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  1. Book ; Online: Pathophysiology and epidemiology of virus-induced asthma

    Kimura, Hirokazu / Ryo, Akihide

    2015  

    Abstract: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent ... ...

    Abstract Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases
    Keywords Botany ; Microbiology ; Science (General)
    Size 1 electronic resource (99 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020090174
    ISBN 9782889194100 ; 2889194108
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Rising stars in virology: 2022.

    Tsunetsugu-Yokota, Yasuko / Magiorkinis, Gkikas / Kimura, Hirokazu

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1205877

    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1205877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Adult Intussusception Associated with a Low-Grade Appendiceal Mucinous Neoplasm-A Case Report].

    Suda, Mutsumi / Kiyama, Teruo / Iijima, Hirokazu / Kimura, Naoya

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 13, Page(s) 1420–1422

    Abstract: A 52-year-old woman patient, who presented with lower abdominal pain, was suspected of having colonic intussusception. An enhanced CT examination indicated that the end of the small intestine or appendix tumor had invaginated into the transverse colon. ... ...

    Abstract A 52-year-old woman patient, who presented with lower abdominal pain, was suspected of having colonic intussusception. An enhanced CT examination indicated that the end of the small intestine or appendix tumor had invaginated into the transverse colon. The CT revealed no evidence of intestinal ischemia, the emergency operation was performed on the following day. After relieving a colonic intussusception, a mass of the appendix was found and we performed laparoscope-assisted ileocolic resection and D3 dissection because of a strong possibility of carcinoma. The patient was discharged 8 days after the surgery and showed no evidence of recurrence for 6 months after the surgery. In postoperative histopathological examination, appendix tumor was diagnosed as a low-grade appendiceal mucinous neoplasm(LAMN). Adult intussusception is a rare disease and most of the cases are caused by malignant lesions, and a treatment strategy for LAMN has not yet been established. We report this case , as there are very few reported cases of adult intussusception caused by LAMN, with a review of the relevant literature.
    MeSH term(s) Female ; Humans ; Middle Aged ; Appendiceal Neoplasms/complications ; Appendiceal Neoplasms/surgery ; Appendix/surgery ; Colectomy ; Intussusception/etiology ; Intussusception/surgery
    Language Japanese
    Publishing date 2024-02-01
    Publishing country Japan
    Document type Case Reports ; Review ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: GATA2 deficiency of a novel missense variant with multiorgan inflammation.

    Baba, Hiroyuki / Kimura, Naoki / Kanegane, Hirokazu / Miya, Fuyuki / Kosaki, Kenjiro / Morio, Tomohiro / Koike, Ryuji

    Rheumatology (Oxford, England)

    2024  

    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  5. Article: Functional characterization of all

    Kimura, Hirokazu / Lahouel, Kamel / Tomasetti, Cristian / Roberts, Nicholas J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Interpretation of variants identified during genetic testing is a significant clinical challenge. In this study, we developed a high-throughput CDKN2A functional assay and characterized all ... ...

    Abstract Interpretation of variants identified during genetic testing is a significant clinical challenge. In this study, we developed a high-throughput CDKN2A functional assay and characterized all possible
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.28.573507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effectiveness of a two-stage posterior-anterior-posterior surgery using subcutaneously preserved autologous bone grafts for adult spinal deformity: a retrospective observational study.

    Kimura, Atsushi / Shiraishi, Yasuyuki / Sawamura, Hideaki / Inoue, Hirokazu / Takeshita, Katsushi

    Journal of orthopaedic surgery and research

    2024  Volume 19, Issue 1, Page(s) 91

    Abstract: Background: To achieve optimal correction of rigid kyphoscoliosis, we developed a novel two-stage posterior-anterior-posterior (PAP) surgery using subcutaneously preserved autologous bone grafts. This study aimed to investigate the effectiveness of two- ... ...

    Abstract Background: To achieve optimal correction of rigid kyphoscoliosis, we developed a novel two-stage posterior-anterior-posterior (PAP) surgery using subcutaneously preserved autologous bone grafts. This study aimed to investigate the effectiveness of two-stage PAP surgery versus single-stage anterior-posterior (AP) surgery.
    Methods: This was a retrospective analysis of patients undergoing combined anterior-posterior long-level fusion for adult spinal deformity (ASD) with a minimum 2-year follow-up. The indications for two-stage PAP surgery were rigid thoracolumbar deformity associated with hypertrophic facet arthritis and/or a large pelvic incidence-lumbar lordosis mismatch of > 25°. In the first stage of PAP surgery, pedicle screw insertion and multilevel Ponte osteotomies were performed. The resected local bone was embedded under sutured fascia. One week later, the embedded bone was retrieved in the right lateral position and used as an autograft for lateral lumbar interbody fusion. Final deformity correction was performed in the prone position.
    Results: From January 2018 to April 2021, 12 and 16 patients with ASD underwent two-stage PAP surgery (PAP group) and single-stage AP surgery (AP group), respectively. Although PAP surgery was associated with a significantly longer operation time, the total blood loss volume was significantly less in the PAP group than the AP group. Compared with the AP group, the PAP group showed significantly larger postoperative changes in radiological parameters in the sagittal and coronal planes. The overall complication rate did not differ significantly between the two groups.
    Conclusion: Two-stage PAP surgery provided effective correction of rigid kyphoscoliosis without increasing blood loss and postoperative complication rates.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Treatment Outcome ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Lordosis/surgery ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Kyphosis/diagnostic imaging ; Kyphosis/surgery ; Spinal Fusion
    Language English
    Publishing date 2024-01-27
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2252548-8
    ISSN 1749-799X ; 1749-799X
    ISSN (online) 1749-799X
    ISSN 1749-799X
    DOI 10.1186/s13018-024-04572-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Severe hemolytic anemia in a glucose-6-phosphate dehydrogenase-deficient child with COVID-19.

    Dofuku, Mika / Tamura, Daisuke / Mizobe, Marina / Kurane, Koyuru / Hayashi, Yuriko / Kimura, Hirokazu / Shimada, Akira

    Pediatrics international : official journal of the Japan Pediatric Society

    2024  Volume 66, Issue 1, Page(s) e15717

    MeSH term(s) Child ; Humans ; Anemia, Hemolytic/diagnosis ; Anemia, Hemolytic/etiology ; COVID-19/complications ; Glucosephosphate Dehydrogenase ; Glucosephosphate Dehydrogenase Deficiency/complications ; Glucosephosphate Dehydrogenase Deficiency/diagnosis ; SARS-CoV-2
    Chemical Substances Glucosephosphate Dehydrogenase (EC 1.1.1.49)
    Language English
    Publishing date 2024-01-12
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 848: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Clinical Study on the Risk Factors for the Recurrence of Papillary Thyroid Carcinoma.

    Masui, Takashi / Adachi, Shiori / Uemura, Hirokazu / Kimura, Takahiro / Kitahara, Tadashi

    ORL; journal for oto-rhino-laryngology and its related specialties

    2023  Volume 85, Issue 2, Page(s) 104–108

    Abstract: Introduction: Papillary thyroid carcinoma is the most common endocrine malignancy and the most common type of thyroid cancer, accounting for approximately 85% of all thyroid cancer cases. It usually has a favorable course, with the 10-year survival rate ...

    Abstract Introduction: Papillary thyroid carcinoma is the most common endocrine malignancy and the most common type of thyroid cancer, accounting for approximately 85% of all thyroid cancer cases. It usually has a favorable course, with the 10-year survival rate exceeding 90%. However, the literature reports a recurrence rate of 7-23% after initial surgical treatment. It is important to consider medical treatment policies for this recurrence.
    Methods: In this study, we examined the risk factors for the recurrence of papillary thyroid carcinoma. We treated 274 patients with thyroid papillary carcinoma at our hospital between 2009 and 2018.
    Results: Recurrence occurred in 20 cases (7.3%). Lympho-vascular invasion and lateral cervical lymph node metastasis made significant independent contributions.
    Conclusion: The selection of the surgical mode should be based on the recurrence and after comprehensive consideration of the clinical features.
    MeSH term(s) Humans ; Thyroid Cancer, Papillary/surgery ; Neck Dissection ; Carcinoma, Papillary/surgery ; Carcinoma, Papillary/secondary ; Thyroidectomy ; Lymphatic Metastasis/pathology ; Retrospective Studies ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Lymph Nodes/pathology ; Risk Factors ; Neoplasm Recurrence, Local/pathology
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 121482-2
    ISSN 1423-0275 ; 0301-1569
    ISSN (online) 1423-0275
    ISSN 0301-1569
    DOI 10.1159/000528540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.115: Show issues Location:
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    Zs.MO 257: Show issues

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  9. Article: Filter-type Protection Device Retrieval Interfered by Deployed Stent during Subclavian Artery Stenosis Treatment: Case Report and Complication Avoidance Recommendation.

    Mitsui, Nobuyuki / Kinoshita, Manabu / Nakazawa, Junji / Ozaki, Hirokazu / Kimura, Teruo

    NMC case report journal

    2023  Volume 10, Page(s) 279–283

    Abstract: Endovascular treatment is a standard procedure for subclavian artery stenosis or obstruction. However, great care should be taken to avoid embolic complications to the vertebral artery, and several methods have previously been reported. Hence, as ... ...

    Abstract Endovascular treatment is a standard procedure for subclavian artery stenosis or obstruction. However, great care should be taken to avoid embolic complications to the vertebral artery, and several methods have previously been reported. Hence, as surgical procedures become increasingly complicated, unintended issues may arise during treatment. Here, the authors report a case where the filter-type protection device was caught in the stent because the patient moved during treatment, leading to open surgery to recover the filter-type protection device． A 78-year-old female suffering from a left subclavian steal syndrome underwent stenting due to subclavian artery stenosis. The stenotic lesion was approached via the transfemoral route, and a filter-type protection device was advanced to the vertebral artery via the transbrachial route to prevent embolic complications. As the procedure was performed under local anesthesia, the patient moved during stent deployment proximally to the left vertebral artery origin, and the stent unintentionally advanced distally, covering the vertebral artery and obstructing the retrieval catheter for the filter-type protection device to advance. Failed attempts in recovering the filter-type protection device required open surgery for retrieval. Fortunately, there was no postoperative neurological and radiographic complication, ameliorating her chief complaint． The retriever catheter for the protection device should be advanced beyond the vertebral artery orifice just proximal to the protection device before stenting to avoid such complications while also thoroughly considering the type of anesthesia during treatment．.
    Language English
    Publishing date 2023-10-14
    Publishing country Japan
    Document type Case Reports
    ISSN 2188-4226
    ISSN 2188-4226
    DOI 10.2176/jns-nmc.2023-0146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Risk factors for the lateral cervical lymph node metastasis of papillary thyroid carcinoma: A clinical study.

    Masui, Takashi / Adachi, Shiori / Uemura, Hirokazu / Kimura, Takahiro / Kitahara, Tadashi

    Molecular and clinical oncology

    2023  Volume 18, Issue 4, Page(s) 25

    Abstract: Currently, there is a lack of evidence-based risk factors for the lateral cervical lymph node metastasis of papillary thyroid carcinoma (PTC). Thus, the risk factors and recurrence rate of lateral cervical lymph node metastasis were investigated in the ... ...

    Abstract Currently, there is a lack of evidence-based risk factors for the lateral cervical lymph node metastasis of papillary thyroid carcinoma (PTC). Thus, the risk factors and recurrence rate of lateral cervical lymph node metastasis were investigated in the present study for patients with PTC who underwent initial radical surgery. The data of 274 patients with PTC who underwent initial radical surgery over a 10-year period from January, 2009 to December, 2018 were retrospectively analyzed. By applying univariate analysis, lymphovascular invasion, venous invasion, extrathyroidal infiltration, paratracheal lymph node metastasis and tumor size were designated as significant risk factors for lateral cervical lymph node metastasis. As regards multivariate analysis, paratracheal lymph node metastasis and tumor size were identified as independent risk factors. The recurrence rate was higher in patients presenting with lateral cervical lymph node metastasis, and the disease-free survival rate was significantly lower in the patient group presenting with lateral cervical lymph node metastasis. On the whole, the present study demonstrated that paratracheal lymph node metastasis and tumor size were independent risk factors for lateral cervical lymph node metastasis.
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2796865-0
    ISSN 2049-9469 ; 2049-9450
    ISSN (online) 2049-9469
    ISSN 2049-9450
    DOI 10.3892/mco.2023.2621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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