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  1. Article ; Online: Severe Acute Respiratory Syndrome-Coronavirus-2 Effects at the Maternal-Fetal Interface.

    DeBiasi, Roberta L

    The Journal of infectious diseases

    2022  Volume 225, Issue 5, Page(s) 745–747

    MeSH term(s) COVID-19 ; Female ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Pregnancy ; Pregnancy Complications, Infectious/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac009
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  2. Article ; Online: Congenital infectious encephalopathies from the intrapartum period to postnatal life.

    Fortin, Olivier / DeBiasi, Roberta L / Mulkey, Sarah B

    Seminars in fetal & neonatal medicine

    2024  , Page(s) 101526

    Abstract: Congenital infections are a common but often underrecognized cause of fetal brain abnormalities, as well as fetal-neonatal morbidity and mortality, that should be considered by all healthcare professionals providing neurological care to fetuses and ... ...

    Abstract Congenital infections are a common but often underrecognized cause of fetal brain abnormalities, as well as fetal-neonatal morbidity and mortality, that should be considered by all healthcare professionals providing neurological care to fetuses and newborns. Maternal infection with various pathogens (cytomegalovirus, Toxoplasmosis, Rubella virus, Parvovirus B19, lymphocytic choriomeningitis virus, syphilis, Zika virus, varicella zoster virus) during pregnancy can be transmitted to the developing fetus, which can cause multisystem dysfunction and destructive or malformative central nervous system lesions. These can be recognized on fetal and neonatal imaging, including ultrasound and MRI. Imaging and clinical features often overlap, but some distinguishing features can help identify specific pathogens and guide subsequent testing strategies. Some pathogens can be specifically treated, and others can be managed with targeted interventions or symptomatic therapy based on expected complications. Neurological and neurodevelopmental complications related to congenital infections vary widely and are likely driven by a combination of pathophysiologic factors, alone or in combination. These include direct invasion of the fetal central nervous system by pathogens, inflammation of the maternal-placental-fetal triad in response to infection, and long-term effects of immunogenic and epigenetic changes in the fetus in response to maternal-fetal infection. Congenital infections and their neurodevelopmental impacts should be seen as an issue of public health policy, given that infection and the associated complications disproportionately affect woman and children from low- and middle-income countries and those with lower socio-economic status in high-income countries. Congenital infections may be preventable and treatable, which can improve long-term neurodevelopmental outcomes in children.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2024.101526
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  3. Article ; Online: Immunotherapy for MIS-C - IVIG, Glucocorticoids, and Biologics.

    DeBiasi, Roberta L

    The New England journal of medicine

    2021  Volume 385, Issue 1, Page(s) 74–75

    MeSH term(s) Biological Products ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulins, Intravenous ; Immunologic Factors/therapeutic use ; Immunotherapy
    Chemical Substances Biological Products ; Glucocorticoids ; Immunoglobulins, Intravenous ; Immunologic Factors
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2108276
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  4. Article ; Online: Reply.

    DeBiasi, Roberta L

    The Journal of pediatrics

    2020  Volume 225, Page(s) 280–281

    MeSH term(s) COVID-19 ; Child ; District of Columbia ; Humans ; Pandemics ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.06.062
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  5. Article ; Online: New Insights into Zika in Infants and Children.

    Mulkey, Sarah B / DeBiasi, Roberta L

    Tropical medicine and infectious disease

    2022  Volume 7, Issue 8

    Abstract: In the original article [ ... ]. ...

    Abstract In the original article [...].
    Language English
    Publishing date 2022-07-30
    Publishing country Switzerland
    Document type Editorial
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed7080158
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  6. Article ; Online: Reply to Correspondence.

    Monaghan, Maureen / Norman, Stephanie / Gierdalski, Marcin / Marques, Adriana / Bost, James E / DeBiasi, Roberta L

    Pediatric research

    2023  Volume 95, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Letter
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02790-0
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  8. Article ; Online: New Insights into Zika in Infants and Children

    Sarah B. Mulkey / Roberta L. DeBiasi

    Tropical Medicine and Infectious Disease, Vol 7, Iss 8, p

    2022  Volume 158

    Abstract: In the original article [.] ...

    Abstract In the original article [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Pediatric Lyme disease: systematic assessment of post-treatment symptoms and quality of life.

    Monaghan, Maureen / Norman, Stephanie / Gierdalski, Marcin / Marques, Adriana / Bost, James E / DeBiasi, Roberta L

    Pediatric research

    2023  Volume 95, Issue 1, Page(s) 174–181

    Abstract: Background: Lyme disease is common among children and adolescents. Antibiotic treatment is effective, yet some patients report persistent symptoms following treatment, with or without functional impairment. This study characterized long-term outcome of ... ...

    Abstract Background: Lyme disease is common among children and adolescents. Antibiotic treatment is effective, yet some patients report persistent symptoms following treatment, with or without functional impairment. This study characterized long-term outcome of pediatric patients with Lyme disease and evaluated the case definition of post-treatment Lyme disease (PTLD) syndrome.
    Methods: The sample included 102 children with confirmed Lyme disease diagnosed 6 months-10 years prior to enrollment (M = 2.0 years). Lyme diagnosis and treatment information was extracted from the electronic health record; parent report identified presence, duration, and impact of symptoms after treatment. Participants completed validated questionnaires assessing health-related quality of life, physical mobility, fatigue, pain, and cognitive impact.
    Results: Most parents reported their child's symptoms resolved completely, although time to full resolution varied. Twenty-two parents (22%) indicated their child had at least one persistent symptom >6 months post-treatment, 13 without functional impairment (PTLD symptoms) and 9 with functional impairment (PTLD syndrome). Children with PTLD syndrome had lower parent-reported Physical Summary scores and greater likelihood of elevated fatigue.
    Conclusions: In the current study, most children with Lyme disease experienced full resolution of symptoms, including those who initially met PTLD syndrome criteria. Effective communication about recovery rates and common symptoms that may persist post-treatment is needed.
    Impact: The majority of pediatric patients treated for all stages of Lyme disease reported full resolution of symptoms within 6 months. 22% of pediatric patients reported one or more symptom persisting >6 months, 9% with and 13% without accompanying functional impairment. Effective communication with families about recovery rates and common symptoms that may persist post-treatment of Lyme disease is needed.
    MeSH term(s) Adolescent ; Humans ; Child ; Quality of Life ; Lyme Disease/diagnosis ; Lyme Disease/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Pain/drug therapy ; Fatigue/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02577-3
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  10. Article ; Online: Laboratory diagnosis of CNS infections in children due to emerging and re-emerging neurotropic viruses.

    Liu, Benjamin M / Mulkey, Sarah B / Campos, Joseph M / DeBiasi, Roberta L

    Pediatric research

    2023  Volume 95, Issue 2, Page(s) 543–550

    Abstract: Recent decades have witnessed the emergence and re-emergence of numerous medically important viruses that cause central nervous system (CNS) infections in children, e.g., Zika, West Nile, and enterovirus/parechovirus. Children with immature immune ... ...

    Abstract Recent decades have witnessed the emergence and re-emergence of numerous medically important viruses that cause central nervous system (CNS) infections in children, e.g., Zika, West Nile, and enterovirus/parechovirus. Children with immature immune defenses and blood-brain barrier are more vulnerable to viral CNS infections and meningitis than adults. Viral invasion into the CNS causes meningitis, encephalitis, brain imaging abnormalities, and long-term neurodevelopmental sequelae. Rapid and accurate detection of neurotropic viral infections is essential for diagnosing CNS diseases and setting up an appropriate patient management plan. The addition of new molecular assays and next-generation sequencing has broadened diagnostic capabilities for identifying infectious meningitis/encephalitis. However, the expansion of test menu has led to new challenges in selecting appropriate tests and making accurate interpretation of test results. There are unmet gaps in development of rapid, sensitive and specific molecular assays for a growing list of emerging and re-emerging neurotropic viruses. Herein we will discuss the advances and challenges in the laboratory diagnosis of viral CNS infections in children. This review not only sheds light on selection and interpretation of a suitable diagnostic test for emerging/re-emerging neurotropic viruses, but also calls for more research on development and clinical utility study of novel molecular assays. IMPACT: Children with immature immune defenses and blood-brain barrier, especially neonates and infants, are more vulnerable to viral central nervous system infections and meningitis than adults. The addition of new molecular assays and next-generation sequencing has broadened diagnostic capabilities for identifying infectious meningitis and encephalitis. There are unmet gaps in the development of rapid, sensitive and specific molecular assays for a growing list of emerging and re-emerging neurotropic viruses.
    MeSH term(s) Adult ; Infant ; Infant, Newborn ; Child ; Humans ; Viruses ; Central Nervous System Infections/diagnosis ; Central Nervous System Viral Diseases/diagnosis ; Encephalitis ; Meningitis ; Clinical Laboratory Techniques ; Zika Virus ; Zika Virus Infection
    Language English
    Publishing date 2023-12-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02930-6
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