LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 549

Search options

  1. Book ; Online: Selected age-diagnostic datums of ODP Site 184-1148, supplementary data to: Li, Qianyu; Wang, Pinxian; Zhao, Quanhong; Shao, Lei; Zhong, Guangfa; Tian, Jun; Cheng, Xinrong; Jian, Zhimin; Su, Xin (2006): A 33 Ma lithostratigraphic record of tectonic and paleoceanographic evolution of the South China Sea. Marine Geology, 230(3-4), 217-235

    Li, Qianyu / Cheng, Xinrong / Jian, Zhimin / Shao, Lei / Su, Xin / Tian, Jun / Wang, Pinxian / Zhao, Quanhong / Zhong, Guangfa

    2006  

    Abstract: The 853 m thick sediment sequence recovered at ODP Site 1148 provides an unprecedented record of tectonic and paleoceanographic evolution in the South China Sea over the past 33 Ma. Litho-, bio-, and chemo-stratigraphic studies helped identify six ... ...

    Abstract The 853 m thick sediment sequence recovered at ODP Site 1148 provides an unprecedented record of tectonic and paleoceanographic evolution in the South China Sea over the past 33 Ma. Litho-, bio-, and chemo-stratigraphic studies helped identify six periods of changes marking the major steps of the South China Sea geohistory. Rapid deposition with sedimentation rates of 60 m/Ma or more characterized the early Oligocene rifting. Several unconformities from the slumped unit between 457 and 495 mcd together erased about 3 Ma late Oligocene record, providing solid evidence of tectonic transition from rifting/slow spreading to rapid spreading in the South China Sea. Slow sedimentation of ~20-30 m/Ma signifies stable seafloor spreading in the early Miocene. Dissolution may have affected the completeness of Miocene-Pleistocene succession with short-term hiatuses beyond current biostratigraphical resolution. Five major dissolution events, D-1 to D-5, characterize the stepwise development of deep water masses in close association to post-Oligocene South China Sea basin transformation. The concurrence of local and global dissolution events in the Miocene and Pliocene suggests climatic forcing as the main mechanism causing deep water circulation changes concomitantly in world oceans and in marginal seas. A return of high sedimentation rate of 60 m/Ma to the late Pliocene and Pleistocene South China Sea was caused by intensified down-slope transport due to frequent sea level fluctuations and exposure of a large shelf area during sea level low-stands. The six paleoceanographic stages, respectively corresponding to rifting (~33-28.5 Ma), changing spreading southward (28.5-23 Ma), stable spreading to end of spreading (23-15 Ma), post-spreading balance (15-9 Ma), further modification and monsoon influence (9-5 Ma), and glacial prevalence (5-0 Ma), had transformed the South China Sea from a series of deep grabens to a rapidly expanding open gulf and finally to a semi-enclosed marginal sea in the past 33 Ma.
    Language English
    Dates of publication 2006-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.margeo.2006.05.006
    DOI 10.1594/PANGAEA.724457
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    More links

    Kategorien

  2. Article ; Online: M1-Type Microglia-Derived Extracellular Vesicles Overexpressing IL-1R1 Promote Postoperative Cognitive Dysfunction by Regulating Neuronal Inflammation.

    Qi, Zheng / Yu, Yang / Su, Yu / Cao, Bin / Shao, Hua / Yang, Jian-Jun

    Inflammation

    2023  Volume 46, Issue 6, Page(s) 2254–2269

    Abstract: Postoperative cognitive dysfunction (POCD) is a common complication after surgical anesthesia, mainly manifested as memory impairment, decreased attention, and cognitive function with mood and personality changes. Activated microglia (M1-type microglia) ... ...

    Abstract Postoperative cognitive dysfunction (POCD) is a common complication after surgical anesthesia, mainly manifested as memory impairment, decreased attention, and cognitive function with mood and personality changes. Activated microglia (M1-type microglia) have been demonstrated to release inflammatory substances (IL-1β, TNF-α, etc.) that cause neuronal degeneration and death by activating the NF-κB signaling pathway and upregulating Caspase-3 and Bax. However, the pathogenesis of POCD is still not fully understood and needs further research. In the present study, we investigated the effect of M1-type microglia-derived extracellular vesicles (EVs
    MeSH term(s) Animals ; Mice ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Extracellular Vesicles/metabolism ; Inflammation/metabolism ; Microglia/metabolism ; Neurons/metabolism ; NF-kappa B/metabolism ; Postoperative Cognitive Complications/genetics ; Postoperative Cognitive Complications/metabolism ; Postoperative Cognitive Complications/pathology
    Chemical Substances NF-kappa B ; IL1R1 protein, mouse
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-023-01875-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Trinuclear Re(I)-Coordinated Organic Cage as the Supramolecular Photocatalyst for Visible-Light-Driven CO

    Song, Jia-Qi / Lu, Yu-Lin / Yi, Shao-Zhe / Zhang, Jian-Hua / Pan, Mei / Su, Cheng-Yong

    Inorganic chemistry

    2023  Volume 62, Issue 31, Page(s) 12565–12572

    Abstract: Photocatalytic reduction of excess ... ...

    Abstract Photocatalytic reduction of excess CO
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01841
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Towards the impact of economic policy uncertainty on food security: Introducing a comprehensive heterogeneous framework for assessment

    Su, Fang / Liu, Yu / Chen, Shao-Jian / Shah, Fahad

    Journal of Cleaner Production. 2023 Feb., v. 386 p.135792-

    2023  

    Abstract: In recent years, economic policy uncertainty (EPU) has become a topic of increasing interest among policymakers in advanced economies, and food security has become an increasingly essential but contentious term since the global food price spike. Based on ...

    Abstract In recent years, economic policy uncertainty (EPU) has become a topic of increasing interest among policymakers in advanced economies, and food security has become an increasingly essential but contentious term since the global food price spike. Based on a heterogeneous framework, this paper empirically investigates the impact of EPU on food security by utilizing panel data of 25 countries for the period of 1995–2019. This article combines the FAO's definition of food security and improves the food security evaluation system based on the existing data, further establishing secondary indicators of food supply, food access, food utilization, and food stability. The results show that the uncertainty of economic policy has a significant negative impact on food security; the results of adjustment effect show that both the fluctuation of grain price and the dependence on foreign trade enhance the inhibition of economic policy uncertainty on food security. Heterogeneity analysis shows that the uncertainty of economic policy has a greater negative impact on the food security of developed countries and food exporting countries. To ensure the world's food security, governmental authorities must strengthen policy support for grain production, concentrate capital investment in grain production, and ensure self-sufficiency in domestic grain production. At the same time, we should also build diversified grain import channels to ensure the stability and sustainability of import sources. In the future, governments should strengthen international cooperation on food security, build a community of human food security, and promote fair and free food trade.
    Keywords economic investment ; economic policy ; food availability ; food prices ; food security ; foods ; imports ; international cooperation ; international trade ; uncertainty ; Economic policy uncertainty (EPU) ; Heterogeneity analysis ; Mechanism of action
    Language English
    Dates of publication 2023-02
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2022.135792
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  5. Article ; Online: Structures and ion transport mechanisms of plant high-affinity potassium transporters.

    Wang, Jiangqin / Luo, Yanping / Ye, Fan / Ding, Zhong Jie / Zheng, Shao Jian / Qiao, Shuai / Wang, Yong / Guo, Jiangtao / Yang, Wei / Su, Nannan

    Molecular plant

    2024  Volume 17, Issue 3, Page(s) 409–422

    Abstract: Plant high-affinity ... ...

    Abstract Plant high-affinity K
    MeSH term(s) Arabidopsis Proteins/metabolism ; Cryoelectron Microscopy ; Symporters ; Arabidopsis/metabolism ; Ion Transport ; Ions/metabolism ; Potassium/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism
    Chemical Substances Arabidopsis Proteins ; Symporters ; Ions ; Potassium (RWP5GA015D) ; Plant Proteins
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2024.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: CUL4B increases platinum-based drug resistance in colorectal cancer through EMT: A study in its mechanism.

    Luo, Jian-Wu / Wang, Chun-Ming / Su, Jian-Wei / Yi, Ting-Zhuang / Tang, Shao-Hui

    Journal of cellular and molecular medicine

    2022  Volume 26, Issue 23, Page(s) 5767–5778

    Abstract: Platinum-based chemotherapy drugs play a very important role in the treatment of patients with advanced colorectal cancer, but the drug resistance of platinum-based chemotherapy drugs is an important topic that puzzles us. If we can find mechanisms of ... ...

    Abstract Platinum-based chemotherapy drugs play a very important role in the treatment of patients with advanced colorectal cancer, but the drug resistance of platinum-based chemotherapy drugs is an important topic that puzzles us. If we can find mechanisms of resistance, it will be revolutionary for us. We analysed the differential genes, core genes and their enrichment pathways in platinum-resistant and non-resistant patients through a public database. Platinum-resistant cell lines were cultured in vitro for in vitro colony and Transwell analysis. Tumorigenesis analysis of nude mice in vivo. Verify the function of core genes. Through differential gene and enrichment analysis, we found that CUL4B was the main factor affecting platinum drug resistance and EMT. Our hypothesis was further verified by in vitro drug-resistant and wild-type cell lines and in vivo tumorigenesis analysis of nude mice. CUL4B leads to platinum drug resistance in colorectal cancer by affecting tumour EMT.
    MeSH term(s) Animals ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinogenesis ; Cell Transformation, Neoplastic ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Drug Resistance/genetics ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Mice, Nude ; Platinum Compounds/pharmacology ; Platinum Compounds/therapeutic use
    Chemical Substances Antineoplastic Agents ; Platinum Compounds
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17585
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Salylic acid minimize cadmium accumulation in rice through regulating the fixation capacity of the cell wall to cadmium.

    Chen, Zhi Jian / Huang, Jing / Li, Su / Shao, Ji Feng / Shen, Ren Fang / Zhu, Xiao Fang

    Plant science : an international journal of experimental plant biology

    2023  Volume 336, Page(s) 111839

    Abstract: Although salylic acid (SA) has been linked to how plants react to cadmium (Cd) stress, the exact mechanism is still unknown. The endogenous SA concentration in the rice (Oryza sativa L.) roots was enhanced by Cd stress in the current investigation, and ... ...

    Abstract Although salylic acid (SA) has been linked to how plants react to cadmium (Cd) stress, the exact mechanism is still unknown. The endogenous SA concentration in the rice (Oryza sativa L.) roots was enhanced by Cd stress in the current investigation, and exogenous SA reduced the hemicellulose content in root cell wall, which in turn inhibited its Cd binding capacity. What's more, exogenous SA also decreased the transcription level of genes such as Natural Resistance-Associated Macrophage Protein 5 (OsNRAMP5) and a major facilitator superfamily gene-OsCd1 that responsible for root Cd absorption. Finally, less Cd was accumulated in the rice as a result of the higher expression of Heavy Metal ATPase 3 (OsHMA3), Cation/Ca exchanger 2 (OsCCX2) and Pleiotropic Drug Resistance 9 (OsPDR9/OsABCG36) that were responsible for separating Cd into vacuole and getting Cd out of cells, respectively. In contrast, mutant with low SA level accumulated more Cd. Additionally, SA enhanced endogenous nitric oxide (NO) levels, and its alleviatory effects were mimicked by a NO donor, sodium nitroprusside (SNP). In conclusion, SA enhanced rice's Cd resistance through regulating the binding capacity of the cell wall to Cd, a pathway that might dependent on the NO accumulation.
    Language English
    Publishing date 2023-08-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 742010-9
    ISSN 1873-2259 ; 0168-9452
    ISSN (online) 1873-2259
    ISSN 0168-9452
    DOI 10.1016/j.plantsci.2023.111839
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Effects of short- and long-term plant functional group loss on alpine meadow community structure and soil nutrients.

    Wei, Jingjing / Zhou, Huakun / Shao, Xinqing / Sun, Jian / Ma, Li / Zhang, Zhonghua / Qin, Ruimin / Su, Hongye / Hu, Xue / Chang, Tao / Shi, Zhengchen / Ade, Haze / Wang, Huichun

    Ecology and evolution

    2024  Volume 14, Issue 3, Page(s) e10919

    Abstract: The rapid loss of global biodiversity can greatly affect the normal functioning of ecosystems. However, how biodiversity losses affect plant community structure and soil nutrients is unclear. We conducted a field experiment to examine the short- and long- ...

    Abstract The rapid loss of global biodiversity can greatly affect the normal functioning of ecosystems. However, how biodiversity losses affect plant community structure and soil nutrients is unclear. We conducted a field experiment to examine the short- and long-term effects of removing plant functional groups (Gramineae, Cyperaceae, legumes, and forbs) on the interrelationships among the species diversity, productivity, community structure, and soil nutrients in an alpine meadow ecosystem at Menyuan County, Qinghai Province. The variations in the species richness, above- and belowground biomass of the community gradually decreased over time. Species richness and productivity were positively correlated, and this correlation tended to be increasingly significant over time. Removal of the Cyperaceae, legumes, and other forbs resulted in fewer Gramineae species in the community. Soil total nitrogen, phosphorus, organic matter, and moisture contents increased significantly in the legume removal treatment. The removal of other forbs led to the lowest negative cohesion values, suggesting that this community may have difficulty recovering its previous equilibrium state within a short time. The effects of species removal on the ecosystem were likely influenced by the species structure and composition within the community. Changes in the number of Gramineae species indicated that they were more sensitive and less resistant to plant functional group removal. Legume removal may also indirectly cause distinct community responses through starvation and compensation effects. In summary, species loss at the community level led to extensive species niche shifts, which caused community resource redistribution and significant changes in community structure.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10919
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy.

    Cheng, Binbin / Shi, Yaru / Shao, Chuxiao / Wang, Shuanghu / Su, Zhenhong / Liu, Jin / Zhou, Yingxing / Fei, Xiaoting / Pan, Wei / Chen, Jianjun / Lu, Yiyu / Xiao, Jian

    Journal of medicinal chemistry

    2024  Volume 67, Issue 8, Page(s) 6253–6267

    Abstract: In this work, a novel series of heterotricyclic DNA-PK inhibitors were rationally designed, synthesized, and assessed for their biological activity. In the DNA-PK biochemical assay, most compounds displayed potent enzymatic activity, with ... ...

    Abstract In this work, a novel series of heterotricyclic DNA-PK inhibitors were rationally designed, synthesized, and assessed for their biological activity. In the DNA-PK biochemical assay, most compounds displayed potent enzymatic activity, with IC
    MeSH term(s) Humans ; Animals ; DNA-Activated Protein Kinase/antagonists & inhibitors ; DNA-Activated Protein Kinase/metabolism ; Biological Availability ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use ; Administration, Oral ; Immunotherapy/methods ; Doxorubicin/pharmacology ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Mice, Inbred BALB C ; Drug Discovery ; Mice, Inbred C57BL ; Cell Line, Tumor ; Drug Synergism ; Female
    Chemical Substances DNA-Activated Protein Kinase (EC 2.7.11.1) ; Antineoplastic Agents ; Protein Kinase Inhibitors ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c02231
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: The climate adaptability evaluation of biogas fermentation assisted by solar greenhouse

    Shao Xiaolu / Su Xing / Tian Shaochen / Cai Jian

    E3S Web of Conferences, Vol 246, p

    2021  Volume 03002

    Abstract: The production efficiency of biogas digesters is largely restricted by the low environment temperature in winter, for most regions of China. As a feasible means of warming and heat preservation, solar greenhouse has the ability to expand the application ... ...

    Abstract The production efficiency of biogas digesters is largely restricted by the low environment temperature in winter, for most regions of China. As a feasible means of warming and heat preservation, solar greenhouse has the ability to expand the application scope and service time of biogas in rural China. The evaluation of climate adaptability of solar greenhouse is of great importance and imminent, due to the fact that both solar energy and biomass resources are affected by climate. In this paper, a complete evaluation index system for climate adaptability of biogas fermentation assisted by solar greenhouse was established. The indicators of the evaluation index system were selected by means of frequency analysis and theoretical analysis. The weights of the indicators, including solar radiation, outdoor air temperature, crop yields and human and animal manure, were determined by analytic hierarchy process combined with literature research, and the scoring rules were based on the objective significance of each indicator. The climate adaptability of typical cities in the Yangtze River Delta was evaluated with the evaluation index system. Among the cities, Hefei shows the best comprehensive adaptability, and then is Xuzhou, Shanghai, Nanjing, and the lowest adaptability, Hangzhou. The comprehensive adaptability results of these cities depend not only on the gas production capacity, but also on the biomass resource and solar radiation.
    Keywords Environmental sciences ; GE1-350
    Subject code 600
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top