare event, often occurring in patients with advanced disease. Genomic alterations associated with extraneural glioma metastasis remain incompletely understood.: Methods: Ten patients at Memorial ... ...

Abstract	Background: Extraneural metastasis of glioma is a rare event, often occurring in patients with advanced disease. Genomic alterations associated with extraneural glioma metastasis remain incompletely understood. Methods: Ten patients at Memorial Sloan Kettering Cancer Center diagnosed with extraneural metastases of glioblastoma (9 patients) and gliosarcoma (1 patient) from 2003 to 2018 were included in our analysis. Patient characteristics, clinical course, and genomic alterations were evaluated. Results: Patient age at diagnosis ranged from 14 to 73, with 7 men and 3 women in this group. The median overall survival from initial diagnosis and from diagnosis of extraneural metastasis was 19.6 months (range 11.2 to 57.5 months) and 5 months (range 1 to 16.1 months), respectively. The most common site of extraneural metastasis was bone, with other sites being lymph nodes, dura, liver, lung, and soft tissues. All patients received surgical resection and radiation, and 9 patients received temozolomide, with subsequent chemotherapy appropriate for individual cases. 1 patient had an Ommaya and then ventriculoperitoneal shunt placed, and 1 patient underwent craniectomy for cerebral edema associated with a brain abscess at the initial site of resection. Genomic analysis of primary tumors and metastatic sites revealed shared and private mutations with a preponderance of tumor suppressor gene alterations, illustrating clonal evolution in extraneural metastases. Conclusions: Several risk factors emerged for extraneural metastasis of glioblastoma and gliosarcoma, including sarcomatous dedifferentiation, disruption of normal anatomic barriers during surgical resection, and tumor suppressor gene alterations. Next steps with this work include validation of these genomic markers of glioblastoma metastases in larger patient populations and the development of preclinical models. This work will lead to a better understanding of the molecular mechanisms of metastasis to develop targeted treatments for these patients.
Language	English
Publishing date	2021-02-03
Publishing country	England
Document type	Case Reports
ZDB-ID	2768945-1
ISSN	2054-2585 ; 2054-2577
ISSN (online)	2054-2585
ISSN	2054-2577
DOI	10.1093/nop/npaa083
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Article ; Online: The Impact of COVID-19 on Physician-Scientist Trainees and Faculty in the United States: A National Survey.

Kwan, Jennifer M / Noch, Evan / Qiu, Yuqing / Toubat, Omar / Christophers, Briana / Azzopardi, Stephanie / Gilmer, Gabrielle / Wiedmeier, Julia Erin / Daye, Dania

Academic medicine : journal of the Association of American Medical Colleges

2022 Volume 97, Issue 10, Page(s) 1536–1545

Abstract: Purpose: Physician-scientists have long been considered an endangered species, and their extended training pathway is vulnerable to disruptions. This study investigated the effects of COVID-19-related challenges on the personal lives, career activities, ...

Abstract	Purpose: Physician-scientists have long been considered an endangered species, and their extended training pathway is vulnerable to disruptions. This study investigated the effects of COVID-19-related challenges on the personal lives, career activities, stress levels, and research productivity of physician-scientist trainees and faculty. Method: The authors surveyed medical students (MS), graduate students (GS), residents/fellows (R/F), and faculty (F) using a tool distributed to 120 U.S. institutions with MD-PhD programs in April-June 2020. Chi-square and Fisher's exact tests were used to compare differences between groups. Machine learning was employed to select variables for multivariate logistic regression analyses aimed at identifying factors associated with stress and impaired productivity. Results: The analyses included 1,929 respondents (MS: n = 679, 35%; GS: n = 676, 35%; R/F: n = 274, 14%; F: n = 300, 16%). All cohorts reported high levels of social isolation, stress from effects of the pandemic, and negative impacts on productivity. R/F and F respondents were more likely than MS and GS respondents to report financial difficulties due to COVID-19. R/F and F respondents with a dual degree expressed more impaired productivity compared with those without a dual degree. Multivariate regression analyses identified impacted research/scholarly activities, financial difficulties, and social isolation as predictors of stress and impaired productivity for both MS and GS cohorts. For both R/F and F cohorts, impacted personal life and research productivity were associated with stress, while dual-degree status, impacted research/scholarly activities, and impacted personal life were predictors of impaired productivity. More female than male respondents reported increased demands at home. Conclusions: This national survey of physician-scientist trainees and faculty found a high incidence of stress and impaired productivity related to the COVID-19 pandemic. Understanding the challenges faced and their consequences may improve efforts to support the physician-scientist workforce in the postpandemic period.
MeSH term(s)	Biomedical Research/education ; COVID-19/epidemiology ; Faculty ; Female ; Humans ; Male ; Pandemics ; Physicians ; Students, Medical ; United States/epidemiology
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000004802
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