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  1. Article ; Online: Novel findings on the anatomy of medial canthus in dogs.

    Saito, Akihiko / Iwashita, Hiroko

    Veterinary ophthalmology

    2023  Volume 26, Issue 4, Page(s) 315–323

    Abstract: Purpose: Severe entropion of the medial canthus results in ocular surface diseases and tear staining syndrome. However, detailed anatomical structures of the medial canthus and lacrimal ducts in dogs are poorly understood. We aimed to understand the ... ...

    Abstract Purpose: Severe entropion of the medial canthus results in ocular surface diseases and tear staining syndrome. However, detailed anatomical structures of the medial canthus and lacrimal ducts in dogs are poorly understood. We aimed to understand the anatomical structures of the medial canthus by analyzing the distances from the medial palpebral commissure to the superior lacrimal punctum (DSP) and to the inferior lacrimal punctum (DIP) and by histological examinations of the medial canthal anatomy.
    Methods: Dogs that underwent modified medial canthoplasty (MMC) between April 2017 and March 2021 were studied. As a reference, non-brachycephalic dogs that underwent other surgeries were also examined. DSP and DIP were measured preoperatively in all dogs in both the non-everted and everted positions. Histological examinations of the medial canthal anatomy were performed in four eyes isolated from beagles.
    Results: The ratios of DIP to DSP (mean ± SD) at the non-everted and everted positions in 242 MMC eyes of 126 dogs were 2.05 ± 0.46 and 1.05 ± 0.13, respectively (p < .01). The ratios of everted to non-everted positions for DIP and DSP were 0.98 ± 0.21 and 1.93 ± 0.49, respectively (p < .01). Histological findings indicated that the orbicularis oculi muscle (OOM) circumjacent lacrimal canaliculus transformed into collagen fibers and were attached to the lacrimal bone.
    Conclusions: Histological studies revealed that the OOM circumjacent lacrimal canaliculus transformed into collagen fibers and these collagen fibers may be related to the difference between DSP and DIP.
    MeSH term(s) Animals ; Dogs ; Lacrimal Apparatus/surgery ; Lacrimal Apparatus/physiology ; Tears ; Eyelids/surgery ; Orbit ; Collagen
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2011043-1
    ISSN 1463-5224 ; 1463-5216
    ISSN (online) 1463-5224
    ISSN 1463-5216
    DOI 10.1111/vop.13072
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  2. Article ; Online: Japanese physicians' perceptions of conflicts of interest with pharmaceutical companies: Estimating two different questioning approaches.

    Saito, Hiroaki / Ozaki, Akihiko / Murakami, Michio / Takebayashi, Yoshitake

    The International journal of health planning and management

    2024  Volume 39, Issue 2, Page(s) 541–555

    Abstract: Despite being one of the world's largest pharmaceutical markets, interactions between Japanese physicians and pharmaceutical companies often remain opaque. Importantly, potential conflicts of interest associated with these interactions can compromise ... ...

    Abstract Despite being one of the world's largest pharmaceutical markets, interactions between Japanese physicians and pharmaceutical companies often remain opaque. Importantly, potential conflicts of interest associated with these interactions can compromise patient care and increase costs. We conducted an online survey of Japanese physicians to elucidate perspectives on pharmaceutical company promotional activities and how these influence physician prescribing patterns. Anticipating that physicians might downplay their reliance on, or the value of, pharmaceutical company-provided information, the survey incorporated a direct questioning method and an unmatched count technique (UCT) to identify hidden perceptions on factors likely to influence prescribing. Overall, 1080 eligible physicians participated. Of these, 105 (9.7%) self-identified as hospital directors or managers. Surprisingly, nearly twice as many participants responding to direct questioning (18.9%) versus those responding to the UCT (10.1%) asserted that information provided by pharmaceutical companies was important when prescribing medicine. Hospital directors or managers (adjusted odds ratio [adjOR] 2.56, 95% confidence interval [95% CI]: 1.00-6.54, reference = physician without title) and frequent interactions with pharmaceutical sales representatives (adjOR 5.96, 95% CI: 1.88-18.9, reference = rare interaction) significantly valued the information from sales representatives and sponsored lectures when considering prescribing decisions. Additionally, 77.1% of respondents believed that sales representatives provide fair, neutral, or relatively honest and unbiased information about their products. Few Japanese physicians acknowledged the influence of industry-provided information on prescribing patterns. Our study uniquely applies two distinct question formats, providing a novel approach to understanding the depth of physician-industry relationships and the effectiveness of various survey methodologies.
    MeSH term(s) Humans ; Conflict of Interest ; Japan ; Drug Industry ; Physicians ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 632786-2
    ISSN 1099-1751 ; 0749-6753
    ISSN (online) 1099-1751
    ISSN 0749-6753
    DOI 10.1002/hpm.3748
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  3. Article ; Online: Novel findings on the anatomy of medial canthus in dogs

    Saito, Akihiko / Iwashita, Hiroko

    Veterinary Ophthalmology. 2023 July, v. 26, no. 4 p.315-323

    2023  

    Abstract: PURPOSE: Severe entropion of the medial canthus results in ocular surface diseases and tear staining syndrome. However, detailed anatomical structures of the medial canthus and lacrimal ducts in dogs are poorly understood. We aimed to understand the ... ...

    Abstract PURPOSE: Severe entropion of the medial canthus results in ocular surface diseases and tear staining syndrome. However, detailed anatomical structures of the medial canthus and lacrimal ducts in dogs are poorly understood. We aimed to understand the anatomical structures of the medial canthus by analyzing the distances from the medial palpebral commissure to the superior lacrimal punctum (DSP) and to the inferior lacrimal punctum (DIP) and by histological examinations of the medial canthal anatomy. METHODS: Dogs that underwent modified medial canthoplasty (MMC) between April 2017 and March 2021 were studied. As a reference, non‐brachycephalic dogs that underwent other surgeries were also examined. DSP and DIP were measured preoperatively in all dogs in both the non‐everted and everted positions. Histological examinations of the medial canthal anatomy were performed in four eyes isolated from beagles. RESULTS: The ratios of DIP to DSP (mean ± SD) at the non‐everted and everted positions in 242 MMC eyes of 126 dogs were 2.05 ± 0.46 and 1.05 ± 0.13, respectively (p < .01). The ratios of everted to non‐everted positions for DIP and DSP were 0.98 ± 0.21 and 1.93 ± 0.49, respectively (p < .01). Histological findings indicated that the orbicularis oculi muscle (OOM) circumjacent lacrimal canaliculus transformed into collagen fibers and were attached to the lacrimal bone. CONCLUSIONS: Histological studies revealed that the OOM circumjacent lacrimal canaliculus transformed into collagen fibers and these collagen fibers may be related to the difference between DSP and DIP.
    Keywords collagen ; entropion ; histology ; muscles ; ophthalmology
    Language English
    Dates of publication 2023-07
    Size p. 315-323.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2011043-1
    ISSN 1463-5224 ; 1463-5216
    ISSN (online) 1463-5224
    ISSN 1463-5216
    DOI 10.1111/vop.13072
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Research and Nonresearch Industry Payments for COVID-19 mRNA Vaccines in the United States.

    Murayama, Anju / Kamamoto, Sae / Saito, Hiroaki / Tanimoto, Tetsuya / Ozaki, Akihiko

    JMA journal

    2023  Volume 6, Issue 2, Page(s) 201–203

    Language English
    Publishing date 2023-03-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 3053329-6
    ISSN 2433-3298 ; 2433-328X
    ISSN (online) 2433-3298
    ISSN 2433-328X
    DOI 10.31662/jmaj.2022-0210
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  5. Article ; Online: Nationalism in Japanese media coverage of domestic pharmaceutical products.

    Hakariya, Hayase / Takahashi, Kenzo / Tanimoto, Tetsuya / Saito, Hiroaki / Ozaki, Akihiko

    Lancet (London, England)

    2023  Volume 402, Issue 10415, Page(s) 1832–1833

    MeSH term(s) Humans ; Pharmaceutical Preparations ; Politics ; Japan ; Mass Media
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01284-9
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  6. Article: Are the issues pointed out by ChatGPT can be applied to Japan? - Examining the reasons behind high COVID-19 excess deaths in Japan.

    Kaneda, Yudai / Tsubokura, Masaharu / Ozaki, Akihiko / Saito, Hiroaki / Tanimoto, Tetsuya

    New microbes and new infections

    2023  Volume 53, Page(s) 101116

    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101116
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  7. Article ; Online: Japan's COVID-19 response: underutilized beds and misused funds.

    Saito, Yoshika / Ozaki, Akihiko / Tanimoto, Tetsuya / Takita, Morihito / Kami, Masahiro

    Frontiers in public health

    2023  Volume 11, Page(s) 1277746

    MeSH term(s) Humans ; Japan ; COVID-19/epidemiology ; Financial Management ; Population Dynamics
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1277746
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  8. Article ; Online: The structure of the rat vitamin B

    Bokhove, Marcel / Kawamura, Takashi / Okumura, Hideo / Goto, Sawako / Kawano, Yoshiaki / Werner, Stefan / Jarczowski, Franziska / Klimyuk, Victor / Saito, Akihiko / Kumasaka, Takashi

    The Journal of biological chemistry

    2024  , Page(s) 107289

    Abstract: ... Vitamin ... ...

    Abstract Vitamin B
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107289
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  9. Article ; Online: Improvements in pincer nail deformity occur earlier and last longer when acetylcysteine gel is added to an overcurvature-correcting device: Results of a phase 3, multicenter, randomized, vehicle-controlled, investigator-blinded study.

    Saito, Masataka / Ikoma, Akihiko / Fujikawa, Akira / Tanaka, Kazuaki

    The Journal of dermatology

    2023  Volume 51, Issue 1, Page(s) 23–29

    Abstract: Acetylcysteine (AC) destabilizes keratin and softens nails, reducing the time needed to correct pincer nail deformity with an overcurvature-correcting device. The objective of this phase 3, multicenter, randomized, investigator-blinded study was to ... ...

    Abstract Acetylcysteine (AC) destabilizes keratin and softens nails, reducing the time needed to correct pincer nail deformity with an overcurvature-correcting device. The objective of this phase 3, multicenter, randomized, investigator-blinded study was to evaluate the early and sustained therapeutic effectiveness and safety of 10% AC gel plus an overcurvature-correcting device to treat pincer nails. Patients aged 12 years and older with hallux pincer nail were fitted with an overcurvature-correcting device for 7 days, with a 24-h application of AC gel (n = 40) or vehicle (n = 39) on day 1. The primary end point (achievement of a distal narrowed nail width ratio ≥70% on day 8) was met by 47.5% in the 10% AC group and 25.6% in the vehicle group (difference 21.9%; p = 0.0439). Secondary end points showed a greater tendency towards improvement with 10% AC. The nail correction effect was maintained for at least 12 weeks in the majority of AC-treated patients, although the study duration was insufficient to assess the long-term probability of recurrence. No AC-related adverse events were reported. In conclusion, a single application of 10% AC gel combined with short-term device use facilitated earlier correction of pincer nails compared with the device alone, with improvements maintained after device removal.
    MeSH term(s) Humans ; Acetylcysteine ; Nail Diseases ; Nails ; Nails, Malformed ; Seizures ; Child ; Adolescent ; Adult
    Chemical Substances Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17010
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  10. Article ; Online: Efficacy and safety of topical acetylcysteine combined with the use of an overcurvature-correcting device in patients with pincer nail deformity: a randomized, vehicle-controlled, investigator-blinded study.

    Saito, Masataka / Ikoma, Akihiko / Fujikawa, Akira / Tanaka, Kazuaki

    The Journal of dermatological treatment

    2023  Volume 34, Issue 1, Page(s) 2248311

    Abstract: Background: While pincer nails may be treated using overcurvature-correcting devices, it takes several months to achieve successful outcomes. Nail-softening drugs may reduce the treatment duration required.: Objective: To evaluate the efficacy and ... ...

    Abstract Background: While pincer nails may be treated using overcurvature-correcting devices, it takes several months to achieve successful outcomes. Nail-softening drugs may reduce the treatment duration required.
    Objective: To evaluate the efficacy and safety of treatment with acetylcysteine (AC) gel added to an overcurvature-correcting device, and define the optimal AC concentration.
    Methods: In this investigator-blinded study, 70 patients with hallux pincer nail were fitted with an overcurvature-correcting device for 7 days and were randomly assigned to receive a single 24-h administration of a gel containing 10%, 20% or 30% AC or vehicle. Nail improvement was objectively evaluated by calculating the distal narrowed nail width (dNNW) ratio.
    Results: All three AC concentrations plus device showed earlier sustained improvement of pincer nails versus vehicle plus device. There was no observable correlation between AC concentration and effectiveness. No clinically problematic adverse events were observed at any AC concentration, and we recommended AC gel at a concentration of 10%.
    Conclusions: By adding AC gel application to an overcurvature-correcting device, early and sustained reductions in transverse curvature were produced compared with using a device alone (vehicle control). The dNNW ratio used in this study was an appropriate objective index for evaluating therapeutic effects.
    MeSH term(s) Humans ; Acetylcysteine/therapeutic use ; Research Design ; Patients
    Chemical Substances Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2248311
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