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  1. Book ; Online: Gene Expression Profiling in Cancer

    Vlachakis, Dimitrios

    2019  

    Keywords Oncology
    Size 1 electronic resource (78 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049762
    ISBN 9781789853834 ; 1789853834
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Systems Biology

    Vlachakis, Dimitrios

    2019  

    Keywords Medical bioinformatics ; immunotherapy, vaccine, gene therapy, bioinformatics, genes, omics
    Language English
    Size 1 electronic resource (106 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030644982
    ISBN 9781838808051 ; 1838808051
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Molecular Docking

    Vlachakis, Dimitrios P

    2018  

    Keywords Molecular biology ; bioinformatics, insecticide resistance, antimicrobial activity, drug repurposing, molecular modeling, hydrogen bond
    Language English
    Size 1 electronic resource (188 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645424
    ISBN 9781838814328 ; 1838814329
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Genetic and structural analyses of ssRNA viruses pave the way for the discovery of novel antiviral pharmacological targets.

    Vlachakis, Dimitrios

    Molecular omics

    2021  Volume 17, Issue 3, Page(s) 357–364

    Abstract: In the era of big data and artificial intelligence, a lot of new discoveries have influenced the fields of antiviral drug design and pharmacophore identification. Viruses have always been a threat to society in terms of public health and economic ... ...

    Abstract In the era of big data and artificial intelligence, a lot of new discoveries have influenced the fields of antiviral drug design and pharmacophore identification. Viruses have always been a threat to society in terms of public health and economic stability. Viruses not only affect humans but also livestock and agriculture with a direct impact on food safety, economy and environmental imprint. Most recently, with the pandemic of COVID-19, it was made clear that a single virus can have a devastating impact on global well-being and economy. In this direction, there is an emerging need for the identification of promising pharmacological targets in viruses. Herein, an effort has been made to discuss the current knowledge, state-of-the-art applications and future implications for the main pharmacological targets of single-stranded RNA viruses.
    MeSH term(s) Antiviral Agents/pharmacology ; Drug Design ; Drug Discovery/methods ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Methyltransferases/chemistry ; Molecular Targeted Therapy ; Peptide Hydrolases/chemistry ; Positive-Strand RNA Viruses/chemistry ; Positive-Strand RNA Viruses/genetics ; SARS-CoV-2/drug effects ; Viral Proteins/chemistry ; Viral Proteins/metabolism
    Chemical Substances Antiviral Agents ; Enzyme Inhibitors ; Viral Proteins ; Methyltransferases (EC 2.1.1.-) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2021-03-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2515-4184
    ISSN (online) 2515-4184
    DOI 10.1039/d0mo00173b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: Zur Rolle der Chemokine IP-10, MIG und I-TAC bei der Rekrutierung von T-Lymphozyten in das Lungengewebe von Patienten mit Sarkoidose und anderen granulomatösen Lungenerkrankungen

    Vlachakis, Dimitrios

    2005  

    Author's details vorgelegt von Dimitrios Vlachakis
    Language German
    Size 86 Bl., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg (Breisgau), Univ., Diss., 2006
    HBZ-ID HT016059380
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 E 1972 order for loan Magazin

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  6. Article ; Online: Future of Exosome Bioinformatics.

    Vlachakis, Dimitrios P / Diakou, Kalliopi Io / Chrousos, George P

    EMBnet.journal

    2023  Volume 28

    Language English
    Publishing date 2023-03-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2226-6089
    ISSN (online) 2226-6089
    DOI 10.14806/ej.28.0.1015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Indications of younger age at menarche in Greek adolescents but with no relation to body mass index.

    Papageorgiou, Anastasia / Charmandari, Evangelia / Efthymiou, Vasiliki / Vlachakis, Dimitrios / Bacopoulou, Flora

    Hormones (Athens, Greece)

    2024  

    Abstract: Purpose: This study aimed to present recent trends in the pubertal timing of a Greek female sample.: Methods: Data were collected retrospectively from medical records of healthy females aged 6-18 years who attended a tertiary Adolescent Friendly ... ...

    Abstract Purpose: This study aimed to present recent trends in the pubertal timing of a Greek female sample.
    Methods: Data were collected retrospectively from medical records of healthy females aged 6-18 years who attended a tertiary Adolescent Friendly Health Center over a 5-year period (2016-2020) and included gestational age, birth anthropometrics, and age of thelarche and/or pubarche and/or menarche, along with corresponding anthropometric, hormonal, and biochemical measurements.
    Results: Data from 298 girls' medical records were included in the analysis. Median age at menarche, thelarche, and pubarche was 12, 9, and 9 years, respectively. The mean interval between pubertal onset and menarche was 1.99 years. The mean body mass index (BMI) at menarche and thelarche was 20.99 kg/m
    Conclusion: The timing of pubertal stages in the Greek female sample studied followed the recent international downward trends. Younger age at menarche was not related to BMI.
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2075912-5
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.1007/s42000-024-00557-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Unraveling Desmin's Head Domain Structure and Function.

    Vlachakis, Dimitrios / Tsilafakis, Konstantinos / Kostavasili, Ioanna / Kossida, Sophia / Mavroidis, Manolis

    Cells

    2024  Volume 13, Issue 7

    Abstract: Understanding the structure and function of intermediate filaments (IFs) is necessary in order to explain why more than 70 related IF genes have evolved in vertebrates while maintaining such dramatically tissue-specific expression. Desmin is a member of ... ...

    Abstract Understanding the structure and function of intermediate filaments (IFs) is necessary in order to explain why more than 70 related IF genes have evolved in vertebrates while maintaining such dramatically tissue-specific expression. Desmin is a member of the large multigene family of IF proteins and is specifically expressed in myocytes. In an effort to elucidate its muscle-specific behavior, we have used a yeast two-hybrid system in order to identify desmin's head binding partners. We described a mitochondrial and a lysosomal protein, NADH ubiquinone oxidoreductase core subunit S2 (NDUFS2), and saposin D, respectively, as direct desmin binding partners. In silico analysis indicated that both interactions at the atomic level occur in a very similar way, by the formation of a three-helix bundle with hydrophobic interactions in the interdomain space and hydrogen bonds at R16 and S32 of the desmin head domain. The interactions, confirmed also by GST pull-down assays, indicating the necessity of the desmin head domain and, furthermore, point out its role in function of mitochondria and lysosomes, organelles which are disrupted in myopathies due to desmin head domain mutations.
    MeSH term(s) Animals ; Desmin/chemistry ; Desmin/metabolism ; Intermediate Filaments/metabolism ; Muscles/metabolism ; Muscular Diseases/genetics ; Muscular Diseases/metabolism ; Mutation ; Humans
    Chemical Substances Desmin
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How Does Meditation Affect the Default Mode Network: A Systematic Review.

    Zagkas, Dimitrios / Bacopoulou, Flora / Vlachakis, Dimitrios / Chrousos, George P / Darviri, Christina

    Advances in experimental medicine and biology

    2023  Volume 1425, Page(s) 229–245

    Abstract: This article provides a systematic review of studies evaluating the effect of meditation on the Default Mode Network (DMN). The review was conducted according to PRISMA guidelines. A literature search of PubMed, Scopus, and Embase was conducted up to ... ...

    Abstract This article provides a systematic review of studies evaluating the effect of meditation on the Default Mode Network (DMN). The review was conducted according to PRISMA guidelines. A literature search of PubMed, Scopus, and Embase was conducted up to June 2020. Search terms included default mode network or DMN and meditation.A total of 306 articles were identified, of which 16 controlled trials with a total of 853 experienced (in Mindfulness, Samatha, Raja Yoga, Transcendental Meditation, Vipassana, Insight meditation Theravada tradition) and non-experienced mediators were finally included in this systematic review. The results showed that meditative interventions affect the operation of DMN and there are differences in functional connectivity between networks. Further research should be undertaken to establish meditation as an effective intervention strategy for well-being.
    MeSH term(s) Humans ; Meditation ; Default Mode Network ; Mindfulness ; Yoga ; Nerve Net
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-31986-0_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article: Collaborative Platforms and Matchmaking Algorithms for Research and Education, Establishment, and Optimization of Consortia.

    Papakonstantinou, Eleni / Efthymiou, Vasiliki / Dragoumani, Konstantina / Christodoulou, Maria / Vlachakis, Dimitrios

    Advances in experimental medicine and biology

    2023  Volume 1424, Page(s) 125–133

    Abstract: Matchmaking has a great position in the rational allocation of resources in several fields, ranging from market operation to people's daily lives. Matchmakers have evolved through artificial intelligence technologies and are being introduced in numerous ... ...

    Abstract Matchmaking has a great position in the rational allocation of resources in several fields, ranging from market operation to people's daily lives. Matchmakers have evolved through artificial intelligence technologies and are being introduced in numerous aspects of industry, research, and academia in solving decision issues, research innovation design, and building robust and efficient networks. The goal of this report is to describe the collaborative platforms and matchmaking algorithms for research and education, as well as the establishment and optimization of consortia.
    MeSH term(s) Humans ; Artificial Intelligence ; Algorithms ; Technology
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-31982-2_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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