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  1. Article: Improved antioxidant activities of spice require enrichment of distinct yet closely-related metabolic pathways.

    Gandhi, Sonia / Saha, Manas Ranjan / Dey, Priyankar

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21392

    Abstract: Improved biosynthesis of commercially and pharmacologically relevant phytometabolites through genetic and metabolic engineering is a lucrative strategy for crop improvement. However, identifying appropriate biosynthetic pathways pertaining to specific ... ...

    Abstract Improved biosynthesis of commercially and pharmacologically relevant phytometabolites through genetic and metabolic engineering is a lucrative strategy for crop improvement. However, identifying appropriate biosynthetic pathways pertaining to specific bioactivities has been challenging since the major metabolic pathways remain closely interconnected. Here we propose a reverse association strategy in which, based on the phytochemical profile, putative target metabolic pathways could be identified for increased production of phytochemicals. Dried seed fruits of
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy.

    Koundal, Sunil / Gandhi, Sonia / Khushu, Subash

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

    2022  Volume 27, Issue 6, Page(s) 562–567

    Abstract: Introduction: The main physiological challenge in high altitude environment is hypoxia which affects the aerobic metabolism reducing the energy supply. These changes may further progress towards extreme environment related diseases. Rarely has the high- ... ...

    Abstract Introduction: The main physiological challenge in high altitude environment is hypoxia which affects the aerobic metabolism reducing the energy supply. These changes may further progress towards extreme environment related diseases. Rarely has the high-altitude biology been studied using system sciences and omics high-throughput technologies.
    Objective: In the present study, 1H-NMR-based metabolomics, along with multivariate analysis, were employed in a preclinical rat model to characterise the serum metabolic changes under chronic hypobaric hypoxia (HH) stress.
    Material and methods: Rats were exposed to simulated hypobaric hypoxia equivalent of 6700 m above the sea level. The serum samples were collected from control and HH-exposure (7, 14, and 21 days) of hypobaric hypoxia.
    Results and discussion: The 1H-NMR metabolomics of the serum showed alterations in the metabolism of membranes, amino-acids altered cellular bioenergetics and osmoregulation. Multivariate statistical analysis revealed alterations in acetoacetate, choline, glutamine, acetate, betaine, ketone bodies and branched amino acid metabolites.
    Conclusion: Present findings establishes the fingerprint biomarkers for chronic environmental hypoxia which will help in understanding extreme environment related health problems, early detection and developing strategies to clinically address high altitude hypoxia.
    MeSH term(s) Animals ; Biomarkers ; Hypoxia ; Magnetic Resonance Spectroscopy ; Metabolomics ; Proton Magnetic Resonance Spectroscopy ; Rats
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1324372-x
    ISSN 1366-5804 ; 1354-750X
    ISSN (online) 1366-5804
    ISSN 1354-750X
    DOI 10.1080/1354750X.2022.2076152
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4864: Show issues Location:
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  3. Article ; Online: Are dental reviews as reliable as we think?

    Gandhi, Sonal

    British dental journal

    2022  Volume 233, Issue 11, Page(s) 944

    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type News
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-022-5337-9
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  4. Article ; Online: Neuropsychiatric Presentation of Anti-DPPX Progressive Encephalomyelitis with Rigidity and Myoclonus.

    Neo, Ray Jen / Mehta, Arpan R / Weston, Mikail / Magrinelli, Francesca / Quattrone, Andrea / Gandhi, Sonia / Joyce, Eileen M / Bhatia, Kailash P

    Movement disorders clinical practice

    2023  Volume 11, Issue 1, Page(s) 97–100

    MeSH term(s) Humans ; Myoclonus/diagnosis ; Encephalomyelitis/diagnosis ; Muscle Rigidity/drug therapy
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Case Reports
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13928
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  5. Article ; Conference proceedings: Frailty Does Not Impact Postoperative Outcomes in Extended Endonasal Approaches for Olfactory Groove Meningiomas Compared with Open Craniotomy

    Ajmera, Sonia / Gandhi, Om H. / Blue, Rachel / Douglas, Jennifer / Jackson, Christina / Adappa, Nithin / Palmer, James N. / Jabarkheel, Rashad / Lee, John Y.

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780138
    Database Thieme publisher's database

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    Zs.A 3425: Show issues Location:
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  6. Article ; Online: Toxicity evaluation of silver nanoparticles synthesized from naringin flavonoid on human promyelocytic leukemic cells and human blood cells.

    Soni, Deepika / Gandhi, Deepa

    Toxicology and industrial health

    2024  Volume 40, Issue 3, Page(s) 125–133

    Abstract: Increasing applications of silver nanoparticles (AgNPs) in multiple products like cosmetics, medicines, drugs, paints, and other new materials have raised concern for their toxic effects on living beings and the surrounding environment. In the present ... ...

    Abstract Increasing applications of silver nanoparticles (AgNPs) in multiple products like cosmetics, medicines, drugs, paints, and other new materials have raised concern for their toxic effects on living beings and the surrounding environment. In the present study, cytotoxicity and genotoxicity of AgNPs synthesized using plant flavonoid (Naringin) as a reducing agent were investigated on human promyelocytic leukemic (HL-60) cells and human blood as an in vitro model. The LC
    MeSH term(s) Humans ; Silver/toxicity ; Metal Nanoparticles/toxicity ; Reactive Oxygen Species/metabolism ; Flavonoids ; Blood Cells/metabolism ; Caspases ; Flavanones
    Chemical Substances Silver (3M4G523W1G) ; naringin (N7TD9J649B) ; Reactive Oxygen Species ; Flavonoids ; Caspases (EC 3.4.22.-) ; Flavanones
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 56831-4
    ISSN 1477-0393 ; 0748-2337
    ISSN (online) 1477-0393
    ISSN 0748-2337
    DOI 10.1177/07482337241227244
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    Zs.A 2268: Show issues Location:
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  7. Article ; Online: Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.

    Devito, Liani G / Zanjani, Zeinab Shadman / Evans, James R / Scardamaglia, Annarita / Houlden, Henry / Gandhi, Sonia / Healy, Lyn

    Stem cell research

    2023  Volume 71, Page(s) 103134

    Abstract: Mutations or multiplications of the SNCA (Synuclein Alpha) gene cause rare autosomal dominant Parkinson's disease (PD). The SNCA G51D missense mutation is associated with a synucleinopathy that shares PD and multiple system atrophy (MSA) characteristics. ...

    Abstract Mutations or multiplications of the SNCA (Synuclein Alpha) gene cause rare autosomal dominant Parkinson's disease (PD). The SNCA G51D missense mutation is associated with a synucleinopathy that shares PD and multiple system atrophy (MSA) characteristics. We generated induced pluripotent stem cell (iPSC) lines from two individuals with SNCA G51D missense mutations at risk of PD. Dermal fibroblasts were reprogrammed to pluripotency using a non-integrating mRNA-based protocol. The resulting human iPSCs displayed normal morphology, expressed markers associated with pluripotency, and differentiated into the three germ layers. The iPSC lines could facilitate disease-modelling and therapy development studies for synucleinopathies.
    MeSH term(s) Humans ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Mutation, Missense ; Induced Pluripotent Stem Cells/metabolism ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Multiple System Atrophy/genetics ; Multiple System Atrophy/metabolism ; Mutation
    Chemical Substances alpha-Synuclein ; SNCA protein, human
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2023.103134
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  8. Article ; Online: Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.

    Choi, Minee L / Gandhi, Sonia

    The FEBS journal

    2018  Volume 285, Issue 19, Page(s) 3631–3644

    Abstract: Misfolding and aggregation of the proteins amyloid-β, tau and alpha-synuclein is the predominant pathology underlying the neurodegenerative disorders, Alzheimer's and Parkinson's disease. While end stage insoluble products of aggregation have been well ... ...

    Abstract Misfolding and aggregation of the proteins amyloid-β, tau and alpha-synuclein is the predominant pathology underlying the neurodegenerative disorders, Alzheimer's and Parkinson's disease. While end stage insoluble products of aggregation have been well characterised in human and animal models of disease, accumulating evidence from biophysical, cellular and in vivo studies has shown that soluble intermediates of aggregation, or oligomers, may be the key species that mediate toxicity and underlie seeding and spreading in disease. Here, we review the process of protein misfolding, and the intrinsic and extrinsic processes that cause the native states of the key aggregating proteins to undergo conformational change to form oligomers and ultimately fibrils. We discuss the structural features of the key toxic intermediate, and describe the putative mechanisms by which oligomers may cause cell toxicity. Finally, we explore the potential therapeutic approaches raised by the oligomer hypothesis in neurodegenerative disease.
    MeSH term(s) Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Animals ; Humans ; Parkinson Disease/physiopathology ; Protein Aggregates ; Protein Conformation ; alpha-Synuclein/chemistry ; alpha-Synuclein/metabolism ; tau Proteins/chemistry ; tau Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; Protein Aggregates ; alpha-Synuclein ; tau Proteins
    Language English
    Publishing date 2018-08-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.14587
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    Zs.A 260: Show issues Location:
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  9. Article ; Online: Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach.

    Gandhi, Sonia / Chinnadurai, Vijayakumar / Bhadra, Kuntal / Gupta, Isha / Kanwar, Ratnesh Singh

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 9070

    Abstract: The main physiological challenge in high altitude environment is hypoxia which affects the aerobic metabolism reducing the energy supply. These changes may further progress toward extreme environment-related diseases. These are further reflected in ... ...

    Abstract The main physiological challenge in high altitude environment is hypoxia which affects the aerobic metabolism reducing the energy supply. These changes may further progress toward extreme environment-related diseases. These are further reflected in changes in small molecular weight metabolites and metabolic pathways. In the present study, metabolic changes due to chronic environmental hypoxia were assessed using 1H NMR metabolomics by analysing the urinary metabolic profile of 70 people at sea level and 40 people at Siachen camp (3700 m) for 1 year. Multivariate statistical analysis was carried out, and PLSDA detected 15 metabolites based on VIP score > 1. ROC analysis detected cis-aconitate, Nicotinamide Mononucleotide, Tyrosine, Choline and Creatinine metabolites with a high range of sensitivity and specificity. Pathway analysis revealed 16 pathways impact > 0.05, and phenylalanine tyrosine and tryptophan biosynthesis was the most prominent altered pathway indicating metabolic remodelling to meet the energy requirements. TCA cycle, Glycine serine and Threonine metabolism, Glutathione metabolism and Cysteine alterations were other metabolic pathways affected during long-term high-altitude hypoxia exposure. Present findings will help unlock a new dimension for the potential application of NMR metabolomics to address extreme environment-related health problems, early detection and developing strategies to combat high altitude hypoxia.
    MeSH term(s) Altitude Sickness ; Humans ; Hypoxia ; Metabolomics/methods ; Proton Magnetic Resonance Spectroscopy ; Tyrosine
    Chemical Substances Tyrosine (42HK56048U)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-13031-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Hall technique of fame?

    Gandhi, Sonal

    British dental journal

    2020  Volume 228, Issue 3, Page(s) 161

    MeSH term(s) Awards and Prizes ; Child ; Dentists ; Humans ; Specialization
    Language English
    Publishing date 2020-02-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-020-1271-x
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    Zs.MO 447: Show issues

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