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Article ; Online: Short Amphiphiles or Micelle Peptides May Help to Fight Against COVID-19.

Manna, Sounik / Chowdhury, Trinath / Mandal, Santi M / Choudhury, Sujata Maiti

2022 Volume 23, Issue 1, Page(s) 33–43

Abstract: Background: COVID-19 is a global threat as a result of the incessant spread of SARS-CoV- 2, necessitating the rapid availability of effective antiviral medications to protect our society. For SARSCoV- 2, a group of peptides has already been indicated, ... ...

Abstract	Background: COVID-19 is a global threat as a result of the incessant spread of SARS-CoV- 2, necessitating the rapid availability of effective antiviral medications to protect our society. For SARSCoV- 2, a group of peptides has already been indicated, although their effectiveness has yet to be shown. SARS-CoV-2 is an enveloped virus with hydrophobic fusion protein and spike glycoproteins. Methods: Here, we have compiled a list of amphiphilic peptides that have been published, as well as their in-silico docking studies with the SARS-CoV-2 spike glycoprotein. Results: The findings demonstrated that spike protein and amphiphilic peptides with increased binding affinity create a complex. It was also observed that PalL1 (ARLPRTMVHPKPAQP), 10AN1 (FWFTLIKTQAKQPARYRRFC), THETA defensin (RCICGRGICRLL), and mucroporin M1 (LFRLIKSLIKRLVSAFK) showed the binding free energy of more than -1000 kcal/mol. Molecular pI and hydrophobicity are also important factors of peptides to enhance the binding affinity with spike protein of SARS-CoV-2. Conclusion: In light of these findings, it is crucial to compare the in-vitro to in-vivo efficacy of amphiphilic peptides in order to produce an efficient anti-SARS-CoV-2 peptide therapy that might assist control the present pandemic scenario.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Humans ; Micelles ; Molecular Docking Simulation ; Peptides/metabolism ; Peptides/pharmacology ; Peptides/therapeutic use ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	Antiviral Agents ; Micelles ; Peptides ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-01-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2045662-1
ISSN	1875-5550 ; 1389-2037
ISSN (online)	1875-5550
ISSN	1389-2037
DOI	10.2174/1389203723666220127154159
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Article ; Online: Inhibition of Human Colorectal Cancer by a Natural Product 7-Acetylhorminone and Interactions with BSA/HSA: Multispectral Analysis and In Silico and In Vitro Studies.

Pakrashy, Sourav / Chakraborty, Souvik / Manna, Sounik / Nanda Goswami, Juli / Bhattacharya, Biswajit / Emmerling, Franziska / Mandal, Jishu / Misra, Sourav / Maiti Choudhury, Sujata / Okla, Mohammad K / Bose, Adity / Maurya, Pawan Kumar / Majhi, Anjoy / Dolai, Malay

ACS applied bio materials

2024 Volume 7, Issue 5, Page(s) 3414–3430

Abstract: We have semi-synthesized a natural product 7-acetylhorminone from crude extract ... ...

Abstract	We have semi-synthesized a natural product 7-acetylhorminone from crude extract of
MeSH term(s)	Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Serum Albumin, Bovine/metabolism ; Serum Albumin, Bovine/chemistry ; Drug Screening Assays, Antitumor ; Biological Products/chemistry ; Biological Products/pharmacology ; Molecular Structure ; Materials Testing ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; HCT116 Cells ; Cell Proliferation/drug effects ; Molecular Docking Simulation ; Cell Survival/drug effects ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/metabolism
Language	English
Publishing date	2024-04-30
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.4c00335
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Article ; Online: Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2

Sounik Manna / Piyush Baindara / Santi M. Mandal

Journal of Infection and Public Health, Vol 13, Iss 10, Pp 1397-

2020 Volume 1404

Abstract: Secondary bacterial infections are commonly associated with prior or concomitant respiratory viral infections. Viral infections damage respiratory airways and simultaneously defects both innate and acquired immune response that provides a favorable ... ...

Abstract	Secondary bacterial infections are commonly associated with prior or concomitant respiratory viral infections. Viral infections damage respiratory airways and simultaneously defects both innate and acquired immune response that provides a favorable environment for bacterial growth, adherence, and facilitates invasion into healthy sites of the respiratory tract. Understanding the molecular mechanism of viral-induced secondary bacterial infections will provide us a chance to develop novel and effective therapeutic approaches for disease prevention. The present study describes details about the secondary bacterial infection during viral infections and their immunological changes.The outcome of discussion avails an opportunity to understand possible secondary bacterial infections associated with novel SARS-CoV-2, presently causing pandemic outbreak COVID-19.
Keywords	Viral infection ; Secondary bacterial infection ; Immune response ; SARS-CoV-2 ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270 ; covid19
Subject code	572
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2. (Special Issue: Novel coronavirus (COVID-19).)

Sounik, Manna Baindara P. / Mandal, S. M.

Journal of Infection and Public Health

Abstract: Secondary bacterial infections are commonly associated with prior or concomitant respiratory viral infections Viral infections damage respiratory airways and simultaneously defects both innate and acquired immune response that provides a favorable ... ...

Abstract	Secondary bacterial infections are commonly associated with prior or concomitant respiratory viral infections Viral infections damage respiratory airways and simultaneously defects both innate and acquired immune response that provides a favorable environment for bacterial growth, adherence, and facilitates invasion into healthy sites of the respiratory tract Understanding the molecular mechanism of viral-induced secondary bacterial infections will provide us a chance to develop novel and effective therapeutic approaches for disease prevention The present study describes details about the secondary bacterial infection during viral infections and their immunological changes The outcome of discussion avails an opportunity to understand possible secondary bacterial infections associated with novel SARS-CoV-2, presently causing pandemic outbreak COVID-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #888663
Database	COVID19

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Article ; Online: Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2.

Manna, Sounik / Baindara, Piyush / Mandal, Santi M

Journal of infection and public health

2020 Volume 13, Issue 10, Page(s) 1397–1404

Abstract	Secondary bacterial infections are commonly associated with prior or concomitant respiratory viral infections. Viral infections damage respiratory airways and simultaneously defects both innate and acquired immune response that provides a favorable environment for bacterial growth, adherence, and facilitates invasion into healthy sites of the respiratory tract. Understanding the molecular mechanism of viral-induced secondary bacterial infections will provide us a chance to develop novel and effective therapeutic approaches for disease prevention. The present study describes details about the secondary bacterial infection during viral infections and their immunological changes.The outcome of discussion avails an opportunity to understand possible secondary bacterial infections associated with novel SARS-CoV-2, presently causing pandemic outbreak COVID-19.
MeSH term(s)	Adaptive Immunity ; Bacteria/growth & development ; Bacterial Adhesion ; Bacterial Infections/immunology ; Bacterial Infections/virology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Humans ; Immune Tolerance ; Immunity, Innate ; Inflammation/complications ; Influenza, Human/complications ; Influenza, Human/immunology ; Microbial Interactions ; Pandemics ; Patient Acuity ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2020.07.003
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Article: Curd-Peptide Based Novel Hydrogel Inhibits Biofilm Formation, Quorum Sensing, Swimming Mortility of Multi-Antibiotic Resistant Clinical Isolates and Accelerates Wound Healing Activity.

Manna, Sounik / Ghosh, Ananta K / Mandal, Santi M

Frontiers in microbiology

2019 Volume 10, Page(s) 951

Abstract: The search for a bioactive natural antibacterial agent with wound healing properties is a common practice for the development of new-generation molecules. Antimicrobial peptides are a good alternative to antibiotics and easy-to-form hydrogels under self- ... ...

Abstract	The search for a bioactive natural antibacterial agent with wound healing properties is a common practice for the development of new-generation molecules. Antimicrobial peptides are a good alternative to antibiotics and easy-to-form hydrogels under self-assembled conditions without pH adjustment. With this in mind, the peptide pool was extracted from a formulated curd composed of a blend of probiotic bacteria such as
Language	English
Publishing date	2019-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.00951
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Article ; Online: Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2

Manna, Sounik / Baindara, Piyush / Mandal, Santi M.

Journal of Infection and Public Health

2020 Volume 13, Issue 10, Page(s) 1397–1404

Keywords	Public Health, Environmental and Occupational Health ; Infectious Diseases ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	1876-0341
DOI	10.1016/j.jiph.2020.07.003
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Probiotics-Derived Peptides and Their Immunomodulatory Molecules Can Play a Preventive Role Against Viral Diseases Including COVID-19

Manna, Sounik / Chowdhury, Trinath / Chakraborty, Ranadhir / Mandal, Santi M

Probiotics and antimicrobial proteins. 2021 June, v. 13, no. 3

2021

Abstract: As of recent, the pandemic episode of COVID-19, a severe acute respiratory syndrome brought about by a novel coronavirus (SARS-CoV-2) expanding the pace of mortality, has affected the disease rate profoundly. Invulnerability is the fundamental choice to ... ...

Abstract	As of recent, the pandemic episode of COVID-19, a severe acute respiratory syndrome brought about by a novel coronavirus (SARS-CoV-2) expanding the pace of mortality, has affected the disease rate profoundly. Invulnerability is the fundamental choice to prevent the ruining event of COVID-19, as the drugs and antibodies are in the phase of preliminary clinical trials. Within this brief period, a few strains of SARS-CoV-2 have been recognized by the vaccine manufacturers, which could be an incorrect guess about the strain that will end up spreading. Since the circulating SARS-CoV-2 strains continue to mutate, immunizations, if at all works, might be for a restricted time. We have not put sufficient time in research to understand the immune responses that correlate with protection as this could help refine vaccines. Here, we have summed up the adequacy of the immunomodulatory component of probiotics for the prevention against viral infections. Furthermore, an in silico data have been provided in support of the “probiotics-derived lipopeptides” role in inactivating spike (S) glycoprotein of SARS-CoV-2 and its host receptor molecule, ACE2. Among well characterized lipopeptides derived from different probiotic strains, subtilisin (Bacillus amyloliquefaciens), curvacin A (Lactobacillus curvatus), sakacin P (Lactobacillus sakei), lactococcin Gb (Lactococcus lactis) was utilized in this study to demonstrate a higher binding proclivity to S-protein of SARS-CoV-2 and human ACE2. The outcome revealed noteworthy capabilities of the lipopeptides, due to their amphiphilic nature, to bind spike protein and receptor molecule, which may act to competitively inhibit the mandatory interaction of SARS-CoV-2 with the host epithelial cell expressing ACE2 for its entry into the cell for reproduction. In the current situation, probiotic treatment alongside chemotherapy may assist in bringing about substantial improvement of the health of COVID-19 patients. At the same time, probiotics may aid towards building up the immune defenses in people to evade COVID-19.
Keywords	Bacillus amyloliquefaciens ; COVID-19 infection ; Lactobacillus curvatus ; Lactobacillus sakei ; Lactococcus lactis ; Severe acute respiratory syndrome coronavirus 2 ; computer simulation ; curvacin A ; drug therapy ; epithelial cells ; glycoproteins ; humans ; lipopeptides ; mortality ; pandemic ; probiotics ; reproduction ; subtilisin ; vaccines
Language	English
Dates of publication	2021-06
Size	p. 611-623.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-020-09727-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fusion Protein Targeted Antiviral Peptides: Fragment-Based Drug Design (FBDD) Guided Rational Design of Dipeptides Against SARS-CoV-2.

Manna, Sounik / Chowdhury, Trinath / Baindara, Piyush / Mandal, Santi M

Current protein & peptide science

2020 Volume 21, Issue 10, Page(s) 938–947

Abstract: Infectious diseases caused by viruses have become a serious public health issue in the recent past, including the current pandemic situation of COVID-19. Enveloped viruses are most commonly known to cause emerging and recurring infectious diseases. Viral ...

Abstract	Infectious diseases caused by viruses have become a serious public health issue in the recent past, including the current pandemic situation of COVID-19. Enveloped viruses are most commonly known to cause emerging and recurring infectious diseases. Viral and cell membrane fusion is the major key event in the case of enveloped viruses that is required for their entry into the cell. Viral fusion proteins play an important role in the fusion process and in infection establishment. Because of this, the fusion process targeting antivirals become an interest to fight against viral diseases caused by the enveloped virus. Lower respiratory tract infections casing viruses like influenza, respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus (SARS-CoV) are examples of such enveloped viruses that are at the top in public health issues. Here, we summarized the viral fusion protein targeted antiviral peptides along with their mechanism and specific design to combat the viral fusion process. The pandemic COVID-19, severe respiratory syndrome disease is an outbreak worldwide. There are no definitive drugs yet, but few are in on-going trials. Here, an approach of fragmentbased drug design (FBDD) methodology is used to identify the broad spectrum agent target to the conserved region of fusion protein of SARS CoV-2. Three dipeptides (DL, LQ and ID) were chosen from the library and designed by the systematic combination along with their possible modifications of amino acids to the target sites. Designed peptides were docked with targeted fusion protein after energy minimization. Results show strong and significant binding affinity (DL = -60.1 kcal/mol; LQ = - 62.8 kcal/mol; ID= -71.5 kcal/mol) during interaction. Anyone of the active peptides from the developed libraries may help to block the target sites competitively to successfully control COVID-19.
MeSH term(s)	Amino Acid Sequence ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Dipeptides/chemistry ; Dipeptides/metabolism ; Dipeptides/pharmacology ; Drug Design ; Membrane Fusion/drug effects ; Molecular Targeted Therapy ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism ; Viral Proteins/metabolism
Chemical Substances	Antiviral Agents ; Dipeptides ; Viral Proteins
Keywords	covid19
Language	English
Publishing date	2020-09-08
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2045662-1
ISSN	1875-5550 ; 1389-2037
ISSN (online)	1875-5550
ISSN	1389-2037
DOI	10.2174/1389203721666200908164641
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5884: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Probiotics-Derived Peptides and Their Immunomodulatory Molecules Can Play a Preventive Role Against Viral Diseases Including COVID-19.

Manna, Sounik / Chowdhury, Trinath / Chakraborty, Ranadhir / Mandal, Santi M

Probiotics and antimicrobial proteins

2020 Volume 13, Issue 3, Page(s) 611–623

Abstract	As of recent, the pandemic episode of COVID-19, a severe acute respiratory syndrome brought about by a novel coronavirus (SARS-CoV-2) expanding the pace of mortality, has affected the disease rate profoundly. Invulnerability is the fundamental choice to prevent the ruining event of COVID-19, as the drugs and antibodies are in the phase of preliminary clinical trials. Within this brief period, a few strains of SARS-CoV-2 have been recognized by the vaccine manufacturers, which could be an incorrect guess about the strain that will end up spreading. Since the circulating SARS-CoV-2 strains continue to mutate, immunizations, if at all works, might be for a restricted time. We have not put sufficient time in research to understand the immune responses that correlate with protection as this could help refine vaccines. Here, we have summed up the adequacy of the immunomodulatory component of probiotics for the prevention against viral infections. Furthermore, an in silico data have been provided in support of the "probiotics-derived lipopeptides" role in inactivating spike (S) glycoprotein of SARS-CoV-2 and its host receptor molecule, ACE2. Among well characterized lipopeptides derived from different probiotic strains, subtilisin (Bacillus amyloliquefaciens), curvacin A (Lactobacillus curvatus), sakacin P (Lactobacillus sakei), lactococcin Gb (Lactococcus lactis) was utilized in this study to demonstrate a higher binding proclivity to S-protein of SARS-CoV-2 and human ACE2. The outcome revealed noteworthy capabilities of the lipopeptides, due to their amphiphilic nature, to bind spike protein and receptor molecule, which may act to competitively inhibit the mandatory interaction of SARS-CoV-2 with the host epithelial cell expressing ACE2 for its entry into the cell for reproduction. In the current situation, probiotic treatment alongside chemotherapy may assist in bringing about substantial improvement of the health of COVID-19 patients. At the same time, probiotics may aid towards building up the immune defenses in people to evade COVID-19.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/metabolism ; COVID-19/prevention & control ; Humans ; Immunologic Factors/therapeutic use ; Peptides/therapeutic use ; Probiotics/therapeutic use ; SARS-CoV-2/metabolism
Chemical Substances	Immunologic Factors ; Peptides
Language	English
Publishing date	2020-11-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-020-09727-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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