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  1. Book ; Online ; E-Book: Developmental neuroendocrinology

    Wray, Susana / Blackshaw, Seth

    (Masterclass in neuroendocrinology ; 9)

    2020  

    Author's details Susan Wray, Seth Blackshaw editors
    Series title Masterclass in neuroendocrinology ; 9
    Collection
    Keywords Neurosciences ; Human anatomy ; Internal medicine
    Subject code 612.8
    Language English
    Size 1 Online-Ressource (x, 468 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020908651
    ISBN 978-3-030-40002-6 ; 9783030400019 ; 3-030-40002-6 ; 3030400018
    DOI 10.1007/978-3-030-40002-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Why Has the Ability to Regenerate Following CNS Injury Been Repeatedly Lost Over the Course of Evolution?

    Blackshaw, Seth

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 831062

    Abstract: While many vertebrates can regenerate both damaged neurons and severed axons in the central nervous system (CNS) following injury, others, including all birds and mammals, have lost this ability for reasons that are still unclear. The repeated ... ...

    Abstract While many vertebrates can regenerate both damaged neurons and severed axons in the central nervous system (CNS) following injury, others, including all birds and mammals, have lost this ability for reasons that are still unclear. The repeated evolutionary loss of regenerative competence seems counterintuitive, and any explanation must account for the fact that regenerative competence is lost in both cold-blooded and all warm-blooded clades, that both injury-induced neurogenesis and axonal regeneration tend to be lost in tandem, and that mammals have evolved dedicated gene regulatory networks to inhibit injury-induced glia-to-neuron reprogramming. Here, different hypotheses that have been proposed to account for evolutionary loss of regenerative competence are discussed in the light of new insights obtained into molecular mechanisms that control regeneration in the central nervous system. These include pleiotropic effects of continuous growth, enhanced thyroid hormone signaling, prevention of neoplasia, and improved memory consolidation. Recent evidence suggests that the most compelling hypothesis, however, may be selection for greater resistance to the spread of intra-CNS infections, which has led to both enhanced reactive gliosis and a loss of injury-induced neurogenesis and axonal regeneration. Means of testing these hypotheses, and additional data that are urgently needed to better understand the evolutionary pressures and mechanisms driving loss of regenerative competence, are also discussed.
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.831062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A super Sonic circadian synchronizer.

    Kim, Dong Won / Blackshaw, Seth

    Science (New York, N.Y.)

    2023  Volume 380, Issue 6648, Page(s) 896–897

    Abstract: Sonic Hedgehog signaling and primary cilia control the core mammalian circadian clock. ...

    Abstract Sonic Hedgehog signaling and primary cilia control the core mammalian circadian clock.
    MeSH term(s) Animals ; Hedgehog Proteins ; Cilia ; Signal Transduction ; Circadian Clocks ; Mammals
    Chemical Substances Hedgehog Proteins
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adi3177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  4. Article ; Online: Turning lead into gold: reprogramming retinal cells to cure blindness.

    Blackshaw, Seth / Sanes, Joshua R

    The Journal of clinical investigation

    2021  Volume 131, Issue 3

    MeSH term(s) Blindness/epidemiology ; Blindness/metabolism ; Blindness/pathology ; Blindness/therapy ; Cellular Reprogramming ; Humans ; Macular Degeneration/epidemiology ; Macular Degeneration/metabolism ; Macular Degeneration/pathology ; Macular Degeneration/therapy ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; United States/epidemiology
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI146134
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  5. Article ; Online: Commercial antibodies: alternative grading for research.

    Blackshaw, Seth / Zhu, Heng

    Nature

    2020  Volume 586, Issue 7830, Page(s) 500

    MeSH term(s) Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-02929-7
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    Zs.A 26: Show issues Location:
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  6. Article: Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.

    Zhang, Xin / Leavey, Patrick / Appel, Haley / Makrides, Neoklis / Blackshaw, Seth

    Trends in genetics : TIG

    2023  Volume 39, Issue 10, Page(s) 736–757

    Abstract: This review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent ... ...

    Abstract This review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily conserved gene regulatory networks (GRNs) that specify early- and late-state retinal progenitor cells (RPCs) and neurogenic progenitors and that control the final steps in determining cell identity. Finally, we discuss findings that provide insight into regulation of species-specific aspects of retinal patterning and neurogenesis, including consideration of key outstanding questions in the field.
    MeSH term(s) Animals ; Retina ; Cell Differentiation/genetics ; Neurogenesis/genetics ; Stem Cells ; Vertebrates/genetics ; Gene Expression Regulation, Developmental/genetics
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2023.06.002
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  7. Article ; Online: Author Correction: A potential role for somatostatin signaling in regulating retinal neurogenesis.

    Weir, Kurt / Kim, Dong Won / Blackshaw, Seth

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 16948

    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-96291-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.

    Le, Nguyet / Appel, Haley / Pannullo, Nicole / Hoang, Thanh / Blackshaw, Seth

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 914386

    Abstract: Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to- ... ...

    Abstract Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to-neuron reprogramming in retina that were conducted using GFAP mini promoter-driven adeno-associated virus (AAV) vectors. In this study, we have addressed these questions using GFAP mini promoter-driven AAV constructs to simultaneously overexpress the mCherry reporter and candidate transcription factors predicted to induce glia-to-neuron conversion, in combination with prospective genetic labeling of retinal Müller glia using inducible Cre-dependent GFP reporters. We find that, while control GFAP-mCherry constructs express faithfully in Müller glia, 5 out of 7 transcription factor overexpression constructs tested are predominantly expressed in amacrine and retinal ganglion cells. These findings demonstrate strong insert-dependent effects on AAV-based GFAP mini promoter specificity that preclude its use in inferring cell lineage relationships when studying glia-to-neuron conversion in retina.
    Language English
    Publishing date 2022-09-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.914386
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  9. Article ; Online: Ptbp1 deletion does not induce astrocyte-to-neuron conversion.

    Hoang, Thanh / Kim, Dong Won / Appel, Haley / Ozawa, Manabu / Zheng, Sika / Kim, Juhyun / Blackshaw, Seth

    Nature

    2023  Volume 618, Issue 7964, Page(s) E1–E7

    MeSH term(s) Humans ; Astrocytes ; Parkinson Disease ; Neurons
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06066-9
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  10. Article ; Online: Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility using scRNA-Seq and scATAC-Seq.

    Weir, Kurt / Leavey, Patrick / Santiago, Clayton / Blackshaw, Seth

    Journal of visualized experiments : JoVE

    2021  , Issue 169

    Abstract: Powerful next generation sequencing techniques offer robust and comprehensive analysis to investigate how retinal gene regulatory networks function during development and in disease states. Single-cell RNA sequencing allows us to comprehensively profile ... ...

    Abstract Powerful next generation sequencing techniques offer robust and comprehensive analysis to investigate how retinal gene regulatory networks function during development and in disease states. Single-cell RNA sequencing allows us to comprehensively profile gene expression changes observed in retinal development and disease at a cellular level, while single-cell ATAC-Seq allows analysis of chromatin accessibility and transcription factor binding to be profiled at similar resolution. Here the use of these techniques in the developing retina is described, and MULTI-Seq is demonstrated, where individual samples are labeled with a modified oligonucleotide-lipid complex, enabling researchers to both increase the scope of individual experiments and substantially reduce costs.
    MeSH term(s) Chromatin/chemistry ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Immunoprecipitation Sequencing/methods ; High-Throughput Nucleotide Sequencing/methods ; Humans ; RNA, Small Cytoplasmic/analysis ; RNA, Small Cytoplasmic/genetics ; RNA, Small Cytoplasmic/metabolism ; Retina/metabolism ; Sequence Analysis, RNA/methods ; Single-Cell Analysis/methods
    Chemical Substances Chromatin ; RNA, Small Cytoplasmic
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/62239
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