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  1. Article ; Online: Identification of thrombosis-related conformational binding epitopes on domain I of β2-glycoprotein I.

    Kim, Seung Joong / Schneidman-Duhovny, Dina / de Groot, Philip G / Urbanus, Rolf T / Carter, Lester / de Laat-Kremers, Romy / Weiss, Thomas M / Chan, Man K / Sali, Andrej / Rand, Jacob H / de Laat, Bas

    Thrombosis research

    2024  Volume 237, Page(s) 145–147

    MeSH term(s) Humans ; Thrombosis/metabolism ; beta 2-Glycoprotein I/immunology ; beta 2-Glycoprotein I/chemistry ; beta 2-Glycoprotein I/metabolism ; Epitopes/immunology ; Protein Domains
    Chemical Substances beta 2-Glycoprotein I ; Epitopes
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.03.025
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  2. Article ; Online: Reimagining the antiphospholipid syndrome, an enigmatic thrombophilic disorder, through the looking glass of microscopic imaging.

    Rand, Jacob H / Taatjes, Douglas J

    Histochemistry and cell biology

    2018  Volume 150, Issue 5, Page(s) 529–543

    Abstract: The antiphospholipid syndrome (APS) is an autoimmune thrombophilic disorder that was described as a diagnostic entity over 30 years ago. And yet the pathogenic mechanisms that are responsible for its clinical manifestations remain to be definitively ... ...

    Abstract The antiphospholipid syndrome (APS) is an autoimmune thrombophilic disorder that was described as a diagnostic entity over 30 years ago. And yet the pathogenic mechanisms that are responsible for its clinical manifestations remain to be definitively established. The syndrome is defined by (1) the concurrence of vascular thrombosis and/or pregnancy complications together with (2) positivity for immunoassays and coagulation tests that were derived from clinical observations of two anomalous laboratory test results-specifically, false positivity for syphilis infection in uninfected individuals and the finding of inhibitors of blood coagulation in patients who lacked any bleeding tendencies. Over the years, these were standardized into immunoassays and coagulation assays for APS. Here, we describe how prior knowledge of the immunologic and coagulation aspects of the disorder led to research involving a range of imaging modalities including light microscopy, immunohistochemistry, confocal scanning laser microscopy, transmission and scanning electron microscopy, and atomic force microscopy. In turn, the results from those studies led to a "reimagining" of APS that has advanced the understanding of pathogenic mechanisms of the disorder and has led to the development of novel mechanistically based diagnostics along with potential new treatment approaches that target disease mechanisms.
    MeSH term(s) Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/pathology ; Antiphospholipid Syndrome/therapy ; Humans ; Immunoassay ; Microscopy ; Molecular Imaging
    Language English
    Publishing date 2018-08-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-018-1709-2
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  3. Article ; Online: A new fish for the β2GPI hook: LPS!

    Rand, Jacob H

    Blood

    2011  Volume 117, Issue 25, Page(s) 6743–6744

    Language English
    Publishing date 2011-06-23
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2011-04-346734
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  4. Article ; Online: A snappy new concept for APS.

    Rand, Jacob H

    Blood

    2010  Volume 116, Issue 8, Page(s) 1193–1194

    Language English
    Publishing date 2010-08-26
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2010-06-288209
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  5. Article ; Online: Home free? Not after 3!

    Rand, Jacob H

    Blood

    2011  Volume 118, Issue 17, Page(s) 4504–4506

    MeSH term(s) Antibodies, Antiphospholipid/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Female ; Humans ; Male ; Thromboembolism/diagnosis ; Thromboembolism/etiology
    Chemical Substances Antibodies, Antiphospholipid
    Language English
    Publishing date 2011-10-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2011-08-369058
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  6. Article ; Online: Absence of Distinct Immunohistochemical Distribution of Annexin A5, C3b, C4d, and C5b-9 in Placentas From Patients With Antiphospholipid Antibodies, Preeclampsia, and Systemic Lupus Erythematosus.

    Matrai, Cathleen E / Rand, Jacob H / Baergen, Rebecca N

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2019  Volume 22, Issue 5, Page(s) 431–439

    Abstract: Introduction: In pregnancy, the presence of preeclampsia (PEC), systemic lupus erythematosus (SLE), and/or antiphospholipid antibody syndrome (APLS) is characterized by poor obstetric outcomes, with potential adverse effects for both mother and fetus. ... ...

    Abstract Introduction: In pregnancy, the presence of preeclampsia (PEC), systemic lupus erythematosus (SLE), and/or antiphospholipid antibody syndrome (APLS) is characterized by poor obstetric outcomes, with potential adverse effects for both mother and fetus. Although the histopathologic changes observed in these entities have been well established, the pathogenic mediators associated with tissue injury are poorly understood.
    Methods: Forty placentas were evaluated, including 10 patients with preeclampsia, 9 with SLE, 11 with APLS, and 10 disease-free controls. Each case was subjected to a panel of immunohistochemical markers including C3b, C4d, Annexin A5, and C5b-9. Staining was graded on intensity and distribution.
    Results: C4d staining was distinctly different among disease groups and controls. Moreover, 6/10 PEC cases, 3/9 SLE cases, and 4/11 APLS cases showed at least focal staining for C4d. All controls were negative. Annexin A5 (AnxA5) staining showed intrinsic variability in all disease groups, while 10/10 controls showed diffuse, strong staining (2+ or 3+). C3b staining was heterogeneous among groups.
    Discussion: Previously, antiphospholipid antibody (aPLA)-associated pregnancy complications have been thought to be a consequence of a unique aPLA-mediated pathogenic mechanism. However, the immunohistochemical similarity (increased complement and decreased AnxA5 staining) observed in placentas from patients with APLS, PEC, and SLE suggests that aPLA-associated pregnancy complications may reflect a more general autoimmune mechanism.
    MeSH term(s) Annexin A5/analysis ; Annexin A5/biosynthesis ; Antiphospholipid Syndrome ; Complement C3b/analysis ; Complement C3b/biosynthesis ; Complement C4b/analysis ; Complement C4b/biosynthesis ; Complement Membrane Attack Complex/analysis ; Complement Membrane Attack Complex/biosynthesis ; Female ; Humans ; Immunohistochemistry ; Lupus Erythematosus, Systemic ; Peptide Fragments/analysis ; Peptide Fragments/biosynthesis ; Placenta/pathology ; Pre-Eclampsia ; Pregnancy ; Pregnancy Complications/immunology ; Retrospective Studies
    Chemical Substances ANXA5 protein, human ; Annexin A5 ; Complement Membrane Attack Complex ; Peptide Fragments ; Complement C3b (80295-43-8) ; Complement C4b (80295-50-7) ; complement C4d (80295-52-9)
    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/1093526619836025
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    Zs.A 5063: Show issues Location:
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  7. Article ; Online: Accelerated thrombin times are associated with thrombotic risk.

    Costa, Victoria / Canver, Matthew C / Harris, Rebecca M / Rand, Jacob H / Greenblatt, Matthew B

    American journal of hematology

    2020  Volume 95, Issue 5, Page(s) E113–E114

    MeSH term(s) Humans ; Risk Factors ; Thrombin Time/methods ; Thrombosis/diagnosis
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25741
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    Zs.A 1251: Show issues Location:
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  8. Article ; Online: Dynamics of Anti-influenza Mucosal IgA Over a Season in a Cohort of Individuals Living or Working in a Long-term Care Facility.

    Hitchings, Matt D T / Borgert, Brooke A / Shir, Adam / Yang, Bingyi / Grantz, Kyra H / Ball, Jacob / Moreno, Carlos A / Rand, Kenneth / Small, Parker A / Fowke, Keith R / Cummings, Derek A T

    The Journal of infectious diseases

    2023  Volume 228, Issue 4, Page(s) 383–390

    Abstract: Background: Serological surveys are used to ascertain influenza infection and immunity, but evidence for the utility of mucosal immunoglobulin A (IgA) as a correlate of infection or protection is limited.: Methods: We performed influenza-like illness ...

    Abstract Background: Serological surveys are used to ascertain influenza infection and immunity, but evidence for the utility of mucosal immunoglobulin A (IgA) as a correlate of infection or protection is limited.
    Methods: We performed influenza-like illness (ILI) surveillance on 220 individuals living or working in a retirement community in Gainesville, Florida from January to May 2018, and took pre- and postseason nasal samples of 11 individuals with polymerase chain reaction (PCR)-confirmed influenza infection and 60 randomly selected controls. Mucosal IgA against 10 strains of influenza was measured from nasal samples.
    Results: Overall, 28.2% and 11.3% of individuals experienced a 2-fold and 4-fold rise, respectively, in mucosal IgA to at least 1 influenza strain. Individuals with PCR-confirmed influenza A had significantly lower levels of preseason IgA to influenza A. Influenza-associated respiratory illness was associated with a higher rise in mucosal IgA to influenza strains of the same subtype, and H3N2-associated respiratory illness was associated with a higher rise in mucosal IgA to other influenza A strains.
    Conclusions: By comparing individuals with and without influenza illness, we demonstrated that mucosal IgA is a correlate of influenza infection. There was evidence for cross-reactivity in mucosal IgA across influenza A subtypes.
    MeSH term(s) Humans ; Influenza A Virus, H3N2 Subtype ; Seasons ; Long-Term Care ; Immunity, Mucosal ; Influenza, Human/prevention & control ; Nasal Mucosa ; Immunoglobulin A ; Nursing Homes ; Influenza Vaccines ; Antibodies, Viral
    Chemical Substances Immunoglobulin A ; Influenza Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad029
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  9. Article: The antiphospholipid syndrome.

    Rand, Jacob H

    Hematology. American Society of Hematology. Education Program

    2007  , Page(s) 136–142

    Abstract: The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is marked by the presence of antibodies that recognize phospholipid-binding proteins. The clinical manifestations of APS include vascular thrombosis and pregnancy ... ...

    Abstract The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is marked by the presence of antibodies that recognize phospholipid-binding proteins. The clinical manifestations of APS include vascular thrombosis and pregnancy complications, especially recurrent spontaneous miscarriages. This article provides an update on diagnostic and therapeutic approaches to this disorder.
    MeSH term(s) Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Hematologic/therapy ; Thrombosis/etiology ; Thrombosis/therapy
    Language English
    Publishing date 2007
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4391
    ISSN 1520-4391
    DOI 10.1182/asheducation-2007.1.136
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  10. Article ; Online: Dos and don'ts in diagnosing antiphospholipid syndrome.

    Rand, Jacob H / Wolgast, Lucia R

    Hematology. American Society of Hematology. Education Program

    2012  Volume 2012, Page(s) 455–459

    Abstract: Antiphospholipid syndrome (APS) is an acquired autoimmune thrombotic tendency that is identified by the presence of abnormal antiphospholipid laboratory tests in patients who have a history of vascular thrombosis and/or pregnancy complications including ... ...

    Abstract Antiphospholipid syndrome (APS) is an acquired autoimmune thrombotic tendency that is identified by the presence of abnormal antiphospholipid laboratory tests in patients who have a history of vascular thrombosis and/or pregnancy complications including recurrent spontaneous miscarriages and a group of other complications due to placental insufficiency. Diagnostic testing for APS is often problematic because of many misconceptions regarding these empirically derived assays. This chapter is intended to provide hematology-oncology consultants with practical information about the uses and limitations of assays used to diagnose APS.
    MeSH term(s) Abortion, Habitual/immunology ; Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/genetics ; Blood Platelets/cytology ; Cardiolipins/metabolism ; Factor VIII/antagonists & inhibitors ; Female ; Hematology/methods ; Humans ; Hypoprothrombinemias/metabolism ; Immunoassay/methods ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Partial Thromboplastin Time ; Pregnancy ; Pregnancy Complications, Hematologic ; Risk ; Thrombosis
    Chemical Substances Antibodies, Antiphospholipid ; Cardiolipins ; Immunoglobulin G ; Immunoglobulin M ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2012.1.455
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