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  1. Article ; Online: Phase transitions in porous media.

    Gavioli, Chiara / Krejčí, Pavel

    Nonlinear differential equations and applications : NoDEA

    2022  Volume 29, Issue 6, Page(s) 72

    Abstract: The full quasistatic thermomechanical system of PDEs, describing water diffusion with the possibility of freezing and melting in a visco-elasto-plastic porous solid, is studied in detail under the hypothesis that the pressure-saturation hysteresis ... ...

    Abstract The full quasistatic thermomechanical system of PDEs, describing water diffusion with the possibility of freezing and melting in a visco-elasto-plastic porous solid, is studied in detail under the hypothesis that the pressure-saturation hysteresis relation is given in terms of the Preisach hysteresis operator. The resulting system of balance equations for mass, momentum, and energy coupled with the phase dynamics equation is shown to admit a global solution under general assumptions on the data.
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1480580-7
    ISSN 1420-9004 ; 1021-9722
    ISSN (online) 1420-9004
    ISSN 1021-9722
    DOI 10.1007/s00030-022-00805-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Geografie bariér

    Šerý, Ondřej / Doboš, Pavel / Suchá Zbiejczuk, Ladislava / Martinek, Jan / Škop, Stanislav / Kaplan, Daniel / Surmařová, Simona / Kotýnková, Veronika / Línová, Jana / Trojan, Jakub / Krejčí, Tomáš / Nováková, Eva / Porkertová, Hana / Osman, Robert

    Příklady dobrých bezbariérových realizací

    2021  

    Keywords Disability: social aspects ; Illness & addiction: social aspects ; Urban economics ; disability geography ; barriers ; accessibility ; politics ; city ; tactical urbanism
    Language 0|c
    Size 1 electronic resource (477 pages)
    Publisher Masaryk University Press
    Document type Book ; Online
    Note Czech ; Open Access
    HBZ-ID HT021610892
    ISBN 9788021099098 ; 8021099097
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia.

    Krejci, Pavel

    The New England journal of medicine

    2019  Volume 381, Issue 13, Page(s) 1291

    MeSH term(s) Achondroplasia ; Child ; Diuretics ; Humans ; Natriuretic Peptide, C-Type ; Natriuretic Peptides
    Chemical Substances Diuretics ; Natriuretic Peptides ; Natriuretic Peptide, C-Type (127869-51-6)
    Language English
    Publishing date 2019-09-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1910394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  4. Book: Pavel Josef Šafařík

    Paul, Karel / Krejčí, Karel

    život a dílo

    1961  

    Institution Československá Akademie Věd / Sekce Jazyka a Literatury
    Author's details Karel Paul. Úvod napsal Karel Krejčí. [Československá Akademie Věd, Sekce jazyka e literatury]
    Language Czech
    Size 357 S, Ill
    Publisher Nákl. Československé Akad. Věd
    Publishing place Praha
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Current Status, Prevention and Treatment of BK Virus Nephropathy.

    Kurašová, Ester / Štěpán, Jakub / Krejčí, Karel / Mrázek, František / Sauer, Pavel / Janečková, Jana / Tichý, Tomáš

    Acta medica (Hradec Kralove)

    2023  Volume 65, Issue 4, Page(s) 119–124

    Abstract: All renal transplant recipients should undergo a regular screening for BK viral (BKV) viremia. Gradual reduction of immunosuppression is recommended in patients with persistent plasma BKV viremia for 3 weeks after the first detection, reflecting the ... ...

    Abstract All renal transplant recipients should undergo a regular screening for BK viral (BKV) viremia. Gradual reduction of immunosuppression is recommended in patients with persistent plasma BKV viremia for 3 weeks after the first detection, reflecting the presence of probable or suspected BKV-associated nephropathy. Reduction of immunosuppression is also a primary intervention in biopsy proven nephropathy associated with BKV (BKVN). Thus, allograft biopsy is not required to treat patients with BKV viremia with stabilized graft function. There is a lack of proper randomised clinical trials recommending treatment in the form of switching from tacrolimus to cyclosporin-A, from mycophenolate to mTOR inhibitors or leflunomide, or the additive use of intravenous immunoglobulins, leflunomide or cidofovir. Fluoroquinolones are not recommended for prophylaxis or therapy. There are on-going studies to evaluate the possibility of using a multi-epitope anti-BKV vaccine, administration of BKV-specific T cell immunotherapy, BKV-specific human monoclonal antibody and RNA antisense oligonucleotides. Retransplantation after allograft loss due to BKVN can be successful if BKV viremia is definitively removed, regardless of allograft nephrectomy.
    MeSH term(s) Humans ; Kidney Transplantation ; Leflunomide/therapeutic use ; BK Virus/genetics ; Viremia/diagnosis ; Viremia/drug therapy ; Kidney Diseases/drug therapy ; Immunosuppressive Agents/therapeutic use ; Polyomavirus Infections/diagnosis ; Polyomavirus Infections/drug therapy
    Chemical Substances Leflunomide (G162GK9U4W) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-02-01
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1360995-6
    ISSN 1805-9694 ; 1211-4286
    ISSN (online) 1805-9694
    ISSN 1211-4286
    DOI 10.14712/18059694.2023.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 908: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Putting the brakes on chondrosarcoma.

    Krejci, Pavel

    Oncotarget

    2015  Volume 6, Issue 28, Page(s) 24598

    MeSH term(s) Animals ; Chondroma/metabolism ; Hedgehog Proteins/metabolism ; Receptor, Fibroblast Growth Factor, Type 3/metabolism ; Up-Regulation
    Chemical Substances Hedgehog Proteins ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
    Language English
    Publishing date 2015-09-22
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.5242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ligand bias underlies differential signaling of multiple FGFs via FGFR1.

    Karl, Kelly / Del Piccolo, Nuala / Light, Taylor / Roy, Tanaya / Deduja, Pooja / Ursachi, Vlad-Constantin / Fafilek, Bohumil / Krejci, Pavel / Hristova, Kalina

    eLife

    2024  Volume 12

    Abstract: The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences ... ...

    Abstract The differential signaling of multiple FGF ligands through a single fibroblast growth factor (FGF) receptor (FGFR) plays an important role in embryonic development. Here, we use quantitative biophysical tools to uncover the mechanism behind differences in FGFR1c signaling in response to FGF4, FGF8, and FGF9, a process which is relevant for limb bud outgrowth. We find that FGF8 preferentially induces FRS2 phosphorylation and extracellular matrix loss, while FGF4 and FGF9 preferentially induce FGFR1c phosphorylation and cell growth arrest. Thus, we demonstrate that FGF8 is a biased FGFR1c ligand, as compared to FGF4 and FGF9. Förster resonance energy transfer experiments reveal a correlation between biased signaling and the conformation of the FGFR1c transmembrane domain dimer. Our findings expand the mechanistic understanding of FGF signaling during development and bring the poorly understood concept of receptor tyrosine kinase ligand bias into the spotlight.
    MeSH term(s) Female ; Pregnancy ; Humans ; Ligands ; Signal Transduction ; Fibroblast Growth Factors ; Phosphorylation ; Bias ; Receptor, Fibroblast Growth Factor, Type 1/genetics
    Chemical Substances Ligands ; Fibroblast Growth Factors (62031-54-3) ; FGFR1 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops.

    Isik, Esin / Shukla, Kaustubh / Pospisilova, Michaela / König, Christiane / Andrs, Martin / Rao, Satyajeet / Rosano, Vinicio / Dobrovolna, Jana / Krejci, Lumir / Janscak, Pavel

    Science advances

    2024  Volume 10, Issue 6, Page(s) eadk2685

    Abstract: Transcription-replication conflicts (TRCs) induce formation of cotranscriptional RNA:DNA hybrids (R-loops) stabilized by G-quadruplexes (G4s) on the displaced DNA strand, which can cause fork stalling. Although it is known that these stalled forks can ... ...

    Abstract Transcription-replication conflicts (TRCs) induce formation of cotranscriptional RNA:DNA hybrids (R-loops) stabilized by G-quadruplexes (G4s) on the displaced DNA strand, which can cause fork stalling. Although it is known that these stalled forks can resume DNA synthesis in a process initiated by MUS81 endonuclease, how TRC-associated G4/R-loops are removed to allow fork passage remains unclear. Here, we identify the mismatch repair protein MutSβ, an MLH1-PMS1 heterodimer termed MutLβ, and the G4-resolving helicase FANCJ as factors that are required for MUS81-initiated restart of DNA replication at TRC sites in human cells. This DNA repair process depends on the G4-binding activity of MutSβ, the helicase activity of FANCJ, and the binding of FANCJ to MLH1. Furthermore, we show that MutSβ, MutLβ, and MLH1-FANCJ interaction mediate FANCJ recruitment to G4s. These data suggest that MutSβ, MutLβ, and FANCJ act in conjunction to eliminate G4/R-loops at TRC sites, allowing replication restart.
    MeSH term(s) Humans ; Fanconi Anemia Complementation Group Proteins/genetics ; Fanconi Anemia Complementation Group Proteins/metabolism ; R-Loop Structures ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA Replication ; DNA/genetics
    Chemical Substances Fanconi Anemia Complementation Group Proteins ; DNA Helicases (EC 3.6.4.-) ; DNA (9007-49-2)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adk2685
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  9. Article ; Online: Transnasal Endoscopic Pituitary Surgery-The Role of a CT Scan in Individual Tailoring of Posterior Septum Size Resection.

    Lubojacký, Jakub / Čábalová, Lenka / Mladoňová, Michaela / Hránková, Viktória / Krejčí, Tomáš / Mičaník, Jakub / Miklošová, Maria / Ličev, Lačezar / Komínek, Pavel / Matoušek, Petr

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 6, Page(s) 2222–2232

    Abstract: Objective: This study was designed to evaluate the possibility of predicting the minimum size of septal resection for safe tumor extraction in transnasal paraseptal pituitary adenoma resection from preoperative computed tomography scans.: Methods: A ... ...

    Abstract Objective: This study was designed to evaluate the possibility of predicting the minimum size of septal resection for safe tumor extraction in transnasal paraseptal pituitary adenoma resection from preoperative computed tomography scans.
    Methods: A retrospective CT scan analysis was performed on 20 patients who underwent endoscopic pituitary surgery at the University Hospital in Ostrava. Virtual insertion of the straight instrument into the sphenoid cavity was simulated using a CT scan. The minimum septal resection size was predicted and compared to various diameters in the nasal cavity. The results were then compared with cadaveric dissections, in which septal resections were performed at 1 cm and 2 cm distances from the anterior sphenoid wall. The association between cadaver dissections and CT scan results was studied.
    Results: A total of 20 patients who underwent endoscopic transnasal surgery for pituitary adenoma between the years 2020 and 2021 were enrolled in the study. The mean virtual posterior septal size resection needed to reach the medial edge of the ICA with the straight instrument, without infracturing the nasal septum, was 13.2 mm. In cadavers with a 1 cm posterior septal resection, the medial edge of the ICA was reached with the straight instrument. In 2 cm resections, it was possible to reach beyond the lateral edge of the ICA.
    Conclusion: There is no significant correlation between the minimum septal size resection and measured diameters in the nasal cavity. According to our study, a 1 cm resection is sufficient for a non-extended pituitary tumor extraction. More extensive septal resections allow for better maneuverability and overview in the surgical field.
    MeSH term(s) Humans ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/surgery ; Pituitary Neoplasms/pathology ; Retrospective Studies ; Endoscopy/methods ; Nasal Cavity/diagnostic imaging ; Nasal Cavity/surgery ; Nasal Cavity/pathology ; Adenoma/diagnostic imaging ; Adenoma/surgery ; Adenoma/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9060172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: Equadiff 13

    Krejčí, Pavel

    book of abstracts ; Prague, Czech Republic, August 26 - 30, 2013

    2013  

    Event/congress Equadiff (13, 2013.08.26-30, Prague)
    Author's details [ed.: Pavel Krejčí]
    Language English
    Size 332 S.
    Publisher Inst. of Mathematics of the Academy of Sciences of the Czech Republic
    Publishing place Prague
    Document type Book ; Conference proceedings
    ISBN 9788085823639 ; 8085823632
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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