LIVIVO - Search results -

Search results

Result 1 - 10 of total 198

Search options

Article: Physiopathologie du chikungunya: les marqueurs de l’infection de la phase aiguë à l’atteinte chronique.

Dupuis-Maguiraga, Laurence / Brun, Sonia / Noret, Marion / Gras, Gabriel / Roques, Pierre

2022 Volume 15, Issue 4, Page(s) 251–268

Abstract: During the 2005-2006 austral summer, an outbreak of fever associated with joint pain hit the Reunion Island inhabitants. Chikungunya virus (CHIKV), the agent involved in this epidemic, was known since 50 years and was thus brought to general attention ... ...

Title translation	Chikungunya physiopathology: Infection data from acute to chronic phase.
Abstract	During the 2005-2006 austral summer, an outbreak of fever associated with joint pain hit the Reunion Island inhabitants. Chikungunya virus (CHIKV), the agent involved in this epidemic, was known since 50 years and was thus brought to general attention together with the risk of emergence or re-emergence of arboviral infections. This arbovirus rapidly spread worldwide, specifically in India with millions of cases, but also in Europe through imported cases (>2,000) and fewautochthonous cases in Italy and in France. Human pathology is characterized by arthralgia and myalgia, which persist for months or years. Development of macaque model of CHIKV disease evidenced the key role of monocytesmacrophages in viral persistence.We are reporting herein the present knowledge about physiopathology of the virus and the CHIKV disease. Comparison of animal model data in chronic phase of infection and data acquired in follow-up of patients allows us to propose explanation of mechanisms of inflammation associated with viral infection. This review is aimed at opening discussion about the relationship between the CHIKV, the immune response and the development of virus-induced chronic arthralgia and myalgia.
Language	French
Publishing date	2022-09-19
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/15-4.2011.17301
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Use of the Capture-Recapture Method to Estimate the Frequency of Community- and Hospital-Acquired Drug-Induced Acute Kidney Injuries in French Databases.

Rey, Amayelle / Gras, Valérie / Moragny, Julien / Choukroun, Gabriel / Masmoudi, Kamel / Liabeuf, Sophie

Frontiers in pharmacology

2022 Volume 13, Page(s) 899164

Abstract: Drug-induced acute kidney injury (AKI) can occur both in primary care (i.e., community-acquired AKI (CA-AKI)) and in hospital settings (i.e., hospital-acquired AKI (HA-AKI)). The reported prevalence of these events varies markedly from one study to ... ...

Abstract	Drug-induced acute kidney injury (AKI) can occur both in primary care (i.e., community-acquired AKI (CA-AKI)) and in hospital settings (i.e., hospital-acquired AKI (HA-AKI)). The reported prevalence of these events varies markedly from one study to another, mainly due to differences in the study design. To estimate the frequency of drug-induced AKIs (both CA-AKIs and HA-AKIs) observed in a French university hospital, we applied the capture-recapture method to 1) the French national pharmacovigilance database (FPVD) and 2) a cohort of hospitalized patients with drug-induced AKIs (documented by analyzing the French national hospital discharge database and the patients' electronic medical records). Drug-induced AKIs were determined according to the Naranjo algorithm and then categorized as CA-AKIs or HA-AKIs. A total number of 1,557 episodes of AKI were record during the study period, of them, the estimated total number of drug-induced AKIs was 593 [95% confidence interval (CI): 485-702], and the estimated prevalence was 38.1% [95%CI: 35.67-40.50]. The prevalences of HA-AKIs and CA-AKIs were similar (39.4% [36.24-42.54] and 37.4% [33.67-41.21], respectively). Only 6.1% of the drug-induced AKIs were recorded in the FPVD, and the proportions of recorded HA-AKIs and CA-AKI differed markedly (3.0% vs. 10.5%, respectively). One of the most frequently involved drug classes were antibiotics in the HA-AKI subgroup (13.0%) and antineoplastics in the CA-AKI subgroup (8.3%). Application of the capture-recapture method to two incomplete data sources can improve the ability to identify and quantify adverse drug reactions like AKIs. The frequency of drug-induced AKI is relatively high and is probably underestimated. The clinical management of an AKI might depend on where it originated.
Language	English
Publishing date	2022-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.899164
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Risk factors for and characteristics of community- and hospital-acquired drug-induced acute kidney injuries.

Rey, Amayelle / Gras-Champel, Valérie / Choukroun, Gabriel / Masmoudi, Kamel / Liabeuf, Sophie

Fundamental & clinical pharmacology

2022 Volume 36, Issue 4, Page(s) 750–761

Abstract: Drugs constitute one of the leading causes of acute kidney injuries (AKIs) and can appear in community (CA-AKI) or hospital (HA-AKI) population. The objectives of the present study of a cohort of hospitalized patients with AKI were to describe the ... ...

Abstract	Drugs constitute one of the leading causes of acute kidney injuries (AKIs) and can appear in community (CA-AKI) or hospital (HA-AKI) population. The objectives of the present study of a cohort of hospitalized patients with AKI were to describe the characteristics of drug-induced AKIs and the patients' short-term outcomes and assess risk factors for drug-induced AKIs overall, CA-AKIs, and HA-AKIs. Based on a cohort of 1557 hospitalized patients suffering from AKIs based on PMSI extraction and chart review (IRA-PMSI), drug-induced AKIs were identified by applying the Naranjo adverse drug reaction (ADR) probability scale. Multivariate logistic regression was used to identify factors associated with CA-AKIs and/or HA-AKIs. When considering the 1557 patients who experienced an AKI, 445 (28.6%) of the injuries were drug-induced (180 CA-AKIs (40.4%) and 265 HA-AKIs (59.6%)). Antibiotics, diuretics, and contrast agents were significantly more likely to be involved in HA-AKIs, whereas antineoplastic, lipid-lowering drugs, antidiabetics, and immunosuppressive were significantly more likely to be involved in CA-AKIs. Female sex (odds ratio [OR] [95%CI] = 1.3 [1.04-1.67]), chronic kidney disease (CKD) (OR = 1.8 [1.40-2.67]), and a history of ADRs of any type (OR = 1.3 [1.05-1.73]) were significant risk factors for drug-induced AKIs. CKD was a risk factor for both CA-AKI and HA-AKI. In view of the long-term impact of AKI on the kidneys and the differences between our CA-AKI and HA-AKI subgroups, our present results are interesting for optimizing treatments, limiting the occurrence of CA- and HA-AKIs and (ultimately) reducing healthcare costs.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Female ; Hospitals ; Humans ; Kidney ; Renal Insufficiency, Chronic/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12758
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2247: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Antidepressant effect r TMS during pregnancy in a case of Major Depression Resistant to Pharmacological Treatment.

Martínez-Gras, Isabel / Jurado-Barba, Rosa / Sánchez-Pastor, Luis / Rubio, Gabriel / Prieto-Montalvo, Julio

Actas espanolas de psiquiatria

2021 Volume 49, Issue 6, Page(s) 282–285

Abstract: Major depressive disorder (MDD) is a common complication of pregnancy and the postpartum period. Approximately 5% of women who have MDD during pregnancy or the postpartum period meet criteria for resistant depression, associated with increased morbidity ... ...

Abstract	Major depressive disorder (MDD) is a common complication of pregnancy and the postpartum period. Approximately 5% of women who have MDD during pregnancy or the postpartum period meet criteria for resistant depression, associated with increased morbidity in both the newborn and the pregnant woman. Currently we have different therapeutic options for the treatment of MDD during pregnancy, although in cases of resistance during that period the treatment criteria are not that well established.
MeSH term(s)	Antidepressive Agents/therapeutic use ; Depression ; Depression, Postpartum ; Depressive Disorder, Major/drug therapy ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications/drug therapy
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2021-11-01
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	1480971-0
ISSN	1578-2735 ; 1575-071X ; 1139-9287
ISSN (online)	1578-2735
ISSN	1575-071X ; 1139-9287
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 792: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Use of a hospital administrative database to identify and characterize community-acquired, hospital-acquired and drug-induced acute kidney injury.

Rey, Amayelle / Gras-Champel, Valérie / Balcaen, Thibaut / Choukroun, Gabriel / Masmoudi, Kamel / Liabeuf, Sophie

Journal of nephrology

2021 Volume 35, Issue 3, Page(s) 955–968

Abstract: Background: Acute kidney injury (AKI) has serious short- and long-term consequences. The objective of the present study of a cohort of hospitalized patients with AKI was to (i) evaluate the proportion of patients with hospital-acquired (HA) AKI and ... ...

Abstract	Background: Acute kidney injury (AKI) has serious short- and long-term consequences. The objective of the present study of a cohort of hospitalized patients with AKI was to (i) evaluate the proportion of patients with hospital-acquired (HA) AKI and community-acquired (CA) AKI, the characteristics of these patients and the AKIs, and the short-term outcomes, and (ii) determine the performance of several ICD-10 codes for identifying AKI (both CA and HA) and drug-induced AKI. Methods: A cohort of hospitalized patients with AKI was constituted by screening hospital's electronic medical records (EMRs) for cases of AKI. We distinguished between and compared CA-AKI and HA-AKI and evaluated the proportion of AKIs that were drug-induced. The EMR data were merged with hospital billing codes (according to the International Classification of Diseases, 10th Edition (ICD-10)) for each hospital stay. The ability of ICD-10 codes to identify AKIs (depending on the type of injury) was determined by calculating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Lastly, we sought to validate specific ICD-10 codes for drug-induced AKI. Results: Of the 2473 patients included, 1557 experienced an AKI (HA-AKI: 59.3%; CA-AKI: 40.7%). Patients with CA-AKI had a better short-term outcome and a lower death rate (7.6%, vs. 20% for HA-AKI). One AKI in three was drug-induced. The combination of AKI codes had a very high specificity (94.8%), a high PPV (94.9%), a moderate NPV (56.7%) and moderate sensitivity (57.4%). The sensitivity was higher for CA-AKI (72.2%, vs. 47.2% for HA-AKI), for more severe AKI (82.8% for grade 3 AKI vs. 43.7% for grade 1 AKI), and for patients with CKD. Use of a specific ICD-10 code for drug-induced AKI (N14x) alone gave a very low sensitivity (1.8%), whereas combining codes for adverse drug reactions with AKI-specific codes increased the sensitivity. Conclusion: Our results show that the combination of an EMR-based analysis with ICD-10-based hospital billing codes gives a comprehensive "real-life" picture of AKI in hospital settings. We expect that this approach will enable researchers to study AKI in more depth.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Hospitals ; Humans ; Length of Stay ; Prevalence ; Risk Factors
Language	English
Publishing date	2021-10-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-021-01174-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3369: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Statin therapy and the incidence of atherosclerotic cardiovascular events after kidney transplantation.

Nazoiri, Charifa / Liabeuf, Sophie / Brazier, François / Nowak, Alban / Bennis, Youssef / Laville, Solène M / Bodeau, Sandra / Gras-Champel, Valérie / Masmoudi, Kamel / Choukroun, Gabriel / Batteux, Benjamin

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 39, Issue 5, Page(s) 818–829

Abstract: Background: Statins are recommended in kidney transplant recipients (KTRs)-a population with a high risk of major cardiovascular (CV) events. However, the literature data on the effectiveness of statins in KTRs are sparse and inconclusive. The present ... ...

Abstract	Background: Statins are recommended in kidney transplant recipients (KTRs)-a population with a high risk of major cardiovascular (CV) events. However, the literature data on the effectiveness of statins in KTRs are sparse and inconclusive. The present study's objective was to evaluate the association between statin exposure and atherosclerotic CV events in KTRs and the biochemical effectiveness of statins on the lipid profile. Methods: A total of 318 consecutive KTRs managed at a single center between 2006 and 2019 were retrospectively included. Those exposed to statins after transplantation were incident users. In all users, statins were indicated for primary CV prevention. Lipid profiles, the occurrence of any atherosclerotic CV events (stroke, myocardial infarction, other atherosclerotic CV events and atherosclerotic CV deaths) were documented comprehensively. We applied Cox models that included statin exposure as a time-dependent covariate fitted with time-varying inverse probability treatment weighting (IPTW) to assess the effectiveness of statins on atherosclerotic CV events and on all CV events. We built linear mixed models to assess the biochemical effectiveness of statins. Results: During a median (interquartile range) follow-up period of 6.0 (3.9-10.0) years, 27 atherosclerotic CV events occurred in 26 patients. In the Cox models fitted with time-varying IPTW, exposure to statins was not associated with a decrease in atherosclerotic CV events; the hazard ratio was 1.16 (95% confidence interval 0.53-2.53) (P = .700). In the linear mixed models, statin exposure was associated with significant decrease over time in triglyceride and low-density lipoprotein cholesterol concentrations (P < .001). These results were consistent when stratified for the intensity of statin therapy. Conclusion: Even though the lipid profile improved, statin exposure was not associated with a decrease in CV events in this real-life, single-center, retrospective, long-term follow-up study of a KTR cohort. Larger, controlled studies are needed to confirm or refute these results.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Female ; Middle Aged ; Atherosclerosis/etiology ; Atherosclerosis/epidemiology ; Atherosclerosis/prevention & control ; Retrospective Studies ; Incidence ; Follow-Up Studies ; Adult ; Aged ; Prognosis ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/epidemiology
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad217
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Drugs associated with incident fragility fractures in kidney transplant recipients.

Batteux, Benjamin / Nowak, Alban / Séjourné, Alice / Penet, Clémence / Masmoudi, Kamel / Brazier, François / Laville, Solène M / Bennis, Youssef / Gras-Champel, Valérie / Choukroun, Gabriel / Liabeuf, Sophie

Clinical kidney journal

2022 Volume 16, Issue 3, Page(s) 571–584

Abstract: Background: The risk of fragility fractures is high in kidney transplant recipients, and steroids are reportedly a major cause. Other drugs known to induce fragility fractures have been studied in the general population but not in kidney transplant ... ...

Abstract	Background: The risk of fragility fractures is high in kidney transplant recipients, and steroids are reportedly a major cause. Other drugs known to induce fragility fractures have been studied in the general population but not in kidney transplant recipients. Here, we investigated the association between exposure over time to drugs that can injure bone (namely vitamin K antagonists, insulin, loop diuretics, proton pump inhibitors, opioids, selective serotonin reuptake inhibitors, antiepileptics and benzodiazepines) and incident fractures and changes over time in T-scores in this population. Methods: A total of 613 consecutive kidney transplant recipients were included between 2006 and 2019. Drug exposures and incident fractures during the study period were comprehensively documented, and dual-energy X-ray absorptiometry was performed regularly. The data were analyzed using Cox proportional hazards models with time-dependent covariates and linear mixed models. Results: Incident fractures occurred in 63 patients, giving a fracture incidence of 16.9 per 1000 person-years. Exposures to loop diuretics [hazard ratio (95% confidence interval) 2.11 (1.17-3.79)] and opioids [5.94 (2.14-16.52)] were associated with incident fractures. Exposure to loop diuretics was associated with a decrease over time in the T-score for the lumbar spine ( Conclusions: This study suggests that the exposure to loop diuretics and opioids increases the risk of fracture in kidney transplant recipients.
Language	English
Publishing date	2022-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfac265
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6587: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: CRT-D replacement strategy: results of the BioCONTINUE study.

Gras, Daniel / Clémenty, Nicolas / Ploux, Sylvain / Guyomar, Yves / Legallois, Damien / Segreti, Luca / Blangy, Hugues / Laurent, Gabriel / Bizeau, Olivier / Fauquembergue, Sophie / Lazarus, Arnaud

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2022 Volume 66, Issue 5, Page(s) 1201–1209

Abstract: Background: In patients with cardiac resynchronization therapy defibrillators (CRT-Ds), the need for implantable cardioverter-defibrillator (ICD) back-up may be questionable at time of CRT-D replacement (REP) if ICD implant criteria are no longer met ... ...

Abstract	Background: In patients with cardiac resynchronization therapy defibrillators (CRT-Ds), the need for implantable cardioverter-defibrillator (ICD) back-up may be questionable at time of CRT-D replacement (REP) if ICD implant criteria are no longer met due to an improved left ventricular ejection fraction (LVEF) and if no major ventricular arrhythmic event (VAE) occurred during the CRT-D lifetime. The aim of our study was to assess the relevance of ICD back-up and predictors of VAE after REP in primary prevention CRT-D patients. Methods: The prospective, observational, international BioCONTINUE study investigated the rate of patients with at least 1 sustained VAE (sVAE) post-REP and searched for predictive factors of sVAE. Results: Two hundred seventy-six patients (70 ± 10 years, 77% men, mean LVEF 40.6 ± 12.6%) were followed for 28.4 ± 10.2 months. The rate of patients with sVAE was 8.3%, 10.3%, and 21.2% at 1, 2, and 4 years post-REP. Patients without persistent ICD indication at REP still had a sVAE rate of 5.7% (95% CI 2.3-11.5%) at 2 years. In multivariate analysis, predictive factors of subsequent sVAE were (i) persistent ICD indication (hazard ratio (HR) 3.6; 95% CI 1.6-8.3; p = 0.003); (ii) 64-72 years of age as compared to ≥ 79 years (HR 3.7; 95% CI 1.4-9.7; p = 0.008); and (iii) ischemic heart disease (HR 4.4; 95% CI 2.1-9.3; p < 0.0001). Conclusions: The risk of sVAE (21.2% at 4 years post-REP) depends on age, ischemic heart disease, and ICD indication at the time of REP. A non-trivial risk of sVAE remains in patients without persistent ICD indication. Clinical trial registration: NCT02323503.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Cardiac Resynchronization Therapy/methods ; Defibrillators, Implantable ; Heart Failure/therapy ; Myocardial Ischemia/therapy ; Prospective Studies ; Risk Factors ; Stroke Volume ; Tachycardia, Ventricular ; Treatment Outcome ; Ventricular Function, Left ; Middle Aged
Language	English
Publishing date	2022-12-02
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-022-01440-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5214: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Efectividad de la vacuna de la gripe para prevenir casos graves. Temporada 2018/2019

Paula Gras-Valentí / Pablo Chico-Sánchez / Natividad Algado-Sellés / María Adelina Gimeno-Gascón / Juan Gabriel Mora-Muriel / José Sánchez-Payá

Gaceta Sanitaria, Vol 35, Iss 4, Pp 339-

2021 Volume 344

Abstract: Resumen: Objetivo: Conocer la efectividad de la vacuna de la gripe de la temporada 2018/2019 para la prevención de casos graves de gripe en un hospital terciario. Método: Estudio de casos y controles. Se incluyeron todos los pacientes hospitalizados con ... ...

Abstract	Resumen: Objetivo: Conocer la efectividad de la vacuna de la gripe de la temporada 2018/2019 para la prevención de casos graves de gripe en un hospital terciario. Método: Estudio de casos y controles. Se incluyeron todos los pacientes hospitalizados con gripe confirmada por laboratorio durante la temporada 2018/2019. Los que cumplieron criterios de caso grave de gripe (neumonía, fallo multiorgánico, shock séptico, ingreso en la unidad de cuidados intensivos o muerte) se consideraron caso. Los que no cumplían criterios de gravedad se consideraron controles. Se calculó la efectividad de la vacuna (EV) cruda y ajustada (para prevenir casos graves de gripe), así como su intervalo de confianza del 95%, mediante la fórmula EV = (1 − odds ratio) × 100. Resultados: La efectividad ajustada por grupo de edad y comorbilidad fue del 60,7% (20,5-80,5). En el análisis ajustado y restringido a cada sexo, grupo de edad y presencia de comorbilidad, la vacuna de la gripe tuvo un efecto positivo en todos los grupos y categorías, siendo la efectividad del 55,0% (2,6-79,2) en el grupo de edad de 65 años o más. Conclusiones: La vacunación antigripal redujo la gravedad de la gripe en los pacientes hospitalizados. Estos hallazgos deberían tenerse en cuenta para mejorar las estrategias de vacunación y alcanzar mejores coberturas vacunales en la población de riesgo, con la finalidad no solo de disminuir los casos de gripe, sino también su gravedad. Abstract: Objective: To know the effectiveness of the 2018/2019 flu vaccine for the prevention of severe cases of flu in a tertiary hospital. Method: Case-control study. We included all patients hospitalized with influenza confirmed by laboratory during 2018/2019 season. Those who met the criteria of severe case of influenza (pneumonia, multiorgan failure, septic shock, ICU admission or death) were considered as cases. Non severe cases of influenza were included in the control group. We calculated the effectiveness of the raw and adjusted vaccine (to prevent severe cases of influenza) and its ...
Keywords	Influenza ; Influenza vaccines ; Vaccine effectiveness ; Disease severity ; Hospitalization ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Development and validation of a rabbit model of

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1297281

Abstract: Background: New drugs targeting antimicrobial resistant pathogens, including : Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with : Results: In a rabbit model of non-ventilated pneumonia, ... ...

Abstract	Background: New drugs targeting antimicrobial resistant pathogens, including Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with Results: In a rabbit model of non-ventilated pneumonia, endobronchial challenge with live Conclusion: The rabbit model may be used to help predict clinical efficacy of new antibacterial drugs for the treatment of non-ventilated
MeSH term(s)	Humans ; Animals ; Rabbits ; Meropenem/therapeutic use ; Pseudomonas aeruginosa ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Tobramycin/pharmacology ; Tobramycin/therapeutic use ; Pneumonia/drug therapy ; Drug Development
Chemical Substances	Meropenem (FV9J3JU8B1) ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1297281
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito